GLI-1 Antibody | Novus Biologicals NB600-600 product information

product summary

company name :

Novus Biologicals

other brands :

IMGENEX

product type :

antibody

product name :

GLI-1 Antibody

catalog :

NB600-600

quantity :

0.1 ml (also 0.025 ml)

price :

349 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, dog

application :

western blot, ELISA, immunohistochemistry, flow cytometry, chromatin immunoprecipitation, immunohistochemistry - paraffin section

more info or order :

Novus Biologicals product webpage

citations: 24

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - paraffin section; human	Jiang H, Li F, He C, Wang X, Li Q, Gao H. Expression of Gli1 and Wnt2B correlates with progression and clinical outcome of pancreatic cancer. Int J Clin Exp Pathol. 2014;7:4531-8 pubmed
chromatin immunoprecipitation; human western blot; human	Nye M, Almada L, Fernández Barrena M, Marks D, Elsawa S, Vrabel A, et al. The transcription factor GLI1 interacts with SMAD proteins to modulate transforming growth factor ?-induced gene expression in a p300/CREB-binding protein-associated factor (PCAF)-dependent manner. J Biol Chem. 2014;289:15495-506 pubmed publisher
western blot; human	Huang L, Walter V, Hayes D, Onaitis M. Hedgehog-GLI signaling inhibition suppresses tumor growth in squamous lung cancer. Clin Cancer Res. 2014;20:1566-75 pubmed publisher
chromatin immunoprecipitation; human western blot; human	Mazumdar T, Sandhu R, Qadan M, DeVecchio J, Magloire V, Agyeman A, et al. Hedgehog signaling regulates telomerase reverse transcriptase in human cancer cells. PLoS ONE. 2013;8:e75253 pubmed publisher
western blot; mouse	Regard J, Malhotra D, Gvozdenovic Jeremic J, Josey M, Chen M, Weinstein L, et al. Activation of Hedgehog signaling by loss of GNAS causes heterotopic ossification. Nat Med. 2013;19:1505-12 pubmed publisher
immunohistochemistry; human	Karlou M, Lu J, Wu G, Maity S, Tzelepi V, Navone N, et al. Hedgehog signaling inhibition by the small molecule smoothened inhibitor GDC-0449 in the bone forming prostate cancer xenograft MDA PCa 118b. Prostate. 2012;72:1638-47 pubmed publisher
immunohistochemistry; human	Tzelepi V, Karlou M, Wen S, Hoang A, Logothetis C, Troncoso P, et al. Expression of hedgehog pathway components in prostate carcinoma microenvironment: shifting the balance towards autocrine signalling. Histopathology. 2011;58:1037-47 pubmed publisher
western blot; human	Mazumdar T, DeVecchio J, Shi T, Jones J, Agyeman A, Houghton J. Hedgehog signaling drives cellular survival in human colon carcinoma cells. Cancer Res. 2011;71:1092-102 pubmed publisher
	Mazzone A, Gibbons S, Eisenman S, Strege P, Zheng T, D Amato M, et al. Direct repression of anoctamin 1 (ANO1) gene transcription by Gli proteins. FASEB J. 2019;33:6632-6642 pubmed publisher
	Wang K, Chen D, Qian Z, Cui D, Gao L, Lou M. Hedgehog/Gli1 signaling pathway regulates MGMT expression and chemoresistance to temozolomide in human glioblastoma. Cancer Cell Int. 2017;17:117 pubmed publisher
	Tanno B, Leonardi S, Babini G, Giardullo P, De Stefano I, Pasquali E, et al. Nanog-driven cell-reprogramming and self-renewal maintenance in Ptch1 +/- granule cell precursors after radiation injury. Sci Rep. 2017;7:14238 pubmed publisher
	Wei R, Lv M, Li F, Cheng T, Zhang Z, Jiang G, et al. Human CAFs promote lymphangiogenesis in ovarian cancer via the Hh-VEGF-C signaling axis. Oncotarget. 2017;8:67315-67328 pubmed publisher
	Schneider R, Mullally A, Dugourd A, Peisker F, Hoogenboezem R, van Strien P, et al. Gli1+ Mesenchymal Stromal Cells Are a Key Driver of Bone Marrow Fibrosis and an Important Cellular Therapeutic Target. Cell Stem Cell. 2017;20:785-800.e8 pubmed publisher
	Xu T, Zhang H, Park S, Venneti S, Kuick R, Ha K, et al. Loss of Pin1 Suppresses Hedgehog-Driven Medulloblastoma Tumorigenesis. Neoplasia. 2017;19:216-225 pubmed publisher
	Puri P, Bushnell D, Schaefer C, Bates C. Six2creFrs2? knockout mice are a novel model of renal cystogenesis. Sci Rep. 2016;6:36736 pubmed publisher
	Wu M, Ingram L, Tolosa E, Vera R, Li Q, Kim S, et al. Gli Transcription Factors Mediate the Oncogenic Transformation of Prostate Basal Cells Induced by a Kras-Androgen Receptor Axis. J Biol Chem. 2016;291:25749-25760 pubmed
	Vidal M, LourenÃ§o S, Soares F, Gurgel C, Studart E, Valverde L, et al. The sonic hedgehog signaling pathway contributes to the development of salivary gland neoplasms regardless of perineural infiltration. Tumour Biol. 2016;37:9587-601 pubmed publisher
	Valverde L, Pereira T, Dias R, GuimarÃ£es V, Ramos E, Santos J, et al. Macrophages and endothelial cells orchestrate tumor-associated angiogenesis in oral cancer via hedgehog pathway activation. Tumour Biol. 2016;37:9233-41 pubmed publisher
	Comba A, Almada L, Tolosa E, Iguchi E, Marks D, Vara Messler M, et al. Nuclear Factor of Activated T Cells-dependent Down-regulation of the Transcription Factor Glioma-associated Protein 1 (GLI1) Underlies the Growth Inhibitory Properties of Arachidonic Acid. J Biol Chem. 2016;291:1933-47 pubmed publisher
	Yeddula N, Xia Y, Ke E, Beumer J, Verma I. Screening for tumor suppressors: Loss of ephrin receptor A2 cooperates with oncogenic KRas in promoting lung adenocarcinoma. Proc Natl Acad Sci U S A. 2015;112:E6476-85 pubmed publisher
	Jackson D, Smith T, Amarsaikhan N, Han W, Neil M, Boi S, et al. Modulation of the IL-6 Receptor Î± Underlies GLI2-Mediated Regulation of Ig Secretion in WaldenstrÃ¶m Macroglobulinemia Cells. J Immunol. 2015;195:2908-16 pubmed publisher
	Mazumdar T, DeVecchio J, Agyeman A, Shi T, Houghton J. Blocking Hedgehog survival signaling at the level of the GLI genes induces DNA damage and extensive cell death in human colon carcinoma cells. Cancer Res. 2011;71:5904-14 pubmed publisher
	Qualtrough D, Buda A, Gaffield W, Williams A, Paraskeva C. Hedgehog signalling in colorectal tumour cells: induction of apoptosis with cyclopamine treatment. Int J Cancer. 2004;110:831-7 pubmed
	Niemann C, Unden A, Lyle S, Zouboulis C, Toftgard R, Watt F. Indian hedgehog and beta-catenin signaling: role in the sebaceous lineage of normal and neoplastic mammalian epidermis. Proc Natl Acad Sci U S A. 2003;100 Suppl 1:11873-80 pubmed

product information

SKU :

NB600-600

product name :

GLI-1 Antibody

unit size :

0.1 ml (also 0.025 ml)

Description :

The GLI-1 Antibody from Novus is a rabbit polyclonal antibody to GLI-1. This antibody reacts with human, mouse, canine. The GLI-1 Antibody has been validated for the following applications: Western Blot, Chromatin Immunoprecipitation, Flow Cytometry, ELISA, Immunohistochemistry, Immunohistochemistry-Paraffin, Immunoblotting, Flow (Intracellular).

target :

GLI-1

category :

Primary Antibodies

buffer :

PBS

clonality :

Polyclonal

concentration :

1 mg/ml

conjugate :

Unconjugated

host :

Rabbit

immunogen :

A synthetic peptide made toward the C-terminus portion of the human GLI-1 protein (between residues 800-850) [Uniprot: P08151]

isotype :

IgG

purity :

Immunogen affinity purified

species :

Human, Mouse, Canine

specificity :

This is directed against Gli1 from mouse brain

gene symbol :

GLI1

catalog number base :

NB600-600

accessionNumbers :

P08151

applications :

Western Blot, Chromatin Immunoprecipitation, Flow Cytometry, ELISA, Immunohistochemistry, Immunohistochemistry-Paraffin, Immunoblotting, Flow (Intracellular)

2020 Proposedprice USD :

349 USD

alt names :

GLI family zinc finger 1, Glioma-associated oncogene, glioma-associated oncogene family zinc finger 1, glioma-associated oncogene homolog 1 (zinc finger protein), GLIzinc finger protein GLI1, Oncogene GLI

storage :

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

more info or order :

Novus Biologicals product webpage