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- immunohistochemistry - paraffin section; mouse; 1:100; loading ...; fig 4a
| Gorth D, Shapiro I, Risbud M. Transgenic mice overexpressing human TNF-α experience early onset spontaneous intervertebral disc herniation in the absence of overt degeneration. Cell Death Dis. 2018;10:7 pubmed publisher |
- western blot; rat; fig 3a
| Lin Z, Wang S, Chen L, Zhuang J, Ke Q, Xiao D, et al. Methylene Blue Mitigates Acute Neuroinflammation after Spinal Cord Injury through Inhibiting NLRP3 Inflammasome Activation in Microglia. Front Cell Neurosci. 2017;11:391 pubmed publisher |
| Quan J, Gao F, Ma T, Ye W, Gao X, Deng M, et al. Toxoplasma gondii Induces Pyroptosis in Human Placental Trophoblast and Amniotic Cells by Inducing ROS Production and Activation of Cathepsin B and NLRP1/NLRP3/NLRC4/AIM2 Inflammasome. Am J Pathol. 2023;193:2047-2065 pubmed publisher |
| Lan T, Zeng Q, Zhu Y, Zheng G, Chen K, Jiang W, et al. Xin-Li formula attenuates heart failure induced by a combination of hyperlipidemia and myocardial infarction in rats via Treg immunomodulation and NLRP3 inflammasome inhibition. J Tradit Complement Med. 2023;13:441-453 pubmed publisher |
| Yu W, Jiang W, Wu W, Wang G, Zhao D, Yan C, et al. Combining idebenone and rosuvastatin prevents atherosclerosis by suppressing oxidative stress and NLRP3 inflammasome activation. Eur J Pharmacol. 2023;955:175911 pubmed publisher |
| Zhang T, Zhang Y, Li S, Ge H, Song Q, Zhang Y, et al. Gentianella acuta-derived Gen-miR-1 suppresses myocardial fibrosis by targeting HAX1/HMG20A/Smads axis to attenuate inflammation in cardiac fibroblasts. Phytomedicine. 2023;118:154923 pubmed publisher |
| Oh D, Na H, Jhun J, Lee J, Um I, Lee S, et al. Bifidobacterium longum BORI inhibits pain behavior and chondrocyte death, and attenuates osteoarthritis progression. PLoS ONE. 2023;18:e0286456 pubmed publisher |
| Eid S, Noureldein M, Kim B, Hinder L, Mendelson F, Hayes J, et al. Single-cell RNA-seq uncovers novel metabolic functions of Schwann cells beyond myelination. J Neurochem. 2023;166:367-388 pubmed publisher |
| Yiu S, Zerbe C, Vanderwall D, Huttlin E, Weekes M, Gewurz B. An Epstein-Barr virus protein interaction map reveals NLRP3 inflammasome evasion via MAVS UFMylation. Mol Cell. 2023;83:2367-2386.e15 pubmed publisher |
| Li J, Wu C, Hu H, Qin G, Wu X, Bai F, et al. Remodeling of the immune and stromal cell compartment by PD-1 blockade in mismatch repair-deficient colorectal cancer. Cancer Cell. 2023;41:1152-1169.e7 pubmed publisher |
| Min H, Na H, Jhun J, Lee S, Choi S, Park G, et al. Identification of gut dysbiosis in axial spondyloarthritis patients and improvement of experimental ankylosing spondyloarthritis by microbiome-derived butyrate with immune-modulating function. Front Immunol. 2023;14:1096565 pubmed publisher |
| Yoon S, Hong H, Lim H, Choi J, Choi Y, Seo S, et al. A novel IRAK4/PIM1 inhibitor ameliorates rheumatoid arthritis and lymphoid malignancy by blocking the TLR/MYD88-mediated NF-κB pathway. Acta Pharm Sin B. 2023;13:1093-1109 pubmed publisher |
| de Dios C, Abadin X, Roca Agujetas V, Jimenez Martinez M, Morales A, Trullas R, et al. Inflammasome activation under high cholesterol load triggers a protective microglial phenotype while promoting neuronal pyroptosis. Transl Neurodegener. 2023;12:10 pubmed publisher |
| Ouhaddi Y, Charbonnier B, Porge J, Zhang Y, Garcia I, Gbureck U, et al. Development of Neovasculature in Axially Vascularized Calcium Phosphate Cement Scaffolds. J Funct Biomater. 2023;14: pubmed publisher |
| Ibrahim T, Wu P, Wang L, Fang Mei C, Murillo J, Merlo J, et al. Sex-dependent Differences in the Genomic Profile of Lingual Sensory Neurons in Naïve and Tongue-Tumor Bearing Mice. bioRxiv. 2023;: pubmed publisher |
| Gao P, Wu B, Ding Y, Yin B, Gu H. circEXOC5 promotes acute lung injury through the PTBP1/Skp2/Runx2 axis to activate autophagy. Life Sci Alliance. 2023;6: pubmed publisher |
| Liu X, Bae C, Liu B, Zhang Y, Zhou X, Zhang D, et al. Development of opioid-induced hyperalgesia depends on reactive astrocytes controlled by Wnt5a signaling. Mol Psychiatry. 2023;28:767-779 pubmed publisher |
| Park J, Yang S, Jeong H, Lee S, Ryu J, Choi J, et al. EC-18 prevents autoimmune arthritis by suppressing inflammatory cytokines and osteoclastogenesis. Arthritis Res Ther. 2022;24:254 pubmed publisher |
| Lee W, Rho J, Yang Y, Lee S, Kweon S, Kim H, et al. Hyaluronic Acid Nanoparticles as a Topical Agent for Treating Psoriasis. ACS Nano. 2022;16:20057-20074 pubmed publisher |
| Keitelman I, Shiromizu C, Zgajnar N, Danieli xe1 n S, Jancic C, Mart xed M, et al. The interplay between serine proteases and caspase-1 regulates the autophagy-mediated secretion of Interleukin-1 beta in human neutrophils. Front Immunol. 2022;13:832306 pubmed publisher |
| Khan A, Singh R, Bhattacharya A, Kumar S, Ghosh A, Nag D, et al. Glucogallin Attenuates RAW 264.7 Cells from Arsenic Trioxide Induced Toxicity via the NF-ҡB/NLRP3 Pathway. Molecules. 2022;27: pubmed publisher |
| Na H, Woo J, Kim J, Lee J, Um I, Cho K, et al. Coenzyme Q10 encapsulated in micelles ameliorates osteoarthritis by inhibiting inflammatory cell death. PLoS ONE. 2022;17:e0270351 pubmed publisher |
| Ellegast J, Alexe G, Hamze A, Lin S, Uckelmann H, Rauch P, et al. Unleashing Cell-Intrinsic Inflammation as a Strategy to Kill AML Blasts. Cancer Discov. 2022;12:1760-1781 pubmed publisher |
| Marconi G, Della Rocca Y, Fonticoli L, Guarnieri S, Carradori S, Rajan T, et al. The Beneficial Effect of Carvacrol in HL-1 Cardiomyocytes Treated with LPS-G: Anti-Inflammatory Pathway Investigations. Antioxidants (Basel). 2022;11: pubmed publisher |
| Park J, Lee D, Yang S, Jeong H, Na H, Cho K, et al. Methotrexate-loaded nanoparticles ameliorate experimental model of autoimmune arthritis by regulating the balance of interleukin-17-producing T cells and regulatory T cells. J Transl Med. 2022;20:85 pubmed publisher |
| Liu X, Bae C, Gelman B, Chung J, Tang S. A neuron-to-astrocyte Wnt5a signal governs astrogliosis during HIV-associated pain pathogenesis. Brain. 2022;145:4108-4123 pubmed publisher |
| Zhou T, He C, Lai P, Yang Z, Liu Y, Xu H, et al. miR-204-containing exosomes ameliorate GVHD-associated dry eye disease. Sci Adv. 2022;8:eabj9617 pubmed publisher |
| Ashraf Uz Zaman M, Ji G, Tidwell D, Yin L, Thakolwiboon S, Pan J, et al. Evaluation of Urea-Based Inhibitors of the Dopamine Transporter Using the Experimental Autoimmune Encephalomyelitis Model of Multiple Sclerosis. ACS Chem Neurosci. 2022;13:217-228 pubmed publisher |
| Penolazzi L, Bergamin L, Lambertini E, Poma V, Sarti A, De Bonis P, et al. The P2X7 purinergic receptor in intervertebral disc degeneration. J Cell Physiol. 2022;237:1418-1428 pubmed publisher |
| Wang J, Xing Y, Li M, Zhang Z, Jin H, Ma J, et al. Panaxadiol inhibits IL-1β secretion by suppressing zinc finger protein 91-regulated activation of non-canonical caspase-8 inflammasome and MAPKs in macrophages. J Ethnopharmacol. 2022;283:114715 pubmed publisher |
| Boss M, Ke Y, Bian L, Harrison L, Lee B, Prebble A, et al. Therapeutic Intervention Using a Smad7-Based Tat Protein to Treat Radiation-Induced Oral Mucositis. Int J Radiat Oncol Biol Phys. 2022;112:759-770 pubmed publisher |
| Liu X, Liu B, Yang Q, Zhou X, Tang S. Microglial ablation does not affect opioid-induced hyperalgesia in rodents. Pain. 2022;163:508-517 pubmed publisher |
| Wang G, Yin W, Shin H, Tian Q, Lu W, Hou S. Neuronal accumulation of peroxidated lipids promotes demyelination and neurodegeneration through the activation of the microglial NLRP3 inflammasome. Nat Aging. 2021;1:1024-1037 pubmed publisher |
| Xing Y, Wang J, Li M, Zhang Z, Jin H, Zuo H, et al. Convallatoxin inhibits IL-1β production by suppressing zinc finger protein 91-mediated pro-IL-1β ubiquitination and caspase-8 inflammasome activity. Br J Pharmacol. 2021;: pubmed publisher |
| Ollewagen T, Powrie Y, Myburgh K, Smith C. Unresolved intramuscular inflammation, not diminished skeletal muscle regenerative capacity, is at the root of rheumatoid cachexia: insights from a rat CIA model. Physiol Rep. 2021;9:e15119 pubmed publisher |
| Liu Y, Peng L, Li L, Huang C, Shi K, Meng X, et al. 3D-bioprinted BMSC-laden biomimetic multiphasic scaffolds for efficient repair of osteochondral defects in an osteoarthritic rat model. Biomaterials. 2021;279:121216 pubmed publisher |
| Chhabra G, Singh C, Guzmán Pérez G, Ndiaye M, Iczkowski K, Ahmad N. Antimelanoma Effects of Concomitant Inhibition of SIRT1 and SIRT3 in BrafV600E/PtenNULL Mice. J Invest Dermatol. 2021;: pubmed publisher |
| Novais E, Tran V, Johnston S, Darris K, Roupas A, Sessions G, et al. Long-term treatment with senolytic drugs Dasatinib and Quercetin ameliorates age-dependent intervertebral disc degeneration in mice. Nat Commun. 2021;12:5213 pubmed publisher |
| Ramachandran A, Kumar B, Waris G, Everly D. Deubiquitination and Activation of the NLRP3 Inflammasome by UCHL5 in HCV-Infected Cells. Microbiol Spectr. 2021;9:e0075521 pubmed publisher |
| Ma X, Qiang P, Chen G, Wang Z, Wang X, Xu Q. Huoxue Jiedu Huayu Formula Alleviates Cell Pyroptosis in Contralateral Kidneys of 6-Month-Old UUO Rats through the NLRP3/Caspase-1/IL-1β Pathway. Evid Based Complement Alternat Med. 2021;2021:5533911 pubmed publisher |
| Kuang H, Wang T, Liu L, Tang C, Li T, Liu M, et al. Treatment of early brain injury after subarachnoid hemorrhage in the rat model by inhibiting p53-induced ferroptosis. Neurosci Lett. 2021;762:136134 pubmed publisher |
| Velásquez Torres M, Shibayama Salas M, Pacheco Yepez J, Silva Olivares A, Sánchez Monroy V, Marchat L, et al. (-)-Epicatechin protects from amebic liver abscess development in hamster. Exp Parasitol. 2021;224:108103 pubmed publisher |
| Fidler T, Xue C, Yalcınkaya M, Hardaway B, Abramowicz S, Xiao T, et al. The AIM2 inflammasome exacerbates atherosclerosis in clonal haematopoiesis. Nature. 2021;592:296-301 pubmed publisher |
| Liu F, Liu T, Sun M, Zhou J, Xue F, Chen S, et al. Maxing Shigan Decoction Mitigates Mycoplasma pneumonia-Induced Pyroptosis in A549 Cells via the NLRP3 Inflammasome. Infect Drug Resist. 2021;14:859-867 pubmed publisher |
| Park W, Han J. Gryllus bimaculatus extract protects against lipopolysaccharide and palmitate-induced production of proinflammatory cytokines and inflammasome formation. Mol Med Rep. 2021;23:1 pubmed publisher |
| Lliberós C, Liew S, Zareie P, La Gruta N, Mansell A, Hutt K. Evaluation of inflammation and follicle depletion during ovarian ageing in mice. Sci Rep. 2021;11:278 pubmed publisher |
| Qin Y, Wang C, Xu S, Wu C, Wang S, Pan D, et al. G protein-coupled receptor 30 activation protects hepatic ischemia-reperfusion injury of liver tissue through inhibiting NLRP3 in the rat model. J Histotechnol. 2021;44:27-36 pubmed publisher |
| Jiang W, Geng H, Lv X, Ma J, Liu F, Lin P, et al. Idebenone Protects against Atherosclerosis in Apolipoprotein E-Deficient Mice Via Activation of the SIRT3-SOD2-mtROS Pathway. Cardiovasc Drugs Ther. 2021;35:1129-1145 pubmed publisher |
| Ménard C, Wilson A, Dejda A, Miloudi K, Binet F, Crespo Garcia S, et al. miR-106b suppresses pathological retinal angiogenesis. Aging (Albany NY). 2020;12:24836-24852 pubmed publisher |
| Yang B, Maddison L, Zaborska K, Dai C, Yin L, Tang Z, et al. RIPK3-mediated inflammation is a conserved β cell response to ER stress. Sci Adv. 2020;6: pubmed publisher |
| Silva G, Gierman L, Rakner J, Stødle G, Mundal S, Thaning A, et al. Cholesterol Crystals and NLRP3 Mediated Inflammation in the Uterine Wall Decidua in Normal and Preeclamptic Pregnancies. Front Immunol. 2020;11:564712 pubmed publisher |
| Capaci V, Bascetta L, Fantuz M, Beznoussenko G, Sommaggio R, Cancila V, et al. Mutant p53 induces Golgi tubulo-vesiculation driving a prometastatic secretome. Nat Commun. 2020;11:3945 pubmed publisher |
| Xiong Z, Ding J, Zhou J, Yao S, Zheng J, Guo X. Correlation between the HIF-1α/Notch signaling pathway and Modic changes in nucleus pulposus cells isolated from patients with low back pain. BMC Musculoskelet Disord. 2020;21:500 pubmed publisher |
| Baek H, Min H, Hong V, Kwon T, Park J, Lee J, et al. Anti-Inflammatory Effects of the Novel PIM Kinase Inhibitor KMU-470 in RAW 264.7 Cells through the TLR4-NF-κB-NLRP3 Pathway. Int J Mol Sci. 2020;21: pubmed publisher |
| Wang Y, Ji N, Gong X, Ni S, Xu L, Zhang H. Thioredoxin-1 attenuates atherosclerosis development through inhibiting NLRP3 inflammasome. Endocrine. 2020;70:65-70 pubmed publisher |
| Zhang Z, Zhang S, Chen H, Mao Y, Li Z, Kong C, et al. The up-regulation of NDRG1 by HIF counteracts the cancer-promoting effect of HIF in VHL-deficient clear cell renal cell carcinoma. Cell Prolif. 2020;53:e12853 pubmed publisher |
| Zong S, Tang Y, Li W, Han S, Shi Q, Ruan X, et al. A Chinese Herbal Formula Suppresses Colorectal Cancer Migration and Vasculogenic Mimicry Through ROS/HIF-1α/MMP2 Pathway in Hypoxic Microenvironment. Front Pharmacol. 2020;11:705 pubmed publisher |
| Ho J, Balukoff N, Theodoridis P, Wang M, Krieger J, Schatz J, et al. A network of RNA-binding proteins controls translation efficiency to activate anaerobic metabolism. Nat Commun. 2020;11:2677 pubmed publisher |
| Ménégaut L, Thomas C, Jalil A, Julla J, Magnani C, Ceroi A, et al. Interplay between Liver X Receptor and Hypoxia Inducible Factor 1α Potentiates Interleukin-1β Production in Human Macrophages. Cell Rep. 2020;31:107665 pubmed publisher |
| Chen Y, Sheu J, Sun C, Huang T, Lin Y, Yip H. MicroRNA-214 modulates the senescence of vascular smooth muscle cells in carotid artery stenosis. Mol Med. 2020;26:46 pubmed publisher |
| Gangwar A, Paul S, Ahmad Y, Bhargava K. Intermittent hypoxia modulates redox homeostasis, lipid metabolism associated inflammatory processes and redox post-translational modifications: Benefits at high altitude. Sci Rep. 2020;10:7899 pubmed publisher |
| Yu S, Li Q, Yu Y, Cui Y, Li W, Liu T, et al. Activated HIF1α of tumor cells promotes chemoresistance development via recruiting GDF15-producing tumor-associated macrophages in gastric cancer. Cancer Immunol Immunother. 2020;: pubmed publisher |
| Tang G, Chen Y, Chen J, Chen Z, Jiang W. Deferoxamine Ameliorates Compressed Spinal Cord Injury by Promoting Neovascularization in Rats. J Mol Neurosci. 2020;70:1437-1444 pubmed publisher |
| Davis J, Bopp A, Henwood M, Baine R, Cox C, Grau J. Pharmacological Transection of Brain-Spinal Cord Communication Blocks Pain-Induced Hemorrhage and Locomotor Deficits after Spinal Cord Injury in Rats. J Neurotrauma. 2020;37:1729-1739 pubmed publisher |
| Shuck S, Nguyen C, Chan Y, O CONNOR T, Ciminera A, Kahn M, et al. Metal-Assisted Protein Quantitation (MAPq): Multiplex Analysis of Protein Expression Using Lanthanide-Modified Antibodies with Detection by Inductively Coupled Plasma Mass Spectrometry. Anal Chem. 2020;92:7556-7564 pubmed publisher |
| Zhang W, Yu L, Han X, Pan J, Deng J, Zhu L, et al. The secretome of human dental pulp stem cells protects myoblasts from hypoxia‑induced injury via the Wnt/β‑catenin pathway. Int J Mol Med. 2020;45:1501-1513 pubmed publisher |
| Weng M, Chen W, Chen X, Lu H, Sun Z, Yu Q, et al. Fasting inhibits aerobic glycolysis and proliferation in colorectal cancer via the Fdft1-mediated AKT/mTOR/HIF1α pathway suppression. Nat Commun. 2020;11:1869 pubmed publisher |
| Imanishi M, Yamakawa Y, Fukushima K, Ikuto R, Maegawa A, Izawa Ishizawa Y, et al. Fibroblast-specific ERK5 deficiency changes tumor vasculature and exacerbates tumor progression in a mouse model. Naunyn Schmiedebergs Arch Pharmacol. 2020;393:1239-1250 pubmed publisher |
| Qiao S, Koh S, Vivekanandan V, Salunke D, Patra K, Zaganjor E, et al. REDD1 loss reprograms lipid metabolism to drive progression of RAS mutant tumors. Genes Dev. 2020;34:751-766 pubmed publisher |
| Wang C, Luo J, Chen Z, Ye M, Hong Y, Liu J, et al. MiR-375 Impairs the Invasive Capabilities of Hepatoma Cells by Targeting HIF1α Under Hypoxia. Dig Dis Sci. 2020;: pubmed publisher |
| Okada K, Mori D, Makii Y, Nakamoto H, Murahashi Y, Yano F, et al. Hypoxia-inducible factor-1 alpha maintains mouse articular cartilage through suppression of NF-κB signaling. Sci Rep. 2020;10:5425 pubmed publisher |
| Tang S, Liu D, Li Y, Wang K, Wang X, Su Z, et al. Caspr1 Facilitates sAPPα Production by Regulating α-Secretase ADAM9 in Brain Endothelial Cells. Front Mol Neurosci. 2020;13:23 pubmed publisher |
| Chen L, Wang Z, Xu Q, Liu Y, Chen L, Guo S, et al. The failure of DAC to induce OCT2 expression and its remission by hemoglobin-based nanocarriers under hypoxia in renal cell carcinoma. Theranostics. 2020;10:3562-3578 pubmed publisher |
| Sharma A, Kilari S, Cai C, Simeon M, Misra S. Increased fibrotic signaling in a murine model for intra-arterial contrast-induced acute kidney injury. Am J Physiol Renal Physiol. 2020;318:F1210-F1219 pubmed publisher |
| Pei X, Kim H, Lee M, Wang N, Shin J, Lee S, et al. Local delivery of cardiac stem cells overexpressing HIF-1α promotes angiogenesis and muscular tissue repair in a hind limb ischemia model. J Control Release. 2020;322:610-621 pubmed publisher |
| Renema P, Hardy K, Housley N, Dunbar G, Annamdevula N, Britain A, et al. cAMP signaling primes lung endothelial cells to activate caspase-1 during Pseudomonas aeruginosa infection. Am J Physiol Lung Cell Mol Physiol. 2020;318:L1074-L1083 pubmed publisher |
| Barbosa D, Fahlbusch P, Herzfeld de Wiza D, Jacob S, Kettel U, Al Hasani H, et al. Rhein, a novel Histone Deacetylase (HDAC) inhibitor with antifibrotic potency in human myocardial fibrosis. Sci Rep. 2020;10:4888 pubmed publisher |
| Dong Z, Li R, Xu L, Xin K, Xu Y, Shi H, et al. Histone hyperacetylation mediates enhanced IL-1β production in LPS/IFN-γ-stimulated macrophages. Immunology. 2020;160:183-197 pubmed publisher |
| Li J, Zhou W, Chen W, Wang H, Zhang Y, Yu T. Mechanism of the hypoxia inducible factor 1/hypoxic response element pathway in rat myocardial ischemia/diazoxide post‑conditioning. Mol Med Rep. 2020;21:1527-1536 pubmed publisher |
| Singh A, Wilson J, Schofield C, Chen R. Hypoxia-inducible factor (HIF) prolyl hydroxylase inhibitors induce autophagy and have a protective effect in an in-vitro ischaemia model. Sci Rep. 2020;10:1597 pubmed publisher |
| Rajendran G, Schonfeld M, Tiwari R, Huang S, Torosyan R, Fields T, et al. Inhibition of Endothelial PHD2 Suppresses Post-Ischemic Kidney Inflammation through Hypoxia-Inducible Factor-1. J Am Soc Nephrol. 2020;31:501-516 pubmed publisher |
| Karshovska E, Wei Y, Subramanian P, Mohibullah R, Geisler C, Baatsch I, et al. HIF-1α (Hypoxia-Inducible Factor-1α) Promotes Macrophage Necroptosis by Regulating miR-210 and miR-383. Arterioscler Thromb Vasc Biol. 2020;40:583-596 pubmed publisher |
| Su C, Hsu T, Hsiao C, Chiu C, Tzang B. Effects of antibodies against human parvovirus B19 on angiogenic signaling. Mol Med Rep. 2020;21:1320-1327 pubmed publisher |
| Roudkenar M, Fukumoto M, Roushandeh A, Kuwahra Y, Uroshihara Y, Harada H, et al. Disturbance in the regulation of miR 17-92 cluster on HIF-1-α expression contributes to clinically relevant radioresistant cells: an in vitro study. Cytotechnology. 2020;72:141-153 pubmed publisher |
| Torigoe K, Obata Y, Torigoe M, Oka S, Yamamoto K, Koji T, et al. Hexapeptide derived from prothymosin alpha attenuates cisplatin-induced acute kidney injury. Clin Exp Nephrol. 2020;: pubmed publisher |
| Pezzuto A, Perrone G, Orlando N, Citarella F, Ciccozzi M, Scarlata S, et al. A close relationship between HIF-1α expression and bone metastases in advanced NSCLC, a retrospective analysis. Oncotarget. 2019;10:7071-7079 pubmed publisher |
| Yoo H, Park S, Nam M, Kang J, Kim K, Yeo J, et al. A Variant of SLC1A5 Is a Mitochondrial Glutamine Transporter for Metabolic Reprogramming in Cancer Cells. Cell Metab. 2019;: pubmed publisher |
| Aguanno S, Petrelli C, Di Siena S, De Angelis L, Pellegrini M, Naro F. A Three-Dimensional Culture Model of Reversibly Quiescent Myogenic Cells. Stem Cells Int. 2019;2019:7548160 pubmed publisher |
| Li S, Lin Q, Shao X, Zhu X, Wu J, Wu B, et al. Drp1-regulated PARK2-dependent mitophagy protects against renal fibrosis in unilateral ureteral obstruction. Free Radic Biol Med. 2019;: pubmed publisher |
| Schaschkow A, Sigrist S, Mura C, Barthes J, Vrana N, Czuba E, et al. Glycaemic control in diabetic rats treated with islet transplantation using plasma combined with hydroxypropylmethyl cellulose hydrogel. Acta Biomater. 2020;102:259-272 pubmed publisher |
| Madsen P, Desu H, de Rivero Vaccari J, Florimon Y, Ellman D, Keane R, et al. Oligodendrocytes modulate the immune-inflammatory response in EAE via TNFR2 signaling. Brain Behav Immun. 2020;84:132-146 pubmed publisher |
| Ghezzi C, Wong A, Chen B, Ribalet B, Damoiseaux R, Clark P. A high-throughput screen identifies that CDK7 activates glucose consumption in lung cancer cells. Nat Commun. 2019;10:5444 pubmed publisher |
| Bommi P, Chand V, Mukhopadhyay N, Raychaudhuri P, Bagchi S. NER-factor DDB2 regulates HIF1α and hypoxia-response genes in HNSCC. Oncogene. 2020;39:1784-1796 pubmed publisher |
| Kang Y, Eo J, Bulutoglu B, Yarmush M, Usta O. Progressive hypoxia-on-a-chip: An in vitro oxygen gradient model for capturing the effects of hypoxia on primary hepatocytes in health and disease. Biotechnol Bioeng. 2020;117:763-775 pubmed publisher |
| Wu J, Huang T, Hsieh Y, Wang Y, Yen C, Lee G, et al. Cancer-Derived Succinate Promotes Macrophage Polarization and Cancer Metastasis via Succinate Receptor. Mol Cell. 2020;77:213-227.e5 pubmed publisher |
| Courtney K, Ma Y, Diaz de Leon A, Christie A, Xie Z, Woolford L, et al. HIF-2 Complex Dissociation, Target Inhibition, and Acquired Resistance with PT2385, a First-in-Class HIF-2 Inhibitor, in Patients with Clear Cell Renal Cell Carcinoma. Clin Cancer Res. 2020;26:793-803 pubmed publisher |
| Romeo Guitart D, Leiva Rodríguez T, Forés J, Casas C. Improved Motor Nerve Regeneration by SIRT1/Hif1a-Mediated Autophagy. Cells. 2019;8: pubmed publisher |
| Zhang D, Tang Z, Huang H, Zhou G, Cui C, Weng Y, et al. Metabolic regulation of gene expression by histone lactylation. Nature. 2019;574:575-580 pubmed publisher |
| Terabe K, Ohashi Y, Tsuchiya S, Ishizuka S, Knudson C, Knudson W. Chondroprotective effects of 4-methylumbelliferone and hyaluronan synthase-2 overexpression involve changes in chondrocyte energy metabolism. J Biol Chem. 2019;294:17799-17817 pubmed publisher |
| Ji Cho M, Yoon S, Kim W, Park J, Lee J, Park J, et al. Oxidative stress-mediated TXNIP loss causes RPE dysfunction. Exp Mol Med. 2019;51:1-13 pubmed publisher |
| Xu Y, Xu Y, Zhu Y, Sun H, Juguilon C, Li F, et al. Macrophage miR-34a Is a Key Regulator of Cholesterol Efflux and Atherosclerosis. Mol Ther. 2020;28:202-216 pubmed publisher |
| Han S, Huang T, Hou F, Yao L, Wang X, Wu X. The prognostic value of hypoxia-inducible factor-1α in advanced cancer survivors: a meta-analysis with trial sequential analysis. Ther Adv Med Oncol. 2019;11:1758835919875851 pubmed publisher |
| Allon I, Vered M, Kaplan I, Nahlieli O, Yahalom R, Shalmon B, et al. Rare variants of head and neck squamous cell carcinoma -differential immunohistochemical profiles. Acta Histochem. 2019;121:151444 pubmed publisher |
| Kim S, Jo C, Kim G. Effects of empagliflozin on nondiabetic salt-sensitive hypertension in uninephrectomized rats. Hypertens Res. 2019;42:1905-1915 pubmed publisher |
| Ben Aicha S, Escate R, Casani L, Padro T, Pena E, Arderiu G, et al. High-density lipoprotein remodelled in hypercholesterolaemic blood induce epigenetically driven down-regulation of endothelial HIF-1α expression in a preclinical animal model. Cardiovasc Res. 2020;116:1288-1299 pubmed publisher |
| David B, Curtin J, Goldberg D, Scorpio K, Kandaswamy V, Hill C. Hypoxia-Inducible Factor 1α (HIF-1α) Counteracts the Acute Death of Cells Transplanted into the Injured Spinal Cord. Eneuro. 2020;7: pubmed publisher |
| Soyal S, Bonova P, Kwik M, Zara G, Auer S, Scharler C, et al. The Expression of CNS-Specific PPARGC1A Transcripts Is Regulated by Hypoxia and a Variable GT Repeat Polymorphism. Mol Neurobiol. 2019;: pubmed publisher |
| Robinson C, Poon B, Kano Y, Pluthero F, Kahr W, Ohh M. A Hypoxia-Inducible HIF1-GAL3ST1-Sulfatide Axis Enhances ccRCC Immune Evasion via Increased Tumor Cell-Platelet Binding. Mol Cancer Res. 2019;17:2306-2317 pubmed publisher |
| Bacci L, Aiello A, Ripoli C, Loria R, Pugliese D, Pierconti F, et al. H19-Dependent Transcriptional Regulation of β3 and β4 Integrins Upon Estrogen and Hypoxia Favors Metastatic Potential in Prostate Cancer. Int J Mol Sci. 2019;20: pubmed publisher |
| Wang Y, Wang B, Qi X, Zhang X, Ren K. Resveratrol Protects Against Post-Contrast Acute Kidney Injury in Rabbits With Diabetic Nephropathy. Front Pharmacol. 2019;10:833 pubmed publisher |
| Lambert W, Carlson B, Ghose P, Vest V, Yao V, Calkins D. Towards A Microbead Occlusion Model of Glaucoma for a Non-Human Primate. Sci Rep. 2019;9:11572 pubmed publisher |
| Imanishi T, Akeda K, Murata K, Sudo A. Effect of diminished flow in rabbit lumbar arteries on intervertebral disc matrix changes using MRI T2-mapping and histology. BMC Musculoskelet Disord. 2019;20:347 pubmed publisher |
| Qi D, Wei M, Jiao S, Song Y, Wang X, Xie G, et al. Hypoxia inducible factor 1α in vascular smooth muscle cells promotes angiotensin II-induced vascular remodeling via activation of CCL7-mediated macrophage recruitment. Cell Death Dis. 2019;10:544 pubmed publisher |
| Wang Y, Zhang X, Hua Z, Xie L, Jiang X, Wang R, et al. Blood Oxygen Level-Dependent Imaging and Intravoxel Incoherent Motion MRI of Early Contrast-Induced Acute Kidney Injury in a Rabbit Model. Kidney Blood Press Res. 2019;44:496-512 pubmed publisher |
| Montemurro C, Nomoto H, Pei L, Parekh V, Vongbunyong K, Vadrevu S, et al. IAPP toxicity activates HIF1α/PFKFB3 signaling delaying β-cell loss at the expense of β-cell function. Nat Commun. 2019;10:2679 pubmed publisher |
| Ock S, Park S, Lee J, Kim J. RANKL blockade suppresses pathological angiogenesis and vascular leakage in ischemic retinopathy. Biochem Biophys Res Commun. 2019;: pubmed publisher |
| Hu M, Chen X, Ma L, Ma Y, Li Y, Song H, et al. AMPK Inhibition Suppresses the Malignant Phenotype of Pancreatic Cancer Cells in Part by Attenuating Aerobic Glycolysis. J Cancer. 2019;10:1870-1878 pubmed publisher |
| Maugeri G, D Amico A, Federico C, Saccone S, Giunta S, Cavallaro S, et al. Involvement of A3 Adenosine Receptor in Neuroblastoma Progression via Modulation of the Hypoxic/Angiogenic Pathway. J Mol Neurosci. 2019;: pubmed publisher |
| Zheng S, Yan C, Duan N, Wang W, Mei X. Penehyclidine hydrochloride suppressed peripheral nerve injury-induced neuropathic pain by inhibiting microglial MAPK/p-p38/IL-1β pathway activation. Mol Pain. 2019;15:1744806919858260 pubmed publisher |
| Xian Y, Chen Z, Deng H, Cai M, Liang H, Xu W, et al. Exenatide mitigates inflammation and hypoxia along with improved angiogenesis in obese fat tissue. J Endocrinol. 2019;: pubmed publisher |
| Singh S, Mishra M, Singh R. Hypoxia-inducible factor-1α induces CX3CR1 expression and promotes the epithelial to mesenchymal transition (EMT) in ovarian cancer cells. J Ovarian Res. 2019;12:42 pubmed publisher |
| Wang Z, Ren K. Evaluation of iodine contrast-induced acute kidney injury via different injection routes using BOLD-MRI. Ren Fail. 2019;41:341-353 pubmed publisher |
| Fujimoto T, Colbert L, Huang Y, Molkentine J, Deorukhkar A, Baseler L, et al. Selective EGLN Inhibition Enables Ablative Radiotherapy and Improves Survival in Unresectable Pancreatic Cancer. Cancer Res. 2019;79:2327-2338 pubmed publisher |
| Tavares Pereira M, Gram A, Nowaczyk R, Boos A, Hoffmann B, Janowski T, et al. Prostaglandin-mediated effects in early canine corpus luteum: In vivo effects on vascular and immune factors. Reprod Biol. 2019;19:100-111 pubmed publisher |
| Cheng C, Chi P, Shen M, Shu C, Wann S, Liu C, et al. Caffeic Acid Phenethyl Ester Rescues Pulmonary Arterial Hypertension through the Inhibition of AKT/ERK-Dependent PDGF/HIF-1α In Vitro and In Vivo. Int J Mol Sci. 2019;20: pubmed publisher |
| Cai C, Yang B, Kilari S, Li Y, Zhao C, Sharma A, et al. Evaluation of Venous Stenosis Angioplasty in a Murine Arteriovenous Fistula Model. J Vasc Interv Radiol. 2019;: pubmed publisher |
| Kaiko G, Chen F, Lai C, Chiang I, Perrigoue J, Stojmirović A, et al. PAI-1 augments mucosal damage in colitis. Sci Transl Med. 2019;11: pubmed publisher |
| Novais E, Diekman B, Shapiro I, Risbud M. p16Ink4a deletion in cells of the intervertebral disc affects their matrix homeostasis and senescence associated secretory phenotype without altering onset of senescence. Matrix Biol. 2019;: pubmed publisher |
| Kengelbach Weigand A, Lotz L, Schmid R, Lang W, Beckmann M, Hoffmann I, et al. Intra- and Postoperative Blood Flow Monitoring in a Sheep Model of Uterus Transplantation. In Vivo. 2019;33:325-336 pubmed publisher |
| Ma X, Chang Y, Xiong Y, Wang Z, Wang X, Xu Q. Eplerenone Ameliorates Cell Pyroptosis in Contralateral Kidneys of Rats with Unilateral Ureteral Obstruction. Nephron. 2019;:1-10 pubmed publisher |
| Zhang F, Li R, Yang Y, Shi C, Shen Y, Lu C, et al. Specific Decrease in B-Cell-Derived Extracellular Vesicles Enhances Post-Chemotherapeutic CD8+ T Cell Responses. Immunity. 2019;50:738-750.e7 pubmed publisher |
| Hong B, Zhou J, Ma K, Zhang J, Xie H, Zhang K, et al. TRIB3 Promotes the Proliferation and Invasion of Renal Cell Carcinoma Cells via Activating MAPK Signaling Pathway. Int J Biol Sci. 2019;15:587-597 pubmed publisher |
| Li H, Zhou Y, Li L, Li S, Long D, Chen X, et al. HIF-1α protects against oxidative stress by directly targeting mitochondria. Redox Biol. 2019;:101109 pubmed publisher |
| Williams P, Braine C, Kizhatil K, Foxworth N, Tolman N, Harder J, et al. Inhibition of monocyte-like cell extravasation protects from neurodegeneration in DBA/2J glaucoma. Mol Neurodegener. 2019;14:6 pubmed publisher |
| Guo L, Fernandez R, Sakamoto A, Cornelissen A, Paek K, Lee P, et al. Vascular Permeability Assay in Human Coronary and Mouse Brachiocephalic Arteries. Bio Protoc. 2018;8: pubmed publisher |
| Laurent V, Toulet A, Attane C, Milhas D, Dauvillier S, Zaidi F, et al. Periprostatic Adipose Tissue Favors Prostate Cancer Cell Invasion in an Obesity-Dependent Manner: Role of Oxidative Stress. Mol Cancer Res. 2019;17:821-835 pubmed publisher |
| Kouvaras E, Christoni Z, Siasios I, Malizos K, Koukoulis G, Ioannou M. Hypoxia-inducible factor 1-alpha and vascular endothelial growth factor in cartilage tumors. Biotech Histochem. 2019;94:283-289 pubmed publisher |
| Liu Z, Zheng Z, Qi J, Wang J, Zhou Q, Hu F, et al. CD24 identifies nucleus pulposus progenitors/notochordal cells for disc regeneration. J Biol Eng. 2018;12:35 pubmed publisher |
| Römmelt C, Munsch T, Drynda A, Lessmann V, Lohmann C, Bertrand J. Periprosthetic hypoxia as consequence of TRPM7 mediated cobalt influx in osteoblasts. J Biomed Mater Res B Appl Biomater. 2019;107:1806-1813 pubmed publisher |
| Seira N, Yamagata K, Fukushima K, Araki Y, Kurata N, Yanagisawa N, et al. Cellular density-dependent increases in HIF-1α compete with c-Myc to down-regulate human EP4 receptor promoter activity through Sp-1-binding region. Pharmacol Res Perspect. 2018;6:e00441 pubmed publisher |
| Hughes A, Dhoot G. Dysregulated cancer cell transdifferentiation into erythrocytes is an additional metabolic stress in hepatocellular carcinoma. Tumour Biol. 2018;40:1010428318811467 pubmed publisher |
| Yan Y, Chen H, Zhang H, Guo C, Yang K, Chen K, et al. Vascularized 3D printed scaffolds for promoting bone regeneration. Biomaterials. 2018;190-191:97-110 pubmed publisher |
| Schunke K, Walton C, Veal D, Mafnas C, Anderson C, Williams A, et al. Protein kinase C binding protein 1 inhibits hypoxia-inducible factor-1 in the heart. Cardiovasc Res. 2019;115:1332-1342 pubmed publisher |
| Lee M, Wang C, Jin S, Labrecque M, Beischlag T, Brockman M, et al. Expression of human inducible nitric oxide synthase in response to cytokines is regulated by hypoxia-inducible factor-1. Free Radic Biol Med. 2019;130:278-287 pubmed publisher |
| Sheng W, Mao H, Wang C, Yang N, Zhang Z, Han J. Dehydrocostus Lactone Enhances Chemotherapeutic Potential of Doxorubicin in Lung Cancer by Inducing Cell Death and Limiting Metastasis. Med Sci Monit. 2018;24:7850-7861 pubmed publisher |
| Leppänen J, Helminen O, Huhta H, Kauppila J, Isohookana J, Haapasaari K, et al. Toll-like receptors 2, 4 and 9 and hypoxia markers HIF-1alpha and CAIX in pancreatic intraepithelial neoplasia. APMIS. 2018;126:852-863 pubmed publisher |
| Kim J, Wang S, Lee C, Sung S, Shin Y, Song K, et al. Blood-Stage Plasmodium Berghei ANKA Infection Promotes Hepatic Fibrosis by Enhancing Hedgehog Signaling in Mice. Cell Physiol Biochem. 2018;50:1414-1428 pubmed publisher |
| Gallo S, Arcidiacono M, Tisato V, Piva R, Penolazzi L, Bosi C, et al. Upregulation of the alternative splicing factor NOVA2 in colorectal cancer vasculature. Onco Targets Ther. 2018;11:6049-6056 pubmed publisher |
| Wang J, Wang Z, Li M, Zhang Z, Mi C, Zuo H, et al. Dictamnine promotes apoptosis and inhibits epithelial-mesenchymal transition, migration, invasion and proliferation by downregulating the HIF-1α and Slug signaling pathways. Chem Biol Interact. 2018;296:134-144 pubmed publisher |
| Lanigan S, Corcoran A, Wall A, Mukandala G, O Connor J. Acute hypoxic exposure and prolyl-hydroxylase inhibition improves synaptic transmission recovery time from a subsequent hypoxic insult in rat hippocampus. Brain Res. 2018;1701:212-218 pubmed publisher |
| Drareni K, Ballaire R, Barilla S, Mathew M, Toubal A, Fan R, et al. GPS2 Deficiency Triggers Maladaptive White Adipose Tissue Expansion in Obesity via HIF1A Activation. Cell Rep. 2018;24:2957-2971.e6 pubmed publisher |
| Mi C, Wang Z, Li M, Zhang Z, Ma J, Jin X. Zinc finger protein 91 positively regulates the production of IL-1β in macrophages by activation of MAPKs and non-canonical caspase-8 inflammasome. Br J Pharmacol. 2018;175:4338-4352 pubmed publisher |
| Jacobo Estrada T, Cárdenas González M, Santoyo Sánchez M, Thevenod F, Barbier O. Intrauterine Exposure to Cadmium Reduces HIF-1 DNA-Binding Ability in Rat Fetal Kidneys. Toxics. 2018;6: pubmed publisher |
| Tatlı Doğan H, Kıran M, Bilgin B, Kilicarslan A, Sendur M, Yalcin B, et al. Prognostic significance of the programmed death ligand 1 expression in clear cell renal cell carcinoma and correlation with the tumor microenvironment and hypoxia-inducible factor expression. Diagn Pathol. 2018;13:60 pubmed publisher |
| Hayashi Y, Zhang Y, Yokota A, Yan X, Liu J, Choi K, et al. Pathobiological Pseudohypoxia as a Putative Mechanism Underlying Myelodysplastic Syndromes. Cancer Discov. 2018;8:1438-1457 pubmed publisher |
| Xing Y, Mi C, Wang Z, Zhang Z, Li M, Zuo H, et al. Fraxinellone has anticancer activity in vivo by inhibiting programmed cell death-ligand 1 expression by reducing hypoxia-inducible factor-1α and STAT3. Pharmacol Res. 2018;135:166-180 pubmed publisher |
| Cheon S, Kim J, Kim E, Kim S, Kam E, Ho C, et al. Intranuclear delivery of synthetic nuclear factor-kappa B p65 reduces inflammasomes after surgery. Biochem Pharmacol. 2018;158:141-152 pubmed publisher |
| Lopez Pascual A, Lorente Cebrián S, Moreno Aliaga M, Martinez J, Gonzalez Muniesa P. Inflammation stimulates hypoxia-inducible factor-1α regulatory activity in 3T3-L1 adipocytes with conditioned medium from lipopolysaccharide-activated RAW 264.7 macrophages. J Cell Physiol. 2018;234:550-560 pubmed publisher |
| Lange C, Lehnert P, Boneva S, Zhang P, Ludwig F, Boeker M, et al. Increased expression of hypoxia-inducible factor-1 alpha and its impact on transcriptional changes and prognosis in malignant tumours of the ocular adnexa. Eye (Lond). 2018;32:1772-1782 pubmed publisher |
| Ha S, Solomon O, Akbari M, Sener A, Kim S. Histone deacetylase 8 protects human proximal tubular epithelial cells from hypoxia-mimetic cobalt- and hypoxia/reoxygenation-induced mitochondrial fission and cytotoxicity. Sci Rep. 2018;8:11332 pubmed publisher |
| Liu Y, Ran H, Xiao Y, Wang H, Chen Y, Chen W, et al. Knockdown of HIF-1α impairs post-ischemic vascular reconstruction in the brain via deficient homing and sprouting bmEPCs. Brain Pathol. 2018;28:860-874 pubmed publisher |
| Xu T, Zhao H, Qiao Z, He B, Shen X. Combined use of external therapeutic ultrasound and tirofiban has synergistic therapeutic effects on no-reflow after myocardial reperfusion. Echocardiography. 2018;35:1671-1679 pubmed publisher |
| Leppänen J, Helminen O, Huhta H, Kauppila J, Isohookana J, Haapasaari K, et al. Weak HIF-1alpha expression indicates poor prognosis in resectable pancreatic ductal adenocarcinoma. World J Surg Oncol. 2018;16:127 pubmed publisher |
| Rizou M, Frangou E, Marineli F, Prakoura N, Zoidakis J, Gakiopoulou H, et al. The family of 14-3-3 proteins and specifically 14-3-3σ are up-regulated during the development of renal pathologies. J Cell Mol Med. 2018;22:4139-4149 pubmed publisher |
| Pooja -, Ghosh D, Bhargava K, Sethy N. Post-translational modifications of eNOS augment nitric oxide availability and facilitates hypoxia adaptation in Ladakhi women. Nitric Oxide. 2018;78:103-112 pubmed publisher |
| Bajpai G, Schneider C, Wong N, Bredemeyer A, Hulsmans M, Nahrendorf M, et al. The human heart contains distinct macrophage subsets with divergent origins and functions. Nat Med. 2018;24:1234-1245 pubmed publisher |
| Lee D, Alhallak K, Jenkins S, Vargas I, Greene N, Quinn K, et al. A Radiosensitizing Inhibitor of HIF-1 alters the Optical Redox State of Human Lung Cancer Cells In Vitro. Sci Rep. 2018;8:8815 pubmed publisher |
| Zhang F, Zhong R, Qi H, Li S, Cheng C, Liu X, et al. Impacts of Acute Hypoxia on Alzheimer's Disease-Like Pathologies in APPswe/PS1dE9 Mice and Their Wild Type Littermates. Front Neurosci. 2018;12:314 pubmed publisher |
| Krishnamachary B, Danhier P, Kakkad S, Bharti S, Bhujwalla Z. Hypoxia-Induced Reporter Genes with Different Half-Lives. Methods Mol Biol. 2018;1790:113-125 pubmed publisher |
| Waltz P, Kautza B, Luciano J, Dyer M, Stolz D, Loughran P, et al. Heme Oxygenase-2 Localizes to Mitochondria and Regulates Hypoxic Responses in Hepatocytes. Oxid Med Cell Longev. 2018;2018:2021645 pubmed publisher |
| Hassan A, Arnold B, Caine S, Toosi B, Verge V, Muir G. Acute intermittent hypoxia and rehabilitative training following cervical spinal injury alters neuronal hypoxia- and plasticity-associated protein expression. PLoS ONE. 2018;13:e0197486 pubmed publisher |
| Li X, Cui X, Chen Y, Wu T, Xu H, Yin H, et al. Therapeutic Potential of a Prolyl Hydroxylase Inhibitor FG-4592 for Parkinson's Diseases in Vitro and in Vivo: Regulation of Redox Biology and Mitochondrial Function. Front Aging Neurosci. 2018;10:121 pubmed publisher |
| Abu Remaileh M, Khalaileh A, Pikarsky E, Aqeilan R. WWOX controls hepatic HIF1α to suppress hepatocyte proliferation and neoplasia. Cell Death Dis. 2018;9:511 pubmed publisher |
| Maugeri G, D Amico A, Rasà D, Saccone S, Federico C, Cavallaro S, et al. PACAP and VIP regulate hypoxia-inducible factors in neuroblastoma cells exposed to hypoxia. Neuropeptides. 2018;69:84-91 pubmed publisher |
| Stødle G, Silva G, Tangerås L, Gierman L, Nervik I, Dahlberg U, et al. Placental inflammation in pre-eclampsia by Nod-like receptor protein (NLRP)3 inflammasome activation in trophoblasts. Clin Exp Immunol. 2018;193:84-94 pubmed publisher |
| Wendeln A, Degenhardt K, Kaurani L, Gertig M, Ulas T, Jain G, et al. Innate immune memory in the brain shapes neurological disease hallmarks. Nature. 2018;556:332-338 pubmed publisher |
| Zhang D, Wu M, Cai Z, Liao N, Ke K, Liu H, et al. Chemotherapeutic Drug Based Metal-Organic Particles for Microvesicle-Mediated Deep Penetration and Programmable pH/NIR/Hypoxia Activated Cancer Photochemotherapy. Adv Sci (Weinh). 2018;5:1700648 pubmed publisher |
| Koeppen M, Lee J, Seo S, Brodsky K, Kreth S, Yang I, et al. Hypoxia-inducible factor 2-alpha-dependent induction of amphiregulin dampens myocardial ischemia-reperfusion injury. Nat Commun. 2018;9:816 pubmed publisher |
| Lin Z, Liu F, Shi P, Song A, Huang Z, Zou D, et al. Fatty acid oxidation promotes reprogramming by enhancing oxidative phosphorylation and inhibiting protein kinase C. Stem Cell Res Ther. 2018;9:47 pubmed publisher |
| Li Z, Ding Q, Ling L, Wu Y, Meng D, Li X, et al. Metformin attenuates motility, contraction, and fibrogenic response of hepatic stellate cells in vivo and in vitro by activating AMP-activated protein kinase. World J Gastroenterol. 2018;24:819-832 pubmed publisher |
| Guo L, Akahori H, Harari E, Smith S, Polavarapu R, Karmali V, et al. CD163+ macrophages promote angiogenesis and vascular permeability accompanied by inflammation in atherosclerosis. J Clin Invest. 2018;128:1106-1124 pubmed publisher |
| Li L, Liang Y, Kang L, Liu Y, Gao S, Chen S, et al. Transcriptional Regulation of the Warburg Effect in Cancer by SIX1. Cancer Cell. 2018;33:368-385.e7 pubmed publisher |
| Deng Q, Chang Y, Cheng X, Luo X, Zhang J, Tang X. Postconditioning with repeated mild hypoxia protects neonatal hypoxia-ischemic rats against brain damage and promotes rehabilitation of brain function. Brain Res Bull. 2018;139:31-37 pubmed publisher |
| De Smet S, D Hulst G, Poffé C, Van Thienen R, Berardi E, Hespel P. High-intensity interval training in hypoxia does not affect muscle HIF responses to acute hypoxia in humans. Eur J Appl Physiol. 2018;118:847-862 pubmed publisher |
| Chen Y, Gao S, Yan Y, Qian J, Chen H. Aerosolized deferoxamine administration in mouse model of bronchopulmonary dysplasia improve pulmonary development. Am J Transl Res. 2018;10:325-332 pubmed |
| Varela Guruceaga M, Milagro F, Martinez J, de Miguel C. Effect of hypoxia on caveolae-related protein expression and insulin signaling in adipocytes. Mol Cell Endocrinol. 2018;473:257-267 pubmed publisher |
| Wang C, Wang Q, Gao W, Zhang Z, Lou Y, Jin H, et al. Highly efficient local delivery of endothelial progenitor cells significantly potentiates angiogenesis and full-thickness wound healing. Acta Biomater. 2018;69:156-169 pubmed publisher |
| Gagner J, Lechpammer M, Zagzag D. Induction and Assessment of Hypoxia in Glioblastoma Cells In Vitro. Methods Mol Biol. 2018;1741:111-123 pubmed publisher |
| Liu Y, Tan X, Liu W, Chen X, Hou X, Shen D, et al. Follistatin-like protein 1 plays a tumor suppressor role in clear-cell renal cell carcinoma. Chin J Cancer. 2018;37:2 pubmed publisher |
| Oe Y, Ko M, Fushima T, Sato E, Karumanchi S, Sato H, et al. Hepatic dysfunction and thrombocytopenia induced by excess sFlt1 in mice lacking endothelial nitric oxide synthase. Sci Rep. 2018;8:102 pubmed publisher |
| Olivares González L, Martinez Fernandez de la Camara C, Hervás D, Millan J, Rodrigo R. HIF-1? stabilization reduces retinal degeneration in a mouse model of retinitis pigmentosa. FASEB J. 2018;: pubmed publisher |
| Ullah K, Rosendahl A, Izzi V, Bergmann U, Pihlajaniemi T, Maki J, et al. Hypoxia-inducible factor prolyl-4-hydroxylase-1 is a convergent point in the reciprocal negative regulation of NF-κB and p53 signaling pathways. Sci Rep. 2017;7:17220 pubmed publisher |
| Wang J, Xu C, Zheng Q, Yang K, Lai N, Wang T, et al. Orai1, 2, 3 and STIM1 promote store-operated calcium entry in pulmonary arterial smooth muscle cells. Cell Death Discov. 2017;3:17074 pubmed publisher |
| Cheng R, Liu W, Zhang R, Feng Y, Bhowmick N, Hu T. Porphyromonas gingivalis-Derived Lipopolysaccharide Combines Hypoxia to Induce Caspase-1 Activation in Periodontitis. Front Cell Infect Microbiol. 2017;7:474 pubmed publisher |
| Carew J, Espitia C, Zhao W, Mita M, Mita A, Nawrocki S. Oncolytic reovirus inhibits angiogenesis through induction of CXCL10/IP-10 and abrogation of HIF activity in soft tissue sarcomas. Oncotarget. 2017;8:86769-86783 pubmed publisher |
| Zheng H, Wang L, Sun B, Li Y, Yang J, Wu C. Oligomer procyanidins (F2) repress HIF-1? expression in human U87 glioma cells by inhibiting the EGFR/ AKT/mTOR and MAPK/ERK1/2 signaling pathways in vitro and in vivo. Oncotarget. 2017;8:85252-85262 pubmed publisher |
| Chen R, Zhu S, Fan X, Wang H, Lotze M, Zeh H, et al. HMGB1 Controls Liver Cancer Initiation through YAP-dependent Aerobic Glycolysis. Hepatology. 2017;: pubmed publisher |
| Masuelli L, Granato M, Benvenuto M, Mattera R, Bernardini R, Mattei M, et al. Chloroquine supplementation increases the cytotoxic effect of curcumin against Her2/neu overexpressing breast cancer cells in vitro and in vivo in nude mice while counteracts it in immune competent mice. Oncoimmunology. 2017;6:e1356151 pubmed publisher |
| Caggiano R, Cattaneo F, Moltedo O, Esposito G, Perrino C, Trimarco B, et al. miR-128 Is Implicated in Stress Responses by Targeting MAFG in Skeletal Muscle Cells. Oxid Med Cell Longev. 2017;2017:9308310 pubmed publisher |
| Gonçalves A, Adlesic M, Brandt S, Hejhal T, Harlander S, Sommer L, et al. Evidence of renal angiomyolipoma neoplastic stem cells arising from renal epithelial cells. Nat Commun. 2017;8:1466 pubmed publisher |
| Komiya H, Shimizu K, Noma N, Tsuboi Y, Honda K, Kanno K, et al. Role of Neuron-Glial Interaction Mediated by IL-1? in Ectopic Tooth Pain. J Dent Res. 2017;:22034517741253 pubmed publisher |
| Suh J, Lai L, Nam D, Kim J, Jo J, Taffet G, et al. Steroid receptor coactivator-2 (SRC-2) coordinates cardiomyocyte paracrine signaling to promote pressure overload-induced angiogenesis. J Biol Chem. 2017;292:21643-21652 pubmed publisher |
| Chen X, Han Y, Zhang B, Liu Y, Wang S, Liao T, et al. Caffeic acid phenethyl ester promotes haematopoietic stem/progenitor cell homing and engraftment. Stem Cell Res Ther. 2017;8:255 pubmed publisher |
| Kang H, Yang K, Xiao L, Guo L, Guo C, Yan Y, et al. Osteoblast Hypoxia-Inducible Factor-1? Pathway Activation Restrains Osteoclastogenesis via the Interleukin-33-MicroRNA-34a-Notch1 Pathway. Front Immunol. 2017;8:1312 pubmed publisher |
| Schafer C, Mohan A, Burford W, Driscoll M, Ludlow A, Wright W, et al. Differential KrasV12 protein levels control a switch regulating lung cancer cell morphology and motility. Converg Sci Phys Oncol. 2016;2:035004 pubmed publisher |
| Zhu W, Krishna S, García C, Lin C, Mitchell B, Scott K, et al. Daam2 driven degradation of VHL promotes gliomagenesis. elife. 2017;6: pubmed publisher |
| Xie C, Yagai T, Luo Y, Liang X, Chen T, Wang Q, et al. Activation of intestinal hypoxia-inducible factor 2α during obesity contributes to hepatic steatosis. Nat Med. 2017;23:1298-1308 pubmed publisher |
| Butt N, Kumar A, Dhar S, Rimando A, Akhtar I, Hancock J, et al. Targeting MTA1/HIF-1? signaling by pterostilbene in combination with histone deacetylase inhibitor attenuates prostate cancer progression. Cancer Med. 2017;6:2673-2685 pubmed publisher |
| Xu F, Wang X, Wu N, He S, Yi W, Xiang S, et al. Bisphenol A induces proliferative effects on both breast cancer cells and vascular endothelial cells through a shared GPER-dependent pathway in hypoxia. Environ Pollut. 2017;231:1609-1620 pubmed publisher |
| Fujii T, Nagamatsu T, Morita K, Schust D, Iriyama T, Komatsu A, et al. Enhanced HIF2α expression during human trophoblast differentiation into syncytiotrophoblast suppresses transcription of placental growth factor. Sci Rep. 2017;7:12455 pubmed publisher |
| Ariazi J, Duffy K, Adams D, Fitch D, Luo L, Pappalardi M, et al. Discovery and Preclinical Characterization of GSK1278863 (Daprodustat), a Small Molecule Hypoxia Inducible Factor-Prolyl Hydroxylase Inhibitor for Anemia. J Pharmacol Exp Ther. 2017;363:336-347 pubmed publisher |
| Du H, Jiang L, Geng W, Li J, Zhang R, Dang J, et al. Evaluation of xenogeneic extracellular matrix fabricated from CuCl2-conditioned mesenchymal stem cell sheets as a bioactive wound dressing material. J Biomater Appl. 2017;32:472-483 pubmed publisher |
| Wang H, Li W, Xu J, Zhang T, Zuo D, Zhou Z, et al. NDRG1 inhibition sensitizes osteosarcoma cells to combretastatin A-4 through targeting autophagy. Cell Death Dis. 2017;8:e3048 pubmed publisher |
| Yamaleyeva L, Sun Y, Bledsoe T, Hoke A, Gurley S, Brosnihan K. Photoacoustic imaging for in vivo quantification of placental oxygenation in mice. FASEB J. 2017;31:5520-5529 pubmed publisher |
| Mishra J, Das J, Kumar N. Janus kinase 3 regulates adherens junctions and epithelial mesenchymal transition through ?-catenin. J Biol Chem. 2017;292:16406-16419 pubmed publisher |
| Lee K, Lee S, Lee H, Choi G, Jung Y, Kim D, et al. Amyloid β1-42 (Aβ1-42) Induces the CDK2-Mediated Phosphorylation of Tau through the Activation of the mTORC1 Signaling Pathway While Promoting Neuronal Cell Death. Front Mol Neurosci. 2017;10:229 pubmed publisher |
| Gu J, Li Y, Zeng J, Wang B, Ji K, Tang Y, et al. Knockdown of HIF-1α by siRNA-expressing plasmid delivered by attenuated Salmonella enhances the antitumor effects of cisplatin on prostate cancer. Sci Rep. 2017;7:7546 pubmed publisher |
| Xu T, Stewart K, Wang X, Liu K, Xie M, Kyu Ryu J, et al. Metabolic control of TH17 and induced Treg cell balance by an epigenetic mechanism. Nature. 2017;548:228-233 pubmed publisher |
| Shimauchi T, Numaga Tomita T, Ito T, Nishimura A, Matsukane R, Oda S, et al. TRPC3-Nox2 complex mediates doxorubicin-induced myocardial atrophy. JCI Insight. 2017;2: pubmed publisher |
| Parra V, Bravo Sagua R, Norambuena Soto I, Hernández Fuentes C, Gómez Contreras A, Verdejo H, et al. Inhibition of mitochondrial fission prevents hypoxia-induced metabolic shift and cellular proliferation of pulmonary arterial smooth muscle cells. Biochim Biophys Acta Mol Basis Dis. 2017;1863:2891-2903 pubmed publisher |
| Lee H, Jung Y, Choi G, Ko S, Lee S, Lee S, et al. BNIP3 induction by hypoxia stimulates FASN-dependent free fatty acid production enhancing therapeutic potential of umbilical cord blood-derived human mesenchymal stem cells. Redox Biol. 2017;13:426-443 pubmed publisher |
| Maugeri G, D Amico A, Rasà D, La Cognata V, Saccone S, Federico C, et al. Nicotine promotes blood retinal barrier damage in a model of human diabetic macular edema. Toxicol In Vitro. 2017;44:182-189 pubmed publisher |
| Shih J, Chiang W, Wu A, Wu M, Wang L, Yu Y, et al. Long noncoding RNA LncHIFCAR/MIR31HG is a HIF-1α co-activator driving oral cancer progression. Nat Commun. 2017;8:15874 pubmed publisher |
| Alhallak K, Jenkins S, Lee D, Greene N, Quinn K, Griffin R, et al. Optical imaging of radiation-induced metabolic changes in radiation-sensitive and resistant cancer cells. J Biomed Opt. 2017;22:60502 pubmed publisher |
| Fukushima S, Endo M, Matsumoto Y, Fukushi J, Matsunobu T, Kawaguchi K, et al. Hypoxia-inducible factor 1 alpha is a poor prognostic factor and potential therapeutic target in malignant peripheral nerve sheath tumor. PLoS ONE. 2017;12:e0178064 pubmed publisher |
| Harlander S, Schönenberger D, Toussaint N, Prummer M, Catalano A, Brandt L, et al. Combined mutation in Vhl, Trp53 and Rb1 causes clear cell renal cell carcinoma in mice. Nat Med. 2017;23:869-877 pubmed publisher |
| Wu X, Qian C, Zhou Y, Yan Y, Luo Q, Yung W, et al. Bi-directionally protective communication between neurons and astrocytes under ischemia. Redox Biol. 2017;13:20-31 pubmed publisher |
| Li W, Chen C, Zhao X, Ye H, Zhao Y, Fu Z, et al. HIF-2? regulates non-canonical glutamine metabolism via activation of PI3K/mTORC2 pathway in human pancreatic ductal adenocarcinoma. J Cell Mol Med. 2017;21:2896-2908 pubmed publisher |
| Das B, Rajagopalan S, Joshi G, Xu L, Luo D, Andersen J, et al. A novel iron (II) preferring dopamine agonist chelator D-607 significantly suppresses ?-syn- and MPTP-induced toxicities in vivo. Neuropharmacology. 2017;123:88-99 pubmed publisher |
| Judge J, Lacy S, Ku W, Owens K, Hernady E, Thatcher T, et al. The Lactate Dehydrogenase Inhibitor Gossypol Inhibits Radiation-Induced Pulmonary Fibrosis. Radiat Res. 2017;188:35-43 pubmed publisher |
| Yamazaki R, Kasuya Y, Fujita T, Umezawa H, Yanagihara M, Nakamura H, et al. Antifibrotic effects of cyclosporine A on TGF-?1-treated lung fibroblasts and lungs from bleomycin-treated mice: role of hypoxia-inducible factor-1?. FASEB J. 2017;31:3359-3371 pubmed publisher |
| Robb K, Cotechini T, Allaire C, Sperou A, Graham C. Inflammation-induced fetal growth restriction in rats is associated with increased placental HIF-1α accumulation. PLoS ONE. 2017;12:e0175805 pubmed publisher |
| Song Y, Zheng S, Wang J, Long H, Fang L, Wang G, et al. Hypoxia-induced PLOD2 promotes proliferation, migration and invasion via PI3K/Akt signaling in glioma. Oncotarget. 2017;8:41947-41962 pubmed publisher |
| An Y, Sun K, Joffin N, Zhang F, Deng Y, Donze O, et al. Angiopoietin-2 in white adipose tissue improves metabolic homeostasis through enhanced angiogenesis. elife. 2017;6: pubmed publisher |
| Mi C, Ma J, Wang K, Zuo H, Wang Z, Li M, et al. Imperatorin suppresses proliferation and angiogenesis of human colon cancer cell by targeting HIF-1? via the mTOR/p70S6K/4E-BP1 and MAPK pathways. J Ethnopharmacol. 2017;203:27-38 pubmed publisher |
| Chung C, Lin M, Lee I, Lee T, Lee M, Yang J. Brain-Derived Neurotrophic Factor Loaded PS80 PBCA Nanocarrier for In Vitro Neural Differentiation of Mouse Induced Pluripotent Stem Cells. Int J Mol Sci. 2017;18: pubmed publisher |
| Li H, Zhou L, Dai J. Retinoic acid receptor-related orphan receptor RORα regulates differentiation and survival of keratinocytes during hypoxia. J Cell Physiol. 2018;233:641-650 pubmed publisher |
| Ponente M, Campanini L, Cuttano R, Piunti A, Delledonne G, Coltella N, et al. PML promotes metastasis of triple-negative breast cancer through transcriptional regulation of HIF1A target genes. JCI Insight. 2017;2:e87380 pubmed publisher |
| Yang X, Yang S, Wang C, Kuang S. The hypoxia-inducible factors HIF1α and HIF2α are dispensable for embryonic muscle development but essential for postnatal muscle regeneration. J Biol Chem. 2017;292:5981-5991 pubmed publisher |
| Feng Q, Zhang C, Lum D, Druso J, Blank B, Wilson K, et al. A class of extracellular vesicles from breast cancer cells activates VEGF receptors and tumour angiogenesis. Nat Commun. 2017;8:14450 pubmed publisher |
| Jeong Y, Jung J, Cho Y, Park S, Oh H, Kang S. Correlation of hypoxia inducible transcription factor in breast cancer and SUVmax of F-18 FDG PET/CT. Nucl Med Rev Cent East Eur. 2017;20:32-38 pubmed publisher |
| Takahara Y, Tokunou T, Kojima H, Hirooka Y, Ichiki T. Deletion of hypoxia-inducible factor-1? in myeloid lineage exaggerates angiotensin II-induced formation of abdominal aortic aneurysm. Clin Sci (Lond). 2017;131:609-620 pubmed publisher |
| Fraga A, Ribeiro R, Coelho A, Vizcaíno J, Coutinho H, Lopes J, et al. Genetic polymorphisms in key hypoxia-regulated downstream molecules and phenotypic correlation in prostate cancer. BMC Urol. 2017;17:12 pubmed publisher |
| Qing L, Lei P, Liu H, Xie J, Wang L, Wen T, et al. Expression of hypoxia-inducible factor-1? in synovial fluid and articular cartilage is associated with disease severity in knee osteoarthritis. Exp Ther Med. 2017;13:63-68 pubmed publisher |
| Revenco T, Lapouge G, Moers V, Brohée S, Sotiropoulou P. Low Dose Radiation Causes Skin Cancer in Mice and Has a Differential Effect on Distinct Epidermal Stem Cells. Stem Cells. 2017;35:1355-1364 pubmed publisher |
| Ridiandries A, Bursill C, Tan J. Broad-Spectrum Inhibition of the CC-Chemokine Class Improves Wound Healing and Wound Angiogenesis. Int J Mol Sci. 2017;18: pubmed publisher |
| Ridiandries A, Tan J, Ravindran D, Williams H, Medbury H, Lindsay L, et al. CC-chemokine class inhibition attenuates pathological angiogenesis while preserving physiological angiogenesis. FASEB J. 2017;31:1179-1192 pubmed publisher |
| Przygodda F, Manfredi L, Machado J, Gonçalves D, Zanon N, Bonagamba L, et al. Acute intermittent hypoxia in rats activates muscle proteolytic pathways through a gluccorticoid-dependent mechanism. J Appl Physiol (1985). 2017;122:1114-1124 pubmed publisher |
| Li F, Li Z, Jiang Z, Tian Y, Wang Z, Yi W, et al. Enhancement of early cardiac differentiation of dedifferentiated fat cells by dimethyloxalylglycine via notch signaling pathway. Am J Transl Res. 2016;8:4791-4801 pubmed |
| Fujino M, Aishima S, Shindo K, Oda Y, Morimatsu K, Tsutsumi K, et al. Expression of glucose transporter-1 is correlated with hypoxia-inducible factor 1? and malignant potential in pancreatic neuroendocrine tumors. Oncol Lett. 2016;12:3337-3343 pubmed |
| Sobhan P, Zhai Q, Green L, Hansford L, Funa K. ASK1 regulates the survival of neuroblastoma cells by interacting with TLX and stabilizing HIF-1?. Cell Signal. 2017;30:104-117 pubmed publisher |
| Serrano Oviedo L, Giménez Bachs J, Nam Cha S, Cimas F, GarcÃa Cano J, Sánchez Prieto R, et al. Implication of VHL, ERK5, and HIF-1alpha in clear cell renal cell carcinoma: Molecular basis. Urol Oncol. 2017;35:114.e15-114.e22 pubmed publisher |
| Heikal L, Ghezzi P, Mengozzi M, Stelmaszczuk B, Feelisch M, Ferns G. Erythropoietin and a nonerythropoietic peptide analog promote aortic endothelial cell repair under hypoxic conditions: role of nitric oxide. Hypoxia (Auckl). 2016;4:121-133 pubmed |
| Zhang Y, Li F, Guo Y, Jiang L, Ma J, Ke Y, et al. (Z)-ligustilide increases ferroportin1 expression and ferritin content in ischemic SH-SY5Y cells. Eur J Pharmacol. 2016;792:48-53 pubmed publisher |
| Ke S, Chen S, Dong Z, Hong C, Zhang Q, Tang L, et al. Erythrocytosis in hepatocellular carcinoma portends poor prognosis by respiratory dysfunction secondary to mitochondrial DNA mutations. Hepatology. 2017;65:134-151 pubmed publisher |
| Soncini M, Corna G, Moresco M, Coltella N, Restuccia U, Maggioni D, et al. 24-Hydroxycholesterol participates in pancreatic neuroendocrine tumor development. Proc Natl Acad Sci U S A. 2016;113:E6219-E6227 pubmed |
| Choi Y, Maki T, Mandeville E, Koh S, Hayakawa K, Arai K, et al. Dual effects of carbon monoxide on pericytes and neurogenesis in traumatic brain injury. Nat Med. 2016;22:1335-1341 pubmed publisher |
| Maugeri G, D Amico A, Saccone S, Federico C, Cavallaro S, D Agata V. PACAP and VIP Inhibit HIF-1?-Mediated VEGF Expression in a Model of Diabetic Macular Edema. J Cell Physiol. 2017;232:1209-1215 pubmed publisher |
| Miyake T, Nakamura S, Zhao M, So K, Inoue K, Numata T, et al. Cold sensitivity of TRPA1 is unveiled by the prolyl hydroxylation blockade-induced sensitization to ROS. Nat Commun. 2016;7:12840 pubmed publisher |
| Cho W, Shin S, Kim S, Hong C, Choi C, Park W, et al. Immunomodulatory effect of captopril and local irradiation on myeloid-derived suppressor cells. Radiat Oncol J. 2016;34:223-229 pubmed |
| Wang X, Yang H, Yanagisawa D, Bellier J, Morino K, Zhao S, et al. Mitochondrial ferritin affects mitochondria by stabilizing HIF-1α in retinal pigment epithelium: implications for the pathophysiology of age-related macular degeneration. Neurobiol Aging. 2016;47:168-179 pubmed publisher |
| Chen W, Hill H, Christie A, Kim M, Holloman E, Pavía Jiménez A, et al. Targeting renal cell carcinoma with a HIF-2 antagonist. Nature. 2016;539:112-117 pubmed publisher |
| Yaghi L, Poras I, Simões R, Donadi E, Tost J, Daunay A, et al. Hypoxia inducible factor-1 mediates the expression of the immune checkpoint HLA-G in glioma cells through hypoxia response element located in exon 2. Oncotarget. 2016;7:63690-63707 pubmed publisher |
| Budda S, Girton A, Henderson J, Zenewicz L. Transcription Factor HIF-1? Controls Expression of the Cytokine IL-22 in CD4 T Cells. J Immunol. 2016;197:2646-52 pubmed publisher |
| Lizama Manibusan B, Klein S, McKenzie J, Cliffel D, McLaughlin B. Analysis of a Nitroreductase-Based Hypoxia Sensor in Primary Neuronal Cultures. ACS Chem Neurosci. 2016;7:1188-91 pubmed publisher |
| Nagamine Y, Tojo K, Yazawa T, Takaki S, Baba Y, Goto T, et al. Inhibition of Prolyl Hydroxylase Attenuates Fas Ligand-Induced Apoptosis and Lung Injury in Mice. Am J Respir Cell Mol Biol. 2016;55:878-888 pubmed |
| Littlewood Evans A, Sarret S, Apfel V, Loesle P, Dawson J, Zhang J, et al. GPR91 senses extracellular succinate released from inflammatory macrophages and exacerbates rheumatoid arthritis. J Exp Med. 2016;213:1655-62 pubmed publisher |
| Zhang Q, Doucet M, Tomlinson R, Han X, Quarles L, Collins M, et al. The hypoxia-inducible factor-1α activates ectopic production of fibroblast growth factor 23 in tumor-induced osteomalacia. Bone Res. 2016;4:16011 pubmed publisher |
| Cui J, Duan B, Zhao X, Chen Y, Sun S, Deng W, et al. MBD3 mediates epigenetic regulation on EPAS1 promoter in cancer. Tumour Biol. 2016;37:13455-13467 pubmed |
| Ahlstrand T, Tuominen H, Beklen A, Torittu A, Oscarsson J, Sormunen R, et al. A novel intrinsically disordered outer membrane lipoprotein of Aggregatibacter actinomycetemcomitans binds various cytokines and plays a role in biofilm response to interleukin-1β and interleukin-8. Virulence. 2017;8:115-134 pubmed publisher |
| Takasaki C, Kobayashi M, Ishibashi H, Akashi T, Okubo K. Expression of hypoxia-inducible factor-1? affects tumor proliferation and antiapoptosis in surgically resected lung cancer. Mol Clin Oncol. 2016;5:295-300 pubmed |
| Stei M, Loeffler K, Kurts C, Hoeller T, Pfarrer C, Holz F, et al. Impact of macrophages on tumor growth characteristics in a murine ocular tumor model. Exp Eye Res. 2016;151:9-18 pubmed publisher |
| Hnatiuk A, Ong S, Olea F, Locatelli P, Riegler J, Lee W, et al. Allogeneic Mesenchymal Stromal Cells Overexpressing Mutant Human Hypoxia-Inducible Factor 1-? (HIF1-?) in an Ovine Model of Acute Myocardial Infarction. J Am Heart Assoc. 2016;5: pubmed publisher |
| Yoon C, Chang K, Lee J, Tap W, Hart C, Simon M, et al. Multimodal targeting of tumor vasculature and cancer stem-like cells in sarcomas with VEGF-A inhibition, HIF-1? inhibition, and hypoxia-activated chemotherapy. Oncotarget. 2016;7:42844-42858 pubmed publisher |
| Schokrpur S, Hu J, Moughon D, Liu P, Lin L, Hermann K, et al. CRISPR-Mediated VHL Knockout Generates an Improved Model for Metastatic Renal Cell Carcinoma. Sci Rep. 2016;6:29032 pubmed publisher |
| Sanagawa A, Iwaki S, Asai M, Sakakibara D, Norimoto H, Sobel B, et al. Sphingosine 1?phosphate induced by hypoxia increases the expression of PAI?1 in HepG2 cells via HIF?1?. Mol Med Rep. 2016;14:1841-8 pubmed publisher |
| Ichimaru S, Nakagawa S, Arai Y, Kishida T, Shin Ya M, Honjo K, et al. Hypoxia Potentiates Anabolic Effects of Exogenous Hyaluronic Acid in Rat Articular Cartilage. Int J Mol Sci. 2016;17: pubmed publisher |
| Ahmad F, Chung Y, Tang Y, Hockman S, Liu S, Khan Y, et al. Phosphodiesterase 3B (PDE3B) regulates NLRP3 inflammasome in adipose tissue. Sci Rep. 2016;6:28056 pubmed publisher |
| Maugeri G, D Amico A, Reitano R, Magro G, Cavallaro S, Salomone S, et al. PACAP and VIP Inhibit the Invasiveness of Glioblastoma Cells Exposed to Hypoxia through the Regulation of HIFs and EGFR Expression. Front Pharmacol. 2016;7:139 pubmed publisher |
| Hoefflin R, Lahrmann B, Warsow G, Hübschmann D, Spath C, Walter B, et al. Spatial niche formation but not malignant progression is a driving force for intratumoural heterogeneity. Nat Commun. 2016;7:ncomms11845 pubmed publisher |
| Tan J, Prosser H, Dunn L, Vanags L, Ridiandries A, Tsatralis T, et al. High-Density Lipoproteins Rescue Diabetes-Impaired Angiogenesis via Scavenger Receptor Class B Type I. Diabetes. 2016;65:3091-103 pubmed publisher |
| Hicks K, Patel T. Sprouty2 Protein Regulates Hypoxia-inducible Factor-? (HIF?) Protein Levels and Transcription of HIF?-responsive Genes. J Biol Chem. 2016;291:16787-801 pubmed publisher |
| Samanta D, Park Y, Andrabi S, Shelton L, Gilkes D, Semenza G. PHGDH Expression Is Required for Mitochondrial Redox Homeostasis, Breast Cancer Stem Cell Maintenance, and Lung Metastasis. Cancer Res. 2016;76:4430-42 pubmed publisher |
| Lo Dico A, Costa V, Martelli C, Diceglie C, Rajata F, Rizzo A, et al. MiR675-5p Acts on HIF-1? to Sustain Hypoxic Responses: A New Therapeutic Strategy for Glioma. Theranostics. 2016;6:1105-18 pubmed publisher |
| Fecher R, Horwath M, Friedrich D, Rupp J, Deepe G. Inverse Correlation between IL-10 and HIF-1? in Macrophages Infected with Histoplasma capsulatum. J Immunol. 2016;197:565-79 pubmed publisher |
| Wert K, Mahajan V, Zhang L, Yan Y, Li Y, Tosi J, et al. Neuroretinal hypoxic signaling in a new preclinical murine model for proliferative diabetic retinopathy. Signal Transduct Target Ther. 2016;1: pubmed |
| Badar T, Handisides D, Benito J, Richie M, Borthakur G, Jabbour E, et al. Phase I study of evofosfamide, an investigational hypoxia-activated prodrug, in patients with advanced leukemia. Am J Hematol. 2016;91:800-5 pubmed publisher |
| Bellanti F, Mirabella L, Mitarotonda D, Blonda M, Tamborra R, Cinnella G, et al. Propofol but not sevoflurane prevents mitochondrial dysfunction and oxidative stress by limiting HIF-1? activation in hepatic ischemia/reperfusion injury. Free Radic Biol Med. 2016;96:323-33 pubmed publisher |
| Ma J, Mi C, Wang K, Lee J, Jin X. Zinc finger protein 91 (ZFP91) activates HIF-1? via NF-?B/p65 to promote proliferation and tumorigenesis of colon cancer. Oncotarget. 2016;7:36551-36562 pubmed publisher |
| Truong A, Lockett M. Oxygen as a chemoattractant: confirming cellular hypoxia in paper-based invasion assays. Analyst. 2016;141:3874-82 pubmed publisher |
| Guinot A, Lehmann H, Wild P, Frew I. Combined deletion of Vhl, Trp53 and Kif3a causes cystic and neoplastic renal lesions. J Pathol. 2016;239:365-73 pubmed publisher |
| Mongiardi M, Savino M, Falchetti M, Illi B, Bozzo F, Valle C, et al. c-MYC inhibition impairs hypoxia response in glioblastoma multiforme. Oncotarget. 2016;7:33257-71 pubmed publisher |
| Luo B, Wang M, Hou N, Hu X, Jia G, Qin X, et al. ATP-Dependent Lon Protease Contributes to Helicobacter pylori-Induced Gastric Carcinogenesis. Neoplasia. 2016;18:242-52 pubmed publisher |
| Kowalik M, Guzzo G, Morandi A, Perra A, Menegon S, Masgras I, et al. Metabolic reprogramming identifies the most aggressive lesions at early phases of hepatic carcinogenesis. Oncotarget. 2016;7:32375-93 pubmed publisher |
| Park S, Kim J, Kim N, Yang K, Shim J, Heo K. Estradiol, TGF-?1 and hypoxia promote breast cancer stemness and EMT-mediated breast cancer migration. Oncol Lett. 2016;11:1895-1902 pubmed |
| Ananthula S, Sinha A, El Gassim M, Batth S, Marshall G, Gardner L, et al. Geminin overexpression-dependent recruitment and crosstalk with mesenchymal stem cells enhance aggressiveness in triple negative breast cancers. Oncotarget. 2016;7:20869-89 pubmed publisher |
| Huang X, He Z, Jiang X, Hou M, Tang Z, Zhen X, et al. Folic Acid Represses Hypoxia-Induced Inflammation in THP-1 Cells through Inhibition of the PI3K/Akt/HIF-1α Pathway. PLoS ONE. 2016;11:e0151553 pubmed publisher |
| Zhang X, Liang D, Fan J, Lian X, Zhao Y, Wang X, et al. Zinc Attenuates Tubulointerstitial Fibrosis in Diabetic Nephropathy Via Inhibition of HIF Through PI-3K Signaling. Biol Trace Elem Res. 2016;173:372-83 pubmed publisher |
| Rossi A, Cadamuro A, Biselli Périco J, Leite K, Severino F, Reis P, et al. Interaction between inflammatory mediators and miRNAs in Helicobacter pylori infection. Cell Microbiol. 2016;18:1444-58 pubmed publisher |
| Karuppagounder S, Alim I, Khim S, Bourassa M, Sleiman S, John R, et al. Therapeutic targeting of oxygen-sensing prolyl hydroxylases abrogates ATF4-dependent neuronal death and improves outcomes after brain hemorrhage in several rodent models. Sci Transl Med. 2016;8:328ra29 pubmed publisher |
| Kubo H, Kitajima Y, Kai K, Nakamura J, Miyake S, Yanagihara K, et al. Regulation and clinical significance of the hypoxia-induced expression of ANGPTL4 in gastric cancer. Oncol Lett. 2016;11:1026-1034 pubmed |
| Chen H, Jia P, Kang H, Zhang H, Liu Y, Yang P, et al. Upregulating Hif-1α by Hydrogel Nanofibrous Scaffolds for Rapidly Recruiting Angiogenesis Relative Cells in Diabetic Wound. Adv Healthc Mater. 2016;5:907-18 pubmed publisher |
| Fujimoto Y, Urashima T, Shimura D, Ito R, Kawachi S, Kajimura I, et al. Low Cardiac Output Leads Hepatic Fibrosis in Right Heart Failure Model Rats. PLoS ONE. 2016;11:e0148666 pubmed publisher |
| Mori H, Yao Y, Learman B, Kurozumi K, Ishida J, Ramakrishnan S, et al. Induction of WNT11 by hypoxia and hypoxia-inducible factor-1α regulates cell proliferation, migration and invasion. Sci Rep. 2016;6:21520 pubmed publisher |
| Mazar J, Qi F, Lee B, Marchica J, Govindarajan S, Shelley J, et al. MicroRNA 211 Functions as a Metabolic Switch in Human Melanoma Cells. Mol Cell Biol. 2016;36:1090-108 pubmed publisher |
| Morita K, Shirabe K, Taketomi A, Soejima Y, Yoshizumi T, Uchiyama H, et al. Relevance of microRNA-18a and microRNA-199a-5p to hepatocellular carcinoma recurrence after living donor liver transplantation. Liver Transpl. 2016;22:665-76 pubmed publisher |
| Ai F, Chen M, Li W, Yang Y, Xu G, Gui F, et al. Danshen improves damaged cardiac angiogenesis and cardiac function induced by myocardial infarction by modulating HIF1α/VEGFA signaling pathway. Int J Clin Exp Med. 2015;8:18311-8 pubmed |
| Chen K, Zeng J, Xiao H, Huang C, Hu J, Yao W, et al. Regulation of glucose metabolism by p62/SQSTM1 through HIF1α. J Cell Sci. 2016;129:817-30 pubmed publisher |
| Maugeri G, D Amico A, Reitano R, Saccone S, Federico C, Cavallaro S, et al. Parkin modulates expression of HIF-1α and HIF-3α during hypoxia in gliobastoma-derived cell lines in vitro. Cell Tissue Res. 2016;364:465-474 pubmed publisher |
| Lee S, Frattini V, Bansal M, Castano A, Sherman D, Hutchinson K, et al. An ID2-dependent mechanism for VHL inactivation in cancer. Nature. 2016;529:172-7 pubmed publisher |
| Nishi H, Sasaki T, Nagamitsu Y, Terauchi F, Nagai T, Nagao T, et al. Hypoxia inducible factor-1 mediates upregulation of urokinase-type plasminogen activator receptor gene transcription during hypoxia in cervical cancer cells. Oncol Rep. 2016;35:992-8 pubmed publisher |
| Danhier P, Krishnamachary B, Bharti S, Kakkad S, Mironchik Y, Bhujwalla Z. Combining Optical Reporter Proteins with Different Half-lives to Detect Temporal Evolution of Hypoxia and Reoxygenation in Tumors. Neoplasia. 2015;17:871-881 pubmed publisher |
| Sharpe M, Baskin D. Monoamine oxidase B levels are highly expressed in human gliomas and are correlated with the expression of HiF-1α and with transcription factors Sp1 and Sp3. Oncotarget. 2016;7:3379-93 pubmed publisher |
| Mousavizadeh R, Scott A, LU A, Ardekani G, Behzad H, Lundgreen K, et al. Angiopoietin-like 4 promotes angiogenesis in the tendon and is increased in cyclically loaded tendon fibroblasts. J Physiol. 2016;594:2971-83 pubmed publisher |
| Yamano S, Gi M, Tago Y, Doi K, Okada S, Hirayama Y, et al. Role of deltaNp63(pos)CD44v(pos) cells in the development of N-nitroso-tris-chloroethylurea-induced peripheral-type mouse lung squamous cell carcinomas. Cancer Sci. 2016;107:123-32 pubmed publisher |
| Tu T, Nagano M, Yamashita T, Hamada H, Ohneda K, Kimura K, et al. A Chemokine Receptor, CXCR4, Which Is Regulated by Hypoxia-Inducible Factor 2α, Is Crucial for Functional Endothelial Progenitor Cells Migration to Ischemic Tissue and Wound Repair. Stem Cells Dev. 2016;25:266-76 pubmed publisher |
| Aiken J, Roudier E, Ciccone J, Drouin G, Stromberg A, Vojnovic J, et al. Phosphorylation of murine double minute-2 on Ser166 is downstream of VEGF-A in exercised skeletal muscle and regulates primary endothelial cell migration and FoxO gene expression. FASEB J. 2016;30:1120-34 pubmed publisher |
| Clancy K, Weerapana E, Thompson P. Detection and identification of protein citrullination in complex biological systems. Curr Opin Chem Biol. 2016;30:1-6 pubmed publisher |
| Cho M, Park C, Park M, Kim W, Cho A, Kim H. Clinicopathologic Features and Molecular Characteristics of Glucose Metabolism Contributing to ¹â¸F-fluorodeoxyglucose Uptake in Gastrointestinal Stromal Tumors. PLoS ONE. 2015;10:e0141413 pubmed publisher |
| Zhang L, Takara K, Yamakawa D, Kidoya H, Takakura N. Apelin as a marker for monitoring the tumor vessel normalization window during antiangiogenic therapy. Cancer Sci. 2016;107:36-44 pubmed publisher |
| Kim K, Abelman S, Yano N, Ribeiro J, Singh R, Tipping M, et al. Tetrathiomolybdate inhibits mitochondrial complex IV and mediates degradation of hypoxia-inducible factor-1α in cancer cells. Sci Rep. 2015;5:14296 pubmed publisher |
| Cui H, Qin Q, Yang M, Zhang H, Liu Z, Yang Y, et al. Bortezomib enhances the radiosensitivity of hypoxic cervical cancer cells by inhibiting HIF-1α expression. Int J Clin Exp Pathol. 2015;8:9032-41 pubmed |
| Abe T, Kitaoka Y, Kikuchi D, Takeda K, Numata O, Takemasa T. High-intensity interval training-induced metabolic adaptation coupled with an increase in Hif-1α and glycolytic protein expression. J Appl Physiol (1985). 2015;119:1297-302 pubmed publisher |
| de la Puente P, Muz B, Gilson R, Azab F, Luderer M, King J, et al. 3D tissue-engineered bone marrow as a novel model to study pathophysiology and drug resistance in multiple myeloma. Biomaterials. 2015;73:70-84 pubmed publisher |
| Yu M, Park K, Park D, Chung Y, Chi S, Kang S. Reactive oxygen species production has a critical role in hypoxia-induced Stat3 activation and angiogenesis in human glioblastoma. J Neurooncol. 2015;125:55-63 pubmed publisher |
| Wong C, Chen A, Liu M, Parker B, Möller A. Loss of Siah2 does not impact angiogenic potential of murine endothelial cells. Microvasc Res. 2015;102:38-45 pubmed publisher |
| Frey J, Stonko D, Faugere M, Riddle R. Hypoxia-inducible factor-1α restricts the anabolic actions of parathyroid hormone. Bone Res. 2014;2:14005 pubmed publisher |
| Donato M, Fanelli M, Mariani M, Raspaglio G, Pandya D, He S, et al. Nek6 and Hif-1α cooperate with the cytoskeletal gateway of drug resistance to drive outcome in serous ovarian cancer. Am J Cancer Res. 2015;5:1862-77 pubmed |
| Belo A, van Vliet S, Maus A, Laan L, Nauta T, Koolwijk P, et al. Hypoxia inducible factor 1α down regulates cell surface expression of α1,2-fucosylated glycans in human pancreatic adenocarcinoma cells. FEBS Lett. 2015;589:2359-66 pubmed publisher |
| Wang I, Sun K, Tsai T, Chen C, Chang S, Yu T, et al. MiR-20a-5p mediates hypoxia-induced autophagy by targeting ATG16L1 in ischemic kidney injury. Life Sci. 2015;136:133-41 pubmed publisher |
| Chan M, Atasoylu O, Hodson E, Tumber A, Leung I, Chowdhury R, et al. Potent and Selective Triazole-Based Inhibitors of the Hypoxia-Inducible Factor Prolyl-Hydroxylases with Activity in the Murine Brain. PLoS ONE. 2015;10:e0132004 pubmed publisher |
| Nakatani K, Watabe T, Masuda D, Imaizumi M, Shimosegawa E, Kobayashi T, et al. Myocardial energy provision is preserved by increased utilization of glucose and ketone bodies in CD36 knockout mice. Metabolism. 2015;64:1165-74 pubmed publisher |
| Lee J, Elly C, Park Y, Liu Y. E3 Ubiquitin Ligase VHL Regulates Hypoxia-Inducible Factor-1? to Maintain Regulatory T Cell Stability and Suppressive Capacity. Immunity. 2015;42:1062-74 pubmed publisher |
| Bohuslavova R, Skvorova L, Cerychova R, Pavlinkova G. Gene expression profiling of changes induced by maternal diabetes in the embryonic heart. Reprod Toxicol. 2015;57:147-56 pubmed publisher |
| Hammami A, Charpentier T, Smans M, Stager S. IRF-5-Mediated Inflammation Limits CD8+ T Cell Expansion by Inducing HIF-1α and Impairing Dendritic Cell Functions during Leishmania Infection. PLoS Pathog. 2015;11:e1004938 pubmed publisher |
| Espana Agusti J, Tuveson D, Adams D, Matakidou A. A minimally invasive, lentiviral based method for the rapid and sustained genetic manipulation of renal tubules. Sci Rep. 2015;5:11061 pubmed publisher |
| Fan Y, Wang L, Liu C, Zhu H, Zhou L, Wang Y, et al. Local renin-angiotensin system regulates hypoxia-induced vascular endothelial growth factor synthesis in mesenchymal stem cells. Int J Clin Exp Pathol. 2015;8:2505-14 pubmed |
| Sun L, Xu C, Chen G, Yu M, Yang S, Qiu Y, et al. A Novel Role of OS-9 in the Maintenance of Intestinal Barrier Function from Hypoxia-induced Injury via p38-dependent Pathway. Int J Biol Sci. 2015;11:664-71 pubmed publisher |
| Joo H, Yun M, Jeong J, Park E, Shin H, Woo S, et al. SIRT1 deacetylates and stabilizes hypoxia-inducible factor-1α (HIF-1α) via direct interactions during hypoxia. Biochem Biophys Res Commun. 2015;462:294-300 pubmed publisher |
| Zhang Z, Pang X, Tang Z, Yin D, Wang Z. Overexpression of hypoxia-inducible factor prolyl hydoxylase-2 attenuates hypoxia-induced vascular endothelial growth factor expression in luteal cells. Mol Med Rep. 2015;12:3809-3814 pubmed publisher |
| Park H, Lee D, Yim M, Choi Y, Park S, Seo S, et al. 3,3'-Diindolylmethane inhibits VEGF expression through the HIF-1α and NF-κB pathways in human retinal pigment epithelial cells under chemical hypoxic conditions. Int J Mol Med. 2015;36:301-8 pubmed publisher |
| Takata S, Masuda T, Nakamura S, Kuchimaru T, Tsuruma K, Shimazawa M, et al. The effect of triamcinolone acetonide on laser-induced choroidal neovascularization in mice using a hypoxia visualization bio-imaging probe. Sci Rep. 2015;5:9898 pubmed publisher |
| Bimpis A, Papalois A, Voumvourakis K, Oláh O, Tiszlavicz L, Liapi C. Neuronal tumour necrosis factor-α and interleukin-1β expression in a porcine model of intracerebral haemorrhage: Modulation by U-74389G. Brain Res. 2015;1615:98-105 pubmed publisher |
| Liu X, Chen Z, Xu C, Leng X, Cao H, Ouyang G, et al. Repression of hypoxia-inducible factor α signaling by Set7-mediated methylation. Nucleic Acids Res. 2015;43:5081-98 pubmed publisher |
| Brandes F, Schmidt K, Wagner C, Redekopf J, Schlitt H, Geissler E, et al. Targeting cMET with INC280 impairs tumour growth and improves efficacy of gemcitabine in a pancreatic cancer model. BMC Cancer. 2015;15:71 pubmed publisher |
| Shao J, Zhang Y, Yang T, Qi J, Zhang L, Deng L. HIF-1α disturbs osteoblasts and osteoclasts coupling in bone remodeling by up-regulating OPG expression. In Vitro Cell Dev Biol Anim. 2015;51:808-14 pubmed publisher |
| Chan N, He S, Spee C, Ishikawa K, Hinton D. Attenuation of choroidal neovascularization by histone deacetylase inhibitor. PLoS ONE. 2015;10:e0120587 pubmed publisher |
| Lehmann H, Vicari D, Wild P, Frew I. Combined Deletion of Vhl and Kif3a Accelerates Renal Cyst Formation. J Am Soc Nephrol. 2015;26:2778-88 pubmed publisher |
| Wang F, Zhang G, Xing T, Lu Z, Li J, Peng C, et al. Renalase contributes to the renal protection of delayed ischaemic preconditioning via the regulation of hypoxia-inducible factor-1α. J Cell Mol Med. 2015;19:1400-9 pubmed publisher |
| Fillmore N, Huqi A, Jaswal J, Mori J, Paulin R, Haromy A, et al. Effect of fatty acids on human bone marrow mesenchymal stem cell energy metabolism and survival. PLoS ONE. 2015;10:e0120257 pubmed publisher |
| Srivastava S, Thakkar B, Yeoh K, Ho K, Teh M, Soong R, et al. Expression of proteins associated with hypoxia and Wnt pathway activation is of prognostic significance in hepatocellular carcinoma. Virchows Arch. 2015;466:541-8 pubmed publisher |
| Paeng S, Jung W, Park W, Lee D, Kim G, Choi Y, et al. Caffeic acid phenethyl ester reduces the secretion of vascular endothelial growth factor through the inhibition of the ROS, PI3K and HIF-1α signaling pathways in human retinal pigment epithelial cells under hypoxic conditions. Int J Mol Med. 2015;35:1419-26 pubmed publisher |
| Rees M, Subramaniam J, Li Y, Hamilton D, Frazier O, Taegtmeyer H. A PKM2 signature in the failing heart. Biochem Biophys Res Commun. 2015;459:430-6 pubmed publisher |
| Hasan A, Ohmori K, Konishi K, Igarashi J, Hashimoto T, Kamitori K, et al. Eicosapentaenoic acid upregulates VEGF-A through both GPR120 and PPARγ mediated pathways in 3T3-L1 adipocytes. Mol Cell Endocrinol. 2015;406:10-8 pubmed publisher |
| Li R, Wang Y, Yang Z, He Y, Zhao T, Fan M, et al. Hypoxia-inducible factor-1α regulates the expression of L-type voltage-dependent Ca(2+) channels in PC12 cells under hypoxia. Cell Stress Chaperones. 2015;20:507-16 pubmed publisher |
| Colbert L, Fisher S, Balci S, Saka B, Chen Z, Kim S, et al. High nuclear hypoxia-inducible factor 1 alpha expression is a predictor of distant recurrence in patients with resected pancreatic adenocarcinoma. Int J Radiat Oncol Biol Phys. 2015;91:631-9 pubmed publisher |
| Wang W, Chen M, Leong H, Kuo Y, Kuo C, Lee C. Connexin 43 suppresses tumor angiogenesis by down-regulation of vascular endothelial growth factor via hypoxic-induced factor-1α. Int J Mol Sci. 2014;16:439-51 pubmed publisher |
| Hung Y, Chang S, Huang C, Yin J, Hwang C, Yang L, et al. Inhibitor of Differentiation-1 and Hypoxia-Inducible Factor-1 Mediate Sonic Hedgehog Induction by Amyloid Beta-Peptide in Rat Cortical Neurons. Mol Neurobiol. 2016;53:793-809 pubmed publisher |
| Jeong S, Park H, Hong S, Yum S, Kim W, Jung Y. Lipophilic modification enhances anti-colitic properties of rosmarinic acid by potentiating its HIF-prolyl hydroxylases inhibitory activity. Eur J Pharmacol. 2015;747:114-22 pubmed publisher |
| Rutz S, Kayagaki N, Phung Q, Eidenschenk C, Noubade R, Wang X, et al. Deubiquitinase DUBA is a post-translational brake on interleukin-17 production in T cells. Nature. 2015;518:417-21 pubmed publisher |
| Samanta D, Gilkes D, Chaturvedi P, Xiang L, Semenza G. Hypoxia-inducible factors are required for chemotherapy resistance of breast cancer stem cells. Proc Natl Acad Sci U S A. 2014;111:E5429-38 pubmed publisher |
| Gillespie D, Aguirre M, Ravichandran S, Leishman L, Berrondo C, Gamboa J, et al. RNA interference targeting hypoxia-inducible factor 1α via a novel multifunctional surfactant attenuates glioma growth in an intracranial mouse model. J Neurosurg. 2015;122:331-41 pubmed publisher |
| Wu X, He L, Chen F, He X, Cai Y, Zhang G, et al. Impaired autophagy contributes to adverse cardiac remodeling in acute myocardial infarction. PLoS ONE. 2014;9:e112891 pubmed publisher |
| Sato Y, Miyauchi Y, Yoshida S, Morita M, Kobayashi T, Kanagawa H, et al. The vitamin D analogue ED71 but Not 1,25(OH)2D3 targets HIF1α protein in osteoclasts. PLoS ONE. 2014;9:e111845 pubmed publisher |
| Rahman S, Lee M, Baek J, Ryoo H, Woo K. The prolyl hydroxylase inhibitor dimethyloxalylglycine enhances dentin sialophoshoprotein expression through VEGF-induced Runx2 stabilization. PLoS ONE. 2014;9:e112078 pubmed publisher |
| El Assar M, Sánchez Puelles J, Royo I, López Hernández E, Sánchez Ferrer A, Aceña J, et al. FM19G11 reverses endothelial dysfunction in rat and human arteries through stimulation of the PI3K/Akt/eNOS pathway, independently of mTOR/HIF-1α activation. Br J Pharmacol. 2015;172:1277-91 pubmed publisher |
| Funk K, Scheerer N, Verhaegh R, Pütter C, Fandrey J, de Groot H. Severe blunt muscle trauma in rats: only marginal hypoxia in the injured area. PLoS ONE. 2014;9:e111151 pubmed publisher |
| Marhold M, Tomasich E, El Gazzar A, Heller G, Spittler A, Horvat R, et al. HIF1α Regulates mTOR Signaling and Viability of Prostate Cancer Stem Cells. Mol Cancer Res. 2015;13:556-64 pubmed publisher |
| He Y, Li M, Wu L, Zhao T, Di Y, Huang X, et al. Enhanced hypoxia-inducible factor (HIF)-1? stability induced by 5-hydroxymethyl-2-furfural (5-HMF) contributes to protection against hypoxia. Mol Med. 2015;20:590-600 pubmed publisher |
| Yoshikawa N, Shimizu N, Ojima H, Kobayashi H, Hosono O, Tanaka H. Down-regulation of hypoxia-inducible factor-1 alpha and vascular endothelial growth factor by HEXIM1 attenuates myocardial angiogenesis in hypoxic mice. Biochem Biophys Res Commun. 2014;453:600-5 pubmed publisher |
| Su B, Luo T, Zhu J, Fu J, Zhao X, Chen L, et al. Interleukin-1β/Iinterleukin-1 receptor-associated kinase 1 inflammatory signaling contributes to persistent Gankyrin activation during hepatocarcinogenesis. Hepatology. 2015;61:585-97 pubmed publisher |
| Kasper L, Qu C, Obenauer J, McGoldrick D, Brindle P. Genome-wide and single-cell analyses reveal a context dependent relationship between CBP recruitment and gene expression. Nucleic Acids Res. 2014;42:11363-82 pubmed publisher |
| Bordji K, Grandval A, Cuhna Alves L, Lechapt Zalcman E, Bernaudin M. Hypoxia-inducible factor-2α (HIF-2α), but not HIF-1α, is essential for hypoxic induction of class III β-tubulin expression in human glioblastoma cells. FEBS J. 2014;281:5220-36 pubmed publisher |
| Shinohara M, Kibi M, Riley I, Chiang N, Dalli J, Kraft B, et al. Cell-cell interactions and bronchoconstrictor eicosanoid reduction with inhaled carbon monoxide and resolvin D1. Am J Physiol Lung Cell Mol Physiol. 2014;307:L746-57 pubmed publisher |
| Lee H, Kim K, Lim H, Choi M, Kim H, Ahn H, et al. Priming Wharton's jelly-derived mesenchymal stromal/stem cells with ROCK inhibitor improves recovery in an intracerebral hemorrhage model. J Cell Biochem. 2015;116:310-9 pubmed publisher |
| Fujikuni N, Yamamoto H, Tanabe K, Naito Y, Sakamoto N, Tanaka Y, et al. Hypoxia-mediated CD24 expression is correlated with gastric cancer aggressiveness by promoting cell migration and invasion. Cancer Sci. 2014;105:1411-20 pubmed publisher |
| Queisser M, Dada L, Deiss Yehiely N, Angulo M, Zhou G, Kouri F, et al. HOIL-1L functions as the PKCζ ubiquitin ligase to promote lung tumor growth. Am J Respir Crit Care Med. 2014;190:688-98 pubmed publisher |
| Huang T, Huang W, Zhang Z, Yu L, Xie C, Zhu D, et al. Hypoxia-inducible factor-1? upregulation in microglia following hypoxia protects against ischemia-induced cerebral infarction. Neuroreport. 2014;25:1122-8 pubmed publisher |
| Gu J, Fan Y, Liu X, Zhou L, Cheng J, Cai R, et al. SENP1 protects against myocardial ischaemia/reperfusion injury via a HIF1?-dependent pathway. Cardiovasc Res. 2014;104:83-92 pubmed publisher |
| Yang X, Zhu H, Ge Y, Liu J, Cai J, Qin Q, et al. Melittin enhances radiosensitivity of hypoxic head and neck squamous cell carcinoma by suppressing HIF-1α. Tumour Biol. 2014;35:10443-8 pubmed publisher |
| Zhou W, Marinescu M, Veltkamp R. Only very early oxygen therapy attenuates posthemorrhagic edema formation and blood-brain barrier disruption in murine intracerebral hemorrhage. Neurocrit Care. 2015;22:121-32 pubmed publisher |
| Abu Remaileh M, Aqeilan R. Tumor suppressor WWOX regulates glucose metabolism via HIF1? modulation. Cell Death Differ. 2014;21:1805-14 pubmed publisher |
| Kalamida D, Karagounis I, Giatromanolaki A, Koukourakis M. Important role of autophagy in endothelial cell response to ionizing radiation. PLoS ONE. 2014;9:e102408 pubmed publisher |
| Privat M, Radosevic Robin N, Aubel C, Cayre A, Penault Llorca F, Marceau G, et al. BRCA1 induces major energetic metabolism reprogramming in breast cancer cells. PLoS ONE. 2014;9:e102438 pubmed publisher |
| Huang M, Chen Q, Xiao J, Yao T, Bian L, Liu C, et al. Overexpression of hypoxia-inducible factor-1α is a predictor of poor prognosis in cervical cancer: a clinicopathologic study and a meta-analysis. Int J Gynecol Cancer. 2014;24:1054-64 pubmed publisher |
| Yang M, Chiao M, Lee H, Chen C, Yang Y, Shen C, et al. An innovative three-dimensional gelatin foam culture system for improved study of glioblastoma stem cell behavior. J Biomed Mater Res B Appl Biomater. 2015;103:618-28 pubmed publisher |
| Wu J, Shao C, Li X, Shi C, Li Q, Hu P, et al. Near-infrared fluorescence imaging of cancer mediated by tumor hypoxia and HIF1?/OATPs signaling axis. Biomaterials. 2014;35:8175-85 pubmed publisher |
| Narise K, Okuda K, Enomoto Y, Hirayama T, Nagasawa H. Optimization of biguanide derivatives as selective antitumor agents blocking adaptive stress responses in the tumor microenvironment. Drug Des Devel Ther. 2014;8:701-17 pubmed publisher |
| Vorrink S, Sarsour E, Olivier A, Robertson L, Goswami P, Domann F. PCB 126 perturbs hypoxia-induced HIF-1? activity and glucose consumption in human HepG2 cells. Exp Toxicol Pathol. 2014;66:377-82 pubmed publisher |
| Salman S, Holloway A, Nurse C. Chronic opioids regulate KATP channel subunit Kir6.2 and carbonic anhydrase I and II expression in rat adrenal chromaffin cells via HIF-2? and protein kinase A. Am J Physiol Cell Physiol. 2014;307:C266-77 pubmed publisher |
| Zhang L, Sun Y, Fei M, Tan C, Wu J, Zheng J, et al. Disruption of chaperone-mediated autophagy-dependent degradation of MEF2A by oxidative stress-induced lysosome destabilization. Autophagy. 2014;10:1015-35 pubmed publisher |
| Arreola A, Cowey C, Coloff J, Rathmell J, Rathmell W. HIF1α and HIF2α exert distinct nutrient preferences in renal cells. PLoS ONE. 2014;9:e98705 pubmed publisher |
| Williamson D, Li Z, Tuder R, Feinstein E, Kimball S, Dungan C. Altered nutrient response of mTORC1 as a result of changes in REDD1 expression: effect of obesity vs. REDD1 deficiency. J Appl Physiol (1985). 2014;117:246-56 pubmed publisher |
| Xiong Y, Qu Z, Chen N, Gong H, Song M, Chen X, et al. The local corticotropin-releasing hormone receptor 2 signalling pathway partly mediates hypoxia-induced increases in lipolysis via the cAMP-protein kinase A signalling pathway in white adipose tissue. Mol Cell Endocrinol. 2014;392:106-14 pubmed publisher |
| Xu W, Kwon J, Moon Y, Kim Y, Yu Y, Lee N, et al. Influence of preoperative transcatheter arterial chemoembolization on gene expression in the HIF-1? pathway in patients with hepatocellular carcinoma. J Cancer Res Clin Oncol. 2014;140:1507-15 pubmed publisher |
| Schiffer D, Mellai M, Annovazzi L, Caldera V, Piazzi A, Denysenko T, et al. Stem cell niches in glioblastoma: a neuropathological view. Biomed Res Int. 2014;2014:725921 pubmed publisher |
| Kim Y, Lee H, Lim J, Kim Y, Jung C, Yoo S, et al. ?-Carotene inhibits neuroblastoma cell invasion and metastasis in vitro and in vivo by decreasing level of hypoxia-inducible factor-1?. J Nutr Biochem. 2014;25:655-64 pubmed publisher |
| Zheng J, Song F, Lu S, Wang X. Dynamic hypoxia in scar tissue during human hypertrophic scar progression. Dermatol Surg. 2014;40:511-8 pubmed publisher |
| Chang M, Chiu C, Shang F, Taylor A. High glucose activates ChREBP-mediated HIF-1? and VEGF expression in human RPE cells under normoxia. Adv Exp Med Biol. 2014;801:609-21 pubmed publisher |
| Raspaglio G, Petrillo M, Martinelli E, Li Puma D, Mariani M, De Donato M, et al. Sox9 and Hif-2? regulate TUBB3 gene expression and affect ovarian cancer aggressiveness. Gene. 2014;542:173-81 pubmed publisher |
| Zhang W, He L, Shi X, Wu S, Zhang B, Mei L, et al. Regulation of transplanted mesenchymal stem cells by the lung progenitor niche in rats with chronic obstructive pulmonary disease. Respir Res. 2014;15:33 pubmed publisher |
| Sano M, Sasaki T, Hirakawa S, Sakabe J, Ogawa M, Baba S, et al. Lymphangiogenesis and angiogenesis in abdominal aortic aneurysm. PLoS ONE. 2014;9:e89830 pubmed publisher |
| Chen J, Li T, Liu Q, Jiao H, Yang W, Liu X, et al. Clinical and prognostic significance of HIF-1?, PTEN, CD44v6, and survivin for gastric cancer: a meta-analysis. PLoS ONE. 2014;9:e91842 pubmed publisher |
| Pan W, Wong J, Fang E, Chan Y, Ng T, Cheung R. Preferential cytotoxicity of the type I ribosome inactivating protein alpha-momorcharin on human nasopharyngeal carcinoma cells under normoxia and hypoxia. Biochem Pharmacol. 2014;89:329-39 pubmed publisher |
| Zhao L, Yang Y, Gao Y, Wang S, Wang L, Zuo H, et al. Upregulation of HIF-1? via activation of ERK and PI3K pathway mediated protective response to microwave-induced mitochondrial injury in neuron-like cells. Mol Neurobiol. 2014;50:1024-34 pubmed publisher |
| Gauter Fleckenstein B, Reboucas J, Fleckenstein K, Tovmasyan A, Owzar K, Jiang C, et al. Robust rat pulmonary radioprotection by a lipophilic Mn N-alkylpyridylporphyrin, MnTnHex-2-PyP(5+). Redox Biol. 2014;2:400-10 pubmed publisher |
| Shan F, Li J, Huang Q. HIF-1 alpha-induced up-regulation of miR-9 contributes to phenotypic modulation in pulmonary artery smooth muscle cells during hypoxia. J Cell Physiol. 2014;229:1511-20 pubmed publisher |
| Imamura Y, Tomita S, Imanishi M, Kihira Y, Ikeda Y, Ishizawa K, et al. HIF-2?/ARNT complex regulates hair development via induction of p21(Waf1/Cip1) and p27(Kip1). FASEB J. 2014;28:2517-24 pubmed publisher |
| Huang Y, Lin M, Wang P, Wu Y, Chiang H, Wang Y, et al. Hypoxia inducible factor 2?/insulin-like growth factor receptor signal loop supports the proliferation and Oct-4 maintenance of mouse germline stem cells. Mol Hum Reprod. 2014;20:526-37 pubmed publisher |
| Li Y, Chen J, Zeng T, Lei D, Chen L, Zhou D. Expression of HIF-1? and MDR1/P-glycoprotein in refractory mesial temporal lobe epilepsy patients and pharmacoresistant temporal lobe epilepsy rat model kindled by coriaria lactone. Neurol Sci. 2014;35:1203-8 pubmed publisher |
| Zhao W, Chang C, Cui Y, Zhao X, Yang J, Shen L, et al. Steroid receptor coactivator-3 regulates glucose metabolism in bladder cancer cells through coactivation of hypoxia inducible factor 1?. J Biol Chem. 2014;289:11219-29 pubmed publisher |
| Lall R, Ganapathy S, Yang M, Xiao S, Xu T, Su H, et al. Low-dose radiation exposure induces a HIF-1-mediated adaptive and protective metabolic response. Cell Death Differ. 2014;21:836-44 pubmed publisher |
| He M, Lu Y, Xu S, Mao L, Zhang L, Duan W, et al. MiRNA-210 modulates a nickel-induced cellular energy metabolism shift by repressing the iron-sulfur cluster assembly proteins ISCU1/2 in Neuro-2a cells. Cell Death Dis. 2014;5:e1090 pubmed publisher |
| Zhang X, Fryknäs M, Hernlund E, Fayad W, De Milito A, Olofsson M, et al. Induction of mitochondrial dysfunction as a strategy for targeting tumour cells in metabolically compromised microenvironments. Nat Commun. 2014;5:3295 pubmed publisher |
| Mateo J, Izquierdo Garcia D, Badimon J, Fayad Z, Fuster V. Noninvasive assessment of hypoxia in rabbit advanced atherosclerosis using ¹?F-fluoromisonidazole positron emission tomographic imaging. Circ Cardiovasc Imaging. 2014;7:312-20 pubmed publisher |
| Bohuslavova R, Kolar F, Sedmera D, Skvorova L, Papousek F, Neckar J, et al. Partial deficiency of HIF-1? stimulates pathological cardiac changes in streptozotocin-induced diabetic mice. BMC Endocr Disord. 2014;14:11 pubmed publisher |
| White N, Masui O, Newsted D, Scorilas A, Romaschin A, Bjarnason G, et al. Galectin-1 has potential prognostic significance and is implicated in clear cell renal cell carcinoma progression through the HIF/mTOR signaling axis. Br J Cancer. 2014;110:1250-9 pubmed publisher |
| Weisel F, Kloepping C, Pichl A, Sydykov A, Kojonazarov B, Wilhelm J, et al. Impact of S-adenosylmethionine decarboxylase 1 on pulmonary vascular remodeling. Circulation. 2014;129:1510-23 pubmed publisher |
| Wang E, Zhang C, Polavaram N, Liu F, Wu G, Schroeder M, et al. The role of factor inhibiting HIF (FIH-1) in inhibiting HIF-1 transcriptional activity in glioblastoma multiforme. PLoS ONE. 2014;9:e86102 pubmed publisher |
| Chen Z, Liu X, Mei Z, Wang Z, Xiao W. EAF2 suppresses hypoxia-induced factor 1? transcriptional activity by disrupting its interaction with coactivator CBP/p300. Mol Cell Biol. 2014;34:1085-99 pubmed publisher |
| Pantel A, Teixeira A, Haddad E, Wood E, Steinman R, Longhi M. Direct type I IFN but not MDA5/TLR3 activation of dendritic cells is required for maturation and metabolic shift to glycolysis after poly IC stimulation. PLoS Biol. 2014;12:e1001759 pubmed publisher |
| Garofalo C, Capristo M, Manara M, Mancarella C, Landuzzi L, Belfiore A, et al. Metformin as an adjuvant drug against pediatric sarcomas: hypoxia limits therapeutic effects of the drug. PLoS ONE. 2013;8:e83832 pubmed publisher |
| Ganapathy S, Xiao S, Yang M, Qi M, Choi D, Ha C, et al. A low-dose arsenic-induced p53 protein-mediated metabolic mechanism of radiotherapy protection. J Biol Chem. 2014;289:5340-7 pubmed publisher |
| Kind K, Tam K, Banwell K, Gauld A, Russell D, Macpherson A, et al. Oxygen-regulated gene expression in murine cumulus cells. Reprod Fertil Dev. 2015;27:407-18 pubmed publisher |
| Engelhardt S, Al Ahmad A, Gassmann M, Ogunshola O. Hypoxia selectively disrupts brain microvascular endothelial tight junction complexes through a hypoxia-inducible factor-1 (HIF-1) dependent mechanism. J Cell Physiol. 2014;229:1096-105 pubmed publisher |
| Miyazaki S, Kikuchi H, Iino I, Uehara T, Setoguchi T, Fujita T, et al. Anti-VEGF antibody therapy induces tumor hypoxia and stanniocalcin 2 expression and potentiates growth of human colon cancer xenografts. Int J Cancer. 2014;135:295-307 pubmed publisher |
| Ji X, Wang H, Zhu J, Zhu L, Pan H, Li W, et al. Knockdown of Nrf2 suppresses glioblastoma angiogenesis by inhibiting hypoxia-induced activation of HIF-1?. Int J Cancer. 2014;135:574-84 pubmed publisher |
| Kawakami T, Yoshimi M, Kadota Y, Inoue M, Sato M, Suzuki S. Prolonged endoplasmic reticulum stress alters placental morphology and causes low birth weight. Toxicol Appl Pharmacol. 2014;275:134-44 pubmed publisher |
| Ouyang W, Torigoe C, Fang H, Xie T, Frucht D. Anthrax lethal toxin inhibits translation of hypoxia-inducible factor 1? and causes decreased tolerance to hypoxic stress. J Biol Chem. 2014;289:4180-90 pubmed publisher |
| Popescu C, Sutherland M, Cloutier A, Benoit G, Bertagnolli M, Yzydorczyk C, et al. Hyperoxia exposure impairs nephrogenesis in the neonatal rat: role of HIF-1?. PLoS ONE. 2013;8:e82421 pubmed publisher |
| An X, Xu G, Yang L, Wang Y, Li Y, McHepange U, et al. Expression of hypoxia-inducible factor-1?, vascular endothelial growth factor and prolyl hydroxylase domain protein 2 in cutaneous squamous cell carcinoma and precursor lesions and their relationship with histological stages and clinical features. J Dermatol. 2014;41:76-83 pubmed publisher |
| Park H, Kim M, Kim S, Bae S, Bae M. Hypoxia regulates the expression of the neuromedin B receptor through a mechanism dependent on hypoxia-inducible factor-1?. PLoS ONE. 2013;8:e82868 pubmed publisher |
| Fujimura A, Michiue H, Cheng Y, Uneda A, Tani Y, Nishiki T, et al. Cyclin G2 promotes hypoxia-driven local invasion of glioblastoma by orchestrating cytoskeletal dynamics. Neoplasia. 2013;15:1272-81 pubmed |
| Fernandes B, Coates J, Odashiro A, Quezada C, Huynh A, Odashiro P, et al. Hypoxia-inducible factor-1? and its role in the proliferation of retinoblastoma cells. Pathol Oncol Res. 2014;20:557-63 pubmed publisher |
| Chen T, Shih Y, Tseng J, Lai M, Wu C, Li Y, et al. Overexpression of FGF9 in colon cancer cells is mediated by hypoxia-induced translational activation. Nucleic Acids Res. 2014;42:2932-44 pubmed publisher |
| Takano N, Peng Y, Kumar G, Luo W, Hu H, Shimoda L, et al. Hypoxia-inducible factors regulate human and rat cystathionine ?-synthase gene expression. Biochem J. 2014;458:203-11 pubmed publisher |
| Zhang C, Yang X, Zhang Q, Yang B, Xu L, Qin Q, et al. Berberine radiosensitizes human nasopharyngeal carcinoma by suppressing hypoxia-inducible factor-1? expression. Acta Otolaryngol. 2014;134:185-92 pubmed publisher |
| Chen Z, He X, Xia W, Huang Q, Zhang Z, Ye J, et al. Prognostic value and clinicopathological differences of HIFs in colorectal cancer: evidence from meta-analysis. PLoS ONE. 2013;8:e80337 pubmed publisher |
| Jensen R, Mumert M, Gillespie D, Kinney A, Schabel M, Salzman K. Preoperative dynamic contrast-enhanced MRI correlates with molecular markers of hypoxia and vascularity in specific areas of intratumoral microenvironment and is predictive of patient outcome. Neuro Oncol. 2014;16:280-91 pubmed publisher |
| Watson C, Collier P, Tea I, Neary R, Watson J, Robinson C, et al. Hypoxia-induced epigenetic modifications are associated with cardiac tissue fibrosis and the development of a myofibroblast-like phenotype. Hum Mol Genet. 2014;23:2176-88 pubmed publisher |
| Ma Z, Moruzzi N, Catrina S, Grill V, Bjorklund A. Hyperoxia inhibits glucose-induced insulin secretion and mitochondrial metabolism in rat pancreatic islets. Biochem Biophys Res Commun. 2014;443:223-8 pubmed publisher |
| Przybyla B, Shafirstein G, Vishal S, Dennis R, Griffin R. Molecular changes in bone marrow, tumor and serum after conductive ablation of murine 4T1 breast carcinoma. Int J Oncol. 2014;44:600-8 pubmed publisher |
| Bertozzi D, Marinello J, Manzo S, Fornari F, Gramantieri L, Capranico G. The natural inhibitor of DNA topoisomerase I, camptothecin, modulates HIF-1? activity by changing miR expression patterns in human cancer cells. Mol Cancer Ther. 2014;13:239-48 pubmed publisher |
| Liu X, Tu Y, Zhang L, Qi J, Ma T, Deng L. Prolyl hydroxylase inhibitors protect from the bone loss in ovariectomy rats by increasing bone vascularity. Cell Biochem Biophys. 2014;69:141-9 pubmed publisher |
| Koide N, Odkhuu E, Naiki Y, Tsolmongyn B, Ito K, Komatsu T, et al. Augmentation of LPS-induced vascular endothelial cell growth factor production in macrophages by transforming growth factor-?1. Innate Immun. 2014;20:816-25 pubmed publisher |
| Zhang Y, Marsboom G, Toth P, Rehman J. Mitochondrial respiration regulates adipogenic differentiation of human mesenchymal stem cells. PLoS ONE. 2013;8:e77077 pubmed publisher |
| Park E, Lee C, Lee E, Kim J, Cova A, Lee S, et al. HNF4? contributes to glucose formation in aged rat hepatocytes. Exp Gerontol. 2013;48:1518-25 pubmed publisher |
| Huang S, Chen T, Chiu C, Chang L, Liao K, Tan H, et al. GDNF increases cell motility in human colon cancer through VEGF-VEGFR1 interaction. Endocr Relat Cancer. 2014;21:73-84 pubmed publisher |
| Madej J, Madej J, Dziegiel P, Pula B, Nowak M. Expression of hypoxia-inducible factor-1? and vascular density in mammary adenomas and adenocarcinomas in bitches. Acta Vet Scand. 2013;55:73 pubmed publisher |
| Cheng Y, Park J, Manzanero S, Choi Y, Baik S, Okun E, et al. Evidence that collaboration between HIF-1α and Notch-1 promotes neuronal cell death in ischemic stroke. Neurobiol Dis. 2014;62:286-95 pubmed publisher |
| Eckle T, Brodsky K, Bonney M, Packard T, Han J, Borchers C, et al. HIF1A reduces acute lung injury by optimizing carbohydrate metabolism in the alveolar epithelium. PLoS Biol. 2013;11:e1001665 pubmed publisher |
| Zhang L, Xu J, Sun N, Cai H, Ren M, Zhang J, et al. The presence of adenosine A2a receptor in thyrocytes and its involvement in Graves' IgG-induced VEGF expression. Endocrinology. 2013;154:4927-38 pubmed publisher |
| Hu P, Chung L, Berel D, Frierson H, Yang H, Liu C, et al. Convergent RANK- and c-Met-mediated signaling components predict survival of patients with prostate cancer: an interracial comparative study. PLoS ONE. 2013;8:e73081 pubmed publisher |
| Wall A, Corcoran A, O Halloran K, O Connor J. Effects of prolyl-hydroxylase inhibition and chronic intermittent hypoxia on synaptic transmission and plasticity in the rat CA1 and dentate gyrus. Neurobiol Dis. 2014;62:8-17 pubmed publisher |
| Gallaher A, Das S, Xiao Z, Andresson T, Kieffer Kwon P, Happel C, et al. Proteomic screening of human targets of viral microRNAs reveals functions associated with immune evasion and angiogenesis. PLoS Pathog. 2013;9:e1003584 pubmed publisher |
| Cowburn A, Alexander L, Southwood M, Nizet V, Chilvers E, Johnson R. Epidermal deletion of HIF-2α stimulates wound closure. J Invest Dermatol. 2014;134:801-808 pubmed publisher |
| Minoia C, Quero C, Asselti M, Galise I, Marzano A, Iacobazzi A, et al. Changes in angiogenesis and hypoxia-inducible factor-1? protein expression in relapsed/refractory indolent non-Hodgkin lymphomas. Br J Haematol. 2013;163:640-5 pubmed publisher |
| Yang X, Yang B, Cai J, Zhang C, Zhang Q, Xu L, et al. Berberine enhances radiosensitivity of esophageal squamous cancer by targeting HIF-1α in vitro and in vivo. Cancer Biol Ther. 2013;14:1068-73 pubmed publisher |
| Miyauchi Y, Sato Y, Kobayashi T, Yoshida S, Mori T, Kanagawa H, et al. HIF1α is required for osteoclast activation by estrogen deficiency in postmenopausal osteoporosis. Proc Natl Acad Sci U S A. 2013;110:16568-73 pubmed publisher |
| Tan J, Prosser H, Vanags L, Monger S, Ng M, Bursill C. High-density lipoproteins augment hypoxia-induced angiogenesis via regulation of post-translational modulation of hypoxia-inducible factor 1?. FASEB J. 2014;28:206-17 pubmed publisher |
| Ding G, Huang G, Liu H, Liang H, Ni Y, Ding Z, et al. MiR-199a suppresses the hypoxia-induced proliferation of non-small cell lung cancer cells through targeting HIF1?. Mol Cell Biochem. 2013;384:173-80 pubmed |
| Wang W, Liang H, Cai Y, Yang H. DMOG ameliorates IFN-?-induced intestinal barrier dysfunction by suppressing PHD2-dependent HIF-1? degradation. J Interferon Cytokine Res. 2014;34:60-9 pubmed publisher |
| Lin W, Wang X, Wang C, Zhang L, Li N, Wang F, et al. Polymorphism in the hypoxia-inducible factor 1alpha gene may confer susceptibility to LDD in Chinese cohort. PLoS ONE. 2013;8:e73158 pubmed publisher |
| Pawlus M, Wang L, Murakami A, Dai G, Hu C. STAT3 or USF2 contributes to HIF target gene specificity. PLoS ONE. 2013;8:e72358 pubmed publisher |
| Cao Y, Eble J, Moon E, Yuan H, Weitzel D, Landon C, et al. Tumor cells upregulate normoxic HIF-1? in response to doxorubicin. Cancer Res. 2013;73:6230-42 pubmed publisher |
| Wang S, Yu C, Hong J, Tsai C, Chiang C. Radiation therapy-induced tumor invasiveness is associated with SDF-1-regulated macrophage mobilization and vasculogenesis. PLoS ONE. 2013;8:e69182 pubmed publisher |
| Shin J, Jeong Y, Cho H, Park K, Chung I, Lee I, et al. Melittin suppresses HIF-1?/VEGF expression through inhibition of ERK and mTOR/p70S6K pathway in human cervical carcinoma cells. PLoS ONE. 2013;8:e69380 pubmed publisher |
| Ma Z, Moruzzi N, Catrina S, Hals I, Oberholzer J, Grill V, et al. Preconditioning with associated blocking of Ca2+ inflow alleviates hypoxia-induced damage to pancreatic ?-cells. PLoS ONE. 2013;8:e67498 pubmed publisher |
| Jung J, Im S, Jung E, Kang C. Clinicopathological implications of the expression of hypoxia-related proteins in gastric cancer. Int J Med Sci. 2013;10:1217-23 pubmed publisher |
| Takibuchi G, Imanishi H, Morimoto M, Ishikawa K, Nakada K, Toyama Sorimachi N, et al. Polymorphic mutations in mouse mitochondrial DNA regulate a tumor phenotype. Mitochondrion. 2013;13:881-7 pubmed publisher |
| Zaccagnini G, Maimone B, Di Stefano V, Fasanaro P, Greco S, Perfetti A, et al. Hypoxia-induced miR-210 modulates tissue response to acute peripheral ischemia. Antioxid Redox Signal. 2014;21:1177-88 pubmed publisher |
| Al Greene N, Means A, Lu P, Jiang A, Schmidt C, Chakravarthy A, et al. Four jointed box 1 promotes angiogenesis and is associated with poor patient survival in colorectal carcinoma. PLoS ONE. 2013;8:e69660 pubmed publisher |
| Belloli S, Brioschi A, Politi L, Ronchetti F, Calderoni S, Raccagni I, et al. Characterization of biological features of a rat F98 GBM model: a PET-MRI study with [18F]FAZA and [18F]FDG. Nucl Med Biol. 2013;40:831-40 pubmed publisher |
| Sun Y, Lin S, Lin H, Hung C, Wang C, Lin Y, et al. Cell type-specific dependency on the PI3K/Akt signaling pathway for the endogenous Epo and VEGF induction by baicalein in neurons versus astrocytes. PLoS ONE. 2013;8:e69019 pubmed publisher |
| Park Y, Park B, Lee S, Choi K, Moon Y, Park H. Hypoxia-inducible factor-2?-dependent hypoxic induction of Wnt10b expression in adipogenic cells. J Biol Chem. 2013;288:26311-22 pubmed publisher |
| Xu H, Li B, Yu W, Wang H, Zhao X, Yao Y, et al. Correlation between ¹?F-FDG uptake and the expression of glucose transporter-1 and hypoxia-inducible factor-1? in transplanted VX2 tumors. Nucl Med Commun. 2013;34:953-8 pubmed publisher |
| You Q, Holt M, Yin H, Li G, Hu C, Ju C. Role of hepatic resident and infiltrating macrophages in liver repair after acute injury. Biochem Pharmacol. 2013;86:836-43 pubmed publisher |
| Allon I, Kaplan I, Allon D, Vered H, Shlomi B, Hirshberg A. HIF-1?, VEGF, and EGFR: contributing factors in the pathogenesis of necrotizing sialometaplasia. Oral Dis. 2014;20:440-5 pubmed publisher |
| Takikawa T, Masamune A, Hamada S, Nakano E, Yoshida N, Shimosegawa T. miR-210 regulates the interaction between pancreatic cancer cells and stellate cells. Biochem Biophys Res Commun. 2013;437:433-9 pubmed publisher |
| Wang W, McKinnie S, Patel V, Haddad G, Wang Z, Zhabyeyev P, et al. Loss of Apelin exacerbates myocardial infarction adverse remodeling and ischemia-reperfusion injury: therapeutic potential of synthetic Apelin analogues. J Am Heart Assoc. 2013;2:e000249 pubmed publisher |
| Xie L, Collins J. Transcription factors Sp1 and Hif2α mediate induction of the copper-transporting ATPase (Atp7a) gene in intestinal epithelial cells during hypoxia. J Biol Chem. 2013;288:23943-52 pubmed publisher |
| Sundelin J, Lidberg U, Nik A, Carlsson P, Boren J. Hypoxia-induced regulation of the very low density lipoprotein receptor. Biochem Biophys Res Commun. 2013;437:274-9 pubmed publisher |
| Wu C, Zhou Y, Chang J, Xiao Y. Delivery of dimethyloxallyl glycine in mesoporous bioactive glass scaffolds to improve angiogenesis and osteogenesis of human bone marrow stromal cells. Acta Biomater. 2013;9:9159-68 pubmed publisher |
| Kondrashina A, Papkovsky D, Dmitriev R. Measurement of cell respiration and oxygenation in standard multichannel biochips using phosphorescent O2-sensitive probes. Analyst. 2013;138:4915-21 pubmed publisher |
| Sato Y, Yoshizato T, Shiraishi Y, Maekawa S, Okuno Y, Kamura T, et al. Integrated molecular analysis of clear-cell renal cell carcinoma. Nat Genet. 2013;45:860-7 pubmed publisher |
| Shimomura M, Hinoi T, Kuroda S, Adachi T, Kawaguchi Y, Sasada T, et al. Overexpression of hypoxia inducible factor-1 alpha is an independent risk factor for recurrence after curative resection of colorectal liver metastases. Ann Surg Oncol. 2013;20 Suppl 3:S527-36 pubmed publisher |
| Zhang H, Tang L, Chen S, Yang Y, Chen M, Luo J. Effect of advanced glycation end products on the expression of hypoxia-inducible factor-1? and vascular endothelial growth factor proteins in RF/6A cells. Exp Ther Med. 2013;5:1519-1522 pubmed |
| Park G, Lee M, Roh J, Choi S, Nam S, Kim S, et al. Phospho-Rb (Ser780) as a biomarker in patients with cervical lymph node metastases from an unknown primary tumour: a retrospective cohort study. Clin Otolaryngol. 2013;38:313-21 pubmed publisher |
| Coudyzer P, Lemoine P, Jordan B, Gallez B, Galant C, Nisolle M, et al. Hypoxia is not required for human endometrial breakdown or repair in a xenograft model of menstruation. FASEB J. 2013;27:3711-9 pubmed publisher |
| Loukovaara S, Koivunen P, Inglés M, Escobar J, Vento M, Andersson S. Elevated protein carbonyl and HIF-1? levels in eyes with proliferative diabetic retinopathy. Acta Ophthalmol. 2014;92:323-7 pubmed publisher |
| Hutter R, Speidl W, Valdiviezo C, Sauter B, Corti R, Fuster V, et al. Macrophages transmit potent proangiogenic effects of oxLDL in vitro and in vivo involving HIF-1? activation: a novel aspect of angiogenesis in atherosclerosis. J Cardiovasc Transl Res. 2013;6:558-69 pubmed publisher |
| Janardhanan R, Yang B, Vohra P, Roy B, Withers S, Bhattacharya S, et al. Simvastatin reduces venous stenosis formation in a murine hemodialysis vascular access model. Kidney Int. 2013;84:338-52 pubmed publisher |
| Musyoka J, Liu M, Pouniotis D, Wong C, Bowtell D, Little P, et al. Siah2-deficient mice show impaired skin wound repair. Wound Repair Regen. 2013;21:437-47 pubmed publisher |
| Bohuslavova R, Skvorova L, Sedmera D, Semenza G, Pavlinkova G. Increased susceptibility of HIF-1? heterozygous-null mice to cardiovascular malformations associated with maternal diabetes. J Mol Cell Cardiol. 2013;60:129-41 pubmed publisher |
| Albers J, Rajski M, Schönenberger D, Harlander S, Schraml P, von Teichman A, et al. Combined mutation of Vhl and Trp53 causes renal cysts and tumours in mice. EMBO Mol Med. 2013;5:949-64 pubmed publisher |
| Pawlus M, Wang L, Hu C. STAT3 and HIF1? cooperatively activate HIF1 target genes in MDA-MB-231 and RCC4 cells. Oncogene. 2014;33:1670-9 pubmed publisher |
| Park S, Kim J, Son T, Yi J, Kim N, Yang K, et al. The histone demethylase JMJD1A regulates adrenomedullin-mediated cell proliferation in hepatocellular carcinoma under hypoxia. Biochem Biophys Res Commun. 2013;434:722-7 pubmed publisher |
| Bendinelli P, Maroni P, Matteucci E, Luzzati A, Perrucchini G, Desiderio M. Hypoxia inducible factor-1 is activated by transcriptional co-activator with PDZ-binding motif (TAZ) versus WWdomain-containing oxidoreductase (WWOX) in hypoxic microenvironment of bone metastasis from breast cancer. Eur J Cancer. 2013;49:2608-18 pubmed publisher |
| Chou Y, Zhan G, Zhu Y, Fenik P, Panossian L, Li Y, et al. C/EBP homologous binding protein (CHOP) underlies neural injury in sleep apnea model. Sleep. 2013;36:481-92 pubmed publisher |
| Li C, Xia M, Abais J, Liu X, Li N, Boini K, et al. Protective role of growth hormone against hyperhomocysteinemia-induced glomerular injury. Naunyn Schmiedebergs Arch Pharmacol. 2013;386:551-61 pubmed publisher |
| Shizu R, Shindo S, Yoshida T, Numazawa S. Cross-talk between constitutive androstane receptor and hypoxia-inducible factor in the regulation of gene expression. Toxicol Lett. 2013;219:143-50 pubmed publisher |
| Kakinuma Y, Tsuda M, Okazaki K, Akiyama T, Arikawa M, Noguchi T, et al. Heart-specific overexpression of choline acetyltransferase gene protects murine heart against ischemia through hypoxia-inducible factor-1?-related defense mechanisms. J Am Heart Assoc. 2013;2:e004887 pubmed publisher |
| Kawedia J, Yang F, Sartor M, Gozal D, CZYZYK KRZESKA M, Menon A. Hypoxia and hypoxia mimetics decrease aquaporin 5 (AQP5) expression through both hypoxia inducible factor-1? and proteasome-mediated pathways. PLoS ONE. 2013;8:e57541 pubmed publisher |
| Veerman K, Venegas Pino D, Shi Y, Khan M, Gerstein H, Werstuck G. Hyperglycaemia is associated with impaired vasa vasorum neovascularization and accelerated atherosclerosis in apolipoprotein-E deficient mice. Atherosclerosis. 2013;227:250-8 pubmed publisher |
| Heir P, Sufan R, Greer S, Poon B, Lee J, Ohh M. DCNL1 functions as a substrate sensor and activator of cullin 2-RING ligase. Mol Cell Biol. 2013;33:1621-31 pubmed publisher |
| Zimmermann S, Würgler Hauri C, Wanner G, Simmen H, Werner C. Echinomycin in the prevention of heterotopic ossification - an experimental antibiotic agent shows promising results in a murine model. Injury. 2013;44:570-5 pubmed publisher |
| Kurt B, Paliege A, Willam C, Schwarzensteiner I, Schucht K, Neymeyer H, et al. Deletion of von Hippel-Lindau protein converts renin-producing cells into erythropoietin-producing cells. J Am Soc Nephrol. 2013;24:433-44 pubmed publisher |
| Yeh Y, Chuang C, Chao K, Wang L. MicroRNA-138 suppresses ovarian cancer cell invasion and metastasis by targeting SOX4 and HIF-1?. Int J Cancer. 2013;133:867-78 pubmed publisher |
| Nechemia Arbely Y, Khamaisi M, Rosenberger C, Koesters R, Shina A, Geva C, et al. In vivo evidence suggesting reciprocal renal hypoxia-inducible factor-1 upregulation and signal transducer and activator of transcription 3 activation in response to hypoxic and non-hypoxic stimuli. Clin Exp Pharmacol Physiol. 2013;40:262-72 pubmed publisher |
| Emerling B, Benes C, Poulogiannis G, Bell E, Courtney K, Liu H, et al. Identification of CDCP1 as a hypoxia-inducible factor 2? (HIF-2?) target gene that is associated with survival in clear cell renal cell carcinoma patients. Proc Natl Acad Sci U S A. 2013;110:3483-8 pubmed publisher |
| Nagara Y, Tateishi T, Yamasaki R, Hayashi S, Kawamura M, Kikuchi H, et al. Impaired cytoplasmic-nuclear transport of hypoxia-inducible factor-1? in amyotrophic lateral sclerosis. Brain Pathol. 2013;23:534-46 pubmed publisher |
| Feliciano D, Zhang S, Quon J, Bordey A. Hypoxia-inducible factor 1a is a Tsc1-regulated survival factor in newborn neurons in tuberous sclerosis complex. Hum Mol Genet. 2013;22:1725-34 pubmed publisher |
| Hsieh Y, Yang S, Yang C, Chou L. Dry needling at myofascial trigger spots of rabbit skeletal muscles modulates the biochemicals associated with pain, inflammation, and hypoxia. Evid Based Complement Alternat Med. 2012;2012:342165 pubmed publisher |
| El Hasnaoui Saadani R, Marchant D, Pichon A, Escoubet B, Pezet M, Hilfiker Kleiner D, et al. Epo deficiency alters cardiac adaptation to chronic hypoxia. Respir Physiol Neurobiol. 2013;186:146-54 pubmed publisher |
| Towner R, Gillespie D, Schwager A, Saunders D, Smith N, Njoku C, et al. Regression of glioma tumor growth in F98 and U87 rat glioma models by the Nitrone OKN-007. Neuro Oncol. 2013;15:330-40 pubmed publisher |
| Chaturvedi P, Gilkes D, Wong C, Luo W, Zhang H, Wei H, et al. Hypoxia-inducible factor-dependent breast cancer-mesenchymal stem cell bidirectional signaling promotes metastasis. J Clin Invest. 2013;123:189-205 pubmed publisher |
| Liang Y, Zheng T, Song R, Wang J, Yin D, Wang L, et al. Hypoxia-mediated sorafenib resistance can be overcome by EF24 through Von Hippel-Lindau tumor suppressor-dependent HIF-1? inhibition in hepatocellular carcinoma. Hepatology. 2013;57:1847-57 pubmed publisher |
| Xie P, Zhang W, Yuan S, Chen Z, Yang Q, Yuan D, et al. Suppression of experimental choroidal neovascularization by curcumin in mice. PLoS ONE. 2012;7:e53329 pubmed publisher |
| Tanaka H, Sasayama T, Tanaka K, Nakamizo S, Nishihara M, Mizukawa K, et al. MicroRNA-183 upregulates HIF-1? by targeting isocitrate dehydrogenase 2 (IDH2) in glioma cells. J Neurooncol. 2013;111:273-83 pubmed publisher |
| Hebron M, Lonskaya I, Sharpe K, Weerasinghe P, Algarzae N, Shekoyan A, et al. Parkin ubiquitinates Tar-DNA binding protein-43 (TDP-43) and promotes its cytosolic accumulation via interaction with histone deacetylase 6 (HDAC6). J Biol Chem. 2013;288:4103-15 pubmed publisher |
| Crotty Alexander L, Akong Moore K, Feldstein S, Johansson P, Nguyen A, McEachern E, et al. Myeloid cell HIF-1α regulates asthma airway resistance and eosinophil function. J Mol Med (Berl). 2013;91:637-44 pubmed publisher |
| YOON J, Juhn K, Ko J, Yoon S, Ko Y, Lee C, et al. Effects of oxygen tension and IGF-I on HIF-1? protein expression in mouse blastocysts. J Assist Reprod Genet. 2013;30:99-105 pubmed publisher |
| Kelleher A, Kimball S, Dennis M, Schilder R, Jefferson L. The mTORC1 signaling repressors REDD1/2 are rapidly induced and activation of p70S6K1 by leucine is defective in skeletal muscle of an immobilized rat hindlimb. Am J Physiol Endocrinol Metab. 2013;304:E229-36 pubmed publisher |
| Menon J, Doebele R, Gomes S, Bevilacqua E, Reindl K, Rosner M. A novel interplay between Rap1 and PKA regulates induction of angiogenesis in prostate cancer. PLoS ONE. 2012;7:e49893 pubmed publisher |
| Cicchillitti L, Di Stefano V, Isaia E, Crimaldi L, Fasanaro P, Ambrosino V, et al. Hypoxia-inducible factor 1-? induces miR-210 in normoxic differentiating myoblasts. J Biol Chem. 2012;287:44761-71 pubmed publisher |
| Zhou H, Chen X, Zhang W, Zhu L, Cheng L. HIF-1? inhibition reduces nasal inflammation in a murine allergic rhinitis model. PLoS ONE. 2012;7:e48618 pubmed publisher |
| Ortiz Masia D, Díez I, Calatayud S, Hernandez C, Cosin Roger J, Hinojosa J, et al. Induction of CD36 and thrombospondin-1 in macrophages by hypoxia-inducible factor 1 and its relevance in the inflammatory process. PLoS ONE. 2012;7:e48535 pubmed publisher |
| Kitamoto S, Yokoyama S, Higashi M, Yamada N, Takao S, Yonezawa S. MUC1 enhances hypoxia-driven angiogenesis through the regulation of multiple proangiogenic factors. Oncogene. 2013;32:4614-21 pubmed publisher |
| Rider P, Kaplanov I, Romzova M, Bernardis L, Braiman A, Voronov E, et al. The transcription of the alarmin cytokine interleukin-1 alpha is controlled by hypoxia inducible factors 1 and 2 alpha in hypoxic cells. Front Immunol. 2012;3:290 pubmed publisher |
| Sirvent A, Vigy O, Orsetti B, Urbach S, Roche S. Analysis of SRC oncogenic signaling in colorectal cancer by stable isotope labeling with heavy amino acids in mouse xenografts. Mol Cell Proteomics. 2012;11:1937-50 pubmed publisher |
| Ciofani M, Madar A, Galan C, Sellars M, Mace K, Pauli F, et al. A validated regulatory network for Th17 cell specification. Cell. 2012;151:289-303 pubmed publisher |
| Kitamoto S, Yokoyama S, Higashi M, Yamada N, Matsubara S, Takao S, et al. Expression of MUC17 is regulated by HIF1?-mediated hypoxic responses and requires a methylation-free hypoxia responsible element in pancreatic cancer. PLoS ONE. 2012;7:e44108 pubmed publisher |
| Pawlus M, Wang L, Ware K, Hu C. Upstream stimulatory factor 2 and hypoxia-inducible factor 2? (HIF2?) cooperatively activate HIF2 target genes during hypoxia. Mol Cell Biol. 2012;32:4595-610 pubmed publisher |
| Chou C, Wang C, Wu C, Lin Y, Lee Y, Cheng Y, et al. Tumor cycling hypoxia induces chemoresistance in glioblastoma multiforme by upregulating the expression and function of ABCB1. Neuro Oncol. 2012;14:1227-38 pubmed |
| Zhdanov A, Dmitriev R, Papkovsky D. Bafilomycin A1 activates HIF-dependent signalling in human colon cancer cells via mitochondrial uncoupling. Biosci Rep. 2012;32:587-95 pubmed publisher |
| Krishnamachary B, Penet M, Nimmagadda S, Mironchik Y, Raman V, Solaiyappan M, et al. Hypoxia regulates CD44 and its variant isoforms through HIF-1? in triple negative breast cancer. PLoS ONE. 2012;7:e44078 pubmed publisher |
| Yamasaki T, Kamba T, Kanno T, Inoue T, Shibasaki N, Arakaki R, et al. Tumor microvasculature with endothelial fenestrations in VHL null clear cell renal cell carcinomas as a potent target of anti-angiogenic therapy. Cancer Sci. 2012;103:2027-37 pubmed publisher |
| Bai H, Ge S, Lu J, Qian G, Xu R. Hypoxia inducible factor-1?-mediated activation of survivin in cervical cancer cells. J Obstet Gynaecol Res. 2013;39:555-63 pubmed publisher |
| Kim K, Choi J, Kang I, Kim K, Jeong C, Jeong J. Melatonin suppresses tumor progression by reducing angiogenesis stimulated by HIF-1 in a mouse tumor model. J Pineal Res. 2013;54:264-70 pubmed publisher |
| Chiabrando D, Fiorito V, Marro S, Silengo L, Altruda F, Tolosano E. Cell-specific regulation of Ferroportin transcription following experimentally-induced acute anemia in mice. Blood Cells Mol Dis. 2013;50:25-30 pubmed publisher |
| Zhang D, Li J, Zhang M, Gao G, Zuo Z, Yu Y, et al. The requirement of c-Jun N-terminal kinase 2 in regulation of hypoxia-inducing factor-1? mRNA stability. J Biol Chem. 2012;287:34361-71 pubmed publisher |
| Chaudhuri S, McCullough S, Hennings L, Brown A, Li S, Simpson P, et al. Effect of trifluoperazine on toxicity, HIF-1? induction and hepatocyte regeneration in acetaminophen toxicity in mice. Toxicol Appl Pharmacol. 2012;264:192-201 pubmed publisher |
| Tamaki Y, Nakade Y, Yamauchi T, Makino Y, Yokohama S, Okada M, et al. Angiotensin II type 1 receptor antagonist prevents hepatic carcinoma in rats with nonalcoholic steatohepatitis. J Gastroenterol. 2013;48:491-503 pubmed publisher |
| Tsukamoto S, Yamashita S, Kim Y, Kumazoe M, Huang Y, Yamada K, et al. Oxygen partial pressure modulates 67-kDa laminin receptor expression, leading to altered activity of the green tea polyphenol, EGCG. FEBS Lett. 2012;586:3441-7 pubmed publisher |
| Li L, Liu B, Håversen L, Lu E, Magnusson L, Ståhlman M, et al. The importance of GLUT3 for de novo lipogenesis in hypoxia-induced lipid loading of human macrophages. PLoS ONE. 2012;7:e42360 pubmed publisher |
| Cal R, Juan Babot O, Brossa V, Roura S, Gálvez Monton C, Portoles M, et al. Low density lipoprotein receptor-related protein 1 expression correlates with cholesteryl ester accumulation in the myocardium of ischemic cardiomyopathy patients. J Transl Med. 2012;10:160 pubmed publisher |
| Sato K, Morimoto N, Kurata T, Mimoto T, Miyazaki K, Ikeda Y, et al. Impaired response of hypoxic sensor protein HIF-1? and its downstream proteins in the spinal motor neurons of ALS model mice. Brain Res. 2012;1473:55-62 pubmed publisher |
| Shim B, Jung J, Lee K, Kim H, Hong S, Kim S, et al. Glucose transporter 1 (GLUT1) of anaerobic glycolysis as predictive and prognostic values in neoadjuvant chemoradiotherapy and laparoscopic surgery for locally advanced rectal cancer. Int J Colorectal Dis. 2013;28:375-83 pubmed publisher |
| Roudier E, Forn P, Perry M, Birot O. Murine double minute-2 expression is required for capillary maintenance and exercise-induced angiogenesis in skeletal muscle. FASEB J. 2012;26:4530-9 pubmed publisher |
| Broderick T, Parrott C, Wang D, Jankowski M, Gutkowska J. Expression of cardiac GATA4 and downstream genes after exercise training in the db/db mouse. Pathophysiology. 2012;19:193-203 pubmed publisher |
| Boysen G, Bausch Fluck D, Thoma C, Nowicka A, Stiehl D, Cima I, et al. Identification and functional characterization of pVHL-dependent cell surface proteins in renal cell carcinoma. Neoplasia. 2012;14:535-46 pubmed |
| Chintala S, Najrana T, Toth K, Cao S, Durrani F, Pili R, et al. Prolyl hydroxylase 2 dependent and Von-Hippel-Lindau independent degradation of Hypoxia-inducible factor 1 and 2 alpha by selenium in clear cell renal cell carcinoma leads to tumor growth inhibition. BMC Cancer. 2012;12:293 pubmed publisher |
| Gautier Stein A, Soty M, Chilloux J, Zitoun C, Rajas F, Mithieux G. Glucotoxicity induces glucose-6-phosphatase catalytic unit expression by acting on the interaction of HIF-1? with CREB-binding protein. Diabetes. 2012;61:2451-60 pubmed |
| Kiss J, Mollenhauer M, Walmsley S, Kirchberg J, Radhakrishnan P, Niemietz T, et al. Loss of the oxygen sensor PHD3 enhances the innate immune response to abdominal sepsis. J Immunol. 2012;189:1955-65 pubmed publisher |
| Xu X, Kriegel A, Liu Y, Usa K, Mladinov D, Liu H, et al. Delayed ischemic preconditioning contributes to renal protection by upregulation of miR-21. Kidney Int. 2012;82:1167-75 pubmed publisher |
| Takeda T, Okuyama H, Nishizawa Y, Tomita S, Inoue M. Hypoxia inducible factor-1? is necessary for invasive phenotype in Vegf-deleted islet cell tumors. Sci Rep. 2012;2:494 pubmed publisher |
| Lee J, Jung E, Hyun J, Park D. Ultraviolet A regulates the stemness of human adipose tissue-derived mesenchymal stem cells through downregulation of the HIF-1? via activation of PGE(2)-cAMP signaling. J Cell Biochem. 2012;113:3681-91 pubmed publisher |
| Hsieh C, Wu C, Lee H, Liang J, Yu C, Lin Y. NADPH oxidase subunit 4 mediates cycling hypoxia-promoted radiation resistance in glioblastoma multiforme. Free Radic Biol Med. 2012;53:649-58 pubmed publisher |
| Shafighi M, Olariu R, Brun C, Fathi A, Djafarzadeh S, Jakob S, et al. The role of androgens on hypoxia-inducible factor (HIF)-1?-induced angiogenesis and on the survival of ischemically challenged skin flaps in a rat model. Microsurgery. 2012;32:475-81 pubmed publisher |
| Singh A, Mukhopadhyay C, Biswas S, Singh V, Mukhopadhyay C. Intracellular pathogen Leishmania donovani activates hypoxia inducible factor-1 by dual mechanism for survival advantage within macrophage. PLoS ONE. 2012;7:e38489 pubmed publisher |
| Matsumoto S, Saito K, Yasui H, Morris H, Munasinghe J, Lizak M, et al. EPR oxygen imaging and hyperpolarized 13C MRI of pyruvate metabolism as noninvasive biomarkers of tumor treatment response to a glycolysis inhibitor 3-bromopyruvate. Magn Reson Med. 2013;69:1443-50 pubmed publisher |
| Zhu Q, Liu M, Han W, Li P, Wang Z, Li N. Overexpression of HIF prolyl-hydoxylase-2 transgene in the renal medulla induced a salt sensitive hypertension. J Cell Mol Med. 2012;16:2701-7 pubmed publisher |
| Kim Y, Lee H, Kim T, Eisinger Mathason T, Zhang A, Schmidt B, et al. Overcoming evasive resistance from vascular endothelial growth factor a inhibition in sarcomas by genetic or pharmacologic targeting of hypoxia-inducible factor 1?. Int J Cancer. 2013;132:29-41 pubmed publisher |
| Pourvali K, Matak P, Latunde Dada G, Solomou S, Mastrogiannaki M, Peyssonnaux C, et al. Basal expression of copper transporter 1 in intestinal epithelial cells is regulated by hypoxia-inducible factor 2?. FEBS Lett. 2012;586:2423-7 pubmed publisher |
| Ke X, Fei F, Chen Y, Xu L, Zhang Z, Huang Q, et al. Hypoxia upregulates CD147 through a combined effect of HIF-1α and Sp1 to promote glycolysis and tumor progression in epithelial solid tumors. Carcinogenesis. 2012;33:1598-607 pubmed publisher |
| Yamada T, Uchida M, Kwang Lee K, Kitamura N, Yoshimura T, Sasabe E, et al. Correlation of metabolism/hypoxia markers and fluorodeoxyglucose uptake in oral squamous cell carcinomas. Oral Surg Oral Med Oral Pathol Oral Radiol. 2012;113:464-71 pubmed publisher |
| Bhawal U, Ito Y, Tanimoto K, Sato F, Fujimoto K, Kawamoto T, et al. IL-1?-mediated up-regulation of DEC1 in human gingiva cells via the Akt pathway. J Cell Biochem. 2012;113:3246-53 pubmed publisher |
| Koch Y, van Fürden B, Kaiser S, Klein D, Kibschull M, Schorle H, et al. Connexin 31 (GJB3) deficiency in mouse trophoblast stem cells alters giant cell differentiation and leads to loss of oxygen sensing. Biol Reprod. 2012;87:37 pubmed publisher |
| Wang H, Chen Q, Lee S, Choi Y, Johnson F, Pignolo R. Impairment of osteoblast differentiation due to proliferation-independent telomere dysfunction in mouse models of accelerated aging. Aging Cell. 2012;11:704-13 pubmed publisher |
| Yang L, Tan P, Zhou W, Zhu X, Cui Y, Zhu L, et al. N-acetylcysteine protects against hypoxia mimetic-induced autophagy by targeting the HIF-1? pathway in retinal ganglion cells. Cell Mol Neurobiol. 2012;32:1275-85 pubmed publisher |
| Lee J, Yang S, Lee H, Kim B, Cho J, Paik J, et al. Soluble epoxide hydrolase activity determines the severity of ischemia-reperfusion injury in kidney. PLoS ONE. 2012;7:e37075 pubmed publisher |
| Jackson I, Zhang X, Hadley C, Rabbani Z, Zhang Y, Marks S, et al. Temporal expression of hypoxia-regulated genes is associated with early changes in redox status in irradiated lung. Free Radic Biol Med. 2012;53:337-46 pubmed publisher |
| Nogami Y, Takase B, Kinoshita M, Shono S, Kaneda S, Tanaka Y, et al. Liposome-encapsulated hemoglobin attenuates cardiac dysfunction and sympathetic activity during hypohemoglobinemic shock. Shock. 2012;38:159-64 pubmed publisher |
| Sakamoto K, Hashimoto N, Kondoh Y, Imaizumi K, Aoyama D, Kohnoh T, et al. Differential modulation of surfactant protein D under acute and persistent hypoxia in acute lung injury. Am J Physiol Lung Cell Mol Physiol. 2012;303:L43-53 pubmed publisher |
| Grebhardt S, Veltkamp C, Strobel P, Mayer D. Hypoxia and HIF-1 increase S100A8 and S100A9 expression in prostate cancer. Int J Cancer. 2012;131:2785-94 pubmed publisher |
| Giani J, Burghi V, Veiras L, Tomat A, Muñoz M, Cao G, et al. Angiotensin-(1-7) attenuates diabetic nephropathy in Zucker diabetic fatty rats. Am J Physiol Renal Physiol. 2012;302:F1606-15 pubmed publisher |
| Jensen R, Lee J. Predicting outcomes of patients with intracranial meningiomas using molecular markers of hypoxia, vascularity, and proliferation. Neurosurgery. 2012;71:146-56 pubmed publisher |
| Warren G, Romano M, Kudrimoti M, Randall M, McGarry R, Singh A, et al. Nicotinic modulation of therapeutic response in vitro and in vivo. Int J Cancer. 2012;131:2519-27 pubmed publisher |
| Song Z, Zhou W, Shu R, Ni J. Hypoxia induces apoptosis and autophagic cell death in human periodontal ligament cells through HIF-1? pathway. Cell Prolif. 2012;45:239-48 pubmed publisher |
| Xue X, Taylor M, Anderson E, Hao C, Qu A, Greenson J, et al. Hypoxia-inducible factor-2α activation promotes colorectal cancer progression by dysregulating iron homeostasis. Cancer Res. 2012;72:2285-93 pubmed publisher |
| Natsuizaka M, Naganuma S, Kagawa S, Ohashi S, Ahmadi A, Subramanian H, et al. Hypoxia induces IGFBP3 in esophageal squamous cancer cells through HIF-1?-mediated mRNA transcription and continuous protein synthesis. FASEB J. 2012;26:2620-30 pubmed publisher |
| Wang Y, Roche O, Xu C, Moriyama E, Heir P, Chung J, et al. Hypoxia promotes ligand-independent EGF receptor signaling via hypoxia-inducible factor-mediated upregulation of caveolin-1. Proc Natl Acad Sci U S A. 2012;109:4892-7 pubmed publisher |
| Abraham S, Hu N, Jensen R. Hypoxia-inducible factor-1-regulated protein expression and oligodendroglioma patient outcome: comparison with established biomarkers and preoperative UCSF low-grade scoring system. J Neurooncol. 2012;108:459-68 pubmed publisher |
| Jansen J, Carlson D, Lu Y, Stambuk H, Moreira A, Singh B, et al. Correlation of a priori DCE-MRI and (1)H-MRS data with molecular markers in neck nodal metastases: Initial analysis. Oral Oncol. 2012;48:717-22 pubmed publisher |
| Xu Y, Li Q, Li X, Yang Q, Xu W, Liu G. Short-term anti-vascular endothelial growth factor treatment elicits vasculogenic mimicry formation of tumors to accelerate metastasis. J Exp Clin Cancer Res. 2012;31:16 pubmed publisher |
| Hayashi H, Nakagami H, Takeichi M, Shimamura M, Koibuchi N, Oiki E, et al. HIG1, a novel regulator of mitochondrial ?-secretase, maintains normal mitochondrial function. FASEB J. 2012;26:2306-17 pubmed publisher |
| Hsieh Y, Chou L, Chang P, Yang C, Kao M, Hong C. Low-level laser therapy alleviates neuropathic pain and promotes function recovery in rats with chronic constriction injury: possible involvements in hypoxia-inducible factor 1? (HIF-1?). J Comp Neurol. 2012;520:2903-16 pubmed publisher |
| Shiau A, Shen Y, Hsieh J, Wu C, Lee C. Scutellaria barbata inhibits angiogenesis through downregulation of HIF-1 ? in lung tumor. Environ Toxicol. 2014;29:363-70 pubmed publisher |
| Du F, Fan M, Gong Q, Zhu L, Zhu Z, Lu L, et al. Effects of hypoxic preconditioning on the expression of iron influx and efflux proteins in primary neuron culture. Neurochem Int. 2012;60:335-43 pubmed publisher |
| Lim C, Kiriakidis S, Paleolog E, Davies A. Increased activation of the hypoxia-inducible factor pathway in varicose veins. J Vasc Surg. 2012;55:1427-39 pubmed publisher |
| Shirakawa M, Fujiwara Y, Sugita Y, Moon J, Takiguchi S, Nakajima K, et al. Assessment of stanniocalcin-1 as a prognostic marker in human esophageal squamous cell carcinoma. Oncol Rep. 2012;27:940-6 pubmed publisher |
| Yang L, Fan M, Du F, Gong Q, Bi Z, Zhu Z, et al. Hypoxic preconditioning increases iron transport rate in astrocytes. Biochim Biophys Acta. 2012;1822:500-8 pubmed publisher |
| Doe M, Ascano J, Kaur M, Cole M. Myc posttranscriptionally induces HIF1 protein and target gene expression in normal and cancer cells. Cancer Res. 2012;72:949-57 pubmed publisher |
| Tanaka H, Li Z, Ikuta K, Addo L, Akutsu H, Nakamura M, et al. Iron facilitator LS081 reduces hypoxia-inducible factor-1? protein and functions as anticancer agent in hepatocellular carcinoma. Cancer Sci. 2012;103:767-74 pubmed publisher |
| Wilson G, Brimacombe C, Rowe I, Reynolds G, Fletcher N, Stamataki Z, et al. A dual role for hypoxia inducible factor-1? in the hepatitis C virus lifecycle and hepatoma migration. J Hepatol. 2012;56:803-9 pubmed publisher |
| Bohonowych J, Peng S, Gopal U, Hance M, Wing S, Argraves K, et al. Comparative analysis of novel and conventional Hsp90 inhibitors on HIF activity and angiogenic potential in clear cell renal cell carcinoma: implications for clinical evaluation. BMC Cancer. 2011;11:520 pubmed publisher |
| Mimouna S, Gonçalvès D, Barnich N, Darfeuille Michaud A, Hofman P, Vouret Craviari V. Crohn disease-associated Escherichia coli promote gastrointestinal inflammatory disorders by activation of HIF-dependent responses. Gut Microbes. 2011;2:335-46 pubmed publisher |
| Tang X, Lucas J, Chen J, LaMonte G, Wu J, Wang M, et al. Functional interaction between responses to lactic acidosis and hypoxia regulates genomic transcriptional outputs. Cancer Res. 2012;72:491-502 pubmed publisher |
| Mahabeleshwar G, Qureshi M, Takami Y, Sharma N, Lingrel J, Jain M. A myeloid hypoxia-inducible factor 1?-Krüppel-like factor 2 pathway regulates gram-positive endotoxin-mediated sepsis. J Biol Chem. 2012;287:1448-57 pubmed publisher |
| Ly A, Yee P, Vessey K, Phipps J, Jobling A, Fletcher E. Early inner retinal astrocyte dysfunction during diabetes and development of hypoxia, retinal stress, and neuronal functional loss. Invest Ophthalmol Vis Sci. 2011;52:9316-26 pubmed publisher |
| Schrobback K, Malda J, Crawford R, Upton Z, Leavesley D, Klein T. Effects of oxygen on zonal marker expression in human articular chondrocytes. Tissue Eng Part A. 2012;18:920-33 pubmed publisher |
| Cartee T, White K, Newton West M, Swerlick R. Hypoxia and hypoxia mimetics inhibit TNF-dependent VCAM1 induction in the 5A32 endothelial cell line via a hypoxia inducible factor dependent mechanism. J Dermatol Sci. 2012;65:86-94 pubmed publisher |
| Han M, Lee H, Cho K, Kim J, Roh J, Choi S, et al. Role of FDG-PET as a biological marker for predicting the hypoxic status of tongue cancer. Head Neck. 2012;34:1395-402 pubmed publisher |
| Milesi Hallé A, McCullough S, Hinson J, Kurten R, Lamps L, Brown A, et al. Echinomycin decreases induction of vascular endothelial growth factor and hepatocyte regeneration in acetaminophen toxicity in mice. Basic Clin Pharmacol Toxicol. 2012;110:327-34 pubmed publisher |
| Morine Y, Shimada M, Iwahashi S, Utsunomiya T, Imura S, Ikemoto T, et al. Role of histone deacetylase expression in intrahepatic cholangiocarcinoma. Surgery. 2012;151:412-9 pubmed publisher |
| El Guerrab A, Zegrour R, Nemlin C, Vigier F, Cayre A, Penault Llorca F, et al. Differential impact of EGFR-targeted therapies on hypoxia responses: implications for treatment sensitivity in triple-negative metastatic breast cancer. PLoS ONE. 2011;6:e25080 pubmed publisher |
| Morine Y, Shimada M, Utsunomiya T, Imura S, Ikemoto T, Mori H, et al. Hypoxia inducible factor expression in intrahepatic cholangiocarcinoma. Hepatogastroenterology. 2011;58:1439-44 pubmed publisher |
| Hsieh C, Shyu W, Chiang C, Kuo J, Shen W, Liu R. NADPH oxidase subunit 4-mediated reactive oxygen species contribute to cycling hypoxia-promoted tumor progression in glioblastoma multiforme. PLoS ONE. 2011;6:e23945 pubmed publisher |
| Tsai Y, Yang Y, Wang P, Wang R. Intermittent hypoxia after transient focal ischemia induces hippocampal neurogenesis and c-Fos expression and reverses spatial memory deficits in rats. PLoS ONE. 2011;6:e24001 pubmed publisher |
| Liu C, Tsai A, Chen Y, Fan S, Huang C, Wu C, et al. Facilitation of human osteoblast apoptosis by sulindac and indomethacin under hypoxic injury. J Cell Biochem. 2012;113:148-55 pubmed publisher |
| Dang E, Barbi J, Yang H, Jinasena D, Yu H, Zheng Y, et al. Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1. Cell. 2011;146:772-84 pubmed publisher |
| Hattori H, Okuda K, Murase T, Shigetsura Y, Narise K, Semenza G, et al. Isolation, identification, and biological evaluation of HIF-1-modulating compounds from Brazilian green propolis. Bioorg Med Chem. 2011;19:5392-401 pubmed publisher |
| Kwon T, Zhao X, Yang Q, Li Y, Ge C, Zhao G, et al. Physical and functional interactions between Runx2 and HIF-1? induce vascular endothelial growth factor gene expression. J Cell Biochem. 2011;112:3582-93 pubmed publisher |
| Kumar P, Mendelson C. Estrogen-related receptor gamma (ERRgamma) mediates oxygen-dependent induction of aromatase (CYP19) gene expression during human trophoblast differentiation. Mol Endocrinol. 2011;25:1513-26 pubmed publisher |
| Zhang X, Yan Z, Sheng W, Xiao J, Zhang Z, Ye Z. Activation of hypoxia-inducible factor-1 ameliorates postischemic renal injury via inducible nitric oxide synthase. Mol Cell Biochem. 2011;358:287-95 pubmed publisher |
| Sengupta T, Abraham G, Xu Y, Clurman B, Minella A. Hypoxia-inducible factor 1 is activated by dysregulated cyclin E during mammary epithelial morphogenesis. Mol Cell Biol. 2011;31:3885-95 pubmed publisher |
| Nonoguchi N, Miyatake S, Fukumoto M, Furuse M, Hiramatsu R, Kawabata S, et al. The distribution of vascular endothelial growth factor-producing cells in clinical radiation necrosis of the brain: pathological consideration of their potential roles. J Neurooncol. 2011;105:423-31 pubmed publisher |
| Lehwald N, Tao G, Jang K, Sorkin M, Knoefel W, Sylvester K. Wnt-?-catenin signaling protects against hepatic ischemia and reperfusion injury in mice. Gastroenterology. 2011;141:707-18, 718.e1-5 pubmed publisher |
| Kummar S, Raffeld M, Juwara L, Horneffer Y, Strassberger A, Allen D, et al. Multihistology, target-driven pilot trial of oral topotecan as an inhibitor of hypoxia-inducible factor-1α in advanced solid tumors. Clin Cancer Res. 2011;17:5123-31 pubmed publisher |
| Leh S, Hultström M, Rosenberger C, Iversen B. Afferent arteriolopathy and glomerular collapse but not segmental sclerosis induce tubular atrophy in old spontaneously hypertensive rats. Virchows Arch. 2011;459:99-108 pubmed publisher |
| Noh H, Yu M, Kim H, Jeon J, Kwon S, Jin S, et al. Uremia induces functional incompetence of bone marrow-derived stromal cells. Nephrol Dial Transplant. 2012;27:218-25 pubmed publisher |
| Chen B, Yuping S, Ni J. Rapamycin decreases survivin expression to induce NSCLC cell apoptosis under hypoxia through inhibiting HIF-1? induction. Mol Biol Rep. 2012;39:185-91 pubmed publisher |
| Namas R, Metukuri M, Dhupar R, Velosa C, Jefferson B, Myer E, et al. Hypoxia-induced overexpression of BNIP3 is not dependent on hypoxia-inducible factor 1? in mouse hepatocytes. Shock. 2011;36:196-202 pubmed publisher |
| Baek J, Reiter C, Manalo D, Buehler P, Hider R, Alayash A. Induction of hypoxia inducible factor (HIF-1?) in rat kidneys by iron chelation with the hydroxypyridinone, CP94. Biochim Biophys Acta. 2011;1809:262-8 pubmed publisher |
| Kang Y, Jo J, Cho M, Yu H, Ock M, Cha H. Trichinella spiralis infection induces angiogenic factor thymosin ?4 expression. Vet Parasitol. 2011;181:222-8 pubmed publisher |
| Silver M, Paul P, Sowjanya P, Ramakrishna G, Vedantham H, Kalpana B, et al. Shedding of Epstein-Barr virus and cytomegalovirus from the genital tract of women in a periurban community in Andhra Pradesh, India. J Clin Microbiol. 2011;49:2435-9 pubmed publisher |
| Zhang X, Sarkar K, Rey S, Sebastian R, Andrikopoulou E, Marti G, et al. Aging impairs the mobilization and homing of bone marrow-derived angiogenic cells to burn wounds. J Mol Med (Berl). 2011;89:985-95 pubmed publisher |
| He Q, Gao Z, Yin J, Zhang J, Yun Z, Ye J. Regulation of HIF-1{alpha} activity in adipose tissue by obesity-associated factors: adipogenesis, insulin, and hypoxia. Am J Physiol Endocrinol Metab. 2011;300:E877-85 pubmed publisher |
| Higashimura Y, Nakajima Y, Yamaji R, Harada N, Shibasaki F, Nakano Y, et al. Up-regulation of glyceraldehyde-3-phosphate dehydrogenase gene expression by HIF-1 activity depending on Sp1 in hypoxic breast cancer cells. Arch Biochem Biophys. 2011;509:1-8 pubmed publisher |
| Tamama K, Kawasaki H, Kerpedjieva S, Guan J, Ganju R, Sen C. Differential roles of hypoxia inducible factor subunits in multipotential stromal cells under hypoxic condition. J Cell Biochem. 2011;112:804-17 pubmed publisher |
| Chaudhuri S, McCullough S, Hennings L, Letzig L, Simpson P, Hinson J, et al. Acetaminophen hepatotoxicity and HIF-1? induction in acetaminophen toxicity in mice occurs without hypoxia. Toxicol Appl Pharmacol. 2011;252:211-20 pubmed publisher |
| Sato Y, Endo H, Okuyama H, Takeda T, Iwahashi H, Imagawa A, et al. Cellular hypoxia of pancreatic beta-cells due to high levels of oxygen consumption for insulin secretion in vitro. J Biol Chem. 2011;286:12524-32 pubmed publisher |
| Valsecchi V, Pignataro G, Del Prete A, Sirabella R, Matrone C, Boscia F, et al. NCX1 is a novel target gene for hypoxia-inducible factor-1 in ischemic brain preconditioning. Stroke. 2011;42:754-63 pubmed publisher |
| Milkiewicz M, Roudier E, Doyle J, Trifonova A, Birot O, Haas T. Identification of a mechanism underlying regulation of the anti-angiogenic forkhead transcription factor FoxO1 in cultured endothelial cells and ischemic muscle. Am J Pathol. 2011;178:935-44 pubmed publisher |
| Kim J, Kim S, Do I, Jin J, Nam D, Ko Y, et al. Hypoxia-associated protein expression in primary central nervous system diffuse large B-cell lymphoma: does it predict prognosis?. Leuk Lymphoma. 2011;52:205-13 pubmed publisher |
| Lunde I, Anton S, Bruusgaard J, Rana Z, Ellefsen S, Gundersen K. Hypoxia inducible factor 1 links fast-patterned muscle activity and fast muscle phenotype in rats. J Physiol. 2011;589:1443-54 pubmed publisher |
| Trisciuoglio D, Gabellini C, Desideri M, Ragazzoni Y, De Luca T, Ziparo E, et al. Involvement of BH4 domain of bcl-2 in the regulation of HIF-1-mediated VEGF expression in hypoxic tumor cells. Cell Death Differ. 2011;18:1024-35 pubmed publisher |
| Spagnuolo R, Recalcati S, Tacchini L, Cairo G. Role of hypoxia-inducible factors in the dexrazoxane-mediated protection of cardiomyocytes from doxorubicin-induced toxicity. Br J Pharmacol. 2011;163:299-312 pubmed publisher |
| Jian J, Yang Q, Dai J, Eckard J, Axelrod D, Axelrod D, et al. Effects of iron deficiency and iron overload on angiogenesis and oxidative stress-a potential dual role for iron in breast cancer. Free Radic Biol Med. 2011;50:841-7 pubmed publisher |
| Nakamura K, Tan F, Li Z, Thiele C. NGF activation of TrkA induces vascular endothelial growth factor expression via induction of hypoxia-inducible factor-1α. Mol Cell Neurosci. 2011;46:498-506 pubmed publisher |
| Espinosa I, José Carnicer M, Catasus L, Canet B, D Angelo E, Zannoni G, et al. Myometrial invasion and lymph node metastasis in endometrioid carcinomas: tumor-associated macrophages, microvessel density, and HIF1A have a crucial role. Am J Surg Pathol. 2010;34:1708-14 pubmed publisher |
| Manisterski M, Golan M, Amir S, Weisman Y, Mabjeesh N. Hypoxia induces PTHrP gene transcription in human cancer cells through the HIF-2?. Cell Cycle. 2010;9:3723-9 pubmed |
| Li L, Madu C, Lu A, Lu Y. HIF-1? Promotes A Hypoxia-Independent Cell Migration. Open Biol J. 2010;3:8-14 pubmed |
| Deng A, Arndt M, Satriano J, Singh P, Rieg T, Thomson S, et al. Renal protection in chronic kidney disease: hypoxia-inducible factor activation vs. angiotensin II blockade. Am J Physiol Renal Physiol. 2010;299:F1365-73 pubmed publisher |
| Chen H, Kluz T, Zhang R, Costa M. Hypoxia and nickel inhibit histone demethylase JMJD1A and repress Spry2 expression in human bronchial epithelial BEAS-2B cells. Carcinogenesis. 2010;31:2136-44 pubmed publisher |
| Dimova E, Kietzmann T. Hypoxia-inducible factors: post-translational crosstalk of signaling pathways. Methods Mol Biol. 2010;647:215-36 pubmed publisher |
| Mashiko R, Takano S, Ishikawa E, Yamamoto T, Nakai K, Matsumura A. Hypoxia-inducible factor 1? expression is a prognostic biomarker in patients with astrocytic tumors associated with necrosis on MR image. J Neurooncol. 2011;102:43-50 pubmed publisher |
| Wu D, Paulson R. Hypoxia regulates BMP4 expression in the murine spleen during the recovery from acute anemia. PLoS ONE. 2010;5:e11303 pubmed publisher |
| Ioannou M, Mylonis I, Kouvaras E, Papamichali R, Daponte A, Paraskeva E, et al. Validated analysis of HIF-1alpha expression in cancer cells using a controlled and comparative immunoassay. Oncol Rep. 2010;24:161-9 pubmed |
| Hammers H, Verheul H, Salumbides B, Sharma R, Rudek M, Jaspers J, et al. Reversible epithelial to mesenchymal transition and acquired resistance to sunitinib in patients with renal cell carcinoma: evidence from a xenograft study. Mol Cancer Ther. 2010;9:1525-35 pubmed publisher |
| Hirota S, Fines K, Ng J, Traboulsi D, Lee J, Ihara E, et al. Hypoxia-inducible factor signaling provides protection in Clostridium difficile-induced intestinal injury. Gastroenterology. 2010;139:259-69.e3 pubmed publisher |
| Zhang J, Lu A, Li L, Yue J, Lu Y. p16 Modulates VEGF expression via its interaction with HIF-1alpha in breast cancer cells. Cancer Invest. 2010;28:588-97 pubmed publisher |
| Vaughan M, Toth K, Chintala S, Rustum Y. Double immunohistochemical staining method for HIF-1alpha and its regulators PHD2 and PHD3 in formalin-fixed paraffin-embedded tissues. Appl Immunohistochem Mol Morphol. 2010;18:375-81 pubmed publisher |
| Wen W, Ding J, Sun W, Wu K, Ning B, Gong W, et al. Suppression of cyclin D1 by hypoxia-inducible factor-1 via direct mechanism inhibits the proliferation and 5-fluorouracil-induced apoptosis of A549 cells. Cancer Res. 2010;70:2010-9 pubmed publisher |
| Ogane N, Yasuda M, Shimizu M, Miyazawa M, Kamoshida S, Ueda A, et al. Clinicopathological implications of expressions of hypoxia-related molecules in esophageal superficial squamous cell carcinoma. Ann Diagn Pathol. 2010;14:23-9 pubmed publisher |
| Gauter Fleckenstein B, Fleckenstein K, Owzar K, Jiang C, Reboucas J, Batinic Haberle I, et al. Early and late administration of MnTE-2-PyP5+ in mitigation and treatment of radiation-induced lung damage. Free Radic Biol Med. 2010;48:1034-43 pubmed publisher |
| Yoshida T, Zhang H, Iwase T, Shen J, Semenza G, Campochiaro P. Digoxin inhibits retinal ischemia-induced HIF-1alpha expression and ocular neovascularization. FASEB J. 2010;24:1759-67 pubmed publisher |
| Evens A, Sehn L, Farinha P, Nelson B, Raji A, Lu Y, et al. Hypoxia-inducible factor-1 {alpha} expression predicts superior survival in patients with diffuse large B-cell lymphoma treated with R-CHOP. J Clin Oncol. 2010;28:1017-24 pubmed publisher |
| Tanaka T, Wakamatsu T, Daijo H, Oda S, Kai S, Adachi T, et al. Persisting mild hypothermia suppresses hypoxia-inducible factor-1alpha protein synthesis and hypoxia-inducible factor-1-mediated gene expression. Am J Physiol Regul Integr Comp Physiol. 2010;298:R661-71 pubmed publisher |
| Lee J, Natsuizaka M, Ohashi S, Wong G, Takaoka M, Michaylira C, et al. Hypoxia activates the cyclooxygenase-2-prostaglandin E synthase axis. Carcinogenesis. 2010;31:427-34 pubmed publisher |
| Rouschop K, van den Beucken T, Dubois L, Niessen H, Bussink J, Savelkouls K, et al. The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5. J Clin Invest. 2010;120:127-41 pubmed publisher |
| Nakamura J, Kitajima Y, Kai K, Hashiguchi K, Hiraki M, Noshiro H, et al. HIF-1alpha is an unfavorable determinant of relapse in gastric cancer patients who underwent curative surgery followed by adjuvant 5-FU chemotherapy. Int J Cancer. 2010;127:1158-71 pubmed publisher |
| Neusser M, Lindenmeyer M, Moll A, Segerer S, Edenhofer I, Sen K, et al. Human nephrosclerosis triggers a hypoxia-related glomerulopathy. Am J Pathol. 2010;176:594-607 pubmed publisher |
| Regazzetti C, Bost F, Le Marchand Brustel Y, Tanti J, Giorgetti Peraldi S. Insulin induces REDD1 expression through hypoxia-inducible factor 1 activation in adipocytes. J Biol Chem. 2010;285:5157-64 pubmed publisher |
| Choy M, Movassagh M, Bennett M, Foo R. PKB/Akt activation inhibits p53-mediated HIF1A degradation that is independent of MDM2. J Cell Physiol. 2010;222:635-9 pubmed publisher |
| Rey S, Lee K, Wang C, Gupta K, Chen S, McMillan A, et al. Synergistic effect of HIF-1alpha gene therapy and HIF-1-activated bone marrow-derived angiogenic cells in a mouse model of limb ischemia. Proc Natl Acad Sci U S A. 2009;106:20399-404 pubmed publisher |
| Luo W, Zhong J, Chang R, Hu H, Pandey A, Semenza G. Hsp70 and CHIP selectively mediate ubiquitination and degradation of hypoxia-inducible factor (HIF)-1alpha but Not HIF-2alpha. J Biol Chem. 2010;285:3651-63 pubmed publisher |
| Rezvani H, Mahfouf W, Ali N, Chemin C, Ged C, Kim A, et al. Hypoxia-inducible factor-1alpha regulates the expression of nucleotide excision repair proteins in keratinocytes. Nucleic Acids Res. 2010;38:797-809 pubmed publisher |
| Hsieh C, Kuo J, Lee Y, Chang C, Gelovani J, Liu R. Construction of mutant TKGFP for real-time imaging of temporal dynamics of HIF-1 signal transduction activity mediated by hypoxia and reoxygenation in tumors in living mice. J Nucl Med. 2009;50:2049-57 pubmed publisher |
| Nishimura R, Okuda K. Hypoxia is important for establishing vascularization during corpus luteum formation in cattle. J Reprod Dev. 2010;56:110-6 pubmed |
| Lee K, Zhang H, Qian D, Rey S, Liu J, Semenza G. Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization. Proc Natl Acad Sci U S A. 2009;106:17910-5 pubmed publisher |
| Sims J, Lee S, Topalkara K, Qiu J, Xu J, Zhou Z, et al. Sonic hedgehog regulates ischemia/hypoxia-induced neural progenitor proliferation. Stroke. 2009;40:3618-26 pubmed publisher |
| Hammerschmidt E, Loeffler I, Wolf G. Morg1 heterozygous mice are protected from acute renal ischemia-reperfusion injury. Am J Physiol Renal Physiol. 2009;297:F1273-87 pubmed publisher |
| Nakamura J, Kitajima Y, Kai K, Mitsuno M, Ide T, Hashiguchi K, et al. Hypoxia-inducible factor-1alpha expression predicts the response to 5-fluorouracil-based adjuvant chemotherapy in advanced gastric cancer. Oncol Rep. 2009;22:693-9 pubmed |
| Tsuruda T, Hatakeyama K, Masuyama H, Sekita Y, Imamura T, Asada Y, et al. Pharmacological stimulation of soluble guanylate cyclase modulates hypoxia-inducible factor-1alpha in rat heart. Am J Physiol Heart Circ Physiol. 2009;297:H1274-80 pubmed publisher |
| Hu Y, Kirito K, Yoshida K, Mitsumori T, Nakajima K, Nozaki Y, et al. Inhibition of hypoxia-inducible factor-1 function enhances the sensitivity of multiple myeloma cells to melphalan. Mol Cancer Ther. 2009;8:2329-38 pubmed publisher |
| Thangarajah H, Yao D, Chang E, Shi Y, Jazayeri L, Vial I, et al. The molecular basis for impaired hypoxia-induced VEGF expression in diabetic tissues. Proc Natl Acad Sci U S A. 2009;106:13505-10 pubmed publisher |
| Chen A, Cuevas I, Kenny P, Miyake H, Mace K, Ghajar C, et al. Endothelial cell migration and vascular endothelial growth factor expression are the result of loss of breast tissue polarity. Cancer Res. 2009;69:6721-9 pubmed publisher |
| Nomura M, Ishii H, Kawakami A, Yoshida M. Inhibition of hepatic Niemann-Pick C1-like 1 improves hepatic insulin resistance. Am J Physiol Endocrinol Metab. 2009;297:E1030-8 pubmed publisher |
| Mahimainathan L, Ghosh Choudhury N, Venkatesan B, Das F, Mandal C, Dey N, et al. TSC2 deficiency increases PTEN via HIF1alpha. J Biol Chem. 2009;284:27790-8 pubmed publisher |
| Doroudgar S, Thuerauf D, Marcinko M, Belmont P, Glembotski C. Ischemia activates the ATF6 branch of the endoplasmic reticulum stress response. J Biol Chem. 2009;284:29735-45 pubmed publisher |
| Bhaskar P, Nogueira V, Patra K, Jeon S, Park Y, Robey R, et al. mTORC1 hyperactivity inhibits serum deprivation-induced apoptosis via increased hexokinase II and GLUT1 expression, sustained Mcl-1 expression, and glycogen synthase kinase 3beta inhibition. Mol Cell Biol. 2009;29:5136-47 pubmed publisher |
| Rapisarda A, Hollingshead M, Uranchimeg B, Bonomi C, Borgel S, Carter J, et al. Increased antitumor activity of bevacizumab in combination with hypoxia inducible factor-1 inhibition. Mol Cancer Ther. 2009;8:1867-77 pubmed publisher |
| Hsu K, Chi N, Gucek M, Van Eyk J, Cole R, Lin M, et al. Miltenberger blood group antigen type III (Mi.III) enhances the expression of band 3. Blood. 2009;114:1919-28 pubmed publisher |
| Aubert S, Fauquette V, Hemon B, Lepoivre R, Briez N, Bernard D, et al. MUC1, a new hypoxia inducible factor target gene, is an actor in clear renal cell carcinoma tumor progression. Cancer Res. 2009;69:5707-15 pubmed publisher |
| Loinard C, Ginouves A, Vilar J, Cochain C, Zouggari Y, Recalde A, et al. Inhibition of prolyl hydroxylase domain proteins promotes therapeutic revascularization. Circulation. 2009;120:50-9 pubmed publisher |
| Halberg N, Khan T, Trujillo M, Wernstedt Asterholm I, Attie A, Sherwani S, et al. Hypoxia-inducible factor 1alpha induces fibrosis and insulin resistance in white adipose tissue. Mol Cell Biol. 2009;29:4467-83 pubmed publisher |
| Shackelford D, Vasquez D, Corbeil J, Wu S, Leblanc M, Wu C, et al. mTOR and HIF-1alpha-mediated tumor metabolism in an LKB1 mouse model of Peutz-Jeghers syndrome. Proc Natl Acad Sci U S A. 2009;106:11137-42 pubmed publisher |
| Benita Y, Kikuchi H, Smith A, Zhang M, Chung D, Xavier R. An integrative genomics approach identifies Hypoxia Inducible Factor-1 (HIF-1)-target genes that form the core response to hypoxia. Nucleic Acids Res. 2009;37:4587-602 pubmed publisher |
| Kawanami D, Mahabeleshwar G, Lin Z, Atkins G, Hamik A, Haldar S, et al. Kruppel-like factor 2 inhibits hypoxia-inducible factor 1alpha expression and function in the endothelium. J Biol Chem. 2009;284:20522-30 pubmed publisher |
| Fang H, Hughes R, Murdoch C, Coffelt S, Biswas S, Harris A, et al. Hypoxia-inducible factors 1 and 2 are important transcriptional effectors in primary macrophages experiencing hypoxia. Blood. 2009;114:844-59 pubmed publisher |
| Guma M, Rius J, Duong Polk K, Haddad G, Lindsey J, Karin M. Genetic and pharmacological inhibition of JNK ameliorates hypoxia-induced retinopathy through interference with VEGF expression. Proc Natl Acad Sci U S A. 2009;106:8760-5 pubmed publisher |
| Torii S, Kobayashi K, Takahashi M, Katahira K, Goryo K, Matsushita N, et al. Magnesium deficiency causes loss of response to intermittent hypoxia in paraganglion cells. J Biol Chem. 2009;284:19077-89 pubmed publisher |
| Bullock J, Mehta S, Lin Y, Lolla P, Li P. Hyperglycemia-enhanced ischemic brain damage in mutant manganese SOD mice is associated with suppression of HIF-1alpha. Neurosci Lett. 2009;456:89-92 pubmed publisher |
| Rhoads R, Johnson R, Rathbone C, Liu X, Temm Grove C, Sheehan S, et al. Satellite cell-mediated angiogenesis in vitro coincides with a functional hypoxia-inducible factor pathway. Am J Physiol Cell Physiol. 2009;296:C1321-8 pubmed publisher |
| Irwin D, McCord J, Nozik Grayck E, Beckly G, Foreman B, Sullivan T, et al. A potential role for reactive oxygen species and the HIF-1alpha-VEGF pathway in hypoxia-induced pulmonary vascular leak. Free Radic Biol Med. 2009;47:55-61 pubmed publisher |
| Ghosh A, Shanafelt T, Cimmino A, Taccioli C, Volinia S, Liu C, et al. Aberrant regulation of pVHL levels by microRNA promotes the HIF/VEGF axis in CLL B cells. Blood. 2009;113:5568-74 pubmed publisher |
| Kim J, Bagchi I, Bagchi M. Signaling by hypoxia-inducible factors is critical for ovulation in mice. Endocrinology. 2009;150:3392-400 pubmed publisher |
| Kimbrel E, Kung A. The F-box protein beta-TrCp1/Fbw1a interacts with p300 to enhance beta-catenin transcriptional activity. J Biol Chem. 2009;284:13033-44 pubmed publisher |
| Amann T, Maegdefrau U, Hartmann A, Agaimy A, Marienhagen J, Weiss T, et al. GLUT1 expression is increased in hepatocellular carcinoma and promotes tumorigenesis. Am J Pathol. 2009;174:1544-52 pubmed publisher |
| Hong S, Yoo J, Kang H, Kim S, Lee D. HIF-1alpha-dependent gene expression program during the nucleic acid-triggered antiviral innate immune responses. Mol Cells. 2009;27:243-50 pubmed publisher |
| Shen F, Li N, Gade P, Kalvakolanu D, Weibley T, Doble B, et al. IL-17 receptor signaling inhibits C/EBPbeta by sequential phosphorylation of the regulatory 2 domain. Sci Signal. 2009;2:ra8 pubmed publisher |
| Zhu K, Chan W, Heymach J, Wilkinson M, McConkey D. Control of HIF-1alpha expression by eIF2 alpha phosphorylation-mediated translational repression. Cancer Res. 2009;69:1836-43 pubmed publisher |
| Klatte T, Seligson D, Larochelle J, Shuch B, Said J, Riggs S, et al. Molecular signatures of localized clear cell renal cell carcinoma to predict disease-free survival after nephrectomy. Cancer Epidemiol Biomarkers Prev. 2009;18:894-900 pubmed publisher |
| Klatte T, Pantuck A, Said J, Seligson D, Rao N, LaRochelle J, et al. Cytogenetic and molecular tumor profiling for type 1 and type 2 papillary renal cell carcinoma. Clin Cancer Res. 2009;15:1162-9 pubmed publisher |
| Lam W, Bussom S, Cheng Y. Effect of hypoxia on the expression of phosphoglycerate kinase and antitumor activity of troxacitabine and gemcitabine in non-small cell lung carcinoma. Mol Cancer Ther. 2009;8:415-23 pubmed publisher |
| Lomb D, Desouza L, Franklin J, Freeman R. Prolyl hydroxylase inhibitors depend on extracellular glucose and hypoxia-inducible factor (HIF)-2alpha to inhibit cell death caused by nerve growth factor (NGF) deprivation: evidence that HIF-2alpha has a role in NGF-promoted survival of sympathetic. Mol Pharmacol. 2009;75:1198-209 pubmed publisher |
| Osorio Fuentealba C, Valdés J, Riquelme D, Hidalgo J, Hidalgo C, Carrasco M. Hypoxia stimulates via separate pathways ERK phosphorylation and NF-kappaB activation in skeletal muscle cells in primary culture. J Appl Physiol (1985). 2009;106:1301-10 pubmed publisher |
| Tyagi A, Singh R, Ramasamy K, Raina K, Redente E, Dwyer Nield L, et al. Growth inhibition and regression of lung tumors by silibinin: modulation of angiogenesis by macrophage-associated cytokines and nuclear factor-kappaB and signal transducers and activators of transcription 3. Cancer Prev Res (Phila). 2009;2:74-83 pubmed publisher |
| Miyazawa M, Yasuda M, Fujita M, Kajiwara H, Hirabayashi K, Takekoshi S, et al. Therapeutic strategy targeting the mTOR-HIF-1alpha-VEGF pathway in ovarian clear cell adenocarcinoma. Pathol Int. 2009;59:19-27 pubmed publisher |
| Yeh S, Hung J, Gean P, Chang W. Hypoxia-inducible factor-1alpha protects cultured cortical neurons from lipopolysaccharide-induced cell death via regulation of NR1 expression. J Neurosci. 2008;28:14259-70 pubmed publisher |
| El Hasnaoui Saadani R, Pichon A, Marchant D, Olivier P, Launay T, Quidu P, et al. Cerebral adaptations to chronic anemia in a model of erythropoietin-deficient mice exposed to hypoxia. Am J Physiol Regul Integr Comp Physiol. 2009;296:R801-11 pubmed publisher |
| Wong W, Goehring A, Kapiloff M, Langeberg L, Scott J. mAKAP compartmentalizes oxygen-dependent control of HIF-1alpha. Sci Signal. 2008;1:ra18 pubmed publisher |
| Keely S, Glover L, MacManus C, Campbell E, Scully M, Furuta G, et al. Selective induction of integrin beta1 by hypoxia-inducible factor: implications for wound healing. FASEB J. 2009;23:1338-46 pubmed publisher |
| Gilbert J, Gilbert S, Arany M, Granger J. Hypertension produced by placental ischemia in pregnant rats is associated with increased soluble endoglin expression. Hypertension. 2009;53:399-403 pubmed publisher |
| Zhang H, Qian D, Tan Y, Lee K, Gao P, Ren Y, et al. Digoxin and other cardiac glycosides inhibit HIF-1alpha synthesis and block tumor growth. Proc Natl Acad Sci U S A. 2008;105:19579-86 pubmed publisher |
| Thomas R, Kim M. A HIF-1alpha-dependent autocrine feedback loop promotes survival of serum-deprived prostate cancer cells. Prostate. 2009;69:263-75 pubmed publisher |
| Ngan B, Forte V, Campisi P. Molecular angiogenic signaling in angiofibromas after embolization: implications for therapy. Arch Otolaryngol Head Neck Surg. 2008;134:1170-6 pubmed publisher |
| Shibata R, Ueda S, Yamagishi S, Kaida Y, Matsumoto Y, Fukami K, et al. Involvement of asymmetric dimethylarginine (ADMA) in tubulointerstitial ischaemia in the early phase of diabetic nephropathy. Nephrol Dial Transplant. 2009;24:1162-9 pubmed publisher |
| Akoyev V, Das S, Jena S, Grauer L, Takemoto D. Hypoxia-regulated activity of PKCepsilon in the lens. Invest Ophthalmol Vis Sci. 2009;50:1271-82 pubmed publisher |
| Sreekumar P, Ding Y, Ryan S, Kannan R, Hinton D. Regulation of thioredoxin by ceramide in retinal pigment epithelial cells. Exp Eye Res. 2009;88:410-7 pubmed publisher |
| Regazzetti C, Peraldi P, Gremeaux T, Najem Lendom R, Ben Sahra I, Cormont M, et al. Hypoxia decreases insulin signaling pathways in adipocytes. Diabetes. 2009;58:95-103 pubmed publisher |
| Thangarajah H, Vial I, Chang E, El Ftesi S, Januszyk M, Chang E, et al. IFATS collection: Adipose stromal cells adopt a proangiogenic phenotype under the influence of hypoxia. Stem Cells. 2009;27:266-74 pubmed publisher |
| Kim H, Jo Y, Lee J, Lee S, Yoon K. The C1772T genetic polymorphism in human HIF-1alpha gene associates with expression of HIF-1alpha protein in breast cancer. Oncol Rep. 2008;20:1181-7 pubmed |
| Nørregaard R, Bødker T, Jensen B, Stødkilde L, Nielsen S, Frøkiaer J. Increased renal adrenomedullin expression in rats with ureteral obstruction. Am J Physiol Regul Integr Comp Physiol. 2009;296:R185-92 pubmed publisher |
| Lysiak J, Kirby J, Tremblay J, Woodson R, Reardon M, Palmer L, et al. Hypoxia-inducible factor-1alpha is constitutively expressed in murine Leydig cells and regulates 3beta-hydroxysteroid dehydrogenase type 1 promoter activity. J Androl. 2009;30:146-56 pubmed publisher |
| Alam H, Weck J, Maizels E, Park Y, Lee E, Ashcroft M, et al. Role of the phosphatidylinositol-3-kinase and extracellular regulated kinase pathways in the induction of hypoxia-inducible factor (HIF)-1 activity and the HIF-1 target vascular endothelial growth factor in ovarian granulosa cells in response to foll. Endocrinology. 2009;150:915-28 pubmed publisher |
| Yang G, Sun Q, Teng Y, Li F, Weng T, Yang X. PTEN deficiency causes dyschondroplasia in mice by enhanced hypoxia-inducible factor 1alpha signaling and endoplasmic reticulum stress. Development. 2008;135:3587-97 pubmed publisher |
| Trollmann R, Strasser K, Keller S, Antoniou X, Grenacher B, Ogunshola O, et al. Placental HIFs as markers of cerebral hypoxic distress in fetal mice. Am J Physiol Regul Integr Comp Physiol. 2008;295:R1973-81 pubmed publisher |
| Hlushchuk R, Riesterer O, Baum O, Wood J, Gruber G, Pruschy M, et al. Tumor recovery by angiogenic switch from sprouting to intussusceptive angiogenesis after treatment with PTK787/ZK222584 or ionizing radiation. Am J Pathol. 2008;173:1173-85 pubmed publisher |
| Hughes D, Fu A, Puggioni A, Glockner J, Anwer B, McGuire A, et al. Adventitial transplantation of blood outgrowth endothelial cells in porcine haemodialysis grafts alleviates hypoxia and decreases neointimal proliferation through a matrix metalloproteinase-9-mediated pathway--a pilot study. Nephrol Dial Transplant. 2009;24:85-96 pubmed publisher |
| Mancino A, Schioppa T, Larghi P, Pasqualini F, Nebuloni M, Chen I, et al. Divergent effects of hypoxia on dendritic cell functions. Blood. 2008;112:3723-34 pubmed publisher |
| Kimura K, Iwano M, Higgins D, Yamaguchi Y, Nakatani K, Harada K, et al. Stable expression of HIF-1alpha in tubular epithelial cells promotes interstitial fibrosis. Am J Physiol Renal Physiol. 2008;295:F1023-9 pubmed publisher |
| Wang Y, Luo J, Chen X, Chen H, Cramer S, Sun D. Gene inactivation of Na+/H+ exchanger isoform 1 attenuates apoptosis and mitochondrial damage following transient focal cerebral ischemia. Eur J Neurosci. 2008;28:51-61 pubmed publisher |
| Moser C, Lang S, Mori A, Hellerbrand C, Schlitt H, Geissler E, et al. ENMD-1198, a novel tubulin-binding agent reduces HIF-1alpha and STAT3 activity in human hepatocellular carcinoma(HCC) cells, and inhibits growth and vascularization in vivo. BMC Cancer. 2008;8:206 pubmed publisher |
| Roh J, Cho K, Kwon G, Ryu C, Chang H, Choi S, et al. The prognostic value of hypoxia markers in T2-staged oral tongue cancer. Oral Oncol. 2009;45:63-8 pubmed publisher |
| Das S, Lin D, Jena S, Shi A, Battina S, Hua D, et al. Protection of retinal cells from ischemia by a novel gap junction inhibitor. Biochem Biophys Res Commun. 2008;373:504-8 pubmed publisher |
| Champion K, Guinea M, Dammai V, Hsu T. Endothelial function of von Hippel-Lindau tumor suppressor gene: control of fibroblast growth factor receptor signaling. Cancer Res. 2008;68:4649-57 pubmed publisher |
| Tacchini L, Gammella E, De Ponti C, Recalcati S, Cairo G. Role of HIF-1 and NF-kappaB transcription factors in the modulation of transferrin receptor by inflammatory and anti-inflammatory signals. J Biol Chem. 2008;283:20674-86 pubmed publisher |
| Rosenberger C, Rosen S, Shina A, Frei U, Eckardt K, Flippin L, et al. Activation of hypoxia-inducible factors ameliorates hypoxic distal tubular injury in the isolated perfused rat kidney. Nephrol Dial Transplant. 2008;23:3472-8 pubmed publisher |
| Frew I, Thoma C, Georgiev S, Minola A, Hitz M, Montani M, et al. pVHL and PTEN tumour suppressor proteins cooperatively suppress kidney cyst formation. EMBO J. 2008;27:1747-57 pubmed publisher |
| Lin S, Shun C, Kok S, Wang C, Hsiao T, Liu C. Hypoxia-stimulated vascular endothelial growth factor production in human nasal polyp fibroblasts: effect of epigallocatechin-3-gallate on hypoxia-inducible factor-1 alpha synthesis. Arch Otolaryngol Head Neck Surg. 2008;134:522-7 pubmed publisher |
| Frew I, Minola A, Georgiev S, Hitz M, Moch H, Richard S, et al. Combined VHLH and PTEN mutation causes genital tract cystadenoma and squamous metaplasia. Mol Cell Biol. 2008;28:4536-48 pubmed publisher |
| Oh S, Kwon H, Kim S, Jang J, Kim M, Kim K, et al. Clinicopathologic significance of HIF-1alpha, p53, and VEGF expression and preoperative serum VEGF level in gastric cancer. BMC Cancer. 2008;8:123 pubmed publisher |
| Yamashita T, Ohneda O, Sakiyama A, Iwata F, Ohneda K, Fujii Kuriyama Y. The microenvironment for erythropoiesis is regulated by HIF-2alpha through VCAM-1 in endothelial cells. Blood. 2008;112:1482-92 pubmed publisher |
| Roh J, Cho K, Kwon G, Choi S, Nam S, Kim S. Prognostic values of pathologic findings and hypoxia markers in 21 patients with salivary duct carcinoma. J Surg Oncol. 2008;97:596-600 pubmed publisher |
| Korgaonkar S, Feng X, Ross M, Lu T, D AGATI V, Iyengar R, et al. HIV-1 upregulates VEGF in podocytes. J Am Soc Nephrol. 2008;19:877-83 pubmed publisher |
| Evens A, Schumacker P, Helenowski I, Singh A, Dokic D, Keswani A, et al. Hypoxia inducible factor-alpha activation in lymphoma and relationship to the thioredoxin family. Br J Haematol. 2008;141:676-80 pubmed publisher |
| Han S, Wang G, Qi X, Lee H, Englander E, Greeley G. A possible role for hypoxia-induced apelin expression in enteric cell proliferation. Am J Physiol Regul Integr Comp Physiol. 2008;294:R1832-9 pubmed publisher |
| Borger D, Gavrilescu L, Bucur M, Ivan M, DeCaprio J. AMP-activated protein kinase is essential for survival in chronic hypoxia. Biochem Biophys Res Commun. 2008;370:230-4 pubmed publisher |
| Li N, Chen L, Yi F, Xia M, Li P. Salt-sensitive hypertension induced by decoy of transcription factor hypoxia-inducible factor-1alpha in the renal medulla. Circ Res. 2008;102:1101-8 pubmed publisher |
| Murphy B, Kimura T, Sato B, Shi Y, Andrews G. Metallothionein induction by hypoxia involves cooperative interactions between metal-responsive transcription factor-1 and hypoxia-inducible transcription factor-1alpha. Mol Cancer Res. 2008;6:483-90 pubmed publisher |
| Nagao K, Taniyama Y, Kietzmann T, Doi T, Komuro I, Morishita R. HIF-1alpha signaling upstream of NKX2.5 is required for cardiac development in Xenopus. J Biol Chem. 2008;283:11841-9 pubmed publisher |
| Rimon E, Chen B, Shanks A, Nelson D, Sadovsky Y. Hypoxia in human trophoblasts stimulates the expression and secretion of connective tissue growth factor. Endocrinology. 2008;149:2952-8 pubmed publisher |
| Zhang H, Bosch Marce M, Shimoda L, Tan Y, Baek J, Wesley J, et al. Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia. J Biol Chem. 2008;283:10892-903 pubmed publisher |
| Weidemann A, Bernhardt W, Klanke B, Daniel C, Buchholz B, Campean V, et al. HIF activation protects from acute kidney injury. J Am Soc Nephrol. 2008;19:486-94 pubmed publisher |
| Iwazu Y, Muto S, Fujisawa G, Nakazawa E, Okada K, Ishibashi S, et al. Spironolactone suppresses peritubular capillary loss and prevents deoxycorticosterone acetate/salt-induced tubulointerstitial fibrosis. Hypertension. 2008;51:749-54 pubmed publisher |
| Villanueva S, Cespedes C, Gonzalez A, Roessler E, Vio C. Inhibition of bFGF-receptor type 2 increases kidney damage and suppresses nephrogenic protein expression after ischemic acute renal failure. Am J Physiol Regul Integr Comp Physiol. 2008;294:R819-28 pubmed publisher |
| Miyazaki Y, Hara A, Kato K, Oyama T, Yamada Y, Mori H, et al. The effect of hypoxic microenvironment on matrix metalloproteinase expression in xenografts of human oral squamous cell carcinoma. Int J Oncol. 2008;32:145-51 pubmed |
| Gauter Fleckenstein B, Fleckenstein K, Owzar K, Jiang C, Batinic Haberle I, Vujaskovic Z. Comparison of two Mn porphyrin-based mimics of superoxide dismutase in pulmonary radioprotection. Free Radic Biol Med. 2008;44:982-9 pubmed |
| Engebretsen B, Irwin D, Valdez M, O Donovan M, Tucker A, van Patot M. Acute hypobaric hypoxia (5486 m) induces greater pulmonary HIF-1 activation in hilltop compared to madison rats. High Alt Med Biol. 2007;8:312-21 pubmed |
| Kaukinen A, Kuusniemi A, Lautenschlager I, Jalanko H. Glomerular endothelium in kidneys with congenital nephrotic syndrome of the Finnish type (NPHS1). Nephrol Dial Transplant. 2008;23:1224-32 pubmed |
| Rosenberger C, Goldfarb M, Shina A, Bachmann S, Frei U, Eckardt K, et al. Evidence for sustained renal hypoxia and transient hypoxia adaptation in experimental rhabdomyolysis-induced acute kidney injury. Nephrol Dial Transplant. 2008;23:1135-43 pubmed |
| Higgins D, Kimura K, Bernhardt W, Shrimanker N, Akai Y, Hohenstein B, et al. Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition. J Clin Invest. 2007;117:3810-20 pubmed |
| Ryu J, Lee C, Hong K, Shin J, Lim S, Park C, et al. Activation of fractalkine/CX3CR1 by vascular endothelial cells induces angiogenesis through VEGF-A/KDR and reverses hindlimb ischaemia. Cardiovasc Res. 2008;78:333-40 pubmed |
| Kimura Y, Sumiyoshi M. High-fat, high-sucrose, and high-cholesterol diets accelerate tumor growth and metastasis in tumor-bearing mice. Nutr Cancer. 2007;59:207-16 pubmed |
| Mace K, Yu D, Paydar K, Boudreau N, Young D. Sustained expression of Hif-1alpha in the diabetic environment promotes angiogenesis and cutaneous wound repair. Wound Repair Regen. 2007;15:636-45 pubmed |
| Liu Y, Hubbi M, Pan F, McDonald K, Mansharamani M, Cole R, et al. Calcineurin promotes hypoxia-inducible factor 1alpha expression by dephosphorylating RACK1 and blocking RACK1 dimerization. J Biol Chem. 2007;282:37064-73 pubmed |
| Black S, Devol J, Wedgwood S. Regulation of fibroblast growth factor-2 expression in pulmonary arterial smooth muscle cells involves increased reactive oxygen species generation. Am J Physiol Cell Physiol. 2008;294:C345-54 pubmed publisher |
| Baek J, Liu Y, McDonald K, Wesley J, Zhang H, Semenza G. Spermidine/spermine N(1)-acetyltransferase-1 binds to hypoxia-inducible factor-1alpha (HIF-1alpha) and RACK1 and promotes ubiquitination and degradation of HIF-1alpha. J Biol Chem. 2007;282:33358-66 pubmed |
| Hu C, Sataur A, Wang L, Chen H, Simon M. The N-terminal transactivation domain confers target gene specificity of hypoxia-inducible factors HIF-1alpha and HIF-2alpha. Mol Biol Cell. 2007;18:4528-42 pubmed |
| Hunt T, Aslam R, Beckert S, Wagner S, Ghani Q, Hussain M, et al. Aerobically derived lactate stimulates revascularization and tissue repair via redox mechanisms. Antioxid Redox Signal. 2007;9:1115-24 pubmed |
| Lam W, Leung C, Bussom S, Cheng Y. The impact of hypoxic treatment on the expression of phosphoglycerate kinase and the cytotoxicity of troxacitabine and gemcitabine. Mol Pharmacol. 2007;72:536-44 pubmed |
| Baek J, Liu Y, McDonald K, Wesley J, Hubbi M, Byun H, et al. Spermidine/spermine-N1-acetyltransferase 2 is an essential component of the ubiquitin ligase complex that regulates hypoxia-inducible factor 1alpha. J Biol Chem. 2007;282:23572-80 pubmed |
| Wang Y, Wan C, Deng L, Liu X, Cao X, Gilbert S, et al. The hypoxia-inducible factor alpha pathway couples angiogenesis to osteogenesis during skeletal development. J Clin Invest. 2007;117:1616-26 pubmed |
| Ide T, Kitajima Y, Miyoshi A, Ohtsuka T, Mitsuno M, Ohtaka K, et al. The hypoxic environment in tumor-stromal cells accelerates pancreatic cancer progression via the activation of paracrine hepatocyte growth factor/c-Met signaling. Ann Surg Oncol. 2007;14:2600-7 pubmed |
| Zhang H, Gao P, Fukuda R, Kumar G, Krishnamachary B, Zeller K, et al. HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity. Cancer Cell. 2007;11:407-20 pubmed |
| Rankin E, Biju M, Liu Q, Unger T, Rha J, Johnson R, et al. Hypoxia-inducible factor-2 (HIF-2) regulates hepatic erythropoietin in vivo. J Clin Invest. 2007;117:1068-77 pubmed |
| Bateman R, Tokunaga C, Kareco T, Dorscheid D, Walley K. Myocardial hypoxia-inducible HIF-1alpha, VEGF, and GLUT1 gene expression is associated with microvascular and ICAM-1 heterogeneity during endotoxemia. Am J Physiol Heart Circ Physiol. 2007;293:H448-56 pubmed |
| Shimojo N, Jesmin S, Zaedi S, Otsuki T, Maeda S, Yamaguchi N, et al. Contributory role of VEGF overexpression in endothelin-1-induced cardiomyocyte hypertrophy. Am J Physiol Heart Circ Physiol. 2007;293:H474-81 pubmed |
| Lang S, Klein D, Moser C, Gaumann A, Glockzin G, Dahlke M, et al. Inhibition of heat shock protein 90 impairs epidermal growth factor-mediated signaling in gastric cancer cells and reduces tumor growth and vascularization in vivo. Mol Cancer Ther. 2007;6:1123-32 pubmed |
| Jeong C, Lee H, Cha J, Kim J, Kim K, Kim J, et al. Hypoxia-inducible factor-1 alpha inhibits self-renewal of mouse embryonic stem cells in Vitro via negative regulation of the leukemia inhibitory factor-STAT3 pathway. J Biol Chem. 2007;282:13672-9 pubmed |
| Chin B, Jiang G, Wegiel B, Wang H, Macdonald T, Zhang X, et al. Hypoxia-inducible factor 1alpha stabilization by carbon monoxide results in cytoprotective preconditioning. Proc Natl Acad Sci U S A. 2007;104:5109-14 pubmed |
| Kojima I, Tanaka T, Inagi R, Kato H, Yamashita T, Sakiyama A, et al. Protective role of hypoxia-inducible factor-2alpha against ischemic damage and oxidative stress in the kidney. J Am Soc Nephrol. 2007;18:1218-26 pubmed |
| Jayle C, Favreau F, Zhang K, Doucet C, Goujon J, Hebrard W, et al. Comparison of protective effects of trimetazidine against experimental warm ischemia of different durations: early and long-term effects in a pig kidney model. Am J Physiol Renal Physiol. 2007;292:F1082-93 pubmed |
| Ronkainen V, Ronkainen J, Hänninen S, Leskinen H, Ruas J, Pereira T, et al. Hypoxia inducible factor regulates the cardiac expression and secretion of apelin. FASEB J. 2007;21:1821-30 pubmed |
| Bernhardt W, Wiesener M, Weidemann A, Schmitt R, Weichert W, Lechler P, et al. Involvement of hypoxia-inducible transcription factors in polycystic kidney disease. Am J Pathol. 2007;170:830-42 pubmed |
| Zhang X, Zhou K, Wang R, Cui J, Lipton S, Liao F, et al. Hypoxia-inducible factor 1alpha (HIF-1alpha)-mediated hypoxia increases BACE1 expression and beta-amyloid generation. J Biol Chem. 2007;282:10873-80 pubmed |
| Creighton Gutteridge M, Cardellina J, Stephen A, Rapisarda A, Uranchimeg B, Hite K, et al. Cell type-specific, topoisomerase II-dependent inhibition of hypoxia-inducible factor-1alpha protein accumulation by NSC 644221. Clin Cancer Res. 2007;13:1010-8 pubmed |
| LaRusch G, Jackson M, Dunbar J, Warren R, Donner D, Mayo L. Nutlin3 blocks vascular endothelial growth factor induction by preventing the interaction between hypoxia inducible factor 1alpha and Hdm2. Cancer Res. 2007;67:450-4 pubmed |
| Winner M, Koong A, Rendon B, Zundel W, Mitchell R. Amplification of tumor hypoxic responses by macrophage migration inhibitory factor-dependent hypoxia-inducible factor stabilization. Cancer Res. 2007;67:186-93 pubmed |
| Liao H, Hyman M, Lawrence D, Pinsky D. Molecular regulation of the PAI-1 gene by hypoxia: contributions of Egr-1, HIF-1alpha, and C/EBPalpha. FASEB J. 2007;21:935-49 pubmed |
| Groenman F, Rutter M, Caniggia I, Tibboel D, Post M. Hypoxia-inducible factors in the first trimester human lung. J Histochem Cytochem. 2007;55:355-63 pubmed |
| Rosenberger C, Pratschke J, Rudolph B, Heyman S, Schindler R, Babel N, et al. Immunohistochemical detection of hypoxia-inducible factor-1alpha in human renal allograft biopsies. J Am Soc Nephrol. 2007;18:343-51 pubmed |
| Komatsu D, Bosch Marce M, Semenza G, Hadjiargyrou M. Enhanced bone regeneration associated with decreased apoptosis in mice with partial HIF-1alpha deficiency. J Bone Miner Res. 2007;22:366-74 pubmed |
| Kang S, Cho H, Devi S, Zhang Z, Escuin D, Liang Z, et al. Antitumor effect of 2-methoxyestradiol in a rat orthotopic brain tumor model. Cancer Res. 2006;66:11991-7 pubmed |
| Nickols N, Jacobs C, Farkas M, Dervan P. Improved nuclear localization of DNA-binding polyamides. Nucleic Acids Res. 2007;35:363-70 pubmed |
| Mizokami K, Kakeji Y, Oda S, Maehara Y. Relationship of hypoxia-inducible factor 1alpha and p21WAF1/CIP1 expression to cell apoptosis and clinical outcome in patients with gastric cancer. World J Surg Oncol. 2006;4:94 pubmed |
| Pore N, Gupta A, Cerniglia G, Maity A. HIV protease inhibitors decrease VEGF/HIF-1alpha expression and angiogenesis in glioblastoma cells. Neoplasia. 2006;8:889-95 pubmed |
| Shintani K, Matsumine A, Kusuzaki K, Matsubara T, Satonaka H, Wakabayashi T, et al. Expression of hypoxia-inducible factor (HIF)-1alpha as a biomarker of outcome in soft-tissue sarcomas. Virchows Arch. 2006;449:673-81 pubmed |
| Nemetski S, Gardner L. Hypoxic regulation of Id-1 and activation of the unfolded protein response are aberrant in neuroblastoma. J Biol Chem. 2007;282:240-8 pubmed |
| Biswas S, Gupta M, Chattopadhyay D, Mukhopadhyay C. Insulin-induced activation of hypoxia-inducible factor-1 requires generation of reactive oxygen species by NADPH oxidase. Am J Physiol Heart Circ Physiol. 2007;292:H758-66 pubmed |
| Lukashev D, Klebanov B, Kojima H, Grinberg A, Ohta A, Berenfeld L, et al. Cutting edge: hypoxia-inducible factor 1alpha and its activation-inducible short isoform I.1 negatively regulate functions of CD4+ and CD8+ T lymphocytes. J Immunol. 2006;177:4962-5 pubmed |
| Khan Z, Michalopoulos G, Stolz D. Peroxisomal localization of hypoxia-inducible factors and hypoxia-inducible factor regulatory hydroxylases in primary rat hepatocytes exposed to hypoxia-reoxygenation. Am J Pathol. 2006;169:1251-69 pubmed |
| Makino H, Miyamoto Y, Sawai K, Mori K, Mukoyama M, Nakao K, et al. Altered gene expression related to glomerulogenesis and podocyte structure in early diabetic nephropathy of db/db mice and its restoration by pioglitazone. Diabetes. 2006;55:2747-56 pubmed |
| Khurana A, Nakayama K, Williams S, Davis R, Mustelin T, RONAI Z. Regulation of the ring finger E3 ligase Siah2 by p38 MAPK. J Biol Chem. 2006;281:35316-26 pubmed |
| Pore N, Gupta A, Cerniglia G, Jiang Z, Bernhard E, Evans S, et al. Nelfinavir down-regulates hypoxia-inducible factor 1alpha and VEGF expression and increases tumor oxygenation: implications for radiotherapy. Cancer Res. 2006;66:9252-9 pubmed |
| Chen H, Yan Y, Davidson T, Shinkai Y, Costa M. Hypoxic stress induces dimethylated histone H3 lysine 9 through histone methyltransferase G9a in mammalian cells. Cancer Res. 2006;66:9009-16 pubmed |
| McLaren A, Marsden P, Mazer C, Baker A, Stewart D, Tsui A, et al. Increased expression of HIF-1alpha, nNOS, and VEGF in the cerebral cortex of anemic rats. Am J Physiol Regul Integr Comp Physiol. 2007;292:R403-14 pubmed |
| Chavez J, Baranova O, Lin J, Pichiule P. The transcriptional activator hypoxia inducible factor 2 (HIF-2/EPAS-1) regulates the oxygen-dependent expression of erythropoietin in cortical astrocytes. J Neurosci. 2006;26:9471-81 pubmed |
| Sumiyoshi Y, Kakeji Y, Egashira A, Mizokami K, Orita H, Maehara Y. Overexpression of hypoxia-inducible factor 1alpha and p53 is a marker for an unfavorable prognosis in gastric cancer. Clin Cancer Res. 2006;12:5112-7 pubmed |
| Shen F, Su H, Fan Y, Chen Y, Zhu Y, Liu W, et al. Adeno-associated viral-vector-mediated hypoxia-inducible vascular endothelial growth factor gene expression attenuates ischemic brain injury after focal cerebral ischemia in mice. Stroke. 2006;37:2601-6 pubmed |
| Hwang I, Watson I, Der S, Ohh M. Loss of VHL confers hypoxia-inducible factor (HIF)-dependent resistance to vesicular stomatitis virus: role of HIF in antiviral response. J Virol. 2006;80:10712-23 pubmed |
| Tanaka T, Kato H, Kojima I, Ohse T, Son D, Tawakami T, et al. Hypoxia and expression of hypoxia-inducible factor in the aging kidney. J Gerontol A Biol Sci Med Sci. 2006;61:795-805 pubmed |
| Lin A, Mannikarottu A, Kogan B, Whitbeck C, Chichester P, Leggett R, et al. Estrogen induces angiogenesis of the female rabbit bladder. J Endocrinol. 2006;190:241-6 pubmed |
| Brooks C, Wang J, Yang T, Dong Z. Characterization of cell clones isolated from hypoxia-selected renal proximal tubular cells. Am J Physiol Renal Physiol. 2007;292:F243-52 pubmed |
| Dews M, Homayouni A, Yu D, Murphy D, Sevignani C, Wentzel E, et al. Augmentation of tumor angiogenesis by a Myc-activated microRNA cluster. Nat Genet. 2006;38:1060-5 pubmed |
| Grimmer C, Balbus N, Lang U, Aigner T, Cramer T, Müller L, et al. Regulation of type II collagen synthesis during osteoarthritis by prolyl-4-hydroxylases: possible influence of low oxygen levels. Am J Pathol. 2006;169:491-502 pubmed |
| Villanueva S, Cespedes C, Gonzalez A, Vio C. bFGF induces an earlier expression of nephrogenic proteins after ischemic acute renal failure. Am J Physiol Regul Integr Comp Physiol. 2006;291:R1677-87 pubmed |
| McMahon S, Charbonneau M, Grandmont S, Richard D, Dubois C. Transforming growth factor beta1 induces hypoxia-inducible factor-1 stabilization through selective inhibition of PHD2 expression. J Biol Chem. 2006;281:24171-81 pubmed |
| Chade A, Zhu X, Mushin O, Napoli C, Lerman A, Lerman L. Simvastatin promotes angiogenesis and prevents microvascular remodeling in chronic renal ischemia. FASEB J. 2006;20:1706-8 pubmed |
| Pacary E, Legros H, Valable S, Duchatelle P, Lecocq M, Petit E, et al. Synergistic effects of CoCl(2) and ROCK inhibition on mesenchymal stem cell differentiation into neuron-like cells. J Cell Sci. 2006;119:2667-78 pubmed |
| Bernhardt W, Campean V, Kany S, Jurgensen J, Weidemann A, Warnecke C, et al. Preconditional activation of hypoxia-inducible factors ameliorates ischemic acute renal failure. J Am Soc Nephrol. 2006;17:1970-8 pubmed |
| Bracken C, Fedele A, Linke S, Balrak W, Lisy K, Whitelaw M, et al. Cell-specific regulation of hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha stabilization and transactivation in a graded oxygen environment. J Biol Chem. 2006;281:22575-85 pubmed |
| Nishimura R, Sakumoto R, Tatsukawa Y, Acosta T, Okuda K. Oxygen concentration is an important factor for modulating progesterone synthesis in bovine corpus luteum. Endocrinology. 2006;147:4273-80 pubmed |
| Stevens H, Meays D, Frangos J. Pressure gradients and transport in the murine femur upon hindlimb suspension. Bone. 2006;39:565-72 pubmed |
| Wang R, Zhang Y, Zhang X, Liu R, Zhang X, Hong S, et al. Transcriptional regulation of APH-1A and increased gamma-secretase cleavage of APP and Notch by HIF-1 and hypoxia. FASEB J. 2006;20:1275-7 pubmed |
| Grammas P, Samany P, Thirumangalakudi L. Thrombin and inflammatory proteins are elevated in Alzheimer's disease microvessels: implications for disease pathogenesis. J Alzheimers Dis. 2006;9:51-8 pubmed |
| Fernando M, Simpson J, Matthews F, Brayne C, Lewis C, Barber R, et al. White matter lesions in an unselected cohort of the elderly: molecular pathology suggests origin from chronic hypoperfusion injury. Stroke. 2006;37:1391-8 pubmed |
| Hu C, Iyer S, Sataur A, Covello K, Chodosh L, Simon M. Differential regulation of the transcriptional activities of hypoxia-inducible factor 1 alpha (HIF-1alpha) and HIF-2alpha in stem cells. Mol Cell Biol. 2006;26:3514-26 pubmed |
| Zampino M, Yuzhakova M, Hansen J, McKinney R, Goldspink P, Geenen D, et al. Sex-related dimorphic response of HIF-1 alpha expression in myocardial ischemia. Am J Physiol Heart Circ Physiol. 2006;291:H957-64 pubmed |
| Franco M, Man S, Chen L, Emmenegger U, Shaked Y, Cheung A, et al. Targeted anti-vascular endothelial growth factor receptor-2 therapy leads to short-term and long-term impairment of vascular function and increase in tumor hypoxia. Cancer Res. 2006;66:3639-48 pubmed |
| Schoppmann S, Fenzl A, Schindl M, Bachleitner Hofmann T, Nagy K, Gnant M, et al. Hypoxia inducible factor-1alpha correlates with VEGF-C expression and lymphangiogenesis in breast cancer. Breast Cancer Res Treat. 2006;99:135-41 pubmed |
| Fath D, Kong X, Liang D, Lin Z, Chou A, Jiang Y, et al. Histone deacetylase inhibitors repress the transactivation potential of hypoxia-inducible factors independently of direct acetylation of HIF-alpha. J Biol Chem. 2006;281:13612-9 pubmed |
| Pore N, Jiang Z, Gupta A, Cerniglia G, Kao G, Maity A. EGFR tyrosine kinase inhibitors decrease VEGF expression by both hypoxia-inducible factor (HIF)-1-independent and HIF-1-dependent mechanisms. Cancer Res. 2006;66:3197-204 pubmed |
| Lee K, Kim S, Park S, Lee H, Park H, Min K, et al. Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) reduces vascular endothelial growth factor expression in allergen-induced airway inflammation. Mol Pharmacol. 2006;69:1829-39 pubmed |
| Tian Y, Mole D, Ratcliffe P, Gleadle J. Characterization of different isoforms of the HIF prolyl hydroxylase PHD1 generated by alternative initiation. Biochem J. 2006;397:179-86 pubmed |
| Hui A, Bauer A, Striet J, Schnell P, Czyzyk Krzeska M. Calcium signaling stimulates translation of HIF-alpha during hypoxia. FASEB J. 2006;20:466-75 pubmed |
| Luo Y, Jiang C, Belanger A, Akita G, Wadsworth S, Gregory R, et al. A constitutively active hypoxia-inducible factor-1alpha/VP16 hybrid factor activates expression of the human B-type natriuretic peptide gene. Mol Pharmacol. 2006;69:1953-62 pubmed |
| Hsu T, Adereth Y, Kose N, Dammai V. Endocytic function of von Hippel-Lindau tumor suppressor protein regulates surface localization of fibroblast growth factor receptor 1 and cell motility. J Biol Chem. 2006;281:12069-80 pubmed |
| Zhang W, Petrovic J, Callaghan D, Jones A, Cui H, Howlett C, et al. Evidence that hypoxia-inducible factor-1 (HIF-1) mediates transcriptional activation of interleukin-1beta (IL-1beta) in astrocyte cultures. J Neuroimmunol. 2006;174:63-73 pubmed |
| Oda T, Hirota K, Nishi K, Takabuchi S, Oda S, Yamada H, et al. Activation of hypoxia-inducible factor 1 during macrophage differentiation. Am J Physiol Cell Physiol. 2006;291:C104-13 pubmed |
| Trentin D, Hall H, Wechsler S, Hubbell J. Peptide-matrix-mediated gene transfer of an oxygen-insensitive hypoxia-inducible factor-1alpha variant for local induction of angiogenesis. Proc Natl Acad Sci U S A. 2006;103:2506-11 pubmed |
| Galabova Kovacs G, Matzen D, Piazzolla D, Meissl K, Plyushch T, Chen A, et al. Essential role of B-Raf in ERK activation during extraembryonic development. Proc Natl Acad Sci U S A. 2006;103:1325-30 pubmed |
| Higami Y, Barger J, Page G, Allison D, Smith S, Prolla T, et al. Energy restriction lowers the expression of genes linked to inflammation, the cytoskeleton, the extracellular matrix, and angiogenesis in mouse adipose tissue. J Nutr. 2006;136:343-52 pubmed |
| Quintero M, Brennan P, Thomas G, Moncada S. Nitric oxide is a factor in the stabilization of hypoxia-inducible factor-1alpha in cancer: role of free radical formation. Cancer Res. 2006;66:770-4 pubmed |
| Villanueva S, Cespedes C, Vio C. Ischemic acute renal failure induces the expression of a wide range of nephrogenic proteins. Am J Physiol Regul Integr Comp Physiol. 2006;290:R861-70 pubmed |
| Rodriguez Porcel M, Zhu X, Chade A, Amores Arriaga B, Caplice N, Ritman E, et al. Functional and structural remodeling of the myocardial microvasculature in early experimental hypertension. Am J Physiol Heart Circ Physiol. 2006;290:H978-84 pubmed |
| Wang J, Hoshijima M, Lam J, Zhou Z, Jokiel A, Dalton N, et al. Cardiomyopathy associated with microcirculation dysfunction in laminin alpha4 chain-deficient mice. J Biol Chem. 2006;281:213-20 pubmed |
| Kong D, Park E, Stephen A, Calvani M, Cardellina J, Monks A, et al. Echinomycin, a small-molecule inhibitor of hypoxia-inducible factor-1 DNA-binding activity. Cancer Res. 2005;65:9047-55 pubmed |
| Liu W, Guo M, Xu Y, Li D, Zhou Z, Wu Y, et al. Induction of tumor arrest and differentiation with prolonged survival by intermittent hypoxia in a mouse model of acute myeloid leukemia. Blood. 2006;107:698-707 pubmed |
| Kato H, Inoue T, Asanoma K, Nishimura C, Matsuda T, Wake N. Induction of human endometrial cancer cell senescence through modulation of HIF-1alpha activity by EGLN1. Int J Cancer. 2006;118:1144-53 pubmed |
| Hayashi M, Sakata M, Takeda T, Tahara M, Yamamoto T, Okamoto Y, et al. Up-regulation of c-met protooncogene product expression through hypoxia-inducible factor-1alpha is involved in trophoblast invasion under low-oxygen tension. Endocrinology. 2005;146:4682-9 pubmed |
| Behan A, Doyle S, Farrell M. Adaptive responses to mitochondrial dysfunction in the rho degrees Namalwa cell. Mitochondrion. 2005;5:173-93 pubmed |
| Zagzag D, Krishnamachary B, Yee H, Okuyama H, Chiriboga L, Ali M, et al. Stromal cell-derived factor-1alpha and CXCR4 expression in hemangioblastoma and clear cell-renal cell carcinoma: von Hippel-Lindau loss-of-function induces expression of a ligand and its receptor. Cancer Res. 2005;65:6178-88 pubmed |
| Maltepe E, Krampitz G, Okazaki K, Red Horse K, Mak W, Simon M, et al. Hypoxia-inducible factor-dependent histone deacetylase activity determines stem cell fate in the placenta. Development. 2005;132:3393-403 pubmed |
| Alberghini A, Recalcati S, Tacchini L, Santambrogio P, Campanella A, Cairo G. Loss of the von Hippel Lindau tumor suppressor disrupts iron homeostasis in renal carcinoma cells. J Biol Chem. 2005;280:30120-8 pubmed |
| Kim S, Rabbani Z, Dewhirst M, Vujaskovic Z, Vollmer R, Schreiber E, et al. Expression of HIF-1alpha, CA IX, VEGF, and MMP-9 in surgically resected non-small cell lung cancer. Lung Cancer. 2005;49:325-35 pubmed |
| Wang B, Zou Y, Li H, Yan H, Pan J, Yuan Z. Genistein inhibited retinal neovascularization and expression of vascular endothelial growth factor and hypoxia inducible factor 1alpha in a mouse model of oxygen-induced retinopathy. J Ocul Pharmacol Ther. 2005;21:107-13 pubmed |
| Li Y, Zhou B, Deng J, Pan Y, Hay N, Hung M. A hypoxia-independent hypoxia-inducible factor-1 activation pathway induced by phosphatidylinositol-3 kinase/Akt in HER2 overexpressing cells. Cancer Res. 2005;65:3257-63 pubmed |
| Kazi A, Jones J, Koos R. Chromatin immunoprecipitation analysis of gene expression in the rat uterus in vivo: estrogen-induced recruitment of both estrogen receptor alpha and hypoxia-inducible factor 1 to the vascular endothelial growth factor promoter. Mol Endocrinol. 2005;19:2006-19 pubmed |
| Matsuyama T, Nakanishi K, Hayashi T, Yoshizumi Y, Aiko S, Sugiura Y, et al. Expression of hypoxia-inducible factor-1alpha in esophageal squamous cell carcinoma. Cancer Sci. 2005;96:176-82 pubmed |
| Irie N, Matsuo T, Nagata I. Protocol of radiotherapy for glioblastoma according to the expression of HIF-1. Brain Tumor Pathol. 2004;21:1-6 pubmed |
| Aminova L, Chavez J, Lee J, Ryu H, Kung A, Lamanna J, et al. Prosurvival and prodeath effects of hypoxia-inducible factor-1alpha stabilization in a murine hippocampal cell line. J Biol Chem. 2005;280:3996-4003 pubmed |
| Knies Bamforth U, Fox S, Poulsom R, Evan G, Harris A. c-Myc interacts with hypoxia to induce angiogenesis in vivo by a vascular endothelial growth factor-dependent mechanism. Cancer Res. 2004;64:6563-70 pubmed |
| TEZEL G, Wax M. Hypoxia-inducible factor 1alpha in the glaucomatous retina and optic nerve head. Arch Ophthalmol. 2004;122:1348-56 pubmed |
| Swinson D, Jones J, Cox G, Richardson D, Harris A, O Byrne K. Hypoxia-inducible factor-1 alpha in non small cell lung cancer: relation to growth factor, protease and apoptosis pathways. Int J Cancer. 2004;111:43-50 pubmed |
| Mansfield K, Simon M, Keith B. Hypoxic reduction in cellular glutathione levels requires mitochondrial reactive oxygen species. J Appl Physiol (1985). 2004;97:1358-66 pubmed |
| Nishi H, Nakada T, Hokamura M, Osakabe Y, Itokazu O, Huang L, et al. Hypoxia-inducible factor-1 transactivates transforming growth factor-beta3 in trophoblast. Endocrinology. 2004;145:4113-8 pubmed |
| Tissot van Patot M, Bendrick Peart J, Beckey V, Serkova N, Zwerdlinger L. Greater vascularity, lowered HIF-1/DNA binding, and elevated GSH as markers of adaptation to in vivo chronic hypoxia. Am J Physiol Lung Cell Mol Physiol. 2004;287:L525-32 pubmed |
| Reichner J, Albina J. Determination of the role of hypoxia-inducible factor 1 in wound healing. Methods Enzymol. 2004;381:527-38 pubmed |
| Pascual O, Roux J, Soulage C, Morin Surun M, Denavit Saubié M, Pequignot J. Carotid chemodenervation approach to study oxygen sensing in brain stem catecholaminergic cells. Methods Enzymol. 2004;381:422-49 pubmed |
| Yatabe N, Kyo S, Maida Y, Nishi H, Nakamura M, Kanaya T, et al. HIF-1-mediated activation of telomerase in cervical cancer cells. Oncogene. 2004;23:3708-15 pubmed |
| Wykoff C, Sotiriou C, Cockman M, Ratcliffe P, Maxwell P, Liu E, et al. Gene array of VHL mutation and hypoxia shows novel hypoxia-induced genes and that cyclin D1 is a VHL target gene. Br J Cancer. 2004;90:1235-43 pubmed |
| Erler J, Cawthorne C, Williams K, Koritzinsky M, Wouters B, Wilson C, et al. Hypoxia-mediated down-regulation of Bid and Bax in tumors occurs via hypoxia-inducible factor 1-dependent and -independent mechanisms and contributes to drug resistance. Mol Cell Biol. 2004;24:2875-89 pubmed |
| Palladino M, Powell J, Korah N, Hermo L. Expression and localization of hypoxia-inducible factor-1 subunits in the adult rat epididymis. Biol Reprod. 2004;70:1121-30 pubmed |
| Hu C, Wang L, Chodosh L, Keith B, Simon M. Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation. Mol Cell Biol. 2003;23:9361-74 pubmed |
| Liu M, Poellinger L, Walker C. Up-regulation of hypoxia-inducible factor 2alpha in renal cell carcinoma associated with loss of Tsc-2 tumor suppressor gene. Cancer Res. 2003;63:2675-80 pubmed |
| Park J, Kim T, Jong H, Kim T, Chun Y, Park J, et al. Gastric epithelial reactive oxygen species prevent normoxic degradation of hypoxia-inducible factor-1alpha in gastric cancer cells. Clin Cancer Res. 2003;9:433-40 pubmed |
| Ivan M, Haberberger T, Gervasi D, Michelson K, Gunzler V, Kondo K, et al. Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor. Proc Natl Acad Sci U S A. 2002;99:13459-64 pubmed |
| Des Tombe A, van Beek Harmsen B, Lee De Groot M, van der Laarse W. Calibrated histochemistry applied to oxygen supply and demand in hypertrophied rat myocardium. Microsc Res Tech. 2002;58:412-20 pubmed |
| Powell J, Elshtein R, Forest D, Palladino M. Stimulation of hypoxia-inducible factor-1 alpha (HIF-1alpha) protein in the adult rat testis following ischemic injury occurs without an increase in HIF-1alpha messenger RNA expression. Biol Reprod. 2002;67:995-1002 pubmed |
| Schindl M, Schoppmann S, Samonigg H, Hausmaninger H, Kwasny W, Gnant M, et al. Overexpression of hypoxia-inducible factor 1alpha is associated with an unfavorable prognosis in lymph node-positive breast cancer. Clin Cancer Res. 2002;8:1831-7 pubmed |
| Min J, Yang H, Ivan M, Gertler F, Kaelin W, Pavletich N. Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling. Science. 2002;296:1886-9 pubmed |
| Shoshani T, Faerman A, Mett I, Zelin E, Tenne T, Gorodin S, et al. Identification of a novel hypoxia-inducible factor 1-responsive gene, RTP801, involved in apoptosis. Mol Cell Biol. 2002;22:2283-93 pubmed |
| Pascual O, Denavit Saubie M, Dumas S, Kietzmann T, Ghilini G, Mallet J, et al. Selective cardiorespiratory and catecholaminergic areas express the hypoxia-inducible factor-1alpha (HIF-1alpha) under in vivo hypoxia in rat brainstem. Eur J Neurosci. 2001;14:1981-91 pubmed |
| Arsham A, Plas D, Thompson C, Simon M. Phosphatidylinositol 3-kinase/Akt signaling is neither required for hypoxic stabilization of HIF-1 alpha nor sufficient for HIF-1-dependent target gene transcription. J Biol Chem. 2002;277:15162-70 pubmed |
| Stokes D, Liu G, Coimbra I, Piera Velazquez S, Crowl R, Jimenez S. Assessment of the gene expression profile of differentiated and dedifferentiated human fetal chondrocytes by microarray analysis. Arthritis Rheum. 2002;46:404-19 pubmed |
| Albina J, Mastrofrancesco B, Vessella J, Louis C, Henry W, Reichner J. HIF-1 expression in healing wounds: HIF-1alpha induction in primary inflammatory cells by TNF-alpha. Am J Physiol Cell Physiol. 2001;281:C1971-7 pubmed |
| Kurebayashi J, Otsuki T, Moriya T, Sonoo H. Hypoxia reduces hormone responsiveness of human breast cancer cells. Jpn J Cancer Res. 2001;92:1093-101 pubmed |
| Duyndam M, Hulscher T, Fontijn D, Pinedo H, Boven E. Induction of vascular endothelial growth factor expression and hypoxia-inducible factor 1alpha protein by the oxidative stressor arsenite. J Biol Chem. 2001;276:48066-76 pubmed |
| Schindl M, Oberhuber G, Pichlbauer E, Obermair A, Birner P, Kelley M. DNA repair-redox enzyme apurinic endonuclease in cervical cancer: evaluation of redox control of HIF-1alpha and prognostic significance. Int J Oncol. 2001;19:799-802 pubmed |
| Birner P, Gatterbauer B, Oberhuber G, Schindl M, Rossler K, Prodinger A, et al. Expression of hypoxia-inducible factor-1 alpha in oligodendrogliomas: its impact on prognosis and on neoangiogenesis. Cancer. 2001;92:165-71 pubmed |
| Birner P, Schindl M, Obermair A, Breitenecker G, Oberhuber G. Expression of hypoxia-inducible factor 1alpha in epithelial ovarian tumors: its impact on prognosis and on response to chemotherapy. Clin Cancer Res. 2001;7:1661-8 pubmed |
| Ivan M, Kondo K, Yang H, Kim W, Valiando J, Ohh M, et al. HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing. Science. 2001;292:464-8 pubmed |
| Jaakkola P, Mole D, Tian Y, Wilson M, Gielbert J, Gaskell S, et al. Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science. 2001;292:468-72 pubmed |
| Birner P, Schindl M, Obermair A, Plank C, Breitenecker G, Oberhuber G. Overexpression of hypoxia-inducible factor 1alpha is a marker for an unfavorable prognosis in early-stage invasive cervical cancer. Cancer Res. 2000;60:4693-6 pubmed |
| Kamura T, Sato S, Iwai K, Czyzyk Krzeska M, Conaway R, Conaway J. Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex. Proc Natl Acad Sci U S A. 2000;97:10430-5 pubmed |
| Wang G, Hazra T, Mitra S, Lee H, Englander E. Mitochondrial DNA damage and a hypoxic response are induced by CoCl(2) in rat neuronal PC12 cells. Nucleic Acids Res. 2000;28:2135-40 pubmed |
| Sutter C, Laughner E, Semenza G. Hypoxia-inducible factor 1alpha protein expression is controlled by oxygen-regulated ubiquitination that is disrupted by deletions and missense mutations. Proc Natl Acad Sci U S A. 2000;97:4748-53 pubmed |
| Gothié E, Richard D, Berra E, Pages G, Pouyssegur J. Identification of alternative spliced variants of human hypoxia-inducible factor-1alpha. J Biol Chem. 2000;275:6922-7 pubmed |
| Zhong H, De Marzo A, Laughner E, Lim M, Hilton D, Zagzag D, et al. Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases. Cancer Res. 1999;59:5830-5 pubmed |
