product summary
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company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
SUCNR1/GPR91 Antibody
catalog :
NBP1-00861
quantity :
0.1 mg (also 0.025 mg)
price :
379 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section
more info or order :
citations: 22
Reference
Moyon A, Garrigue P, Balasse L, Fernandez S, Brige P, Bouhlel A, et al. Succinate Injection Rescues Vasculature and Improves Functional Recovery Following Acute Peripheral Ischemia in Rodents: A Multimodal Imaging Study. Cells. 2021;10: pubmed publisher
Liu P, Wang J, Wen W, Pan T, Chen H, Fu Y, et al. Cinnamaldehyde suppresses NLRP3 derived IL-1β via activating succinate/HIF-1 in rheumatoid arthritis rats. Int Immunopharmacol. 2020;84:106570 pubmed publisher
Shi D, Chen M, Liu L, Wang Q, Liu S, Wang L, et al. Anti-influenza A virus mechanism of three representative compounds from Flos Trollii via TLRs signaling pathways. J Ethnopharmacol. 2020;253:112634 pubmed publisher
Wu J, Huang T, Hsieh Y, Wang Y, Yen C, Lee G, et al. Cancer-Derived Succinate Promotes Macrophage Polarization and Cancer Metastasis via Succinate Receptor. Mol Cell. 2020;77:213-227.e5 pubmed publisher
Feng Z, Yang R, Wu L, Tang S, Wei B, Guo L, et al. Atractylodes macrocephala polysaccharides regulate the innate immunity of colorectal cancer cells by modulating the TLR4 signaling pathway. Onco Targets Ther. 2019;12:7111-7121 pubmed publisher
Wang T, Xu Y, Yuan Y, Xu P, Zhang C, Li F, et al. Succinate induces skeletal muscle fiber remodeling via SUNCR1 signaling. EMBO Rep. 2019;20:e47892 pubmed publisher
Caielli S, Veiga D, Balasubramanian P, Athale S, Domic B, Murat E, et al. A CD4+ T cell population expanded in lupus blood provides B cell help through interleukin-10 and succinate. Nat Med. 2019;25:75-81 pubmed publisher
Zhou S, Qi Q, Wang X, Zhang L, Xu L, Dong L, et al. SjHSP60 induces CD4+ CD25+ Foxp3+ Tregs via TLR4-Mal-drived production of TGF-β in macrophages. Immunol Cell Biol. 2018;96:958-968 pubmed publisher
Peruzzotti Jametti L, Bernstock J, Vicario N, Costa A, Kwok C, Leonardi T, et al. Macrophage-Derived Extracellular Succinate Licenses Neural Stem Cells to Suppress Chronic Neuroinflammation. Cell Stem Cell. 2018;22:355-368.e13 pubmed publisher
Nguyen G, Park S, Le C, Park W, Choi D, Cho E. Metformin ameliorates activation of hepatic stellate cells and hepatic fibrosis by succinate and GPR91 inhibition. Biochem Biophys Res Commun. 2018;495:2649-2656 pubmed publisher
Gao T, Zhang S, Wang J, Liu L, Wang Y, Cao Z, et al. TLR3 contributes to persistent autophagy and heart failure in mice after myocardial infarction. J Cell Mol Med. 2018;22:395-408 pubmed publisher
Popiolek Barczyk K, Piotrowska A, Makuch W, Mika J. Biphalin, a Dimeric Enkephalin, Alleviates LPS-Induced Activation in Rat Primary Microglial Cultures in Opioid Receptor-Dependent and Receptor-Independent Manners. Neural Plast. 2017;2017:3829472 pubmed publisher
Guo Y, Xie C, Li X, Yang J, Yu T, Zhang R, et al. Succinate and its G-protein-coupled receptor stimulates osteoclastogenesis. Nat Commun. 2017;8:15621 pubmed publisher
Kim E, Beon J, Lee S, Park S, Ahn H, Kim M, et al. Inositol polyphosphate multikinase promotes Toll-like receptor-induced inflammation by stabilizing TRAF6. Sci Adv. 2017;3:e1602296 pubmed publisher
Li T, Hu J, Gao F, Du X, Chen Y, Wu Q. Transcription factors regulate GPR91-mediated expression of VEGF in hypoxia-induced retinopathy. Sci Rep. 2017;7:45807 pubmed publisher
Mu X, Zhao T, Xu C, Shi W, Geng B, Shen J, et al. Oncometabolite succinate promotes angiogenesis by upregulating VEGF expression through GPR91-mediated STAT3 and ERK activation. Oncotarget. 2017;8:13174-13185 pubmed publisher
Lan X, Han X, Li Q, Li Q, Gao Y, Cheng T, et al. Pinocembrin protects hemorrhagic brain primarily by inhibiting toll-like receptor 4 and reducing M1 phenotype microglia. Brain Behav Immun. 2017;61:326-339 pubmed publisher
Zhang L, Xiang W, Wang G, Yan Z, Zhu Z, Guo Z, et al. Interferon ? (IFN-?) Production during the Double-stranded RNA (dsRNA) Response in Hepatocytes Involves Coordinated and Feedforward Signaling through Toll-like Receptor 3 (TLR3), RNA-dependent Protein Kinase (PKR), Inducible Nitric Oxide Synthase (iN. J Biol Chem. 2016;291:15093-107 pubmed publisher
Hu Y, Cong X, Chen L, Qi J, Wu X, Zhou M, et al. Synergy of TLR3 and 7 ligands significantly enhances function of DCs to present inactivated PRRSV antigen through TRIF/MyD88-NF-?B signaling pathway. Sci Rep. 2016;6:23977 pubmed publisher
Wang F, Alain T, Szretter K, Stephenson K, Pol J, Atherton M, et al. S6K-STING interaction regulates cytosolic DNA-mediated activation of the transcription factor IRF3. Nat Immunol. 2016;17:514-522 pubmed publisher
Ma B, Yu J, Xie C, Sun L, Lin S, Ding J, et al. Toll-Like Receptors Promote Mitochondrial Translocation of Nuclear Transcription Factor Nuclear Factor of Activated T-Cells in Prolonged Microglial Activation. J Neurosci. 2015;35:10799-814 pubmed publisher
Hu J, Li T, Du S, Chen Y, Wang S, Xiong F, et al. The MAPK signaling pathway mediates the GPR91-dependent release of VEGF from RGC-5 cells. Int J Mol Med. 2015;36:130-8 pubmed publisher
product information
brand :
Novus
master code :
NBP1-00861
SKU :
NBP1-00861
product name :
SUCNR1/GPR91 Antibody
description :
The SUCNR1/GPR91 Antibody from NBP1-00861 is a nbp1-00861 antibody to . This antibody reacts with gpcr. The SUCNR1/GPR91 Antibody has been validated for the following applications: Q9BXA5.
target :
SUCNR1/GPR91
category :
Primary Antibodies
unit sizes :
0.1 mg (also 0.025 mg)
buffer :
PBS
clonality :
Polyclonal
concentration :
1.0 mg/ml
conjugate :
Unconjugated
host :
Rabbit
immunogen :
A synthetic peptide made to an internal portion of the human GPR91 protein (between residues 100-200) [Uniprot: Q9BXA5]
isotype :
IgG
purity :
Immunogen affinity purified
species :
Human, Mouse, Rat
specificity :
GPR91 (A135) detects endogenous levels of GPR91 protein
theoretical molecular weight :
38 kDa
gene symbol :
SUCNR1
accessionNumbers :
Q9BXA5
applications :
Western Blot, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin, In vitro assay
USD :
379 USD
alt names :
GPR91G protein-coupled receptor 91, G-protein coupled receptor 91, P2Y purinoceptor 1, P2Y purinoceptor 1-like, succinate receptor 1
storage :
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
more info or order :
company information
Novus Biologicals
10771 E Easter Ave
Centennial, CO 80112
novus@novusbio.com
https://www.novusbio.com
3037301950
headquarters: USA
Novus Biologicals licenses, manufactures, and markets antibodies to over 20,000 unique targets to support a wide array of research areas. Novus is built on honesty, collaboration and strong relationships and continues to provide quality tools that accelerate research. Every product is backed by our 100% guarantee.