product summary
request information :
company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
Mouse Monoclonal Beclin 1/ATG6 Antibody
catalog :
NBP1-00085R
quantity :
0.1 ml
price :
319.00 USD
clonality :
monoclonal
host :
mouse
conjugate :
DyLight 550
reactivity :
human, mouse, rat, chicken, cow
application :
western blot, immunohistochemistry, immunohistochemistry - paraffin section
more info or order :
Novus Biologicals product webpage
product information
Catalog Number :
NBP1-00085R
Product Name :
Mouse Monoclonal Beclin 1/ATG6 Antibody
List Price :
319.00 USD
Product Type :
Primary Antibodies
Package Size :
0.1 ml
AltNames :
Coiled-coil myosin-like BCL2-interacting protein, GT197, Protein GT197, VPS30, ATG6, ATG6 autophagy related 6 homolog, beclin 1 (coiled-coil, moesin-like BCL2 interacting protein), beclin 1 (coiled-coil, moesin-like BCL2-interacting protein), beclin 1, autophagy related, beclin1, beclin-1
Background :
Beclin 1 is the first identified mammalian gene to mediate autophagy and also has tumor suppressor and antiviral function. Autophagy, a process of bulk protein degradation through an autophagosomic-lysosomal pathway, is important for differentiation, survival during nutrient deprivation, and normal growth control, and is often defective in tumor cells. Beclin 1 was originally isolated in a yeast two hybrid screen to identify Bcl-2-binding partners and maps to a tumor susceptibility locus on human chromosome 17q21 that is frequently monoallelically deleted in human breast, ovarian and prostate cancer. Beclin 1 encodes an evolutionarily conserved 60 kDa coiled coil protein that is expressed in human muscle, epithelial cells and neurons. In gene transfer studies, beclin 1 promotes nutrient deprivation-induced autophagy, inhibits mammary tumorigenesis, and inhibits viral replication. Expression of the Beclin 1 protein is frequently decreased in malignant breast epithelial cells. Based upon these observations, it is speculated that beclin 1 may work through induction of autophagy to negatively regulate tumorigenesis and to control viral infections. Beclin 1 may also play a role in other biological processes in which autophagy is important such as cell differentiation and nutritional stress responses.
Buffer :
50mM sodium borate
Clonality :
Monoclonal
Clone :
4H10
Conjugate :
DyLight 550
Application Summary :
Western Blot, Immunohistochemistry, Immunohistochemistry-Paraffin
Host :
Mouse
Immunogen :
Full length human Beclin 1 protein [Swiss-Prot# Q14457]
Isotype :
IgG1 Kappa
Localization :
Cell Membrane, Cytoplasmic and Golgi Apparatus. Expressed in dendrites and cell bodies of cerebellar Purkinje cells.
Preservative :
No Preservative
Purity :
Protein G purified
CrossReactivity :
Human. 99% sequence identity with monkey, 98% identity with mouse and bovine, 97% identity with porcine, rat and horse, 91% identity with chicken.
Storage :
Store at 4C in the dark.
Swissprot Human :
Q14457
TMW :
52 kDa
Uses :
This Beclin 1 antibody is useful for Immunohistochemistry paraffin embedded sections and Western Blot, where a band is seen ~52 kDa.
Research Area :
Apoptosis, Autophagy, Cancer, Hypoxia, Immunology, Innate Immunity, mTOR Pathway, Tumor Suppressors
more info or order :
Novus Biologicals product webpage
company information
Novus Biologicals
8100 Southpark Way, A-8
Littleton, CO 80120
novus@novusbio.com
www.novusbio.com
3037301950
headquarters: USA
The mission of Novus Biologicals, LLC is to accelerate scientific discovery by developing and marketing unique products in the forefront of science. Novus Biologicals was organized to provide the biological research community with a mechanism for commercializing unique biological materials. We also focus on continually monitoring scientific trends and supply materials to serve these trends. By making these products widely available to institutional and commercial researchers, Novus Biologicals plays an important role in furthering biological research. All of Novus Biologicals products are supplied with detailed technical information and ongoing support. By serving niche and emerging markets, Novus Biologicals has become specialists in markets and has formed and will continue to form ongoing partnerships with our customers.