Aggrecan Antibody (BC-3) - BSA Free | Novus Biologicals NB600-504-0.1mg product information

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product summary

company name :

Novus Biologicals

other brands :

IMGENEX

product type :

antibody

product name :

Aggrecan Antibody (BC-3) - BSA Free

catalog :

NB600-504-0.1mg

quantity :

0.1 mg (also 0.025 mg)

price :

409 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

BC-3

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

citations: 17

Reference
Qingxin S, Kai J, Dandan Z, Linyu J, Xiuyuan C, Yubo F, et al. Programmable DNA hydrogel provides suitable microenvironment for enhancing autophagy-based therapies in intervertebral disc degeneration treatment. J Nanobiotechnology. 2023;21:350 pubmed publisher
Esmaeili A, Hosseini S, Kamali A, Hosseinzadeh M, Shekari F, Baghaban Eslaminejad M. Co-aggregation of MSC/chondrocyte in a dynamic 3D culture elevates the therapeutic effect of secreted extracellular vesicles on osteoarthritis in a rat model. Sci Rep. 2022;12:19827 pubmed publisher
Hosseinzadeh M, Kamali A, Hosseini S, Baghaban Eslaminejad M. Higher Chondrogenic Potential of Extracellular Vesicles Derived from Mesenchymal Stem Cells Compared to Chondrocytes-EVs In Vitro. Biomed Res Int. 2021;2021:9011548 pubmed publisher
Jung H, McClellan P, Welter J, Akkus O. Chondrogenesis of Mesenchymal Stem Cells through Local Release of TGF-β3 from Heparinized Collagen Biofabric. Tissue Eng Part A. 2021;: pubmed publisher
Hurley Novatny A, Arumugasaamy N, Kimicata M, Baker H, Mikos A, Fisher J. Concurrent multi-lineage differentiation of mesenchymal stem cells through spatial presentation of growth factors. Biomed Mater. 2020;15:055035 pubmed publisher
Si H, Yang T, Li L, Tian M, Zhou L, Li D, et al. miR-140 Attenuates the Progression of Early-Stage Osteoarthritis by Retarding Chondrocyte Senescence. Mol Ther Nucleic Acids. 2020;19:15-30 pubmed publisher
Cheng B, Liu Y, Zhao Y, Li Q, Liu Y, Wang J, et al. The role of anthrax toxin protein receptor 1 as a new mechanosensor molecule and its mechanotransduction in BMSCs under hydrostatic pressure. Sci Rep. 2019;9:12642 pubmed publisher
Liu Z, Zhang Z, Zhang A, Zhang F, Du W, Zhang Y, et al. Osteogenic protein-1 alleviates high glucose microenvironment-caused degenerative changes in nucleus pulposus cells. Biosci Rep. 2019;39: pubmed publisher
Chen L, Liu G, Li W, Wu X. Chondrogenic differentiation of bone marrow-derived mesenchymal stem cells following transfection with Indian hedgehog and sonic hedgehog using a rotary cell culture system. Cell Mol Biol Lett. 2019;24:16 pubmed publisher
Jia J, Wang S, Ma L, Yu J, Guo Y, Wang C. The Differential Effects of Leukocyte-Containing and Pure Platelet-Rich Plasma on Nucleus Pulposus-Derived Mesenchymal Stem Cells: Implications for the Clinical Treatment of Intervertebral Disc Degeneration. Stem Cells Int. 2018;2018:7162084 pubmed publisher
Yang D, Zhu D, Zhu S, Feng F, Gong C, Chen C, et al. 17β-Estradiol/extrogen receptor β alleviates apoptosis and enhances matrix biosynthesis of nucleus pulposus cells through regulating oxidative damage under a high glucose condition. Biomed Pharmacother. 2018;107:1004-1009 pubmed publisher
Ma S, Xie Z, Guo Y, Yu J, Lu J, Zhang W, et al. Effect of Acupotomy on FAK-PI3K Signaling Pathways in KOA Rabbit Articular Cartilages. Evid Based Complement Alternat Med. 2017;2017:4535326 pubmed publisher
Han M, Kim S, Kim H, Yim H, Bencherif S, Kim T, et al. Extracellular matrix-based cryogels for cartilage tissue engineering. Int J Biol Macromol. 2016;93:1410-1419 pubmed publisher
Bouhenni R, Hart M, Al Jastaneiah S, Alkatan H, Edward D. Immunohistochemical expression and distribution of proteoglycans and collagens in sclerocornea. Int Ophthalmol. 2013;33:691-700 pubmed publisher
Yurube T, Takada T, Suzuki T, Kakutani K, Maeno K, Doita M, et al. Rat tail static compression model mimics extracellular matrix metabolic imbalances of matrix metalloproteinases, aggrecanases, and tissue inhibitors of metalloproteinases in intervertebral disc degeneration. Arthritis Res Ther. 2012;14:R51 pubmed publisher
Swearingen C, Chambers M, Lin C, Marimuthu J, Rito C, Carter Q, et al. A short-term pharmacodynamic model for monitoring aggrecanase activity: injection of monosodium iodoacetate (MIA) in rats and assessment of aggrecan neoepitope release in synovial fluid using novel ELISAs. Osteoarthritis Cartilage. 2010;18:1159-66 pubmed publisher
Little C, Hughes C, Curtis C, Janusz M, Bohne R, Wang Weigand S, et al. Matrix metalloproteinases are involved in C-terminal and interglobular domain processing of cartilage aggrecan in late stage cartilage degradation. Matrix Biol. 2002;21:271-88 pubmed

product information

brand :

Novus Biologicals, a Bio-Techne Brand

catalog number base :

NB600-504

SKU :

NB600-504-0.1mg

product name :

Aggrecan Antibody (BC-3) - BSA Free

Description :

The Aggrecan Antibody (BC-3) - BSA Free from Novus is a mouse monoclonal antibody to Aggrecan. This antibody reacts with human, mouse, rat, porcine, bovine, canine, equine, feline, guinea pig, rabbit, sheep. The Aggrecan Antibody (BC-3) - BSA Free has been validated for the following applications: Western Blot, ELISA, Immunohistochemistry, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen.

target :

Aggrecan

category :

Primary Antibodies

unit size :

0.1 mg (also 0.025 mg)

buffer :

PBS

clonality :

Monoclonal

clone :

BC-3

concentration :

1.0 mg/ml

conjugate :

Unconjugated

host :

Mouse

immunogen :

ARGSV. synthetic peptide conjugate.

isotype :

IgG1 Kappa

purity :

Protein A or G purified

species :

Human, Mouse, Rat, Porcine, Bovine, Canine, Equine, Feline, Guinea Pig, Rabbit, Sheep

specificity :

Recognizes the aggrecanase (ADAMTS-1, -4 & -5)-generated N-terminal neoepitope ARG after cleavage between amino acids EGE and ARG within the interglobular domain of aggrecanase-catabolised aggrecan

theoretical molecular weight :

250 kDa

gene symbol :

ACAN

accessionNumbers :

P16112

applications :

Western Blot, ELISA, Immunohistochemistry, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen

USD :

409 USD

alt names :

AGC1SEDK, aggrecan, aggrecan core protein, Cartilage-specific proteoglycan core protein, Chondroitin sulfate proteoglycan 1, Chondroitin sulfate proteoglycan core protein 1, CSPCP, CSPG1aggrecan 1, CSPGCP, large aggregating proteoglycan, MSK16AGCAN

storage :

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.