product summary
request information :
company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
Rabbit Polyclonal Numb Antibody
catalog :
NB500-178H
quantity :
0.1 ml
price :
319.00 USD
clonality :
polyclonal
host :
rabbit
conjugate :
HRP
reactivity :
human, mouse, chicken
application :
western blot
more info or order :
Novus Biologicals product webpage
product information
Catalog Number :
NB500-178H
Product Name :
Rabbit Polyclonal Numb Antibody
List Price :
319.00 USD
Product Type :
Primary Antibodies
Package Size :
0.1 ml
AltNames :
h-Numb, numb (Drosophila) homolog, numb homolog (Drosophila), protein numb homolog, Protein S171, S171
Background :
Numb is an evolutionarily conserved membrane-associated protein. It exists in four isoforms that differ in two functional domains: a phosphotyrosine-binding (PTB) domain and a proline-rich region (PRR). It plays a role in the control of cell fate decisions during development and antagonizes the actions of Notch. Numb proteins appear to control the self-renewal of all neural progenitor cells and could possibly play similar roles in stem-cell maintenance in other tissues.
Buffer :
PBS
Clonality :
Polyclonal
Conjugate :
HRP
Application Summary :
Western Blot
Host :
Rabbit
Immunogen :
A synthetic peptide made to a C-terminal region of mouse NUMB (between residues 600-653). [UniProt# Q9QZS3]
Localization :
Membrane-associated
Preservative :
No Preservative
Purity :
Immunogen affinity purified
CrossReactivity :
Human, mouse and chicken. Immunogen sequence has 90% identity to rat.
Specificity :
This is specific for all four isoforms of the NUMB protein.
Storage :
Store at 4C in the dark.
Uses :
This NUMB antibody is useful for Western blot and Immunocytochemistry/Immunofluorescence. In WB one may see any or all of the four isoforms. The molecular weight of human and mouse NUMB is 72 kDa (isoform 1), 66 kDa (isoform 2), 71 kDa (isoform 3), and 65 kDa (isoform 4). Multiple non-specific bands may be seen with lower dilutions and/or longer exposure times than suggested in the protocol we used to obtain our data.
Research Area :
Cell Cycle and Replication, Growth and Development, Neuronal Cell Markers, Neuroscience, Stem Cell Markers
more info or order :
Novus Biologicals product webpage
company information
Novus Biologicals
8100 Southpark Way, A-8
Littleton, CO 80120
novus@novusbio.com
www.novusbio.com
3037301950
headquarters: USA
The mission of Novus Biologicals, LLC is to accelerate scientific discovery by developing and marketing unique products in the forefront of science. Novus Biologicals was organized to provide the biological research community with a mechanism for commercializing unique biological materials. We also focus on continually monitoring scientific trends and supply materials to serve these trends. By making these products widely available to institutional and commercial researchers, Novus Biologicals plays an important role in furthering biological research. All of Novus Biologicals products are supplied with detailed technical information and ongoing support. By serving niche and emerging markets, Novus Biologicals has become specialists in markets and has formed and will continue to form ongoing partnerships with our customers.