product summary
request information :
company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
Rabbit Polyclonal Survivin Antibody
catalog :
NB500-236H
quantity :
0.1 ml
price :
269.00 USD
clonality :
polyclonal
host :
rabbit
conjugate :
HRP
reactivity :
human, mouse, cow
application :
western blot
more info or order :
Novus Biologicals product webpage
product information
Catalog Number :
NB500-236H
Product Name :
Rabbit Polyclonal Survivin Antibody
List Price :
269.00 USD
Product Type :
Primary Antibodies
Package Size :
0.1 ml
AltNames :
EPR-1, IAP4, API4 survivin variant 3 alpha, Apoptosis inhibitor 4 baculoviral IAP repeat-containing protein 5, Apoptosis inhibitor survivin, baculoviral IAP repeat-containing 5, BIRC5
Background :
Regulated inhibition of programmed cell death (apoptosis) preserves normal homeostasis and tissue and organ morphogenesis. Aberrations in this process contribute to human diseases and cancer by abnormally prolonging cell viability. Recently, several apoptosis inhibitors related to the baculovirus iap gene have been found in various species, including human. IAP proteins contain one/three Cys/His baculovirus IAP repeats plus a C-terminal RING finger and are thought to block an evolutionary conserved step in apoptosis. Survivin encodes a structurally unique inhibitor of apoptosis (IAP). Survivin expression is turned off during fetal development and is not found in non-neoplastic adult human tissues. Survivin becomes abundantly re-expressed in transformed cells and in all of the most common cancers of lung, colon, pancreas, breast and prostate in vivo. Survivin appears to be situated at the crossroads of cell death and cell division, governing a checkpoint involved in cytokinesis while also suppressing apoptosis. Survivin is also abundantly expressed in brain tissues (astrocytes and some neurons) of adult rats following traumatic brain injury. Survivin has been found co-expressed with NeuN (mature neuronal marker) and PCNA (a cell cycle protein). Survivin might affect regulation of neural cell proliferative responses after brain injury.
Buffer :
PBS
Clonality :
Polyclonal
Conjugate :
HRP
Application Summary :
Western Blot
Host :
Rabbit
Immunogen :
A synthetic peptide with a phosphorylated Threonine (amino acid 34) corresponding to human Survivin. [UniProt# O15392]
Localization :
Nuclear
Modification :
p Thr34
Preservative :
No Preservative
Purity :
Immunogen affinity purified
CrossReactivity :
Human and mouse. Immunogen sequence has 100% identity to feline and primate, and 94% identity to canine, porcine, and bovine.
Specificity :
NB500-236 is specific for phosphorylated survivin.
Storage :
Store at 4C in the dark.
Swissprot Human :
O15392
Uses :
This Survivin [p Thr34] antibody is useful for Western Blot, and Immunocytochemistry/Immunofluorescence. This antibody has been limited to the detection of phosphorylated Survivin recombinant protein and has not yet been successfully used to detect endogenous phosphorylated Survivin.
Research Area :
Angiogenesis, Apoptosis, Astrocyte Markers, Cancer, Cellular Markers, Core ESC Like Genes, Glia Markers, Growth and Development, Mitotic Regulators, Neurodegeneration, Neuronal Cell Markers, Neuroscience, Stem Cell Markers, Tumor Suppressors
more info or order :
Novus Biologicals product webpage
company information
Novus Biologicals
8100 Southpark Way, A-8
Littleton, CO 80120
novus@novusbio.com
www.novusbio.com
3037301950
headquarters: USA
The mission of Novus Biologicals, LLC is to accelerate scientific discovery by developing and marketing unique products in the forefront of science. Novus Biologicals was organized to provide the biological research community with a mechanism for commercializing unique biological materials. We also focus on continually monitoring scientific trends and supply materials to serve these trends. By making these products widely available to institutional and commercial researchers, Novus Biologicals plays an important role in furthering biological research. All of Novus Biologicals products are supplied with detailed technical information and ongoing support. By serving niche and emerging markets, Novus Biologicals has become specialists in markets and has formed and will continue to form ongoing partnerships with our customers.