TOR/mTOR [p Ser2448] Antibody | Novus Biologicals NB600-607 product information

product summary

company name :

Novus Biologicals

other brands :

IMGENEX

product type :

antibody

product name :

TOR/mTOR [p Ser2448] Antibody

catalog :

NB600-607

quantity :

0.1 mg

price :

559 USD

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

S68

reactivity :

human, rat

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section

more info or order :

Novus Biologicals product webpage

citations: 11

Reference
Serafin V, Porcù E, Cortese G, Mariotto E, Veltri G, Bresolin S, et al. SYK Targeting Represents a Potential Therapeutic Option for Relapsed Resistant Pediatric ETV6-RUNX1 B-Acute Lymphoblastic Leukemia Patients. Int J Mol Sci. 2019;20: pubmed publisher
Cappoli N, Mezzogori D, Tabolacci E, Coletta I, Navarra P, Pani G, et al. The mTOR kinase inhibitor rapamycin enhances the expression and release of pro-inflammatory cytokine interleukin 6 modulating the activation of human microglial cells. EXCLI J. 2019;18:779-798 pubmed publisher
Lisi L, Ciotti G, Chiavari M, Pizzoferrato M, Mangiola A, Kalinin S, et al. Phospho-mTOR expression in human glioblastoma microglia-macrophage cells. Neurochem Int. 2019;129:104485 pubmed publisher
Chiavari M, Ciotti G, Navarra P, Lisi L. Pro-Inflammatory Activation of A New Immortalized Human Microglia Cell Line. Brain Sci. 2019;9: pubmed publisher
Zhou X, Yue G, Chan A, Tsui S, Fung K, Sun H, et al. Eriocalyxin B, a novel autophagy inducer, exerts anti-tumor activity through the suppression of Akt/mTOR/p70S6K signaling pathway in breast cancer. Biochem Pharmacol. 2017;142:58-70 pubmed publisher
Juraszek B, Nałęcz K. Protein phosphatase PP2A - a novel interacting partner of carnitine transporter OCTN2 (SLC22A5) in rat astrocytes. J Neurochem. 2016;139:537-551 pubmed publisher
Tanti G, Goswami S. SG2NA recruits DJ-1 and Akt into the mitochondria and membrane to protect cells from oxidative damage. Free Radic Biol Med. 2014;75:1-13 pubmed publisher
Tran H, Bustos D, Yeh R, Rubinfeld B, Lam C, Shriver S, et al. HectD1 E3 ligase modifies adenomatous polyposis coli (APC) with polyubiquitin to promote the APC-axin interaction. J Biol Chem. 2013;288:3753-67 pubmed publisher
Moreno C, Lane W, Pallas D. A mammalian homolog of yeast MOB1 is both a member and a putative substrate of striatin family-protein phosphatase 2A complexes. J Biol Chem. 2001;276:24253-60 pubmed
Yu X, Du X, Moreno C, Green R, Ogris E, Feng Q, et al. Methylation of the protein phosphatase 2A catalytic subunit is essential for association of Balpha regulatory subunit but not SG2NA, striatin, or polyomavirus middle tumor antigen. Mol Biol Cell. 2001;12:185-99 pubmed
Moreno C, Park S, Nelson K, Ashby D, Hubalek F, Lane W, et al. WD40 repeat proteins striatin and S/G(2) nuclear autoantigen are members of a novel family of calmodulin-binding proteins that associate with protein phosphatase 2A. J Biol Chem. 2000;275:5257-63 pubmed

product information

brand :

Novus Biologicals, a Bio-Techne brand

catalog number base :

NB600-607

SKU :

NB600-607

product name :

TOR/mTOR [p Ser2448] Antibody

description :

The TOR/mTOR [p Ser2448] Antibody from Novus Biologicals is a rabbit polyclonal antibody to TOR/mTOR. This antibody reacts with human,rat. The TOR/mTOR [p Ser2448] Antibody has been validated for the following applications: ELISA,Immunohistochemistry,IF/IHC,Western Blot,Immunohistochemistry-Paraffin.

target :

TOR/mTOR

unit size :

0.1 mg

category :

Primary Antibodies

buffer :

0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

clonality :

Polyclonal

conjugate :

Unconjugated

host :

Rabbit

immunogen :

TOR/TOR/mTOR [p Ser2448] Antibody was prepared from whole rabbit serum produced by repeated immunizations with a phosphorylated synthetic peptide corresponding a c-terminal region near Serine 2448 of human TOR/mTOR. (Uniprot: P42345)

isotype :

IgG

purity :

Immunogen affinity purified

species :

Human,Rat

specificity :

Reactivity occurs with phosphorylated mTOR from human derived tissues and cells

storage :

Store at -20C short term. Aliquot and store at -80C long term. Avoid freeze-thaw cycles.

gene symbol :

MTOR

Antibody validation :

Biological Validation

accessionNumbers :

P42345, P42345, P42345, P42345, P42345

applications :

ELISA,Immunohistochemistry,IF/IHC,Western Blot,Immunohistochemistry-Paraffin

USD :

549

USD 2025 :

559 USD

alt names :

EC 2.7.11.1, FK506 binding protein 12-rapamycin associated protein 1, FK506 binding protein 12-rapamycin associated protein 2, FK506-binding protein 12-rapamycin complex-associated protein 1, FKBP12-rapamycin complex-associated protein, FLJ44809, FRAP, FRAP1FKBP12-rapamycin complex-associated protein 1, FRAP2, Mammalian target of rapamycin, Mechanistic target of rapamycin, mechanistic target of rapamycin (serine/threonine kinase), mTOR, RAFT1, rapamycin and FKBP12 target 1, rapamycin associated protein FRAP2, Rapamycin target protein 1, RAPT1FKBP-rapamycin associated protein, serine/threonine-protein kinase mTOR

more info or order :

Novus Biologicals product webpage