product summary
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company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
Eg5 Antibody
catalog :
NB500-181
quantity :
0.1 ml (also 0.025 ml)
price :
399 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
clone name :
MOAB-2
reactivity :
human, mouse, rat
application :
western blot, immunocytochemistry, immunoprecipitation
more info or order :
citations: 37
Reference
Didaskalou S, Efstathiou C, Galtsidis S, Kesisova I, Halavatyi A, Elmali T, et al. HURP localization in metaphase is the result of a multi-step process requiring its phosphorylation at Ser627 residue. Front Cell Dev Biol. 2023;11:981425 pubmed publisher
Rimal S, Li Y, Vartak R, Geng J, Tantray I, Li S, et al. Inefficient quality control of ribosome stalling during APP synthesis generates CAT-tailed species that precipitate hallmarks of Alzheimer's disease. Acta Neuropathol Commun. 2021;9:169 pubmed publisher
Uniyal A, Shantanu P, Vaidya S, Belinskaia D, Shestakova N, Kumar R, et al. Tozasertib Attenuates Neuropathic Pain by Interfering with Aurora Kinase and KIF11 Mediated Nociception. ACS Chem Neurosci. 2021;12:1948-1960 pubmed publisher
Zalenski A, Majumder S, De K, Venere M. An interphase pool of KIF11 localizes at the basal bodies of primary cilia and a reduction in KIF11 expression alters cilia dynamics. Sci Rep. 2020;10:13946 pubmed publisher
Acharya A, Stockmann J, Beyer L, Rudack T, Nabers A, GUMBART J, et al. The Effect of (-)-Epigallocatechin-3-Gallate on the Amyloid-β Secondary Structure. Biophys J. 2020;119:349-359 pubmed publisher
Voth S, Gwin M, FRANCIS C, Balczon R, Frank D, Pittet J, et al. Virulent Pseudomonas aeruginosa infection converts antimicrobial amyloids into cytotoxic prions. FASEB J. 2020;34:9156-9179 pubmed publisher
Liu X, Deng Y, Dai Z, Hu T, Cai W, Liu H, et al. Sodium tanshinone IIA sulfonate protects against Aβ1-42-induced cellular toxicity by modulating Aβ-degrading enzymes in HT22 cells. Int J Biol Macromol. 2020;151:47-55 pubmed publisher
He Y, Ruganzu J, Lin C, Ding B, Zheng Q, Wu X, et al. Tanshinone IIA ameliorates cognitive deficits by inhibiting endoplasmic reticulum stress-induced apoptosis in APP/PS1 transgenic mice. Neurochem Int. 2020;133:104610 pubmed publisher
Joseph E, Villalobos Acosta D, Torres Ramos M, Farfán García E, Gómez López M, Miliar Garcia A, et al. Neuroprotective Effects of Apocynin and Galantamine During the Chronic Administration of Scopolamine in an Alzheimer's Disease Model. J Mol Neurosci. 2020;70:180-193 pubmed publisher
Vargas Hurtado D, Brault J, Piolot T, Leconte L, Da Silva N, Pennetier C, et al. Differences in Mitotic Spindle Architecture in Mammalian Neural Stem Cells Influence Mitotic Accuracy during Brain Development. Curr Biol. 2019;29:2993-3005.e9 pubmed publisher
Prokop S, Miller K, Labra S, Pitkin R, Hoxha K, Narasimhan S, et al. Impact of TREM2 risk variants on brain region-specific immune activation and plaque microenvironment in Alzheimer's disease patient brain samples. Acta Neuropathol. 2019;138:613-630 pubmed publisher
Balczon R, Pittet J, Wagener B, Moser S, Voth S, Vorhees C, et al. Infection-induced endothelial amyloids impair memory. FASEB J. 2019;33:10300-10314 pubmed publisher
Tian C, Liu G, Gao L, Soltys D, Pan C, Stewart T, et al. Erythrocytic α-Synuclein as a potential biomarker for Parkinson's disease. Transl Neurodegener. 2019;8:15 pubmed publisher
El Hajjar J, Chatoo W, Hanna R, Nkanza P, Tétreault N, Tse Y, et al. Heterochromatic genome instability and neurodegeneration sharing similarities with Alzheimer's disease in old Bmi1+/- mice. Sci Rep. 2019;9:594 pubmed publisher
Cristiano C, Volpicelli F, Lippiello P, Buono B, Raucci F, Piccolo M, et al. Neutralization of interleukin-17 rescues amyloid-β-induced neuroinflammation and memory impairment. Br J Pharmacol. 2019;: pubmed publisher
Letort G, Bennabi I, Dmitrieff S, Nedelec F, Verlhac M, Terret M. A computational model of the early stages of acentriolar meiotic spindle assembly. Mol Biol Cell. 2019;30:863-875 pubmed publisher
Collins J, King A, Woodhouse A, Kirkcaldie M, Vickers J. Age moderates the effects of traumatic brain injury on beta-amyloid plaque load in APP/PS1 mice. J Neurotrauma. 2019;: pubmed publisher
Kim D, Lee D, Lim H, Choi S, Oh W, Yang Y, et al. Effect of growth differentiation factor-15 secreted by human umbilical cord blood-derived mesenchymal stem cells on amyloid beta levels in in vitro and in vivo models of Alzheimer's disease. Biochem Biophys Res Commun. 2018;504:933-940 pubmed publisher
Wan X, Zhang Y, Lan M, Pan M, Tang F, Zhang H, et al. Meiotic arrest and spindle defects are associated with altered KIF11 expression in porcine oocytes. Environ Mol Mutagen. 2018;59:805-812 pubmed publisher
Mann B, Wadsworth P. Distribution of Eg5 and TPX2 in mitosis: Insight from CRISPR tagged cells. Cytoskeleton (Hoboken). 2018;: pubmed publisher
Woodhouse A, Fernández Martos C, Atkinson R, Hanson K, Collins J, O Mara A, et al. Repeat propofol anesthesia does not exacerbate plaque deposition or synapse loss in APP/PS1 Alzheimer's disease mice. BMC Anesthesiol. 2018;18:47 pubmed publisher
Kim D, Lim H, Lee D, Choi S, Oh W, Yang Y, et al. Thrombospondin-1 secreted by human umbilical cord blood-derived mesenchymal stem cells rescues neurons from synaptic dysfunction in Alzheimer's disease model. Sci Rep. 2018;8:354 pubmed publisher
Paspalas C, Carlyle B, Leslie S, Preuss T, Crimins J, Huttner A, et al. The aged rhesus macaque manifests Braak stage III/IV Alzheimer's-like pathology. Alzheimers Dement. 2018;14:680-691 pubmed publisher
Muthukumaran K, Kanwar A, Vegh C, Marginean A, Elliott A, Guilbeault N, et al. Ubisol-Q10 (a Nanomicellar Water- Soluble Formulation of CoQ10) Treatment Inhibits Alzheimer-Type Behavioral and Pathological Symptoms in a Double Transgenic Mouse (TgAPEswe, PSEN1dE9) Model of Alzheimer's Disease. J Alzheimers Dis. 2017;: pubmed publisher
Lee D, Hwang C, Choi J, Park M, Song M, Oh K, et al. KRICT-9 inhibits neuroinflammation, amyloidogenesis and memory loss in Alzheimer's disease models. Oncotarget. 2017;8:68654-68667 pubmed publisher
Bickel K, Mann B, Waitzman J, Poor T, Rice S, Wadsworth P. Src family kinase phosphorylation of the motor domain of the human kinesin-5, Eg5. Cytoskeleton (Hoboken). 2017;74:317-330 pubmed publisher
Stuart K, King A, Fernandez Martos C, Summers M, Vickers J. Environmental novelty exacerbates stress hormones and Aβ pathology in an Alzheimer's model. Sci Rep. 2017;7:2764 pubmed publisher
Nalawansha D, Gomes I, Wambua M, Pflum M. HDAC Inhibitor-Induced Mitotic Arrest Is Mediated by Eg5/KIF11 Acetylation. Cell Chem Biol. 2017;24:481-492.e5 pubmed publisher
Balczon R, Morrow K, Zhou C, Edmonds B, Alexeyev M, Pittet J, et al. Pseudomonas aeruginosa infection liberates transmissible, cytotoxic prion amyloids. FASEB J. 2017;31:2785-2796 pubmed publisher
Stuart K, King A, Fernandez Martos C, Dittmann J, Summers M, Vickers J. Mid-life environmental enrichment increases synaptic density in CA1 in a mouse model of A?-associated pathology and positively influences synaptic and cognitive health in healthy ageing. J Comp Neurol. 2017;525:1797-1810 pubmed publisher
Liu Y, Wang Y, Du Z, Yan X, Zheng P, Liu Y. Fbxo30 Regulates Mammopoiesis by Targeting the Bipolar Mitotic Kinesin Eg5. Cell Rep. 2016;15:1111-1122 pubmed publisher
Yu Y, Hsieh T, Chen K, Wu J, Hoffer B, Greig N, et al. Glucose-Dependent Insulinotropic Polypeptide Ameliorates Mild Traumatic Brain Injury-Induced Cognitive and Sensorimotor Deficits and Neuroinflammation in Rats. J Neurotrauma. 2016;33:2044-2054 pubmed
Drechsler H, McAinsh A. Kinesin-12 motors cooperate to suppress microtubule catastrophes and drive the formation of parallel microtubule bundles. Proc Natl Acad Sci U S A. 2016;113:E1635-44 pubmed publisher
Collins J, King A, Woodhouse A, Kirkcaldie M, Vickers J. The effect of focal brain injury on beta-amyloid plaque deposition, inflammation and synapses in the APP/PS1 mouse model of Alzheimer's disease. Exp Neurol. 2015;267:219-29 pubmed publisher
Kim J, Yun H, Jin P, Lee H, Han J, Udumula V, et al. Inhibitory effect of a 2,4-bis(4-hydroxyphenyl)-2-butenal diacetate on neuro-inflammatory reactions via inhibition of STAT1 and STAT3 activation in cultured astrocytes and microglial BV-2 cells. Neuropharmacology. 2014;79:476-87 pubmed publisher
Youmans K, Tai L, Nwabuisi Heath E, JUNGBAUER L, Kanekiyo T, Gan M, et al. APOE4-specific changes in A? accumulation in a new transgenic mouse model of Alzheimer disease. J Biol Chem. 2012;287:41774-86 pubmed publisher
Youmans K, Tai L, Kanekiyo T, Stine W, Michon S, Nwabuisi Heath E, et al. Intraneuronal A? detection in 5xFAD mice by a new A?-specific antibody. Mol Neurodegener. 2012;7:8 pubmed publisher
product information
brand :
Novus Biologicals, a Bio-Techne Brand
catalog number base :
NB500-181
SKU :
NB500-181
product name :
Eg5 Antibody
Description :
The Eg5 Antibody from Novus is a rabbit polyclonal antibody to Eg5. This antibody reacts with human, mouse, rat, porcine, drosophila, mammal, plant. The Eg5 Antibody has been validated for the following applications: Western Blot, Immunocytochemistry/ Immunofluorescence, Immunoprecipitation, Immunoblotting.
target :
Eg5
category :
Primary Antibodies
unit size :
0.1 ml (also 0.025 ml)
buffer :
Whole antisera
clonality :
Polyclonal
conjugate :
Unconjugated
host :
Rabbit
immunogen :
A recombinant segment of the coiled-coil domain of human Eg5 [Uniprot: P52732]
isotype :
IgG
purity :
Unpurified
species :
Human, Mouse, Rat, Porcine, Drosophila, Mammal, Plant
theoretical molecular weight :
125 kDa
gene symbol :
KIF11
accessionNumbers :
P52732
applications :
Western Blot, Immunocytochemistry/ Immunofluorescence, Immunoprecipitation, Immunoblotting
USD :
399 USD
alt names :
Eg5, HKSP, kinesin family member 11, kinesin-like 1, Kinesin-like protein 1, kinesin-like protein KIF11, Kinesin-like spindle protein HKSP, Kinesin-related motor protein Eg5, KNSL1TRIP-5, thyroid receptor interacting protein 5, Thyroid receptor-interacting protein 5, TR-interacting protein 5, TRIP5EG5
storage :
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
more info or order :
company information
Novus Biologicals
10771 E Easter Ave
Centennial, CO 80112
novus@novusbio.com
https://www.novusbio.com
3037301950
headquarters: USA
Novus Biologicals licenses, manufactures, and markets antibodies to over 20,000 unique targets to support a wide array of research areas. Novus is built on honesty, collaboration and strong relationships and continues to provide quality tools that accelerate research. Every product is backed by our 100% guarantee.