TPX2 Antibody | Novus Biologicals NB500-179 product information

product summary

company name :

Novus Biologicals

other brands :

IMGENEX

product type :

antibody

product name :

TPX2 Antibody

catalog :

NB500-179

quantity :

0.1 ml (also 0.025 ml)

price :

399 USD

clonality :

polyclonal

host :

domestic rabbit

conjugate :

DyLight 350

clone name :

reactivity :

human, mouse, rat

application :

western blot, immunocytochemistry, immunoprecipitation, flow cytometry

more info or order :

Novus Biologicals product webpage

citations: 30

Published Application/Species/Sample/Dilution	Reference
immunocytochemistry; human; 1:1000; loading ...; fig 6a western blot; human; loading ...; fig 6g	Chu T, Connell M, Zhou L, He Z, Won J, Chen H, et al. Cell Cycle-Dependent Tumor Engraftment and Migration Are Enabled by Aurora-A. Mol Cancer Res. 2018;16:16-31 pubmed publisher
immunocytochemistry; human; loading ...; fig 3	Schneider M, Christopoulos P, Muley T, Warth A, Klingmueller U, Thomas M, et al. AURKA, DLGAP5, TPX2, KIF11 and CKAP5: Five specific mitosis-associated genes correlate with poor prognosis for non-small cell lung cancer patients. Int J Oncol. 2017;50:365-372 pubmed publisher
immunocytochemistry; human; 1:1000; fig 4	Rao S, Flores Rodriguez N, Page S, Wong C, Robinson P, Chircop M. The Clathrin-dependent Spindle Proteome. Mol Cell Proteomics. 2016;15:2537-53 pubmed publisher
	Asteriti I, Polverino F, Stagni V, Sterbini V, Ascanelli C, Naso F, et al. AurkA nuclear localization is promoted by TPX2 and counteracted by protein degradation. Life Sci Alliance. 2023;6: pubmed publisher
	Wu J, Larreategui Aparicio A, Lambers M, Bodor D, Klaasen S, Tollenaar E, et al. Microtubule nucleation from the fibrous corona by LIC1-pericentrin promotes chromosome congression. Curr Biol. 2023;33:912-925.e6 pubmed publisher
	Tang X, Wei W, Snowball J, Nakayasu E, Bell S, Ansong C, et al. EMC3 regulates mesenchymal cell survival via control of the mitotic spindle assembly. iScience. 2023;26:105667 pubmed publisher
	Li X, Wang Y, Yang S, Liu Y, Ma X, Liu L, et al. Melatonin protects against maternal diabetes-associated meiotic defects by maintaining mitochondrial function. Free Radic Biol Med. 2022;188:386-394 pubmed publisher
	Jabali A, Hoffrichter A, Uzquiano A, Marsoner F, Wilkens R, Siekmann M, et al. Human cerebral organoids reveal progenitor pathology in EML1-linked cortical malformation. EMBO Rep. 2022;23:e54027 pubmed publisher
	Zhang Y, Zheng W, Ren P, Hu H, Tong X, Zhang S, et al. Biallelic mutations in MOS cause female infertility characterized by human early embryonic arrest and fragmentation. EMBO Mol Med. 2021;13:e14887 pubmed publisher
	Sawada J, Matsuno K, Ogo N, Asai A. Various effects of two types of kinesin-5 inhibitors on mitosis and cell proliferation. Biochem Pharmacol. 2021;193:114789 pubmed publisher
	Das R, Sjöström M, Shrestha R, Yogodzinski C, Egusa E, Chesner L, et al. An integrated functional and clinical genomics approach reveals genes driving aggressive metastatic prostate cancer. Nat Commun. 2021;12:4601 pubmed publisher
	Wang X, Baumann C, De La Fuente R, Viveiros M. Loss of acentriolar MTOCs disrupts spindle pole Aurora A and assembly of the liquid-like meiotic spindle domain in oocytes. J Cell Sci. 2021;134: pubmed publisher
	Wang R, Ascanelli C, Abdelbaki A, Fung A, Rasmusson T, Michaelides I, et al. Selective targeting of non-centrosomal AURKA functions through use of a targeted protein degradation tool. Commun Biol. 2021;4:640 pubmed publisher
	Zhang Y, Dong L, Bao H, Liu Y, An F, Zhang G. Inhibition of interleukin-1β plays a protective role in Alzheimer's disease by promoting microRNA-9-5p and downregulating targeting protein for xenopus kinesin-like protein 2. Int Immunopharmacol. 2021;97:107578 pubmed publisher
	Polverino F, Naso F, Asteriti I, Palmerini V, Singh D, Valente D, et al. The Aurora-A/TPX2 Axis Directs Spindle Orientation in Adherent Human Cells by Regulating NuMA and Microtubule Stability. Curr Biol. 2021;31:658-667.e5 pubmed publisher
	Naso F, Sterbini V, Crecca E, Asteriti I, Russo A, Giubettini M, et al. Excess TPX2 Interferes with Microtubule Disassembly and Nuclei Reformation at Mitotic Exit. Cells. 2020;9: pubmed publisher
	Drutovic D, Duan X, Li R, Kalab P, Solc P. RanGTP and importin β regulate meiosis I spindle assembly and function in mouse oocytes. EMBO J. 2020;39:e101689 pubmed publisher
	Capalbo L, Bassi Z, Geymonat M, Todesca S, Copoiu L, Enright A, et al. The midbody interactome reveals unexpected roles for PP1 phosphatases in cytokinesis. Nat Commun. 2019;10:4513 pubmed publisher
	So C, Seres K, Steyer A, Mönnich E, Clift D, Pejkovska A, et al. A liquid-like spindle domain promotes acentrosomal spindle assembly in mammalian oocytes. Science. 2019;364: pubmed publisher
	van Gijn S, Wierenga E, van den Tempel N, Kok Y, Heijink A, Spierings D, et al. TPX2/Aurora kinase A signaling as a potential therapeutic target in genomically unstable cancer cells. Oncogene. 2019;38:852-867 pubmed publisher
	Mann B, Wadsworth P. Distribution of Eg5 and TPX2 in mitosis: Insight from CRISPR tagged cells. Cytoskeleton (Hoboken). 2018;: pubmed publisher
	Hsu W, Wang W, Lin W, Huang Y, Lai C, Liao J, et al. Adducin-1 is essential for spindle pole integrity through its interaction with TPX2. EMBO Rep. 2018;19: pubmed publisher
	Manukyan A, Sargsyan L, Parsons S, Stukenberg P. P190RhoGAP prevents mitotic spindle fragmentation and is required to activate Aurora A kinase at acentriolar poles. Chromosoma. 2018;127:375-386 pubmed publisher
	Park J, Kwon M, Kim E, Lee H, Song E. USP35 regulates mitotic progression by modulating the stability of Aurora B. Nat Commun. 2018;9:688 pubmed publisher
	Connell M, Chen H, Jiang J, Kuan C, Fotovati A, Chu T, et al. HMMR acts in the PLK1-dependent spindle positioning pathway and supports neural development. elife. 2017;6: pubmed publisher
	Mann B, Balchand S, Wadsworth P. Regulation of Kif15 localization and motility by the C-terminus of TPX2 and microtubule dynamics. Mol Biol Cell. 2017;28:65-75 pubmed publisher
	Lee S, Kim E, Kim K, Lee K. Bcl2l10, a new Tpx2 binding partner, is a master regulator of Aurora kinase A in mouse oocytes. Cell Cycle. 2016;15:3296-3305 pubmed
	Franciosi F, Manandhar S, Conti M. FSH Regulates mRNA Translation in Mouse Oocytes and Promotes Developmental Competence. Endocrinology. 2016;157:872-82 pubmed publisher
	Winkler C, De Munter S, Van Dessel N, Lesage B, Heroes E, Boens S, et al. The selective inhibition of protein phosphatase-1 results in mitotic catastrophe and impaired tumor growth. J Cell Sci. 2015;128:4526-37 pubmed publisher
	Barr A, Bakal C. A sensitised RNAi screen reveals a ch-TOG genetic interaction network required for spindle assembly. Sci Rep. 2015;5:10564 pubmed publisher

product information

brand :

Novus Biologicals, a Bio-Techne Brand

catalog number base :

NB500-179

SKU :

NB500-179

product name :

TPX2 Antibody

Description :

The TPX2 Antibody from Novus is a rabbit polyclonal antibody to TPX2. This antibody reacts with human, mouse, rat, porcine, mammal. The TPX2 Antibody has been validated for the following applications: Western Blot, Simple Western, Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Immunoprecipitation, Knockdown Validated.

target :

TPX2

category :

Primary Antibodies

unit size :

0.1 ml (also 0.025 ml)

buffer :

Whole antisera

clonality :

Polyclonal

conjugate :

Unconjugated

host :

Rabbit

immunogen :

A recombinant segment of the C-terminal domain of human TPX2 [UniProt# Q9ULW0]

isotype :

IgG

purity :

Unpurified

species :

Human, Mouse, Rat, Porcine, Mammal

theoretical molecular weight :

100 kDa

gene symbol :

TPX2

accessionNumbers :

Q9ULW0

applications :

Western Blot, Simple Western, Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Immunoprecipitation, Knockdown Validated

USD :

399 USD

alt names :

C20orf1HCTP4, C20orf2, chromosome 20 open reading frame 1, Differentially expressed in cancerous and non-cancerous lung cells 2, differentially expressed in lung cells, DIL2, DIL-2FLS353, HCA519, Hepatocellular carcinoma-associated antigen 519, P100, p100GD:C20orf1, preferentially expressed in colorectal cancer, Protein fls353, REPP86, restricted expression proliferation associated protein 100, Restricted expression proliferation-associated protein 100, targeting protein for Xklp2, TPX2, microtubule-associated protein homolog, TPX2, microtubule-associated, homolog (Xenopus laevis)

storage :

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

more info or order :

Novus Biologicals product webpage