product summary
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company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
IL-6 Antibody
catalog :
NB600-1131
quantity :
0.2 ml (also 0.04 ml)
price :
409 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, western blot knockout validation
more info or order :
citations: 121
Published Application/Species/Sample/DilutionReference
  • western blot knockout validation; human; 1:2000; loading ...; fig 1d
  • immunohistochemistry - paraffin section; human; 1:100; fig s1c
Zhang K, Wang D, Cai H, Cao M, Zhang Y, Zhuang P, et al. IL‑6 plays a crucial role in epithelial‑mesenchymal transition and pro‑metastasis induced by sorafenib in liver cancer. Oncol Rep. 2021;45:1105-1117 pubmed publisher
  • immunohistochemistry; mouse; 1:50; loading ...; fig 2b
Novais E, Tran V, Johnston S, Darris K, Roupas A, Sessions G, et al. Long-term treatment with senolytic drugs Dasatinib and Quercetin ameliorates age-dependent intervertebral disc degeneration in mice. Nat Commun. 2021;12:5213 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:50; loading ...; fig 4a
Gorth D, Shapiro I, Risbud M. Transgenic mice overexpressing human TNF-α experience early onset spontaneous intervertebral disc herniation in the absence of overt degeneration. Cell Death Dis. 2018;10:7 pubmed publisher
Ollewagen T, Benecke R, Smith C. High species homology potentiates quantitative inflammation profiling in zebrafish using immunofluorescence. Heliyon. 2024;10:e23635 pubmed publisher
Park J, Yang S, Song D, Kim S, Choi J, Kang H, et al. A newly developed PLD1 inhibitor ameliorates rheumatoid arthritis by regulating pathogenic T and B cells and inhibiting osteoclast differentiation. Immunol Lett. 2023;263:87-96 pubmed publisher
Liu H, Zhang L, Liu Z, Lin J, He X, Wu S, et al. Galectin-3 as TREM2 upstream factor contributes to lung ischemia-reperfusion injury by regulating macrophage polarization. iScience. 2023;26:107496 pubmed publisher
Zhuang P, Wang D, Zhang K, Wang J, Shen J. Sorafenib promotes hepatocellular carcinoma invasion via interleukin-6/HIF-1α/PFKFB3. J Cancer. 2023;14:1859-1874 pubmed publisher
Lee M, Ryu H, Hwang J, Kim J, Cho E, Choi J, et al. Sirt6 Activation Ameliorates Inflammatory Bone Loss in Ligature-Induced Periodontitis in Mice. Int J Mol Sci. 2023;24: pubmed publisher
Zhang T, Zhang Y, Li S, Ge H, Song Q, Zhang Y, et al. Gentianella acuta-derived Gen-miR-1 suppresses myocardial fibrosis by targeting HAX1/HMG20A/Smads axis to attenuate inflammation in cardiac fibroblasts. Phytomedicine. 2023;118:154923 pubmed publisher
Dib S, Loiola R, Sevin E, Saint Pol J, Shimizu F, Kanda T, et al. TNFα Activates the Liver X Receptor Signaling Pathway and Promotes Cholesterol Efflux from Human Brain Pericytes Independently of ABCA1. Int J Mol Sci. 2023;24: pubmed publisher
Obi A, Sharma S, Elfline M, Luke C, Dowling A, Cai Q, et al. Experimental venous thrombus resolution is driven by IL-6 mediated monocyte actions. Sci Rep. 2023;13:3253 pubmed publisher
Sharma K, Kumar S, Prakash R, Khanka S, Mishra T, Rathur R, et al. Chebulinic acid alleviates LPS-induced inflammatory bone loss by targeting the crosstalk between reactive oxygen species/NFκB signaling in osteoblast cells. Free Radic Biol Med. 2023;194:99-113 pubmed publisher
Zhao R, Lee D, Park C, Yang C, Kim H, Lee M, et al. Acupuncture Inhibits Morphine Induced-Immune Suppress via Antioxidant System. Evid Based Complement Alternat Med. 2022;2022:7971801 pubmed publisher
Franke V, Meyer S, Schulze Tanzil G, Braun T, Kokozidou M, Fischlein T, et al. Complement Regulation in Immortalized Fibroblast-like Synoviocytes and Primary Human Endothelial Cells in Response to SARS-CoV-2 Nucleocapsid Protein and Pro-Inflammatory Cytokine TNFα. Life (Basel). 2022;12: pubmed publisher
Kang E, Yim H, Nam Y, Jeong S, Kim J, Lee J, et al. Exposure to airborne particulate matter induces renal tubular cell injury in vitro: the role of vitamin D signaling and renin-angiotensin system. Heliyon. 2022;8:e10184 pubmed publisher
Ottone O, Kim C, Collins J, Risbud M. The cGAS-STING Pathway Affects Vertebral Bone but Does Not Promote Intervertebral Disc Cell Senescence or Degeneration. Front Immunol. 2022;13:882407 pubmed publisher
Na H, Woo J, Kim J, Lee J, Um I, Cho K, et al. Coenzyme Q10 encapsulated in micelles ameliorates osteoarthritis by inhibiting inflammatory cell death. PLoS ONE. 2022;17:e0270351 pubmed publisher
Chen P, Wu H, Yao H, Zhang J, Fan W, Chen Z, et al. Multi-Omics Analysis Reveals the Systematic Relationship Between Oral Homeostasis and Chronic Sleep Deprivation in Rats. Front Immunol. 2022;13:847132 pubmed publisher
Park J, Chi L, Kwon H, Lee J, Kim S, Hong S. Decaffeinated green tea extract as a nature-derived antibiotic alternative: An application in antibacterial nano-thin coating on medical implants. Food Chem. 2022;383:132399 pubmed publisher
Ashraf Uz Zaman M, Ji G, Tidwell D, Yin L, Thakolwiboon S, Pan J, et al. Evaluation of Urea-Based Inhibitors of the Dopamine Transporter Using the Experimental Autoimmune Encephalomyelitis Model of Multiple Sclerosis. ACS Chem Neurosci. 2022;13:217-228 pubmed publisher
Gutziet O, Iluz R, Ben Asher H, Segal L, Ben Zvi D, Ginsberg Y, et al. Maternal N-Acetyl-Cysteine Prevents Neonatal Hypoxia-Induced Brain Injury in a Rat Model. Int J Mol Sci. 2021;22: pubmed publisher
Ollewagen T, Powrie Y, Myburgh K, Smith C. Unresolved intramuscular inflammation, not diminished skeletal muscle regenerative capacity, is at the root of rheumatoid cachexia: insights from a rat CIA model. Physiol Rep. 2021;9:e15119 pubmed publisher
Chow S, Cui C, Cheng K, Chim Y, Wang J, Wong C, et al. Acute Inflammatory Response in Osteoporotic Fracture Healing Augmented with Mechanical Stimulation is Regulated In Vivo through the p38-MAPK Pathway. Int J Mol Sci. 2021;22: pubmed publisher
Koga Y, Sotokawauchi A, Higashimoto Y, Nishino Y, Hashizume N, Kakuma T, et al. DNA-Aptamer Raised against Receptor for Advanced Glycation End Products Improves Survival Rate in Septic Mice. Oxid Med Cell Longev. 2021;2021:9932311 pubmed publisher
Singh J, Thachil T, Eapen M, Lim A, Sufyan W, RAWSON R, et al. Immunohistochemical investigation of cytokine expression levels as biomarkers in transrectal ultrasound-guided needle biopsy specimens of prostate adenocarcinoma. Mol Clin Oncol. 2021;15:191 pubmed publisher
Li Q, Qin L, Li J. IL-6 signaling pathway contributes to exercise pressor reflex in rats with femoral artery occlusion in association with Kv4 activity in muscle afferent nerves. Physiol Rep. 2021;9:e14935 pubmed publisher
Betsou A, Lambropoulou M, Georgakopoulou A, Kostomitsopoulos N, Konstandi O, Anagnostopoulos K, et al. The hepatoprotective effect of silibinin after hepatic ischemia/reperfusion in a rat model is confirmed by immunohistochemistry and qRT-PCR. J Pharm Pharmacol. 2021;: pubmed publisher
Subburaman M, Edderkaoui B. Evaluation of CCL21 role in post-knee injury inflammation and early cartilage degeneration. PLoS ONE. 2021;16:e0247913 pubmed publisher
Kanno S, Hara A. The mRNA expression of Il6 and Pdcd1 are predictive and protective factors for doxorubicin‑induced cardiotoxicity. Mol Med Rep. 2021;23:1 pubmed publisher
Lee G, Kim J, Lee J, Ko J, Lee E, Yoon J. Role of Proprotein Convertase Subtilisin/Kexin Type 9 in the Pathogenesis of Graves' Orbitopathy in Orbital Fibroblasts. Front Endocrinol (Lausanne). 2020;11:607144 pubmed publisher
Shao H, Li Y, Pastar I, Xiao M, Prokupets R, Liu S, et al. Notch1 signaling determines the plasticity and function of fibroblasts in diabetic wounds. Life Sci Alliance. 2020;3: pubmed publisher
Wu J, Dou Y, Ladiges W. Adverse Neurological Effects of Short-Term Sleep Deprivation in Aging Mice Are Prevented by SS31 Peptide. Clocks Sleep. 2020;2:325-333 pubmed publisher
Balakrishnan I, Danis E, Pierce A, Madhavan K, Wang D, Dahl N, et al. Senescence Induced by BMI1 Inhibition Is a Therapeutic Vulnerability in H3K27M-Mutant DIPG. Cell Rep. 2020;33:108286 pubmed publisher
El Zayadi A, Mohamed S, Arafa M, Mohammed S, Zayed A, Abdelhafez M, et al. Anti-IL-6 receptor monoclonal antibody as a new treatment of endometriosis. Immunol Res. 2020;68:389-397 pubmed publisher
Vaidya F, Sharma R, Shaikh S, Ray D, Aswal V, Pathak C. Pluronic micelles encapsulated curcumin manifests apoptotic cell death and inhibits pro-inflammatory cytokines in human breast adenocarcinoma cells. Cancer Rep (Hoboken). 2019;2:e1133 pubmed publisher
Lee J, You J, Shin D, Roh J. Inhibition of Glutaredoxin 5 predisposes Cisplatin-resistant Head and Neck Cancer Cells to Ferroptosis. Theranostics. 2020;10:7775-7786 pubmed publisher
Kim S, Cho J, Jue S, Park J, Kim J. Effect of Hyaluronic Acid Filler Injection on the Interdental Papilla in a Mouse Model of Open Gingival Embrasure. Int J Environ Res Public Health. 2020;17: pubmed publisher
Liu J, Zhu Y, Guo Y, Lin L, Wang Z, Gu F, et al. Inhibition of GSK3β and RIP1K Attenuates Glial Scar Formation Induced by Ischemic Stroke via Reduction of Inflammatory Cytokine Production. Front Pharmacol. 2020;11:812 pubmed publisher
Tekatas A, Tekatas D, Solmaz V, Karaca T, Pamuk O. Small fiber neuropathy and related factors in patients with systemic lupus erythematosus; the results of cutaneous silent period and skin biopsy. Adv Rheumatol. 2020;60:31 pubmed publisher
Li S, Qian Z, Xu G, Zheng J, Wu Y. Hepatocyte growth factor protects PC12 cells against OGD/R-induced injury by reducing iron. Biosci Rep. 2020;40: pubmed publisher
Wang R, Liu X, Wu J, Liu H, Wang W, Chen X, et al. Role of microRNA-122 in microcystin-leucine arginine-induced dysregulation of hepatic iron homeostasis in mice. Environ Toxicol. 2020;35:822-830 pubmed publisher
Sheng Y, Chen Y, Qian Z, Zheng J, Liu Y. Cyclophosphamide induces a significant increase in iron content in the liver and spleen of mice. Hum Exp Toxicol. 2020;39:973-983 pubmed publisher
Chen X, Li D, Sun H, Wang W, Wu H, Kong W, et al. Relieving ferroptosis may partially reverse neurodegeneration of the auditory cortex. FEBS J. 2020;: pubmed publisher
Schnetz M, Meier J, Rehwald C, Mertens C, Urbschat A, Tomat E, et al. The Disturbed Iron Phenotype of Tumor Cells and Macrophages in Renal Cell Carcinoma Influences Tumor Growth. Cancers (Basel). 2020;12: pubmed publisher
Mesquita G, Silva T, Gomes A, Oliveira P, Alves M, Fernandes R, et al. H-Ferritin is essential for macrophages' capacity to store or detoxify exogenously added iron. Sci Rep. 2020;10:3061 pubmed publisher
Singh K, Leu J, Barnoud T, Vonteddu P, Gnanapradeepan K, Lin C, et al. African-centric TP53 variant increases iron accumulation and bacterial pathogenesis but improves response to malaria toxin. Nat Commun. 2020;11:473 pubmed publisher
Neves J, Gomes A, Costa D, Barroso C, Vaulont S, Cordeiro da Silva A, et al. A role for hepcidin in the anemia caused by Trypanosoma brucei infection. Haematologica. 2020;: pubmed publisher
Yasumura S, Naito Y, Okuno K, Sawada H, Asakura M, Masuyama T, et al. Effects of Heterozygous TfR1 (Transferrin Receptor 1) Deletion in Pathogenesis of Renal Fibrosis in Mice. Hypertension. 2020;75:413-421 pubmed publisher
Chen Y, Qian Z, Sheng Y, Zheng J, Liu Y. Angiotensin II down-regulates transferrin receptor 1 and ferroportin 1 expression in Neuro-2a cells via activation of type-1 receptor. Neurosci Lett. 2020;716:134684 pubmed publisher
Ashok A, Chaudhary S, McDonald D, Kritikos A, Bhargava D, Singh N. Local synthesis of hepcidin in the anterior segment of the eye: A novel observation with physiological and pathological implications. Exp Eye Res. 2020;190:107890 pubmed publisher
Lv Y, Cang W, Li Q, Liao X, Zhan M, Deng H, et al. Erlotinib overcomes paclitaxel-resistant cancer stem cells by blocking the EGFR-CREB/GRβ-IL-6 axis in MUC1-positive cervical cancer. Oncogenesis. 2019;8:70 pubmed publisher
Tessier S, Tran V, Ottone O, Novais E, Doolittle A, DiMuzio M, et al. TonEBP-deficiency accelerates intervertebral disc degeneration underscored by matrix remodeling, cytoskeletal rearrangements, and changes in proinflammatory gene expression. Matrix Biol. 2020;87:94-111 pubmed publisher
Chow S, Chim Y, Wang J, Zhang N, Wong R, Tang N, et al. Vibration treatment modulates macrophage polarisation and enhances early inflammatory response in oestrogen-deficient osteoporotic-fracture healing. Eur Cell Mater. 2019;38:228-245 pubmed publisher
Villalpando Rodriguez G, Blankstein A, Konzelman C, Gibson S. Lysosomal Destabilizing Drug Siramesine and the Dual Tyrosine Kinase Inhibitor Lapatinib Induce a Synergistic Ferroptosis through Reduced Heme Oxygenase-1 (HO-1) Levels. Oxid Med Cell Longev. 2019;2019:9561281 pubmed publisher
Bao Z, Fan L, Zhao L, Xu X, Liu Y, Chao H, et al. Silencing of A20 Aggravates Neuronal Death and Inflammation After Traumatic Brain Injury: A Potential Trigger of Necroptosis. Front Mol Neurosci. 2019;12:222 pubmed publisher
Nobuta H, Yang N, Ng Y, Marro S, Sabeur K, Chavali M, et al. Oligodendrocyte Death in Pelizaeus-Merzbacher Disease Is Rescued by Iron Chelation. Cell Stem Cell. 2019;25:531-541.e6 pubmed publisher
Thompson K, Wessling Resnick M. ZIP14 is degraded in response to manganese exposure. Biometals. 2019;32:829-843 pubmed publisher
Okuno K, Naito Y, Yasumura S, Sawada H, Asakura M, Masuyama T, et al. Haploinsufficiency of Transferrin Receptor 1 Impairs Angiogenesis with Reduced Mitochondrial Complex I in Mice with Limb Ischemia. Sci Rep. 2019;9:13658 pubmed publisher
Chen M, Reed R, Lane A. Chronic Inflammation Directs an Olfactory Stem Cell Functional Switch from Neuroregeneration to Immune Defense. Cell Stem Cell. 2019;25:501-513.e5 pubmed publisher
Pulos Holmes M, Srole D, Juarez M, Lee A, McSwiggen D, Ingolia N, et al. Repression of ferritin light chain translation by human eIF3. elife. 2019;8: pubmed publisher
Nagpal A, Redvers R, Ling X, Ayton S, Fuentes M, Tavancheh E, et al. Neoadjuvant neratinib promotes ferroptosis and inhibits brain metastasis in a novel syngeneic model of spontaneous HER2+ve breast cancer metastasis. Breast Cancer Res. 2019;21:94 pubmed publisher
Bach A, Conzen C, Schubert G, Bleilevens C, Lindauer U. Acute changes of pro-inflammatory markers and corticosterone in experimental subarachnoid haemorrhage: A prerequisite for severity assessment. PLoS ONE. 2019;14:e0220467 pubmed publisher
Yan H, Hu Y, Akk A, Ye K, Bacon J, Pham C. Interleukin-12 and -23 blockade mitigates elastase-induced abdominal aortic aneurysm. Sci Rep. 2019;9:10447 pubmed publisher
Poli M, Anower E Khuda F, Asperti M, Ruzzenenti P, Gryzik M, Denardo A, et al. Hepatic heparan sulfate is a master regulator of hepcidin expression and iron homeostasis in human hepatocytes and mice. J Biol Chem. 2019;294:13292-13303 pubmed publisher
Scindia Y, Wlazlo E, Leeds J, Loi V, Ledesma J, Cechova S, et al. Protective Role of Hepcidin in Polymicrobial Sepsis and Acute Kidney Injury. Front Pharmacol. 2019;10:615 pubmed publisher
Pandur E, Tamási K, Pap R, Varga E, Miseta A, Sipos K. Fractalkine Induces Hepcidin Expression of BV-2 Microglia and Causes Iron Accumulation in SH-SY5Y Cells. Cell Mol Neurobiol. 2019;: pubmed publisher
Melendez Avalos A, Sainz Espuñes T, Castrillón Rivera L, Mendoza Pérez F, Palma Ramos A, Castañeda Sánchez J, et al. Analysis of inflammatory cytokine expression in the urinary tract of BALB/c mice infected with Proteus (P.) mirabilis and enteroaggregative Escherichia (E.) coli (EAEC) strains. Folia Microbiol (Praha). 2019;: pubmed publisher
Adhikari N, Neupane S, Aryal Y, Choi M, Sohn W, Lee Y, et al. Effects of oleanolic acid acetate on bone formation in an experimental periodontitis model in mice. J Periodontal Res. 2019;54:533-545 pubmed publisher
Yue S, Zheng X, Zheng Y. Cell-type-specific role of lamin-B1 in thymus development and its inflammation-driven reduction in thymus aging. Aging Cell. 2019;18:e12952 pubmed publisher
Novais E, Diekman B, Shapiro I, Risbud M. p16Ink4a deletion in cells of the intervertebral disc affects their matrix homeostasis and senescence associated secretory phenotype without altering onset of senescence. Matrix Biol. 2019;: pubmed publisher
Geng S, Zhang Y, Lee C, Li L. Novel reprogramming of neutrophils modulates inflammation resolution during atherosclerosis. Sci Adv. 2019;5:eaav2309 pubmed publisher
Kalainayakan S, Ghosh P, Dey S, FitzGerald K, Sohoni S, Konduri P, et al. Cyclopamine tartrate, a modulator of hedgehog signaling and mitochondrial respiration, effectively arrests lung tumor growth and progression. Sci Rep. 2019;9:1405 pubmed publisher
Katsura Y, Ohara T, Noma K, Ninomiya T, Kashima H, Kato T, et al. A Novel Combination Cancer Therapy with Iron Chelator Targeting Cancer Stem Cells via Suppressing Stemness. Cancers (Basel). 2019;11: pubmed publisher
Gurung S, Reuter N, Preno A, Dubaut J, Nadeau H, Hyatt K, et al. Zika virus infection at mid-gestation results in fetal cerebral cortical injury and fetal death in the olive baboon. PLoS Pathog. 2019;15:e1007507 pubmed publisher
Urak K, Blanco G, Shubham S, Lin L, Dassie J, Thiel W, et al. RNA inhibitors of nuclear proteins responsible for multiple organ dysfunction syndrome. Nat Commun. 2019;10:116 pubmed publisher
Ji P, Lonnerdal B, Kim K, Jinno C. Iron Oversupplementation Causes Hippocampal Iron Overloading and Impairs Social Novelty Recognition in Nursing Piglets. J Nutr. 2019;149:398-405 pubmed publisher
Zhang M, Zhao P, Yung W, Sheng Y, Ke Y, Qian Z. Tissue iron is negatively correlated with TERC or TERT mRNA expression: A heterochronic parabiosis study in mice. Aging (Albany NY). 2018;10:3834-3850 pubmed publisher
Miyazawa M, Bogdan A, Tsuji Y. Perturbation of Iron Metabolism by Cisplatin through Inhibition of Iron Regulatory Protein 2. Cell Chem Biol. 2019;26:85-97.e4 pubmed publisher
Silva J, Rodrigues S, Sampaio Marques B, Gomes P, Neves Carvalho A, Dioli C, et al. Dysregulation of autophagy and stress granule-related proteins in stress-driven Tau pathology. Cell Death Differ. 2018;: pubmed publisher
Shin D, Kim E, Lee J, Roh J. Nrf2 inhibition reverses resistance to GPX4 inhibitor-induced ferroptosis in head and neck cancer. Free Radic Biol Med. 2018;129:454-462 pubmed publisher
Samba Mondonga M, Calvé A, Mallette F, Santos M. MyD88 Regulates the Expression of SMAD4 and the Iron Regulatory Hormone Hepcidin. Front Cell Dev Biol. 2018;6:105 pubmed publisher
Ramakrishnan L, Pedersen S, Toe Q, West L, Mumby S, Casbolt H, et al. The Hepcidin/Ferroportin axis modulates proliferation of pulmonary artery smooth muscle cells. Sci Rep. 2018;8:12972 pubmed publisher
Sajja R, Kaisar M, Vijay V, Desai V, Prasad S, Cucullo L. In Vitro Modulation of Redox and Metabolism Interplay at the Brain Vascular Endothelium: Genomic and Proteomic Profiles of Sulforaphane Activity. Sci Rep. 2018;8:12708 pubmed publisher
Ma J, Zhang F, Zhou G, Bao Y, Shen Y, Qian Z. Different Characteristics of Hepcidin Expression in IL-6+/+ and IL-6-/- Neurons and Astrocytes Treated with Lipopolysaccharides. Neurochem Res. 2018;43:1624-1630 pubmed publisher
Kaisar M, Sivandzade F, Bhalerao A, Cucullo L. Conventional and electronic cigarettes dysregulate the expression of iron transporters and detoxifying enzymes at the brain vascular endothelium: In vivo evidence of a gender-specific cellular response to chronic cigarette smoke exposure. Neurosci Lett. 2018;682:1-9 pubmed publisher
Ashok A, Karmakar S, Chandel R, Ravikumar R, Dalal S, Kong Q, et al. Prion protein modulates iron transport in the anterior segment: Implications for ocular iron homeostasis and prion transmission. Exp Eye Res. 2018;175:1-13 pubmed publisher
Lim D, Kim K, Jeong J, Marques O, Kim H, Song M, et al. The hepcidin-ferroportin axis controls the iron content of Salmonella-containing vacuoles in macrophages. Nat Commun. 2018;9:2091 pubmed publisher
Blanchette Farra N, Kita D, Konstorum A, Tesfay L, Lemler D, Hegde P, et al. Contribution of three-dimensional architecture and tumor-associated fibroblasts to hepcidin regulation in breast cancer. Oncogene. 2018;37:4013-4032 pubmed publisher
Broide E, Reifen R, Matalon S, Berkovich Z, Shirin H, Moshe M. Expression of Duodenal Iron Transporter Proteins in Diabetic Patients with and without Iron Deficiency Anemia. J Diabetes Res. 2018;2018:7494821 pubmed publisher
Puy V, Darwiche W, Trudel S, Gomila C, Lony C, Puy L, et al. Predominant role of microglia in brain iron retention in Sanfilippo syndrome, a pediatric neurodegenerative disease. Glia. 2018;66:1709-1723 pubmed publisher
McCarthy R, Sosa J, Gardeck A, Baez A, Lee C, Wessling Resnick M. Inflammation-induced iron transport and metabolism by brain microglia. J Biol Chem. 2018;293:7853-7863 pubmed publisher
Wang Q, He Z, Huang M, Liu T, Wang Y, Xu H, et al. Vascular niche IL-6 induces alternative macrophage activation in glioblastoma through HIF-2α. Nat Commun. 2018;9:559 pubmed publisher
Mertens C, Mora J, Oren B, Grein S, Winslow S, Scholich K, et al. Macrophage-derived lipocalin-2 transports iron in the tumor microenvironment. Oncoimmunology. 2018;7:e1408751 pubmed publisher
Zhabyeyev P, Das S, Basu R, Shen M, Patel V, Kassiri Z, et al. TIMP3 deficiency exacerbates iron overload-mediated cardiomyopathy and liver disease. Am J Physiol Heart Circ Physiol. 2018;314:H978-H990 pubmed publisher
Raggi C, Gammella E, Correnti M, Buratti P, Forti E, Andersen J, et al. Dysregulation of Iron Metabolism in Cholangiocarcinoma Stem-like Cells. Sci Rep. 2017;7:17667 pubmed publisher
Zhang F, Hou H, Yin Z, Chang L, Li F, Chen Y, et al. Impairment of Hepcidin Upregulation by Lipopolysaccharide in the Interleukin-6 Knockout Mouse Brain. Front Mol Neurosci. 2017;10:367 pubmed publisher
Baba Y, Higa J, Shimada B, Horiuchi K, Suhara T, Kobayashi M, et al. Protective effects of the mechanistic target of rapamycin against excess iron and ferroptosis in cardiomyocytes. Am J Physiol Heart Circ Physiol. 2018;314:H659-H668 pubmed publisher
Neves J, Ramos M, Moreira A, Silva T, Gomes M, Rodrigues P. Hamp1 but not Hamp2 regulates ferroportin in fish with two functionally distinct hepcidin types. Sci Rep. 2017;7:14793 pubmed publisher
Zhang W, Lv T, Huang J, Ou X. Type 4B hereditary hemochromatosis associated with a novel mutation in the SLC40A1 gene: A case report and a review of the literature. Medicine (Baltimore). 2017;96:e8064 pubmed publisher
Pasricha S, Lim P, Duarte T, Casu C, Oosterhuis D, Mleczko Sanecka K, et al. Hepcidin is regulated by promoter-associated histone acetylation and HDAC3. Nat Commun. 2017;8:403 pubmed publisher
Kaito T, Morimoto T, Mori Y, Kanayama S, Makino T, Takenaka S, et al. BMP-2/7 heterodimer strongly induces bone regeneration in the absence of increased soft tissue inflammation. Spine J. 2018;18:139-146 pubmed publisher
Dietrich P, Johnson I, Alli S, Dragatsis I. Elimination of huntingtin in the adult mouse leads to progressive behavioral deficits, bilateral thalamic calcification, and altered brain iron homeostasis. PLoS Genet. 2017;13:e1006846 pubmed publisher
Basuli D, Tesfay L, Deng Z, Paul B, Yamamoto Y, Ning G, et al. Iron addiction: a novel therapeutic target in ovarian cancer. Oncogene. 2017;36:4089-4099 pubmed publisher
Fader K, Nault R, Kirby M, Markous G, Matthews J, Zacharewski T. Convergence of hepcidin deficiency, systemic iron overloading, heme accumulation, and REV-ERBα/β activation in aryl hydrocarbon receptor-elicited hepatotoxicity. Toxicol Appl Pharmacol. 2017;321:1-17 pubmed publisher
Cullis J, Siolas D, Avanzi A, Barui S, Maitra A, Bar Sagi D. Macropinocytosis of Nab-paclitaxel Drives Macrophage Activation in Pancreatic Cancer. Cancer Immunol Res. 2017;5:182-190 pubmed publisher
Mertens C, Akam E, Rehwald C, Brüne B, Tomat E, Jung M. Intracellular Iron Chelation Modulates the Macrophage Iron Phenotype with Consequences on Tumor Progression. PLoS ONE. 2016;11:e0166164 pubmed publisher
Zhang Y, Li F, Guo Y, Jiang L, Ma J, Ke Y, et al. (Z)-ligustilide increases ferroportin1 expression and ferritin content in ischemic SH-SY5Y cells. Eur J Pharmacol. 2016;792:48-53 pubmed publisher
Gasperini L, Meneghetti E, Legname G, Benetti F. In Absence of the Cellular Prion Protein, Alterations in Copper Metabolism and Copper-Dependent Oxidase Activity Affect Iron Distribution. Front Neurosci. 2016;10:437 pubmed
Asperti M, Stuemler T, Poli M, Gryzik M, Lifshitz L, Meyron Holtz E, et al. Heparanase Overexpression Reduces Hepcidin Expression, Affects Iron Homeostasis and Alters the Response to Inflammation. PLoS ONE. 2016;11:e0164183 pubmed publisher
Kim D, Kim Y, Jung Y, Kim K, Jeong J, Lee Y, et al. Orphan nuclear receptor SHP regulates iron metabolism through inhibition of BMP6-mediated hepcidin expression. Sci Rep. 2016;6:34630 pubmed publisher
Rossi A, Cadamuro A, Biselli Périco J, Leite K, Severino F, Reis P, et al. Interaction between inflammatory mediators and miRNAs in Helicobacter pylori infection. Cell Microbiol. 2016;18:1444-58 pubmed publisher
Marques O, Porto G, Rêma A, Faria F, Cruz Paula A, Gomez Lazaro M, et al. Local iron homeostasis in the breast ductal carcinoma microenvironment. BMC Cancer. 2016;16:187 pubmed publisher
Kleme M, Sané A, Garofalo C, Levy E. Targeted CFTR gene disruption with zinc-finger nucleases in human intestinal epithelial cells induces oxidative stress and inflammation. Int J Biochem Cell Biol. 2016;74:84-94 pubmed publisher
Ko A, Jin D, Cho S, Park S, Przybylska M, Yew N, et al. AAV8-mediated expression of N-acetylglucosamine-1-phosphate transferase attenuates bone loss in a mouse model of mucolipidosis II. Mol Genet Metab. 2016;117:447-55 pubmed publisher
Theurl M, Song D, Clark E, Sterling J, Grieco S, Altamura S, et al. Mice with hepcidin-resistant ferroportin accumulate iron in the retina. FASEB J. 2016;30:813-23 pubmed publisher
Mori M, Ito F, Shi L, Wang Y, Ishida C, Hattori Y, et al. Ovarian endometriosis-associated stromal cells reveal persistently high affinity for iron. Redox Biol. 2015;6:578-586 pubmed publisher
Bose C, Megyesi J, Shah S, Hiatt K, Hall K, Karaduta O, et al. Evidence Suggesting a Role of Iron in a Mouse Model of Nephrogenic Systemic Fibrosis. PLoS ONE. 2015;10:e0136563 pubmed publisher
Tesfay L, Clausen K, Kim J, Hegde P, Wang X, Miller L, et al. Hepcidin regulation in prostate and its disruption in prostate cancer. Cancer Res. 2015;75:2254-63 pubmed publisher
Gammella E, Díaz V, Recalcati S, Buratti P, Samaja M, Dey S, et al. Erythropoietin's inhibiting impact on hepcidin expression occurs indirectly. Am J Physiol Regul Integr Comp Physiol. 2015;308:R330-5 pubmed publisher
Katz O, Reifen R, Lerner A. β-Carotene can reverse dysregulation of iron protein in an in vitro model of inflammation. Immunol Res. 2015;61:70-8 pubmed publisher
Jeong S, Lee J, Finley L, Schmidt P, Fleming M, Haigis M. SIRT3 regulates cellular iron metabolism and cancer growth by repressing iron regulatory protein 1. Oncogene. 2015;34:2115-24 pubmed publisher
product information
brand :
Novus Biologicals, a Bio-Techne brand
catalog number base :
NB600-1131
SKU :
NB600-1131
product name :
IL-6 Antibody
description :
The IL-6 Antibody from Novus Biologicals is a rabbit polyclonal antibody to IL-6. This antibody reacts with human,monkey,mouse,primate - macaca mulatta (rhesus macaque),rat. The IL-6 Antibody has been validated for the following applications: Immunoprecipitation,IF/IHC,ELISA,Immunohistochemistry,Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Knockdown Validated,Immunocytochemistry/ Immunofluorescence.
target :
IL-6
unit size :
0.2 ml (also 0.04 ml)
category :
Primary Antibodies
buffer :
0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
clonality :
Polyclonal
conjugate :
Unconjugated
host :
Rabbit
immunogen :
This whole rabbit serum was prepared by repeated immunizations with recombinant human IL-6 produced in E.coli. (Uniprot: P05231)
isotype :
IgG
purity :
Unpurified
species :
Human,Monkey,Mouse,Rat
specificity :
Anti-IL-6 antiserum detects recombinant and native IL-6 present in body fluids and cell supernatants in various assays (ie
storage :
Store at -20C short term. Aliquot and store at -80C long term. Avoid freeze-thaw cycles.
gene symbol :
IL6
accessionNumbers :
P05231, P05231, P05231, P05231, P05231
applications :
Immunoprecipitation,IF/IHC,ELISA,Immunohistochemistry,Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Knockdown Validated,Immunocytochemistry/ Immunofluorescence
USD :
399
USD 2025 :
409 USD
alt names :
B-cell differentiation factor, B-cell stimulatory factor 2, BSF2, BSF-2, CDF, CTL differentiation factor, HSF, hybridoma growth factor, IFNB2, IFN-beta-2, IL-6, Interferon beta-2, interleukin 6 (interferon, beta 2), interleukin BSF-2, interleukin-6
more info or order :
company information
Novus Biologicals
10771 E Easter Ave
Centennial, CO 80112
novus@novusbio.com
https://www.novusbio.com
3037301950
headquarters: USA
Novus Biologicals licenses, manufactures, and markets antibodies to over 20,000 unique targets to support a wide array of research areas. Novus is built on honesty, collaboration and strong relationships and continues to provide quality tools that accelerate research. Every product is backed by our 100% guarantee.