product summary
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company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
Podoplanin Antibody (8.1.1) - BSA Free
catalog :
NB600-1015
quantity :
0.1 ml (also 0.025 ml)
price :
399 USD
clonality :
monoclonal
host :
Syrian golden hamster
conjugate :
nonconjugated
clone name :
8.1.1
reactivity :
human, mouse
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
Novus Biologicals product webpage
citations: 71
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - frozen section; mouse; 1:100; loading ...; fig 5c
Shan Z, Li L, Atkins C, Wang M, Wen Y, Jeong J, et al. Chitinase 3-like-1 contributes to acetaminophen-induced liver injury by promoting hepatic platelet recruitment. elife. 2021;10: pubmed publisher
  • immunohistochemistry - paraffin section; mouse
Jia Y, Chen K, Lin P, Lieber G, Nishi M, Yan R, et al. Treatment of acute lung injury by targeting MG53-mediated cell membrane repair. Nat Commun. 2014;5:4387 pubmed publisher
  • immunohistochemistry - paraffin section; mouse
Sargent L, Porter D, Staska L, Hubbs A, Lowry D, Battelli L, et al. Promotion of lung adenocarcinoma following inhalation exposure to multi-walled carbon nanotubes. Part Fibre Toxicol. 2014;11:3 pubmed publisher
  • western blot; mouse
Kabgani N, Grigoleit T, Schulte K, Sechi A, Sauer Lehnen S, Tag C, et al. Primary cultures of glomerular parietal epithelial cells or podocytes with proven origin. PLoS ONE. 2012;7:e34907 pubmed publisher
  • immunocytochemistry; mouse
  • immunohistochemistry; mouse
Porter D, Hubbs A, Mercer R, Wu N, Wolfarth M, Sriram K, et al. Mouse pulmonary dose- and time course-responses induced by exposure to multi-walled carbon nanotubes. Toxicology. 2010;269:136-47 pubmed publisher
  • immunohistochemistry - paraffin section; mouse
Schacht V, Dadras S, Johnson L, Jackson D, Hong Y, Detmar M. Up-regulation of the lymphatic marker podoplanin, a mucin-type transmembrane glycoprotein, in human squamous cell carcinomas and germ cell tumors. Am J Pathol. 2005;166:913-21 pubmed
  • immunohistochemistry - paraffin section; mouse
Crnic I, Strittmatter K, Cavallaro U, Kopfstein L, Jussila L, Alitalo K, et al. Loss of neural cell adhesion molecule induces tumor metastasis by up-regulating lymphangiogenesis. Cancer Res. 2004;64:8630-8 pubmed
  • immunohistochemistry - frozen section; mouse
  • flow cytometry; mouse
  • immunocytochemistry; mouse
Katakai T, Hara T, Sugai M, Gonda H, Shimizu A. Lymph node fibroblastic reticular cells construct the stromal reticulum via contact with lymphocytes. J Exp Med. 2004;200:783-95 pubmed
  • immunohistochemistry - paraffin section; mouse
Schacht V, Ramirez M, Hong Y, Hirakawa S, Feng D, Harvey N, et al. T1alpha/podoplanin deficiency disrupts normal lymphatic vasculature formation and causes lymphedema. EMBO J. 2003;22:3546-56 pubmed
  • immunohistochemistry - frozen section; mouse
  • western blot; mouse
Farr A, Berry M, Kim A, Nelson A, Welch M, Aruffo A. Characterization and cloning of a novel glycoprotein expressed by stromal cells in T-dependent areas of peripheral lymphoid tissues. J Exp Med. 1992;176:1477-82 pubmed
Guo L, Bao W, Yang S, Liu Y, Lyu J, Wang T, et al. Rhei Radix et Rhizoma in Xuanbai-Chengqi decoction strengthens the intestinal barrier function and promotes lung barrier repair in preventing severe viral pneumonia induced by influenza A virus. J Ethnopharmacol. 2024;319:117231 pubmed publisher
Tang A, Buchholz D, Szigety K, Imbiakha B, Gao S, Frankfurter M, et al. Cell-autonomous requirement for ACE2 across organs in lethal mouse SARS-CoV-2 infection. PLoS Biol. 2023;21:e3001989 pubmed publisher
Fraser K, Hubbs A, Yanamala N, Mercer R, Stueckle T, Jensen J, et al. Histopathology of the broad class of carbon nanotubes and nanofibers used or produced in U.S. facilities in a murine model. Part Fibre Toxicol. 2021;18:47 pubmed publisher
Bombeiro A, Pereira B, Bonfanti A, Oliveira A. Immunomodulation by dimethyl fumarate treatment improves mouse sciatic nerve regeneration. Brain Res Bull. 2020;160:24-32 pubmed publisher
Mandell E, Ryan S, Seedorf G, Gonzalez T, Smith B, Fleet J, et al. Maternal Vitamin D Deficiency Causes Sustained Impairment of Lung Structure and Function and Increases Susceptibility to Hyperoxia-induced Lung Injury in Infant Rats. Am J Respir Cell Mol Biol. 2020;63:79-91 pubmed publisher
Chou P, Lin Y, Wu S, Lin S, Srinivasan P, Hsieh D, et al. Supercritical Carbon Dioxide-decellularized Porcine Acellular Dermal Matrix combined with Autologous Adipose-derived Stem Cells: Its Role in Accelerated Diabetic Wound Healing. Int J Med Sci. 2020;17:354-367 pubmed publisher
Li J, Zhou W, Chen W, Wang H, Zhang Y, Yu T. Mechanism of the hypoxia inducible factor 1/hypoxic response element pathway in rat myocardial ischemia/diazoxide post‑conditioning. Mol Med Rep. 2020;21:1527-1536 pubmed publisher
Gao L, Mei S, Zhang S, Qin Q, Li H, Liao Y, et al. Cardio-renal Exosomes in Myocardial Infarction Serum Regulate Proangiogenic Paracrine Signaling in Adipose Mesenchymal Stem Cells. Theranostics. 2020;10:1060-1073 pubmed publisher
Su C, Hsu T, Hsiao C, Chiu C, Tzang B. Effects of antibodies against human parvovirus B19 on angiogenic signaling. Mol Med Rep. 2020;21:1320-1327 pubmed publisher
Guo Q, Zhang Y, Zhang S, Jin J, Pang S, Wu X, et al. Genome-wide translational reprogramming of genes important for myocyte functions in overload-induced heart failure. Biochim Biophys Acta Mol Basis Dis. 2020;1866:165649 pubmed publisher
Wen G, Xu J, Wu T, Zhang S, Chai Y, Kang Q, et al. Functionalized Polycaprolactone/Hydroxyapatite Composite Microspheres for Promoting Bone Consolidation in a Rat Distraction Osteogenesis Model. J Orthop Res. 2020;38:961-971 pubmed publisher
Militi A, Cutroneo G, Favaloro A, Matarese G, Di Mauro D, Lauritano F, et al. An immunofluorescence study on VEGF and extracellular matrix proteins in human periodontal ligament during tooth movement. Heliyon. 2019;5:e02572 pubmed publisher
Lin Y, Chen R, Liang J, Hung Y, Yeh L, Chang W, et al. Immunohistochemical Biomarkers of Survival in Patients With Adenocarcinoma of the Uterine Cervix Receiving Chemoradiotherapy. Anticancer Res. 2019;39:3231-3240 pubmed publisher
Saito H, Tanaka K, Fujiwara M, Iwasaki T, Numata T, Oda A, et al. Pathological findings of progressive renal involvement in a patient with TAFRO syndrome. CEN Case Rep. 2019;: pubmed publisher
Dewangan J, Srivastava S, Mishra S, Divakar A, Kumar S, Rath S. Salinomycin inhibits breast cancer progression via targeting HIF-1α/VEGF mediated tumor angiogenesis in vitro and in vivo. Biochem Pharmacol. 2019;164:326-335 pubmed publisher
Yan Y, Chen H, Zhang H, Guo C, Yang K, Chen K, et al. Vascularized 3D printed scaffolds for promoting bone regeneration. Biomaterials. 2018;190-191:97-110 pubmed publisher
Neto L, Zufelato N, de Sousa Júnior A, Trentini M, da Costa A, Bakuzis A, et al. Specific T cell induction using iron oxide based nanoparticles as subunit vaccine adjuvant. Hum Vaccin Immunother. 2018;14:2786-2801 pubmed publisher
Chen Y, Gao S, Yan Y, Qian J, Chen H. Aerosolized deferoxamine administration in mouse model of bronchopulmonary dysplasia improve pulmonary development. Am J Transl Res. 2018;10:325-332 pubmed
Asfahani R, Tahoun M, Miller Hodges E, Bellerby J, Virasami A, Sampson R, et al. Activation of podocyte Notch mediates early Wt1 glomerulopathy. Kidney Int. 2018;93:903-920 pubmed publisher
Wang C, Wang Q, Gao W, Zhang Z, Lou Y, Jin H, et al. Highly efficient local delivery of endothelial progenitor cells significantly potentiates angiogenesis and full-thickness wound healing. Acta Biomater. 2018;69:156-169 pubmed publisher
Xu J, Sun Y, Wu T, Liu Y, Shi L, Zhang J, et al. Enhancement of bone regeneration with the accordion technique via HIF-1α/VEGF activation in a rat distraction osteogenesis model. J Tissue Eng Regen Med. 2018;12:e1268-e1276 pubmed publisher
Farjood F, Vargis E. Physical disruption of cell-cell contact induces VEGF expression in RPE cells. Mol Vis. 2017;23:431-446 pubmed
Li H, Yang S, Yu G, Shen L, Fan J, Xu L, et al. Aptamer Internalization via Endocytosis Inducing S-Phase Arrest and Priming Maver-1 Lymphoma Cells for Cytarabine Chemotherapy. Theranostics. 2017;7:1204-1213 pubmed publisher
Du C, Mendelson A, Guan Q, Dairi G, Chafeeva I, da Roza G, et al. Hyperbranched polyglycerol is superior to glucose for long-term preservation of peritoneal membrane in a rat model of chronic peritoneal dialysis. J Transl Med. 2016;14:338 pubmed
Lin Y, Chen R, Chen S, Hsieh T, Yen K, Liang J, et al. Immunohistochemical studies and fluorodeoxyglucose uptake on positron emission tomography in pharyngeal cancer for predicting radiotherapy-based treatment outcomes. Clin Otolaryngol. 2017;42:608-619 pubmed publisher
Su J, Mar A, Wu S, Tai W, Chu P, Wu C, et al. Disrupting VEGF-A paracrine and autocrine loops by targeting SHP-1 suppresses triple negative breast cancer metastasis. Sci Rep. 2016;6:28888 pubmed publisher
Chen S, Lin Y, Chen R, Hsieh T, Yen K, Liang J, et al. Immunohistochemical overexpression of hypoxia-induced factor 1? associated with slow reduction in 18fluoro-2-deoxy-D-glucose uptake for chemoradiotherapy in patients with pharyngeal cancer. Eur J Nucl Med Mol Imaging. 2016;43:2343-2352 pubmed
Chen H, Jia P, Kang H, Zhang H, Liu Y, Yang P, et al. Upregulating Hif-1α by Hydrogel Nanofibrous Scaffolds for Rapidly Recruiting Angiogenesis Relative Cells in Diabetic Wound. Adv Healthc Mater. 2016;5:907-18 pubmed publisher
Ram M, Singh V, Kumawat S, Kant V, Tandan S, Kumar D. Bilirubin modulated cytokines, growth factors and angiogenesis to improve cutaneous wound healing process in diabetic rats. Int Immunopharmacol. 2016;30:137-149 pubmed publisher
Srinivas C, Ramaiah M, Lavanya A, Yerramsetty S, Kavi Kishor P, Basha S, et al. Novel Etoposide Analogue Modulates Expression of Angiogenesis Associated microRNAs and Regulates Cell Proliferation by Targeting STAT3 in Breast Cancer. PLoS ONE. 2015;10:e0142006 pubmed publisher
André H, Tunik S, Aronsson M, Kvanta A. Hypoxia-Inducible Factor-1α Is Associated With Sprouting Angiogenesis in the Murine Laser-Induced Choroidal Neovascularization Model. Invest Ophthalmol Vis Sci. 2015;56:6591-604 pubmed publisher
Ram M, Singh V, Kumawat S, Kumar D, Lingaraju M, Uttam Singh T, et al. Deferoxamine modulates cytokines and growth factors to accelerate cutaneous wound healing in diabetic rats. Eur J Pharmacol. 2015;764:9-21 pubmed publisher
Shao J, Zhang Y, Yang T, Qi J, Zhang L, Deng L. HIF-1α disturbs osteoblasts and osteoclasts coupling in bone remodeling by up-regulating OPG expression. In Vitro Cell Dev Biol Anim. 2015;51:808-14 pubmed publisher
Tam J, Ko C, Lau K, To M, Kwok H, Chan Y, et al. A Chinese 2-herb formula (NF3) promotes hindlimb ischemia-induced neovascularization and wound healing of diabetic rats. J Diabetes Complications. 2014;28:436-47 pubmed publisher
Parlakgumus H, Aka Bolat F, Bulgan Kilicdag E, Simsek E, Parlakgumus A. Atorvastatin for ovarian torsion: effects on follicle counts, AMH, and VEGF expression. Eur J Obstet Gynecol Reprod Biol. 2014;175:186-90 pubmed publisher
Johansen F, Hasseldam H, Rasmussen R, Bisgaard A, Bonfils P, Poulsen S, et al. Drug-induced hypothermia as beneficial treatment before and after cerebral ischemia. Pathobiology. 2014;81:42-52 pubmed publisher
Fedorova L, Sodhi K, Gatto Weis C, Puri N, Hinds T, Shapiro J, et al. Peroxisome proliferator-activated receptor ? agonist, HPP593, prevents renal necrosis under chronic ischemia. PLoS ONE. 2013;8:e64436 pubmed publisher
Milanesi A, Lee J, Li Z, DA Sacco S, Villani V, Cervantes V, et al. ?-Cell regeneration mediated by human bone marrow mesenchymal stem cells. PLoS ONE. 2012;7:e42177 pubmed publisher
Hong D, Kurzrock R, Oh Y, Wheler J, Naing A, Brail L, et al. A phase 1 dose escalation, pharmacokinetic, and pharmacodynamic evaluation of eIF-4E antisense oligonucleotide LY2275796 in patients with advanced cancer. Clin Cancer Res. 2011;17:6582-91 pubmed publisher
Mahtab E, Vicente Steijn R, Hahurij N, Jongbloed M, Wisse L, DeRuiter M, et al. Podoplanin deficient mice show a RhoA-related hypoplasia of the sinus venosus myocardium including the sinoatrial node. Dev Dyn. 2009;238:183-93 pubmed publisher
Kunze D, Wuttig D, Kausch I, Blietz C, Blumhoff L, Burmeister Y, et al. Antisense-mediated inhibition of survivin, hTERT and VEGF in bladder cancer cells in vitro and in vivo. Int J Oncol. 2008;32:1049-56 pubmed
Ptaszynska M, Pendrak M, Bandle R, Stracke M, Roberts D. Positive feedback between vascular endothelial growth factor-A and autotaxin in ovarian cancer cells. Mol Cancer Res. 2008;6:352-63 pubmed publisher
Mahtab E, Wijffels M, Van Den Akker N, Hahurij N, Lie Venema H, Wisse L, et al. Cardiac malformations and myocardial abnormalities in podoplanin knockout mouse embryos: Correlation with abnormal epicardial development. Dev Dyn. 2008;237:847-57 pubmed publisher
Withers D, Kim M, Bekiaris V, Rossi S, Jenkinson W, Gaspal F, et al. The role of lymphoid tissue inducer cells in splenic white pulp development. Eur J Immunol. 2007;37:3240-5 pubmed
Gittenberger de Groot A, Mahtab E, Hahurij N, Wisse L, DeRuiter M, Wijffels M, et al. Nkx2.5-negative myocardium of the posterior heart field and its correlation with podoplanin expression in cells from the developing cardiac pacemaking and conduction system. Anat Rec (Hoboken). 2007;290:115-22 pubmed
Hara T, Katakai T, Lee J, Nambu Y, Nakajima Nagata N, Gonda H, et al. A transmembrane chemokine, CXC chemokine ligand 16, expressed by lymph node fibroblastic reticular cells has the potential to regulate T cell migration and adhesion. Int Immunol. 2006;18:301-11 pubmed
Van der Auwera I, Van Laere S, Van den Eynden G, Benoy I, Van Dam P, Colpaert C, et al. Increased angiogenesis and lymphangiogenesis in inflammatory versus noninflammatory breast cancer by real-time reverse transcriptase-PCR gene expression quantification. Clin Cancer Res. 2004;10:7965-71 pubmed
Couvelard A, O Toole D, Turley H, Leek R, Sauvanet A, Degott C, et al. Microvascular density and hypoxia-inducible factor pathway in pancreatic endocrine tumours: negative correlation of microvascular density and VEGF expression with tumour progression. Br J Cancer. 2005;92:94-101 pubmed
Giatromanolaki A, Koukourakis M, Simopoulos C, Polychronidis A, Sivridis E. Vascular endothelial growth factor (VEGF) expression in operable gallbladder carcinomas. Eur J Surg Oncol. 2003;29:879-83 pubmed
Kapsoritakis A, Sfiridaki A, Maltezos E, Simopoulos K, Giatromanolaki A, Sivridis E, et al. Vascular endothelial growth factor in inflammatory bowel disease. Int J Colorectal Dis. 2003;18:418-22 pubmed
Giatromanolaki A, Koukourakis M, Sivridis E, Turley H, Wykoff C, Gatter K, et al. DEC1 (STRA13) protein expression relates to hypoxia- inducible factor 1-alpha and carbonic anhydrase-9 overexpression in non-small cell lung cancer. J Pathol. 2003;200:222-8 pubmed
Giatromanolaki A, Sivridis E, Maltezos E, Papazoglou D, Simopoulos C, Gatter K, et al. Hypoxia inducible factor 1alpha and 2alpha overexpression in inflammatory bowel disease. J Clin Pathol. 2003;56:209-13 pubmed
Salgado R, Benoy I, Weytjens R, Van Bockstaele D, Van Marck E, Huget P, et al. Arterio-venous gradients of IL-6, plasma and serum VEGF and D-dimers in human cancer. Br J Cancer. 2002;87:1437-44 pubmed
Zhang H, Scott P, Morbidelli L, Peak S, Moore J, Turley H, et al. The 121 amino acid isoform of vascular endothelial growth factor is more strongly tumorigenic than other splice variants in vivo. Br J Cancer. 2000;83:63-8 pubmed
Koukourakis M, Giatromanolaki A, Thorpe P, Brekken R, Sivridis E, Kakolyris S, et al. Vascular endothelial growth factor/KDR activated microvessel density versus CD31 standard microvessel density in non-small cell lung cancer. Cancer Res. 2000;60:3088-95 pubmed
Adams J, Carder P, Downey S, Forbes M, MacLennan K, Allgar V, et al. Vascular endothelial growth factor (VEGF) in breast cancer: comparison of plasma, serum, and tissue VEGF and microvessel density and effects of tamoxifen. Cancer Res. 2000;60:2898-905 pubmed
Giatromanolaki A, Koukourakis M, Sivridis E, O Byrne K, Cox G, Thorpe P, et al. Coexpression of MUC1 glycoprotein with multiple angiogenic factors in non-small cell lung cancer suggests coactivation of angiogenic and migration pathways. Clin Cancer Res. 2000;6:1917-21 pubmed
O Byrne K, Koukourakis M, Giatromanolaki A, Cox G, Turley H, Steward W, et al. Vascular endothelial growth factor, platelet-derived endothelial cell growth factor and angiogenesis in non-small-cell lung cancer. Br J Cancer. 2000;82:1427-32 pubmed
Kakolyris S, Giatromanolaki A, Koukourakis M, Leigh I, Georgoulias V, Kanavaros P, et al. Assessment of vascular maturation in non-small cell lung cancer using a novel basement membrane component, LH39: correlation with p53 and angiogenic factor expression. Cancer Res. 1999;59:5602-7 pubmed
Turley H, Scott P, Watts V, Bicknell R, Harris A, Gatter K. Expression of VEGF in routinely fixed material using a new monoclonal antibody VG1. J Pathol. 1998;186:313-8 pubmed
Farr A, Nelson A, Hosier S. Characterization of an antigenic determinant preferentially expressed by type I epithelial cells in the murine thymus. J Histochem Cytochem. 1992;40:651-64 pubmed
product information
brand :
Novus Biologicals, a Bio-Techne Brand
catalog number base :
NB600-1015
SKU :
NB600-1015
product name :
Podoplanin Antibody (8.1.1) - BSA Free
Description :
The Podoplanin Antibody (8.1.1) - BSA Free from Novus is a golden syrian hamster monoclonal antibody to Podoplanin. This antibody reacts with mouse, human (negative). The Podoplanin Antibody (8.1.1) - BSA Free has been validated for the following applications: Western Blot, Flow Cytometry, Immunohistochemistry, Immunocytochemistry/ Immunofluorescence, Immunoprecipitation, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen, Electron Microscopy, CyTOF-ready.
target :
Podoplanin
category :
Primary Antibodies
unit size :
0.1 ml (also 0.025 ml)
buffer :
PBS
clonality :
Monoclonal
clone :
8.1.1
concentration :
1 mg/ml
conjugate :
Unconjugated
host :
Golden Syrian Hamster
immunogen :
Murine thymic stromal cell lines
isotype :
IgG
purity :
Protein G purified
species :
Mouse, Human (Negative)
theoretical molecular weight :
40 kDa
gene symbol :
PDPN
accessionNumbers :
Q62011
applications :
Western Blot, Flow Cytometry, Immunohistochemistry, Immunocytochemistry/ Immunofluorescence, Immunoprecipitation, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen, Electron Microscopy, CyTOF-ready
USD :
399 USD
product details :
Podoplanin is a mucine-type glycoprotein which induces platelet aggregation. Podoplanin has been implicated in cancer cell migration, invasion, metastasis, and malignant progression. Podoplanin antibodies serve as markers of lymphatic endothelium and fibroblastic reticular cells of lymphoid organs, as well as certain lung injuries. The upregulation of podoplanin in tumor cells has been correlated with an increase in metastasis and motility. Recent research has shown that Podoplanin plays a critical role in immune cells, including T cells and dendritic cells.
alt names :
36-KD, aggrus, Gp36, GP40, HT1A-1, hT1alpha-1, hT1alpha-2, lung type I cell membrane associated glycoprotein, lung type-I cell membrane-associated glycoprotein (T1A-2), OTS 8, OTS8, PA2.26 antigen, podoplanin, T1A, T1-alpha
storage :
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
more info or order :
Novus Biologicals product webpage
company information
Novus Biologicals
10771 E Easter Ave
Centennial, CO 80112
novus@novusbio.com
https://www.novusbio.com
3037301950
headquarters: USA
Novus Biologicals licenses, manufactures, and markets antibodies to over 20,000 unique targets to support a wide array of research areas. Novus is built on honesty, collaboration and strong relationships and continues to provide quality tools that accelerate research. Every product is backed by our 100% guarantee.