product summary
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company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
LC3B Antibody - BSA Free
catalog :
NB600-1384
quantity :
0.1 ml (also 0.025 ml)
price :
479 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
AF647
clone name :
OTI2B3
reactivity :
human, mouse, rat, dogs, bovine, zebrafish
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
citations: 249
Published Application/Species/Sample/DilutionReference
  • western blot; human; 1:500; loading ...; fig 4c
Li R, Hao Y, Wang Q, Meng Y, Wu K, Liu C, et al. ECHS1, an interacting protein of LASP1, induces sphingolipid-metabolism imbalance to promote colorectal cancer progression by regulating ceramide glycosylation. Cell Death Dis. 2021;12:911 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig s8j
Van Alstyne M, Tattoli I, Delestrée N, Recinos Y, Workman E, Shihabuddin L, et al. Gain of toxic function by long-term AAV9-mediated SMN overexpression in the sensorimotor circuit. Nat Neurosci. 2021;24:930-940 pubmed publisher
  • western blot; mouse; loading ...; fig 1e
Tamargo Gómez I, Martínez García G, Suarez M, Rey V, Fueyo A, Codina Martínez H, et al. ATG4D is the main ATG8 delipidating enzyme in mammalian cells and protects against cerebellar neurodegeneration. Cell Death Differ. 2021;: pubmed publisher
  • immunocytochemistry; mouse; loading ...; fig 5c
  • western blot; mouse; loading ...; fig 5c
Shen Z, Ji K, Cai Z, Huang C, He X, Xu H, et al. Inhibition of HDAC6 by Tubastatin A reduces chondrocyte oxidative stress in chondrocytes and ameliorates mouse osteoarthritis by activating autophagy. Aging (Albany NY). 2021;13:9820-9837 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 5s2b
Lieberman O, Frier M, McGuirt A, Griffey C, Rafikian E, Yang M, et al. Cell-type-specific regulation of neuronal intrinsic excitability by macroautophagy. elife. 2020;9: pubmed publisher
  • western blot; human; loading ...; fig 5a
Zheng J, Croteau D, Bohr V, Akbari M. Diminished OPA1 expression and impaired mitochondrial morphology and homeostasis in Aprataxin-deficient cells. Nucleic Acids Res. 2019;: pubmed publisher
  • western blot; human; loading ...; fig 4b
Wang D, Xu Q, Yuan Q, Jia M, Niu H, Liu X, et al. Proteasome inhibition boosts autophagic degradation of ubiquitinated-AGR2 and enhances the antitumor efficiency of bevacizumab. Oncogene. 2019;38:3458-3474 pubmed publisher
  • western blot; mouse; fig s8d
Li F, Li Y, Liang H, Xu T, Kong Y, Huang M, et al. HECTD3 mediates TRAF3 polyubiquitination and type I interferon induction during bacterial infection. J Clin Invest. 2018;128:4148-4162 pubmed publisher
  • immunohistochemistry; rat; 1:200; loading ...; fig 3
  • western blot; rat; 1:1000; loading ...; fig 1a
Gao Y, Zhuang Z, Gao S, Li X, Zhang Z, Ye Z, et al. Tetrahydrocurcumin reduces oxidative stress-induced apoptosis via the mitochondrial apoptotic pathway by modulating autophagy in rats after traumatic brain injury. Am J Transl Res. 2017;9:887-899 pubmed
  • western blot; mouse; 1:1000; loading ...; fig 3a
Vodicka P, Chase K, Iuliano M, Tousley A, Valentine D, Sapp E, et al. Autophagy Activation by Transcription Factor EB (TFEB) in Striatum of HDQ175/Q7 Mice. J Huntingtons Dis. 2016;5:249-260 pubmed
  • western blot; human; fig 5
Kobayashi K, Araya J, Minagawa S, Hara H, Saito N, Kadota T, et al. Involvement of PARK2-Mediated Mitophagy in Idiopathic Pulmonary Fibrosis Pathogenesis. J Immunol. 2016;197:504-16 pubmed publisher
  • western blot; human; fig 6
Ando K, Tomimura K, Sazdovitch V, Suain V, Yilmaz Z, Authelet M, et al. Level of PICALM, a key component of clathrin-mediated endocytosis, is correlated with levels of phosphotau and autophagy-related proteins and is associated with tau inclusions in AD, PSP and Pick disease. Neurobiol Dis. 2016;94:32-43 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:4000; fig 3
  • western blot; human; loading ...; fig 1a
Adams O, Dislich B, Berezowska S, Schläfli A, Seiler C, Kröll D, et al. Prognostic relevance of autophagy markers LC3B and p62 in esophageal adenocarcinomas. Oncotarget. 2016;7:39241-39255 pubmed publisher
  • western blot; human; 1:1000; fig 2
Gschweitl M, Ulbricht A, Barnes C, Enchev R, Stoffel Studer I, Meyer Schaller N, et al. A SPOPL/Cullin-3 ubiquitin ligase complex regulates endocytic trafficking by targeting EPS15 at endosomes. elife. 2016;5:e13841 pubmed publisher
Tamargo G xf3 mez I, Mart xed nez Garc xed a G, Su xe1 rez M, Mayoral P, Bretones G, Astudillo A, et al. Analysis of ATG4C function in vivo. Autophagy. 2023;:1-22 pubmed publisher
Van Acker Z, Perdok A, Hellemans R, North K, Vorsters I, Cappel C, et al. Phospholipase D3 degrades mitochondrial DNA to regulate nucleotide signaling and APP metabolism. Nat Commun. 2023;14:2847 pubmed publisher
Bjerregaard V, Levy A, Batz M, Salehi R, Hildonen M, Hammer T, et al. Involvement of Mitochondrial Dysfunction in FOXG1 Syndrome. Genes (Basel). 2023;14: pubmed publisher
Hoffman H, Prekeris R. HOPS-dependent lysosomal fusion controls Rab19 availability for ciliogenesis in polarized epithelial cells. bioRxiv. 2023;: pubmed publisher
Su S, Xue Y, Lee S, Zhang Y, Fan J, De S, et al. A dual-activity topoisomerase complex promotes both transcriptional activation and repression in response to starvation. Nucleic Acids Res. 2023;51:2415-2433 pubmed publisher
Miller K, Wagner M, Jassey A, Jackson W. SNAP23 is essential for germination of EV-D68 replication organelles. Virology. 2023;578:117-127 pubmed publisher
Ye S, Fang L, Xie S, Hu Y, Chen S, Amin N, et al. Resveratrol alleviates postpartum depression-like behavior by activating autophagy via SIRT1 and inhibiting AKT/mTOR pathway. Behav Brain Res. 2023;438:114208 pubmed publisher
Yamashita G, Takano N, Kazama H, Tsukahara K, Miyazawa K. p53 regulates lysosomal membrane permeabilization as well as cytoprotective autophagy in response to DNA-damaging drugs. Cell Death Discov. 2022;8:502 pubmed publisher
Chumpen Ramirez S, G xf3 mez S xe1 nchez R, Verlhac P, Hardenberg R, Margheritis E, Cosentino K, et al. --Atg9 interactions via its transmembrane domains are required for phagophore expansion during autophagy. Autophagy. 2022;:1-20 pubmed publisher
Gross D, Bischof H, Maier S, Sporbeck K, Birkenfeld A, Malli R, et al. IKCa channels control breast cancer metabolism including AMPK-driven autophagy. Cell Death Dis. 2022;13:902 pubmed publisher
Neupane N, Rajendran J, Kvist J, Harjuhaahto S, Hu B, Kinnunen V, et al. Inter-organellar and systemic responses to impaired mitochondrial matrix protein import in skeletal muscle. Commun Biol. 2022;5:1060 pubmed publisher
Khamis T, Alsemeh A, Abdullah D. Sacubitril/valsartan (LCZ696) ameliorates hyperthyroid-induced cardiac hypertrophy in male rats through modulation of miR-377, let-7 b, autophagy, and fibrotic signaling pathways. Sci Rep. 2022;12:14654 pubmed publisher
Lee J, Kim S, Choi G, Yi E, Park H, Choi W, et al. Sweet taste receptor agonists attenuate macrophage IL-1β expression and eosinophilic inflammation linked to autophagy deficiency in myeloid cells. Clin Transl Med. 2022;12:e1021 pubmed publisher
Zhang L, Liu X, Huang M, Wang R, Zhu W, Li Y, et al. Metformin Inhibits HaCaT Cell Proliferation Under Hyperlipidemia Through Reducing Reactive Oxygen Species via FOXO3 Activation. Clin Cosmet Investig Dermatol. 2022;15:1403-1413 pubmed publisher
Butera A, Quaranta M, Crippa L, Spinello I, Saulle E, Di Carlo N, et al. CD147 Targeting by AC-73 Induces Autophagy and Reduces Intestinal Fibrosis Associated with TNBS Chronic Colitis. J Crohns Colitis. 2022;16:1751-1761 pubmed publisher
Lou C, Fang M, Ye S, Fang Z, Amin N, Chen Y. Fluoxetine protects against inflammation and promotes autophagy in mice model of post-traumatic stress disorder. Behav Brain Res. 2022;433:114004 pubmed publisher
Davidi S, Jacobovitch S, Shteingauz A, Martinez Conde A, Braten O, Tempel Brami C, et al. Tumor Treating Fields (TTFields) Concomitant with Sorafenib Inhibit Hepatocellular Carcinoma In Vitro and In Vivo. Cancers (Basel). 2022;14: pubmed publisher
Kondylis V, Schneider F, Schorn F, Oikonomou N, Straub B, Werner S, et al. p62 Promotes Survival and Hepatocarcinogenesis in Mice with Liver-Specific NEMO Ablation. Cancers (Basel). 2022;14: pubmed publisher
Huo Y, Sawant A, Tan Y, Mahdi A, Li T, Ma H, et al. Tumor suppressor PALB2 maintains redox and mitochondrial homeostasis in the brain and cooperates with ATG7/autophagy to suppress neurodegeneration. PLoS Genet. 2022;18:e1010138 pubmed publisher
Chen H, Zhou J, Chen H, Liang J, Xie C, Gu X, et al. Bmi-1-RING1B prevents GATA4-dependent senescence-associated pathological cardiac hypertrophy by promoting autophagic degradation of GATA4. Clin Transl Med. 2022;12:e574 pubmed publisher
de Mazi xe8 re A, van der Beek J, van Dijk S, de Heus C, Reggiori F, Koike M, et al. An optimized protocol for immuno-electron microscopy of endogenous LC3. Autophagy. 2022;18:3004-3022 pubmed publisher
Ito A, Hashimoto M, Tanihata J, Matsubayashi S, Sasaki R, Fujimoto S, et al. Involvement of Parkin-mediated mitophagy in the pathogenesis of chronic obstructive pulmonary disease-related sarcopenia. J Cachexia Sarcopenia Muscle. 2022;13:1864-1882 pubmed publisher
Moudio S, Rodin F, Albargothy N, Karlsson U, Reyes J, Hallbeck M. Exposure of α-Synuclein Aggregates to Organotypic Slice Cultures Recapitulates Key Molecular Features of Parkinson's Disease. Front Neurol. 2022;13:826102 pubmed publisher
Shan Y, Lu C, Wang J, Li M, Ye S, Wu S, et al. IGF-1 contributes to liver cancer development in diabetes patients by promoting autophagy. Ann Hepatol. 2022;27:100697 pubmed publisher
Suliman M, Case K, Schmidtke M, Lazcano P, Onu C, Greenberg M. Inositol depletion regulates phospholipid metabolism and activates stress signaling in HEK293T cells. Biochim Biophys Acta Mol Cell Biol Lipids. 2022;1867:159137 pubmed publisher
Puertas Neyra K, Galindo Cabello N, Hern xe1 ndez Rodr xed guez L, Gonz xe1 lez P xe9 rez F, Rodr xed guez Cabello J, Gonz xe1 lez Sarmiento R, et al. Programmed Cell Death and Autophagy in an in vitro Model of Spontaneous Neuroretinal Degeneration. Front Neuroanat. 2022;16:812487 pubmed publisher
Beillevaire D, Migneault F, Turgeon J, Gingras D, Rimbaud A, Marcoux G, et al. Autolysosomes and caspase-3 control the biogenesis and release of immunogenic apoptotic exosomes. Cell Death Dis. 2022;13:145 pubmed publisher
Krishnan B, Yasuhara T, Rumde P, Stanzione M, Lu C, Lee H, et al. Active RB causes visible changes in nuclear organization. J Cell Biol. 2022;221: pubmed publisher
Sendino Garv xed E, Masereeuw R, Janssen M. Bioengineered Cystinotic Kidney Tubules Recapitulate a Nephropathic Phenotype. Cells. 2022;11: pubmed publisher
Stempels F, Janssens M, ter Beest M, Mesman R, Revelo N, Ioannidis M, et al. Novel and conventional inhibitors of canonical autophagy differently affect LC3-associated phagocytosis. FEBS Lett. 2022;596:491-509 pubmed publisher
Lin Q, Cao J, Du X, Yang K, Shen Y, Wang W, et al. The HeyL-Aromatase Axis Promotes Cancer Stem Cell Properties by Endogenous Estrogen-Induced Autophagy in Castration-Resistant Prostate Cancer. Front Oncol. 2021;11:787953 pubmed publisher
Thakur A, Luthra Guptasarma M. Differences in Cellular Clearing Mechanisms of Aggregates of Two Subtypes of HLA-B27. Front Immunol. 2021;12:795053 pubmed publisher
Xu Y, Hu X, Li F, Zhang H, Lou J, Wang X, et al. GDF-11 Protects the Traumatically Injured Spinal Cord by Suppressing Pyroptosis and Necroptosis via TFE3-Mediated Autophagy Augmentation. Oxid Med Cell Longev. 2021;2021:8186877 pubmed publisher
Smith S, Fabian L, Sheikh A, Noche R, Cui X, Moore S, et al. Lysosomes and the pathogenesis of merosin-deficient congenital muscular dystrophy. Hum Mol Genet. 2021;: pubmed publisher
McCarthy C, Chakraborty S, Singh G, Yeoh B, Schreckenberger Z, Singh A, et al. Ketone body β-hydroxybutyrate is an autophagy-dependent vasodilator. JCI Insight. 2021;6: pubmed publisher
Miyazaki M, Hiramoto M, Takano N, Kokuba H, Takemura J, Tokuhisa M, et al. Targeted disruption of GAK stagnates autophagic flux by disturbing lysosomal dynamics. Int J Mol Med. 2021;48: pubmed publisher
Hattori K, Takano N, Kazama H, Moriya S, Miyake K, Hiramoto M, et al. Induction of synergistic non-apoptotic cell death by simultaneously targeting proteasomes with bortezomib and histone deacetylase 6 with ricolinostat in head and neck tumor cells. Oncol Lett. 2021;22:680 pubmed publisher
Wang X, Zhu Y, Zhu Y, Sun Y, Huang J, Li Z, et al. Long-term running exercise alleviates cognitive dysfunction in APP/PSEN1 transgenic mice via enhancing brain lysosomal function. Acta Pharmacol Sin. 2021;: pubmed publisher
Tokarchuk I, Janser F, Schläfli A, Pinto M, Humbert M, Niklaus N, et al. Increased LAMP2A levels correlate with a shorter disease-free survival of HER2 negative breast cancer patients and increased breast cancer cell viability. Biochem Biophys Res Commun. 2021;569:47-53 pubmed publisher
Fontaine A, Bellanger D, Guibon R, Bruyere F, Brisson L, Fromont G. Lipophagy and prostate cancer: association with disease aggressiveness and proximity to periprostatic adipose tissue. J Pathol. 2021;255:166-176 pubmed publisher
Akoumianaki T, Vaporidi K, Diamantaki E, Pène F, Beau R, Gresnigt M, et al. Uncoupling of IL-6 signaling and LC3-associated phagocytosis drives immunoparalysis during sepsis. Cell Host Microbe. 2021;29:1277-1293.e6 pubmed publisher
Devenport S, Singhal R, Radyk M, Taranto J, Kerk S, Chen B, et al. Colorectal cancer cells utilize autophagy to maintain mitochondrial metabolism for cell proliferation under nutrient stress. JCI Insight. 2021;6: pubmed publisher
Molinari F, Feraco A, Mirabilii S, Saladini S, Sansone L, Vernucci E, et al. SIRT5 Inhibition Induces Brown Fat-Like Phenotype in 3T3-L1 Preadipocytes. Cells. 2021;10: pubmed publisher
Orhon I, Rocchi C, Villarejo Zori B, Serrano Martinez P, Baanstra M, Brouwer U, et al. Autophagy induction during stem cell activation plays a key role in salivary gland self-renewal. Autophagy. 2021;:1-16 pubmed publisher
Ovejero Sánchez M, Gonzalez Sarmiento R, Herrero A. Synergistic effect of Chloroquine and Panobinostat in ovarian cancer through induction of DNA damage and inhibition of DNA repair. Neoplasia. 2021;23:515-528 pubmed publisher
Schläfli A, Tokarchuk I, Parejo S, Jutzi S, Berezowska S, Engedal N, et al. ALK inhibition activates LC3B-independent, protective autophagy in EML4-ALK positive lung cancer cells. Sci Rep. 2021;11:9011 pubmed publisher
Li J, Tian M, Hua T, Wang H, Yang M, Li W, et al. Combination of autophagy and NFE2L2/NRF2 activation as a treatment approach for neuropathic pain. Autophagy. 2021;:1-21 pubmed publisher
Luo Y, Zheng S, Wu Q, Wu J, Zhou R, Wang C, et al. Long noncoding RNA (lncRNA) EIF3J-DT induces chemoresistance of gastric cancer via autophagy activation. Autophagy. 2021;:1-19 pubmed publisher
Humbert M, Seiler K, Mosimann S, Rentsch V, Sharma K, Pandey A, et al. Reducing FASN expression sensitizes acute myeloid leukemia cells to differentiation therapy. Cell Death Differ. 2021;28:2465-2481 pubmed publisher
Chuang K, Chen F, Tsai M, Shieh J. EGR-1 plays a protective role in AMPK inhibitor compound C-induced apoptosis through ROS-induced ERK activation in skin cancer cells. Oncol Lett. 2021;21:304 pubmed publisher
Mercier A, Prudent R, Pepper M, de Koning L, Nolte E, Peronne L, et al. Characterization of Signalling Pathways That Link Apoptosis and Autophagy to Cell Death Induced by Estrone Analogues Which Reversibly Depolymerize Microtubules. Molecules. 2021;26: pubmed publisher
Rai P, Janardhan K, Meacham J, Madenspacher J, Lin W, Karmaus P, et al. IRGM1 links mitochondrial quality control to autoimmunity. Nat Immunol. 2021;22:312-321 pubmed publisher
Park J, Choi H, Kim Y, Kim S, Kim Y, Gwon Y, et al. Aberrant role of ALK in tau proteinopathy through autophagosomal dysregulation. Mol Psychiatry. 2021;: pubmed publisher
Zhou X, Zhu X, Li C, Li Y, Ye Z, Shapiro V, et al. Stearoyl-CoA Desaturase-Mediated Monounsaturated Fatty Acid Availability Supports Humoral Immunity. Cell Rep. 2021;34:108601 pubmed publisher
Li Y, Pan Y, Cao S, Sasaki K, Wang Y, Niu A, et al. Podocyte EGFR Inhibits Autophagy Through Upregulation of Rubicon in Type 2 Diabetic Nephropathy. Diabetes. 2021;70:562-576 pubmed publisher
Kong J, Wang J, Gong X, Zheng X, Chen T. Punicalagin Inhibits Tert-Butyl Hydroperoxide-Induced Apoptosis and Extracellular Matrix Degradation in Chondrocytes by Activating Autophagy and Ameliorates Murine Osteoarthritis. Drug Des Devel Ther. 2020;14:5521-5533 pubmed publisher
Machiela E, Jeloka R, Caron N, Mehta S, Schmidt M, Baddeley H, et al. The Interaction of Aging and Cellular Stress Contributes to Pathogenesis in Mouse and Human Huntington Disease Neurons. Front Aging Neurosci. 2020;12:524369 pubmed publisher
Takeda A, Takano N, Kokuba H, Hino H, Moriya S, Abe A, et al. Macrolide antibiotics enhance the antitumor effect of lansoprazole resulting in lysosomal membrane permeabilization‑associated cell death. Int J Oncol. 2020;57:1280-1292 pubmed publisher
Kwon Y, Bang Y, Moon S, Kim A, Choi H. Amitriptyline interferes with autophagy-mediated clearance of protein aggregates via inhibiting autophagosome maturation in neuronal cells. Cell Death Dis. 2020;11:874 pubmed publisher
Losmanová T, Janser F, Humbert M, Tokarchuk I, Schläfli A, Neppl C, et al. Chaperone-Mediated Autophagy Markers LAMP2A and HSC70 Are Independent Adverse Prognostic Markers in Primary Resected Squamous Cell Carcinomas of the Lung. Oxid Med Cell Longev. 2020;2020:8506572 pubmed publisher
Li Y, Xiang J, Zhang J, Lin J, Wu Y, Wang X. Inhibition of Brd4 by JQ1 Promotes Functional Recovery From Spinal Cord Injury by Activating Autophagy. Front Cell Neurosci. 2020;14:555591 pubmed publisher
Peintner L, Venkatraman A, Waeldin A, Hofherr A, Busch T, Voronov A, et al. Loss of PKD1/polycystin-1 impairs lysosomal activity in a CAPN (calpain)-dependent manner. Autophagy. 2020;:1-17 pubmed publisher
Chen J, Wang X, Chen L, Tang J, Xia Y, Qian K, et al. A sphingosine kinase 2-mimicking TAT-peptide protects neurons against ischemia-reperfusion injury by activating BNIP3-mediated mitophagy. Neuropharmacology. 2020;181:108326 pubmed publisher
Liu E, Schultz M, Mochida C, Chung C, Paulson H, Lieberman A. Fbxo2 mediates clearance of damaged lysosomes and modifies neurodegeneration in the Niemann-Pick C brain. JCI Insight. 2020;5: pubmed publisher
Yang R, Xu W, Zheng H, Zheng X, Li B, Jiang L, et al. Involvement of oxidative stress-induced annulus fibrosus cell and nucleus pulposus cell ferroptosis in intervertebral disc degeneration pathogenesis. J Cell Physiol. 2020;: pubmed publisher
Chen L, Xia Y, Shen S, Tang J, Chen J, Qian K, et al. Syntaxin 17 inhibits ischemic neuronal injury by resuming autophagy flux and ameliorating endoplasmic reticulum stress. Free Radic Biol Med. 2020;160:319-333 pubmed publisher
Bernard M, Cardin G, Cahuzac M, Ayad T, Bissada E, Guertin L, et al. Dual Inhibition of Autophagy and PI3K/AKT/MTOR Pathway as a Therapeutic Strategy in Head and Neck Squamous Cell Carcinoma. Cancers (Basel). 2020;12: pubmed publisher
Zhou K, Zheng Z, Li Y, Han W, Zhang J, Mao Y, et al. TFE3, a potential therapeutic target for Spinal Cord Injury via augmenting autophagy flux and alleviating ER stress. Theranostics. 2020;10:9280-9302 pubmed publisher
Zhou X, Brooks M, Jiang P, Koga S, Zuberi A, Baker M, et al. Loss of Tmem106b exacerbates FTLD pathologies and causes motor deficits in progranulin-deficient mice. EMBO Rep. 2020;21:e50197 pubmed publisher
Li Z, Zhu Y, Xiang M, Qiu J, Luo S, Lin F. Enhanced lysosomal function is critical for paclitaxel resistance in cancer cells: reversed by artesunate. Acta Pharmacol Sin. 2020;: pubmed publisher
Zhang Z, Qian Q, Li M, Shao F, Ding W, Lira V, et al. The unfolded protein response regulates hepatic autophagy by sXBP1-mediated activation of TFEB. Autophagy. 2020;:1-15 pubmed publisher
Cheung C, Hsu C, Lin T, Chen W, Wang Y, Huang H, et al. ZNF322A-mediated protein phosphorylation induces autophagosome formation through modulation of IRS1-AKT glucose uptake and HSP-elicited UPR in lung cancer. J Biomed Sci. 2020;27:75 pubmed publisher
Deynoux M, Sunter N, Ducrocq E, Dakik H, Guibon R, Burlaud Gaillard J, et al. A comparative study of the capacity of mesenchymal stromal cell lines to form spheroids. PLoS ONE. 2020;15:e0225485 pubmed publisher
Bonam S, Bayry J, Tschan M, Muller S. Progress and Challenges in The Use of MAP1LC3 as a Legitimate Marker for Measuring Dynamic Autophagy In Vivo. Cells. 2020;9: pubmed publisher
Eriksson I, Wäster P, Ollinger K. Restoration of lysosomal function after damage is accompanied by recycling of lysosomal membrane proteins. Cell Death Dis. 2020;11:370 pubmed publisher
Lieberman O, Cartocci V, Pigulevskiy I, Molinari M, Carbonell J, Broseta M, et al. mTOR Suppresses Macroautophagy During Striatal Postnatal Development and Is Hyperactive in Mouse Models of Autism Spectrum Disorders. Front Cell Neurosci. 2020;14:70 pubmed publisher
Tanaka H, Hino H, Moriya S, Kazama H, Miyazaki M, Takano N, et al. Comparison of autophagy inducibility in various tyrosine kinase inhibitors and their enhanced cytotoxicity via inhibition of autophagy in cancer cells in combined treatment with azithromycin. Biochem Biophys Rep. 2020;22:100750 pubmed publisher
Kim H, Lee G, Bhattarai K, Lee M, Back S, Kim H, et al. TMBIM6 (transmembrane BAX inhibitor motif containing 6) enhances autophagy through regulation of lysosomal calcium. Autophagy. 2020;:1-18 pubmed publisher
Dubois Deruy E, Gélinas R, Beauloye C, Esfahani H, Michel L, Dessy C, et al. Beta 3 adrenoreceptors protect from hypertrophic remodelling through AMP-activated protein kinase and autophagy. ESC Heart Fail. 2020;7:920-932 pubmed publisher
Wang C, Li Y, Wu X, Tian H, Jiang S, Xu T, et al. IRF3 and IRF7 contribute to diesel exhaust particles-induced pulmonary inflammation by mediating mTORC1 activation and restraining autophagy in mice. Eur J Immunol. 2020;: pubmed publisher
Zheng J, Akbari M, Schirmer C, Reynaert M, Loyens A, Lefebvre B, et al. Hippocampal tau oligomerization early in tau pathology coincides with a transient alteration of mitochondrial homeostasis and DNA repair in a mouse model of tauopathy. Acta Neuropathol Commun. 2020;8:25 pubmed publisher
Vincent G, Novak E, Siow V, Cunningham K, Griffith B, Comerford T, et al. Nix-Mediated Mitophagy Modulates Mitochondrial Damage During Intestinal Inflammation. Antioxid Redox Signal. 2020;33:1-19 pubmed publisher
Zhou W, Fang C, Zhang L, Wang Q, Li D, Zhu D. Thioredoxin domain-containing protein 9 (TXNDC9) contributes to oxaliplatin resistance through regulation of autophagy-apoptosis in colorectal adenocarcinoma. Biochem Biophys Res Commun. 2020;524:582-588 pubmed publisher
Bernard M, Yang B, Migneault F, Turgeon J, Dieudé M, Olivier M, et al. Autophagy drives fibroblast senescence through MTORC2 regulation. Autophagy. 2020;:1-13 pubmed publisher
Ando K, De Decker R, Vergara C, Yilmaz Z, Mansour S, Suain V, et al. Picalm reduction exacerbates tau pathology in a murine tauopathy model. Acta Neuropathol. 2020;139:773-789 pubmed publisher
Wardman J, Henriksen E, Marthaler A, Nielsen J, Nielsen T. Enhancement of Autophagy and Solubilization of Ataxin-2 Alleviate Apoptosis in Spinocerebellar Ataxia Type 2 Patient Cells. Cerebellum. 2020;19:165-181 pubmed publisher
Zheng Z, Zhou Y, Ye L, Lu Q, Zhang K, Zhang J, et al. Histone deacetylase 6 inhibition restores autophagic flux to promote functional recovery after spinal cord injury. Exp Neurol. 2020;324:113138 pubmed publisher
Codina Martínez H, Fernandez Garcia B, Díez Planelles C, Fernández A, Higarza S, Fernández Sanjurjo M, et al. Autophagy is required for performance adaptive response to resistance training and exercise-induced adult neurogenesis. Scand J Med Sci Sports. 2020;30:238-253 pubmed publisher
Janser F, Ney P, Pinto M, Langer R, Tschan M. The Chick Chorioallantoic Membrane (CAM) Assay as a Three-dimensional Model to Study Autophagy in Cancer Cells. Bio Protoc. 2019;9:e3290 pubmed publisher
Yoon J, Lee K, Seok J, Cheng W, Kwon H, Jeong C, et al. Zearalenone Induces Endoplasmic Reticulum Stress and Modulates the Expression of Phase I/II Enzymes in Human Liver Cells. Toxins (Basel). 2019;12: pubmed publisher
Simon C, Van Alstyne M, Lotti F, Bianchetti E, Tisdale S, Watterson D, et al. Stasimon Contributes to the Loss of Sensory Synapses and Motor Neuron Death in a Mouse Model of Spinal Muscular Atrophy. Cell Rep. 2019;29:3885-3901.e5 pubmed publisher
Shao Q, Yang M, Liang C, Ma L, Zhang W, Jiang Z, et al. C9orf72 and smcr8 mutant mice reveal MTORC1 activation due to impaired lysosomal degradation and exocytosis. Autophagy. 2019;:1-16 pubmed publisher
Yu Y, Xiang N, Lin M, Huang J, Zhang J, Cheng B, et al. miR- 26a Sensitizes Melanoma Cells To Dabrafenib Via Targeting HMGB1-Dependent Autophagy Pathways. Drug Des Devel Ther. 2019;13:3717-3726 pubmed publisher
Wang R, Wang W, Li A, Wang Y, Jin J, Huang Z, et al. Lipopolysaccharide enhances DNA-induced IFN-β expression and autophagy by upregulating cGAS expression in A549 cells. Exp Ther Med. 2019;18:4157-4164 pubmed publisher
Zhang Y, Pan N, Sheng Y, Zhou M, Wen Z, Chen Y, et al. Hypoxia enhances IL-10-producing B cell generation through upregulating high-mobility group B1 on tumor cell-released autophagosomes. Immunol Lett. 2019;216:36-42 pubmed publisher
Frendo Cumbo S, Jaldin Fincati J, Coyaud E, Laurent E, Townsend L, Tan J, et al. Deficiency of the autophagy gene ATG16L1 induces insulin resistance through KLHL9/KLHL13/CUL3-mediated IRS1 degradation. J Biol Chem. 2019;294:16172-16185 pubmed publisher
Hong J, Kim J, Kim H, Lee W, Hwang Y. SB365, Pulsatilla Saponin D Induces Caspase-Independent Cell Death and Augments the Anticancer Effect of Temozolomide in Glioblastoma Multiforme Cells. Molecules. 2019;24: pubmed publisher
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Del Mar N, von Buttlar X, Yu A, Guley N, Reiner A, Honig M. A novel closed-body model of spinal cord injury caused by high-pressure air blasts produces extensive axonal injury and motor impairments. Exp Neurol. 2015;271:53-71 pubmed publisher
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product information
brand :
Novus
MasterCode :
NB600-1384
SKU :
NB600-1384
product name :
LC3B Antibody - BSA Free
Description :
The LC3B Antibody - BSA Free from NB600-1384 is a nb600-1384 antibody to . This antibody reacts with autophagy, cancer, cardiovascular biology, cellular markers, hypoxia, innate immunity, lipid and metabolism, macroautophagy, neuroscience.
target :
LC3B
category :
Primary Antibodies
unit size :
0.1 ml (also 0.025 ml)
buffer :
PBS
clonality :
Polyclonal
concentration :
1.0 mg/ml
conjugate :
Unconjugated
host :
Rabbit
immunogen :
Polyclonal LC3B Antibody was made to a synthetic peptide made to the N-terminal region of the human LC3B protein. [Uniprot: Q9GZQ8]
isotype :
IgG
purity :
Immunogen affinity purified
species :
Human, Mouse, Rat, Porcine, Bacteria, Bovine, Canine, Primate, Yeast, Zebrafish
theoretical molecular weight :
14.688 kDa
gene symbol :
MAP1LC3B
images :
https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/LC3B-Antibody---BSA-Free-Western-Blot-NB600-1384-img0042.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/LC3B-Antibody---BSA-Free-Western-Blot-NB600-1384-img0042.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/LC3B-Antibody---BSA-Free-Western-Blot-NB600-1384-img0042.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/LC3B-Antibody---BSA-Free-Immunocytochemistry-Immunofluorescence-NB600-1384-img0033.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/LC3B-Antibody---BSA-Free-Immunocytochemistry-Immunofluorescence-NB600-1384-img0033.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/LC3B-Antibody---BSA-Free-Immunocytochemistry-Immunofluorescence-NB600-1384-img0033.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/LC3B-Antibody---BSA-Free-Immunohistochemistry-NB600-1384-img0044.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/LC3B-Antibody---BSA-Free-Immunohistochemistry-NB600-1384-img0044.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/LC3B-Antibody---BSA-Free-Immunohistochemistry-NB600-1384-img0044.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/LC3B-Antibody---BSA-Free-Western-Blot-NB600-1384-img0027.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/LC3B-Antibody---BSA-Free-Western-Blot-NB600-1384-img0027.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/LC3B-Antibody---BSA-Free-Western-Blot-NB600-1384-img0027.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/LC3B-Antibody---BSA-Free-Western-Blot-NB600-1384-img0040.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/LC3B-Antibody---BSA-Free-Western-Blot-NB600-1384-img0040.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/LC3B-Antibody---BSA-Free-Western-Blot-NB600-1384-img0040.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/LC3B-Antibody---BSA-Free-Western-Blot-NB600-1384-img0041.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/LC3B-Antibody---BSA-Free-Western-Blot-NB600-1384-img0041.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/LC3B-Antibody---BSA-Free-Western-Blot-NB600-1384-img0041.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/LC3B Antibody - BSA Free-Immunocytochemistry-Immunofluorescence-NB600-1384-img0045.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/LC3B Antibody - BSA Free-Immunocytochemistry-Immunofluorescence-NB600-1384-img0045.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/LC3B Antibody - BSA Free-Immunocytochemistry-Immunofluorescence-NB600-1384-img0045.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/LC3B-Antibody---BSA-Free-Immunocytochemistry-Immunofluorescence-NB600-1384-img0026.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/LC3B-Antibody---BSA-Free-Immunocytochemistry-Immunofluorescence-NB600-1384-img0026.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/LC3B-Antibody---BSA-Free-Immunocytochemistry-Immunofluorescence-NB600-1384-img0026.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/LC3B-Antibody---BSA-Free-Immunocytochemistry-Immunofluorescence-NB600-1384-img0028.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/LC3B-Antibody---BSA-Free-Immunocytochemistry-Immunofluorescence-NB600-1384-img0028.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/LC3B-Antibody---BSA-Free-Immunocytochemistry-Immunofluorescence-NB600-1384-img0028.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/LC3B-Antibody---BSA-Free-Immunocytochemistry-Immunofluorescence-NB600-1384-img0030.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/LC3B-Antibody---BSA-Free-Immunocytochemistry-Immunofluorescence-NB600-1384-img0030.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/LC3B-Antibody---BSA-Free-Immunocytochemistry-Immunofluorescence-NB600-1384-img0030.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/LC3B-Antibody---BSA-Free-Immunohistochemistry-Paraffin-NB600-1384-img0023.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/LC3B-Antibody---BSA-Free-Immunohistochemistry-Paraffin-NB600-1384-img0023.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/LC3B-Antibody---BSA-Free-Immunohistochemistry-Paraffin-NB600-1384-img0023.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/LC3B-Antibody---BSA-Free-Immunohistochemistry-NB600-1384-img0011.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/LC3B-Antibody---BSA-Free-Immunohistochemistry-NB600-1384-img0011.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/LC3B-Antibody---BSA-Free-Immunohistochemistry-NB600-1384-img0011.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/LC3B-Antibody---BSA-Free-Immunohistochemistry-NB600-1384-img0012.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/LC3B-Antibody---BSA-Free-Immunohistochemistry-NB600-1384-img0012.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/LC3B-Antibody---BSA-Free-Immunohistochemistry-NB600-1384-img0012.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/LC3B-Antibody---BSA-Free-Simple-Western-NB600-1384-img0021.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/LC3B-Antibody---BSA-Free-Simple-Western-NB600-1384-img0021.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/LC3B-Antibody---BSA-Free-Simple-Western-NB600-1384-img0021.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/LC3B-Antibody---BSA-Free-Knockdown-Validated-NB600-1384-img0034.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/LC3B-Antibody---BSA-Free-Knockdown-Validated-NB600-1384-img0034.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/LC3B-Antibody---BSA-Free-Knockdown-Validated-NB600-1384-img0034.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/LC3B-Antibody---BSA-Free-Electron-Microscopy-NB600-1384-img0038.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/LC3B-Antibody---BSA-Free-Electron-Microscopy-NB600-1384-img0038.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/LC3B-Antibody---BSA-Free-Electron-Microscopy-NB600-1384-img0038.jpg
applications :
Western Blot, Simple Western, Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunoprecipitation, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen, Immunoblotting, Electron Microscopy, Immunohistochemistry Free-Floating, Knockout Validated, Knockdown Validated
USD :
479 USD
alt names :
ATG8F, Autophagy-related protein LC3 B, Autophagy-related ubiquitin-like modifier LC3 B, LC3B, lc3b autophagy marker, lc3-i, ii, MAP1 light chain 3-like protein 2, MAP1A/1BLC3, MAP1A/MAP1B LC3 B, map1lc3b, MAP1LC3B-a, microtubule associated protein 1 light chain 3 beta, microtubule associated protein 3 b, microtubule associated protein 3 beta, microtubule-associated proteins 1A/1B light chain 3, microtubule-associated proteins 1A/1B light chain 3B
storage :
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
more info or order :
company information
Novus Biologicals
10771 E Easter Ave
Centennial, CO 80112
novus@novusbio.com
https://www.novusbio.com
3037301950
headquarters: USA
Novus Biologicals licenses, manufactures, and markets antibodies to over 20,000 unique targets to support a wide array of research areas. Novus is built on honesty, collaboration and strong relationships and continues to provide quality tools that accelerate research. Every product is backed by our 100% guarantee.