product summary
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company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
UCH-L1/PGP9.5 Antibody (31A3)
catalog :
NB600-1160
quantity :
0.1 mg (also 20 ug)
price :
429 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
31A3
reactivity :
human, mouse, rat, dogs, bovine, zebrafish
application :
western blot, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
citations: 39
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - paraffin section; mouse; 1:1000; loading ...; fig st2
  • immunocytochemistry; mouse; 1:500; loading ...; fig st2
Sundaresan S, Meininger C, Kang A, Photenhauer A, Hayes M, Sahoo N, et al. Gastrin Induces Nuclear Export and Proteasome Degradation of Menin in Enteric Glial Cells. Gastroenterology. 2017;153:1555-1567.e15 pubmed publisher
Lucarini E, Micheli L, Pagnotta E, Toti A, Ferrara V, Ciampi C, et al. The Efficacy of Camelina sativa Defatted Seed Meal against Colitis-Induced Persistent Visceral Hypersensitivity: The Relevance of PPAR α Receptor Activation in Pain Relief. Nutrients. 2022;14: pubmed publisher
Manavis J, Blumbergs P, Jerrett I, Hanshaw D, Uzal F, Finnie J. Heterogeneous immunoreactivity of axonal spheroids in focal symmetrical encephalomalacia produced by Clostridium perfringens type D epsilon toxin in sheep. Vet Pathol. 2021;:3009858211057222 pubmed publisher
Pal P, HALES K, Hales D. The pro-apoptotic actions of 2-methoxyestradiol against ovarian cancer involve catalytic activation of PKCδ signaling. Oncotarget. 2020;11:3646-3659 pubmed publisher
Cicalese S, Okuno K, Elliott K, Kawai T, Scalia R, Rizzo V, et al. 78 kDa Glucose-Regulated Protein Attenuates Protein Aggregation and Monocyte Adhesion Induced by Angiotensin II in Vascular Cells. Int J Mol Sci. 2020;21: pubmed publisher
Moutal A, Ji Y, Bellampalli S, Khanna R. Differential expression of Cdk5-phosphorylated CRMP2 following a spared nerve injury. Mol Brain. 2020;13:97 pubmed publisher
Arnaboldi F, Sommariva M, Opizzi E, Rasile M, Camelliti S, Busnelli M, et al. Expression of Toll-like receptors 4 and 7 in murine peripheral nervous system development. Ann Anat. 2020;231:151526 pubmed publisher
Garufi A, Federici G, Gilardini Montani M, Crispini A, Cirone M, D Orazi G. Interplay between Endoplasmic Reticulum (ER) Stress and Autophagy Induces Mutant p53H273 Degradation. Biomolecules. 2020;10: pubmed publisher
Han L, Bittner S, Dong D, Cortez Y, Bittner A, Chan J, et al. Molecular changes in hepatic metabolism in ZDSD rats-A new polygenic rodent model of obesity, metabolic syndrome, and diabetes. Biochim Biophys Acta Mol Basis Dis. 2020;1866:165688 pubmed publisher
Schmit K, Chen J, Ayama Canden S, Fransolet M, Finet L, Demazy C, et al. Characterization of the role of TMEM45A in cancer cell sensitivity to cisplatin. Cell Death Dis. 2019;10:919 pubmed publisher
Gu R, Huang T, Xiao J, Liao Z, Li J, Lan H, et al. The IRE1α Arm of UPR Regulates Muscle Cells Immune Characters by Restraining p38 MAPK Activation. Front Physiol. 2019;10:1198 pubmed publisher
Srinivasan M, Bhopale K, Amer S, Wan J, Kaphalia L, Ansari G, et al. Linking Dysregulated AMPK Signaling and ER Stress in Ethanol-Induced Liver Injury in Hepatic Alcohol Dehydrogenase Deficient Deer Mice. Biomolecules. 2019;9: pubmed publisher
Xie W, Xie J, Vince R, More S. Guanabenz Attenuates Acetaminophen-Induced Liver Toxicity and Synergizes Analgesia in Mice. Chem Res Toxicol. 2020;33:162-171 pubmed publisher
Kaphalia L, Srinivasan M, Kakumanu R, Kaphalia B, Calhoun W. Ethanol Exposure Impairs AMPK Signaling and Phagocytosis in Human Alveolar Macrophages: Role of Ethanol Metabolism. Alcohol Clin Exp Res. 2019;43:1682-1694 pubmed publisher
Inoue T, Yamakage H, Tanaka M, Kusakabe T, Shimatsu A, Satoh Asahara N. Oxytocin Suppresses Inflammatory Responses Induced by Lipopolysaccharide through Inhibition of the eIF-2-ATF4 Pathway in Mouse Microglia. Cells. 2019;8: pubmed publisher
Serrano R, Yu W, Graham R, Bryan R, Terkeltaub R. A vascular smooth muscle cell X-box binding protein 1 and transglutaminase 2 regulatory circuit limits neointimal hyperplasia. PLoS ONE. 2019;14:e0212235 pubmed publisher
Hsu Y, Chuang H, Lee Y, Lin Y, Chen Y, Hsiao T, et al. Traffic-related particulate matter exposure induces nephrotoxicity in vitro and in vivo. Free Radic Biol Med. 2019;135:235-244 pubmed publisher
Lee M, Bae S, Kim J, Song B, Choi J, Park J, et al. Inhibition of endoplasmic reticulum stress in high-fat-diet-induced obese C57BL/6 mice: Efficacy of a novel extract from mulberry (Morus alba) leaves fermented with Cordyceps militaris. Lab Anim Res. 2018;34:288-294 pubmed publisher
Alberio L, Locarno A, Saponaro A, Romano E, Bercier V, Albadri S, et al. A light-gated potassium channel for sustained neuronal inhibition. Nat Methods. 2018;15:969-976 pubmed publisher
Bretón Romero R, Weisbrod R, Feng B, Holbrook M, Ko D, Stathos M, et al. Liraglutide Treatment Reduces Endothelial Endoplasmic Reticulum Stress and Insulin Resistance in Patients With Diabetes Mellitus. J Am Heart Assoc. 2018;7:e009379 pubmed publisher
Cho Y, Kim D, Lee K, Jeong S, Kwon O. The IRE1α-XBP1s pathway promotes insulin-stimulated glucose uptake in adipocytes by increasing PPARγ activity. Exp Mol Med. 2018;50:102 pubmed publisher
Yang F, Wang S, Liu Y, Zhou Y, Shang L, Feng M, et al. IRE1α aggravates ischemia reperfusion injury of fatty liver by regulating phenotypic transformation of kupffer cells. Free Radic Biol Med. 2018;124:395-407 pubmed publisher
Tripathi M, Zhang C, Singh B, Sinha R, Moe K, DeSilva D, et al. Hyperhomocysteinemia causes ER stress and impaired autophagy that is reversed by Vitamin B supplementation. Cell Death Dis. 2016;7:e2513 pubmed publisher
Novakovic P, Harding J, Al Dissi A, Ladinig A, Detmer S. Pathologic Evaluation of Type 2 Porcine Reproductive and Respiratory Syndrome Virus Infection at the Maternal-Fetal Interface of Late Gestation Pregnant Gilts. PLoS ONE. 2016;11:e0151198 pubmed publisher
Li Y, Zalzala M, Jadhav K, Xu Y, Kasumov T, Yin L, et al. Carboxylesterase 2 prevents liver steatosis by modulating lipolysis, endoplasmic reticulum stress, and lipogenesis and is regulated by hepatocyte nuclear factor 4 alpha in mice. Hepatology. 2016;63:1860-74 pubmed publisher
Kim O, Jun W, Lee J. Effect of Cudrania tricuspidata and Kaempferol in Endoplasmic Reticulum Stress-Induced Inflammation and Hepatic Insulin Resistance in HepG2 Cells. Nutrients. 2016;8: pubmed publisher
Vannuvel K, Van Steenbrugge M, Demazy C, Ninane N, Fattaccioli A, Fransolet M, et al. Effects of a Sublethal and Transient Stress of the Endoplasmic Reticulum on the Mitochondrial Population. J Cell Physiol. 2016;231:1913-31 pubmed publisher
Alnasser H, Guan Q, Zhang F, Gleave M, Nguan C, Du C. Requirement of clusterin expression for prosurvival autophagy in hypoxic kidney tubular epithelial cells. Am J Physiol Renal Physiol. 2016;310:F160-73 pubmed publisher
Quan X, Wang J, Liang C, Zheng H, Zhang L. Melatonin inhibits tunicamycin-induced endoplasmic reticulum stress and insulin resistance in skeletal muscle cells. Biochem Biophys Res Commun. 2015;463:1102-7 pubmed publisher
Corsetti V, Florenzano F, Atlante A, Bobba A, Ciotti M, Natale F, et al. NH2-truncated human tau induces deregulated mitophagy in neurons by aberrant recruitment of Parkin and UCHL-1: implications in Alzheimer's disease. Hum Mol Genet. 2015;24:3058-81 pubmed publisher
Clarke J, Lyra e Silva N, Figueiredo C, Frozza R, Ledo J, Beckman D, et al. Alzheimer-associated Aβ oligomers impact the central nervous system to induce peripheral metabolic deregulation. EMBO Mol Med. 2015;7:190-210 pubmed publisher
Ghosh A, Garg S, Mau T, O Brien M, Liu J, Yung R. Elevated Endoplasmic Reticulum Stress Response Contributes to Adipose Tissue Inflammation in Aging. J Gerontol A Biol Sci Med Sci. 2015;70:1320-9 pubmed publisher
Read N, Gutsol A, Holterman C, Carter A, Coulombe J, Gray D, et al. Ubiquitin C-terminal hydrolase L1 deletion ameliorates glomerular injury in mice with ACTN4-associated focal segmental glomerulosclerosis. Biochim Biophys Acta. 2014;1842:1028-40 pubmed publisher
Böttner M, Zorenkov D, Hellwig I, Barrenschee M, Harde J, Fricke T, et al. Expression pattern and localization of alpha-synuclein in the human enteric nervous system. Neurobiol Dis. 2012;48:474-80 pubmed publisher
Sugimoto K, Kojima K, Baba M, Yasujima M. Olmesartan ameliorates peripheral nerve dysfunction in Zucker diabetic fatty rats. J Hypertens. 2011;29:1337-46 pubmed publisher
Day I, Thompson R. UCHL1 (PGP 9.5): neuronal biomarker and ubiquitin system protein. Prog Neurobiol. 2010;90:327-62 pubmed publisher
Gaunitz C, Gabert J, Lücker E, Seeger J, Stahl T. Suitability of antigens PGP 9.5 and neurofilament light as marker proteins for detection of neuronal tissue in processed meat products. J Food Prot. 2009;72:1070-7 pubmed
Yi Y, Manandhar G, Sutovsky M, Li R, Jonáková V, Oko R, et al. Ubiquitin C-terminal hydrolase-activity is involved in sperm acrosomal function and anti-polyspermy defense during porcine fertilization. Biol Reprod. 2007;77:780-93 pubmed
Ständer S, Schmelz M, Metze D, Luger T, Rukwied R. Distribution of cannabinoid receptor 1 (CB1) and 2 (CB2) on sensory nerve fibers and adnexal structures in human skin. J Dermatol Sci. 2005;38:177-88 pubmed
product information
brand :
Novus Biologicals, a Bio-Techne brand
catalog number base :
NB600-1160
SKU :
NB600-1160
product name :
UCH-L1/PGP9.5 Antibody (31A3)
description :
The UCH-L1/PGP9.5 Antibody (31A3) from Novus Biologicals is a mouse monoclonal antibody to UCH-L1/PGP9.5. This antibody reacts with bovine,canine,human,mouse,porcine,rat,zebrafish,fish - danio rerio (zebrafish). The UCH-L1/PGP9.5 Antibody (31A3) has been validated for the following applications: Flow Cytometry,Immunohistochemistry,Simple Western,IF/IHC,Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunocytochemistry/ Immunofluorescence.
target :
UCH-L1/PGP9.5
unit size :
0.1 mg (also 20 ug)
category :
Primary Antibodies
buffer :
10 mM PBS with 0.05% BSA
clonality :
Monoclonal
clone :
31A3
concentration :
0.2 mg/ml
conjugate :
Unconjugated
host :
Mouse
immunogen :
UCH-L1/PGP9.5 protein from brain (Uniprot: P09936)
isotype :
IgG1 Kappa
marker :
pan-Neuronal Marker
purity :
Protein A or G purified
species :
Bovine,Canine,Human,Mouse,Porcine,Rat,Zebrafish
storage :
Store at 4C.
gene symbol :
UCHL1
accessionNumbers :
P09936
applications :
Flow Cytometry,Immunohistochemistry,Simple Western,IF/IHC,Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunocytochemistry/ Immunofluorescence
USD :
419
USD 2025 :
429 USD
alt names :
EC 3.4.19.12, EC 6.-, Neuron cytoplasmic protein 9.5, PARK5, PGP 9.5, PGP9.5, PGP9.5Uch-L1, PGP95, ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase), ubiquitin carboxyl-terminal hydrolase isozyme L1, ubiquitin C-terminal hydrolase, Ubiquitin thioesterase L1, UCHL1, UCH-L1
more info or order :
company information
Novus Biologicals
10771 E Easter Ave
Centennial, CO 80112
novus@novusbio.com
https://www.novusbio.com
3037301950
headquarters: USA
Novus Biologicals licenses, manufactures, and markets antibodies to over 20,000 unique targets to support a wide array of research areas. Novus is built on honesty, collaboration and strong relationships and continues to provide quality tools that accelerate research. Every product is backed by our 100% guarantee.