product summary
Loading...
company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
TNF-alpha Antibody - Azide Free
catalog :
NB600-587
quantity :
0.2 ml (also 0.04 ml)
price :
329 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
clone name :
L243
reactivity :
human, mouse, rat
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, blocking or activating experiments
more info or order :
citations: 42
Published Application/Species/Sample/DilutionReference
  • blocking or activating experiments; mouse; loading ...; fig 5b
Chen J, Jian D, Lien C, Lin Y, Ting C, Chen L, et al. Adipocytes play an etiological role in the podocytopathy of high-fat diet-fed rats. J Endocrinol. 2016;231:109-120 pubmed
Gutziet O, Iluz R, Ben Asher H, Segal L, Ben Zvi D, Ginsberg Y, et al. Maternal N-Acetyl-Cysteine Prevents Neonatal Hypoxia-Induced Brain Injury in a Rat Model. Int J Mol Sci. 2021;22: pubmed publisher
Ollewagen T, Powrie Y, Myburgh K, Smith C. Unresolved intramuscular inflammation, not diminished skeletal muscle regenerative capacity, is at the root of rheumatoid cachexia: insights from a rat CIA model. Physiol Rep. 2021;9:e15119 pubmed publisher
Ongöz Dede F, Bozkurt Doğan Ş, Balli U, DurmuŞlar M, Avci B, Gulle K, et al. The effect of ellagic acid on the repair process of periodontal defects related to experimental periodontitis in rats. J Appl Oral Sci. 2021;29:e20210160 pubmed publisher
Parvin S, Williams C, Jarrett S, Garraway S. Spinal Cord Injury Increases Pro-inflammatory Cytokine Expression in Kidney at Acute and Sub-chronic Stages. Inflammation. 2021;44:2346-2361 pubmed publisher
Corsetti G, Romano C, Pasini E, Testa C, Dioguardi F. Qualitative Nitrogen Malnutrition Damages Gut and Alters Microbiome in Adult Mice. A Preliminary Histopathological Study. Nutrients. 2021;13: pubmed publisher
Liu L, Fang C, Fu W, Jiang B, Li G, Qin L, et al. Endothelial Cell-Derived Interleukin-18 Released During Ischemia Reperfusion Injury Selectively Expands T Peripheral Helper Cells to Promote Alloantibody Production. Circulation. 2020;141:464-478 pubmed publisher
Bhowmick S, D Mello V, Caruso D, Abdul Muneer P. Traumatic brain injury-induced downregulation of Nrf2 activates inflammatory response and apoptotic cell death. J Mol Med (Berl). 2019;97:1627-1641 pubmed publisher
Lai A, Ho L, Evashwick Rogler T, Watanabe H, Salandra J, Winkelstein B, et al. Dietary polyphenols as a safe and novel intervention for modulating pain associated with intervertebral disc degeneration in an in-vivo rat model. PLoS ONE. 2019;14:e0223435 pubmed publisher
Singh W, Devi H, Kumawat S, Sadam A, Appukuttan A, Patel M, et al. Angiogenic and MMPs modulatory effects of icariin improved cutaneous wound healing in rats. Eur J Pharmacol. 2019;:172466 pubmed publisher
Song C, Wu Y, Yang Z, Kalueff A, Tsao Y, Dong Y, et al. Astrocyte-Conditioned Medium Protects Prefrontal Cortical Neurons from Glutamate-Induced Cell Death by Inhibiting TNF-α Expression. Neuroimmunomodulation. 2019;26:33-42 pubmed publisher
Fauzia E, Barbhuyan T, Shrivastava A, Kumar M, Garg P, Khan M, et al. Chick Embryo: A Preclinical Model for Understanding Ischemia-Reperfusion Mechanism. Front Pharmacol. 2018;9:1034 pubmed publisher
Evashwick Rogler T, Lai A, Watanabe H, Salandra J, Winkelstein B, Cho S, et al. Inhibiting tumor necrosis factor-alpha at time of induced intervertebral disc injury limits long-term pain and degeneration in a rat model. JOR Spine. 2018;1: pubmed publisher
Cesur M, Gulle K, Şirin F, Akpolat M, Öğrenim G, Alkan A, et al. Effects of curcumin and melatonin on bone formation in orthopedically expanded suture in rats: A biochemical, histological and immunohistochemical study. Orthod Craniofac Res. 2018;: pubmed publisher
Shibutani M, Maeda K, Nagahara H, Fukuoka T, Matsutani S, Kashiwagi S, et al. A comparison of the local immune status between the primary and metastatic tumor in colorectal cancer: a retrospective study. BMC Cancer. 2018;18:371 pubmed publisher
Abdel Zaher A, Farghaly H, El Refaiy A, Abd Eldayem A. Protective effect of the standardized leaf extract of Ginkgo biloba (EGb761) against hypertension-induced renal injury in rats. Clin Exp Hypertens. 2018;40:703-714 pubmed publisher
Du C, Zhang T, Xiao X, Shi Y, Duan H, Ren Y. Protease-activated receptor-2 promotes kidney tubular epithelial inflammation by inhibiting autophagy via the PI3K/Akt/mTOR signalling pathway. Biochem J. 2017;474:2733-2747 pubmed publisher
Al Khalaf H, Amir M, Al Mohanna F, Tulbah A, Al Sayed A, Aboussekhra A. Obesity and p16INK4A Downregulation Activate Breast Adipocytes and Promote Their Protumorigenicity. Mol Cell Biol. 2017;37: pubmed publisher
Gunel C, Demirci B, Eryilmaz A, Yilmaz M, Meteoglu I, Omurlu I, et al. Inhibitory Effect of Pycnogenol® on Airway Inflammation in Ovalbumin-Induced Allergic Rhinitis. Balkan Med J. 2016;33:620-626 pubmed
Rossi A, Cadamuro A, Biselli Périco J, Leite K, Severino F, Reis P, et al. Interaction between inflammatory mediators and miRNAs in Helicobacter pylori infection. Cell Microbiol. 2016;18:1444-58 pubmed publisher
Wang X, Parrish A. Loss of α(E)-catenin promotes Fas mediated apoptosis in tubular epithelial cells. Apoptosis. 2015;20:921-9 pubmed publisher
Tessier D, Raha S, Holloway A, Yockell Lelièvre J, Tayade C, Gruslin A. Characterization of immune cells and cytokine localization in the rat utero-placental unit mid- to late gestation. J Reprod Immunol. 2015;110:89-101 pubmed publisher
Chen X, Zhang X, Wang Y, Lei H, Su H, Zeng J, et al. Inhibition of immunoproteasome reduces infarction volume and attenuates inflammatory reaction in a rat model of ischemic stroke. Cell Death Dis. 2015;6:e1626 pubmed publisher
Petersen S, Odintsova E, Haigh T, Rickinson A, Taylor G, Berditchevski F. The role of tetraspanin CD63 in antigen presentation via MHC class II. Eur J Immunol. 2011;41:2556-61 pubmed publisher
Ivanov A, Beers S, Walshe C, Honeychurch J, Alduaij W, Cox K, et al. Monoclonal antibodies directed to CD20 and HLA-DR can elicit homotypic adhesion followed by lysosome-mediated cell death in human lymphoma and leukemia cells. J Clin Invest. 2009;119:2143-59 pubmed publisher
Apps R, Murphy S, Fernando R, Gardner L, Ahad T, Moffett A. Human leucocyte antigen (HLA) expression of primary trophoblast cells and placental cell lines, determined using single antigen beads to characterize allotype specificities of anti-HLA antibodies. Immunology. 2009;127:26-39 pubmed publisher
Wahlstrom J, Dengjel J, Persson B, Duyar H, Rammensee H, Stevanovic S, et al. Identification of HLA-DR-bound peptides presented by human bronchoalveolar lavage cells in sarcoidosis. J Clin Invest. 2007;117:3576-82 pubmed
Setterblad N, Garban F, Weigl R, Assier E, Drillat P, Charron D, et al. Extracorporeal photophoresis increases sensitivity of monocytes from patients with graft-versus-host disease to HLA-DR-mediated cell death. Transfusion. 2008;48:169-77 pubmed
Dengjel J, Schoor O, Fischer R, Reich M, Kraus M, Müller M, et al. Autophagy promotes MHC class II presentation of peptides from intracellular source proteins. Proc Natl Acad Sci U S A. 2005;102:7922-7 pubmed
Ovsyannikova I, Johnson K, Naylor S, Poland G. Identification of HLA-DRB1-bound self-peptides following measles virus infection. J Immunol Methods. 2005;297:153-67 pubmed
Pashine A, Busch R, Belmares M, Munning J, Doebele R, Buckingham M, et al. Interaction of HLA-DR with an acidic face of HLA-DM disrupts sequence-dependent interactions with peptides. Immunity. 2003;19:183-92 pubmed
Gehring A, Rojas R, Canaday D, Lakey D, Harding C, Boom W. The Mycobacterium tuberculosis 19-kilodalton lipoprotein inhibits gamma interferon-regulated HLA-DR and Fc gamma R1 on human macrophages through Toll-like receptor 2. Infect Immun. 2003;71:4487-97 pubmed
Hegde N, Tomazin R, Wisner T, Dunn C, Boname J, Lewinsohn D, et al. Inhibition of HLA-DR assembly, transport, and loading by human cytomegalovirus glycoprotein US3: a novel mechanism for evading major histocompatibility complex class II antigen presentation. J Virol. 2002;76:10929-41 pubmed
Patil N, Pashine A, Belmares M, Liu W, Kaneshiro B, Rabinowitz J, et al. Rheumatoid arthritis (RA)-associated HLA-DR alleles form less stable complexes with class II-associated invariant chain peptide than non-RA-associated HLA-DR alleles. J Immunol. 2001;167:7157-68 pubmed
Kostelny S, Link B, Tso J, Vasquez M, Jorgensen B, Wang H, et al. Humanization and characterization of the anti-HLA-DR antibody 1D10. Int J Cancer. 2001;93:556-65 pubmed
Doebele R, Busch R, Scott H, Pashine A, Mellins E. Determination of the HLA-DM interaction site on HLA-DR molecules. Immunity. 2000;13:517-27 pubmed
Bainbridge D, Ellis S, Sargent I. HLA-G suppresses proliferation of CD4(+) T-lymphocytes. J Reprod Immunol. 2000;48:17-26 pubmed
van Ham M, van Lith M, Lillemeier B, Tjin E, Gruneberg U, Rahman D, et al. Modulation of the major histocompatibility complex class II-associated peptide repertoire by human histocompatibility leukocyte antigen (HLA)-DO. J Exp Med. 2000;191:1127-36 pubmed
Texier C, Pouvelle S, Busson M, Herve M, Charron D, Menez A, et al. HLA-DR restricted peptide candidates for bee venom immunotherapy. J Immunol. 2000;164:3177-84 pubmed
Bertho N, Drenou B, Laupeze B, Berre C, Amiot L, Grosset J, et al. HLA-DR-mediated apoptosis susceptibility discriminates differentiation stages of dendritic/monocytic APC. J Immunol. 2000;164:2379-85 pubmed
Appel H, Gauthier L, Pyrdol J, Wucherpfennig K. Kinetics of T-cell receptor binding by bivalent HLA-DR. Peptide complexes that activate antigen-specific human T-cells. J Biol Chem. 2000;275:312-21 pubmed
Hohn H, Pilch H, Günzel S, Neukirch C, Hilmes C, Kaufmann A, et al. CD4+ tumor-infiltrating lymphocytes in cervical cancer recognize HLA-DR-restricted peptides provided by human papillomavirus-E7. J Immunol. 1999;163:5715-22 pubmed
product information
brand :
Novus
master code :
NB600-587
SKU :
NB600-587
product name :
TNF-alpha Antibody - Azide Free
description :
The TNF-alpha Antibody - Azide Free from Novus Biologicals is a rabbit polyclonal antibody to TNF-alpha. This antibody reacts with human, mouse, rat, chicken, primate. The TNF-alpha Antibody - Azide Free has been validated for the following applications: Western Blot, ELISA, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin.
target :
TNF-alpha
category :
Primary Antibodies
sizes available :
0.2 ml (also 0.04 ml)
buffer :
Antiserum
clonality :
Polyclonal
conjugate :
Unconjugated
host :
Rabbit
immunogen :
The whole rabbit serum was prepared by repeated immunizations with recombinant human TNF-alpha produced in E.coli. (Uniprot: P01375)
isotype :
Serum
purity :
Delipidation and Defibrination
species :
Human, Mouse, Rat, Chicken, Primate
specificity :
The antiserum is directed against mature 17,000 MW human TNF-alpha and is useful in determining its presence in various assays
theoretical molecular weight :
25.64 kDa
gene symbol :
TNF
applications :
Western Blot, ELISA, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin
USD :
323
USD 2023 :
329 USD
alt names :
APC1 protein, Cachectin, DIF, TNF, monocyte-derived, TNF-a, TNF-alphacachectin, TNFATNF, macrophage-derived, TNFSF2TNF superfamily, member 2, tumor necrosis factor, tumor necrosis factor (TNF superfamily, member 2), tumor necrosis factor alpha, Tumor necrosis factor ligand superfamily member 2, tumor necrosis factor-alpha
storage :
Store at -20C short term. Aliquot and store at -80C long term. Avoid freeze-thaw cycles.
more info or order :
company information
Novus Biologicals
10771 E Easter Ave
Centennial, CO 80112
novus@novusbio.com
https://www.novusbio.com
3037301950
headquarters: USA
Novus Biologicals licenses, manufactures, and markets antibodies to over 20,000 unique targets to support a wide array of research areas. Novus is built on honesty, collaboration and strong relationships and continues to provide quality tools that accelerate research. Every product is backed by our 100% guarantee.