product summary
request information :
company name :
Novus Biologicals
product type :
antibody
product name :
Mouse Monoclonal Integrin beta 2/CD18 Antibody
catalog :
NB500-379R
quantity :
0.05 mg
price :
429.00 USD
clonality :
monoclonal
host :
mouse
reactivity :
human
application :
western blot, immunoprecipitation, immunohistochemistry, flow cytometry
more info or order :
Novus Biologicals product webpage
product information
Catalog Number :
NB500-379R
Product Name :
Mouse Monoclonal Integrin beta 2/CD18 Antibody
List Price :
429.00 USD
Product Type :
Primary Antibodies
Package Size :
0.05 mg
AltNames :
959 beta subunit precursor)10, CD18 antigen, CD18beta 2, cell surface adhesion glycoprotein (LFA-1, CR3, integrin beta-2, integrin, beta 2 (antigen CD18 (p95), lymphocyte function-associated antigen 1;macrophage antigen 1 (mac-1) beta subunit), integrin, beta 2 (complement component 3 receptor 3 and 4 subunit), LCAMB, leukocyte cell adhesion molecule CD18, LAD, leukocyte-associated antigens CD18/11A, CD18/11B, CD18/11C, MFI7, MF17, P150
Background :
CD18 is an integrin. Integrins are integral cell surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, beta 2 combines with the alpha L chain to form the integrin LFA1, and combines with the alpha M chain to form the integrin Mac1. Integrins are known to participate in cell adhesion as well as cell surface mediated signalling. CD18 is expressed by most leucocytes. Defects in the CD18 gene result in leukocyte adhesion deficiency.
Buffer :
50mM sodium borate
Clonality :
Monoclonal
Clone :
MEM-48
Concentration :
1.0 mg/ml
Conjugate :
DyLight 550
Application Summary :
Western Blot, Flow Cytometry, Immunohistochemistry, Immunohistochemistry-Frozen, Immunoprecipitation
Host :
Mouse
Immunogen :
Tissue / cell preparation (Human). (Leucocytes of a patient suffering from a LGL-type leukaemia).
Isotype :
IgG1
Preservative :
No Preservative
Purity :
Affinity purified
CrossReactivity :
Cross-reacts with Human.
Specificity :
Human CD18 antigen. This recognizes all three leucocyte integrins.
Storage :
Store at 4C in the dark.
Uses :
Flow Cytometry Use at an assay dependant concentration. FuncS: Use at an assay dependant dilution. The antibody induces high-affinity conformation of LFA-1 complex.IHC-Fr: Use at an assay dependant concentration. IP: Use at an assay dependant concentration. WB: Use at an assay dependant concentration. Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user.
Research Area :
Apoptosis, Cytokine Research, Immunology
more info or order :
Novus Biologicals product webpage
company information
Novus Biologicals
8100 Southpark Way, A-8
Littleton, CO 80120
novus@novusbio.com
www.novusbio.com
3037301950
headquarters: usa
The mission of Novus Biologicals, LLC is to accelerate scientific discovery by developing and marketing unique products in the forefront of science. Novus Biologicals was organized to provide the biological research community with a mechanism for commercializing unique biological materials. We also focus on continually monitoring scientific trends and supply materials to serve these trends. By making these products widely available to institutional and commercial researchers, Novus Biologicals plays an important role in furthering biological research. All of Novus Biologicals products are supplied with detailed technical information and ongoing support. By serving niche and emerging markets, Novus Biologicals has become specialists in markets and has formed and will continue to form ongoing partnerships with our customers.