product summary
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company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
NuMA Antibody
catalog :
NB500-174
quantity :
0.1 ml (also 0.025 ml)
price :
399 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
citations: 29
Published Application/Species/Sample/DilutionReference
  • immunocytochemistry; human; 1:100; loading ...; fig s5a
Mahale S, Kumar M, Sharma A, Babu A, Ranjan S, Sachidanandan C, et al. The Light Intermediate Chain 2 Subpopulation of Dynein Regulates Mitotic Spindle Orientation. Sci Rep. 2016;6:22 pubmed publisher
Chen Q, Weng K, Lin M, Jiang M, Fang Y, Chung S, et al. SOX9 Modulates the Transformation of Gastric Stem Cells Through Biased Symmetric Cell Division. Gastroenterology. 2023;164:1119-1136.e12 pubmed publisher
Pascal A, Gallaud E, Giet R, Benaud C. Annexin A2 and Ahnak control cortical NuMA-dynein localization and mitotic spindle orientation. J Cell Sci. 2022;135: pubmed publisher
Serra Marques A, Houtekamer R, Hintzen D, Canty J, Yildiz A, Dumont S. The mitotic protein NuMA plays a spindle-independent role in nuclear formation and mechanics. J Cell Biol. 2020;219: pubmed publisher
Tsutaho A, Hashimoto A, Hashimoto S, Hata S, Kachi S, Hirano S, et al. High expression of AMAP1, an ARF6 effector, is associated with elevated levels of PD-L1 and fibrosis of pancreatic cancer. Cell Commun Signal. 2020;18:101 pubmed publisher
Li Z, Zhang C, Du J, Zhao J, Shi M, Jin M, et al. Adipocytes promote tumor progression and induce PD-L1 expression via TNF-α/IL-6 signaling. Cancer Cell Int. 2020;20:179 pubmed publisher
Sosunov A, Wu X, McGovern R, Mikell C, McKhann G, Goldman J. Abnormal mitosis in reactive astrocytes. Acta Neuropathol Commun. 2020;8:47 pubmed publisher
Wang Y, Stear J, Swain A, Xu X, Bryce N, Carnell M, et al. Drug Targeting the Actin Cytoskeleton Potentiates the Cytotoxicity of Low Dose Vincristine by Abrogating Actin-Mediated Repair of Spindle Defects. Mol Cancer Res. 2020;18:1074-1087 pubmed publisher
Liu C, Ma Z, Cai Z, Zhang F, Liu C, Chen T, et al. Identification of primordial germ cell-like cells as liver metastasis initiating cells in mouse tumour models. Cell Discov. 2020;6:15 pubmed publisher
Gemble S, Simon A, Pennetier C, Dumont M, Hervé S, Meitinger F, et al. Centromere Dysfunction Compromises Mitotic Spindle Pole Integrity. Curr Biol. 2019;29:3072-3080.e5 pubmed publisher
Yang Q, Peng J, Shi K, Xiao Y, Liu Q, Han R, et al. Rationally designed peptide-conjugated gold/platinum nanosystem with active tumor-targeting for enhancing tumor photothermal-immunotherapy. J Control Release. 2019;308:29-43 pubmed publisher
Wang X, Wu W, Gao J, Li Z, Dong B, Lin X, et al. Autophagy inhibition enhances PD-L1 expression in gastric cancer. J Exp Clin Cancer Res. 2019;38:140 pubmed publisher
Hueschen C, Galstyan V, Amouzgar M, Phillips R, Dumont S. Microtubule End-Clustering Maintains a Steady-State Spindle Shape. Curr Biol. 2019;29:700-708.e5 pubmed publisher
Chakrabarti J, Holokai L, Syu L, Steele N, Chang J, Wang J, et al. Hedgehog signaling induces PD-L1 expression and tumor cell proliferation in gastric cancer. Oncotarget. 2018;9:37439-37457 pubmed publisher
Xing Y, Mi C, Wang Z, Zhang Z, Li M, Zuo H, et al. Fraxinellone has anticancer activity in vivo by inhibiting programmed cell death-ligand 1 expression by reducing hypoxia-inducible factor-1α and STAT3. Pharmacol Res. 2018;135:166-180 pubmed publisher
Maisel K, Merrilees M, Atochina Vasserman E, Lian L, Obraztsova K, Rue R, et al. Immune Checkpoint Ligand PD-L1 is Upregulated in Pulmonary Lymphangioleiomyomatosis (LAM). Am J Respir Cell Mol Biol. 2018;: pubmed publisher
Zhang P, Liu J, Li W, Li S, Han X. Lactoferricin B reverses cisplatin resistance in head and neck squamous cell carcinoma cells through targeting PD-L1. Cancer Med. 2018;: pubmed publisher
He H, Zhou Y, Zhou Y, Zhuang J, He X, Wang S, et al. Dexmedetomidine mitigates microglia-mediated neuroinflammation through up-regulation of programmed cell death protein 1 in a rat spinal cord injury model. J Neurotrauma. 2018;: pubmed publisher
Sun J, Lian M, Ma H, Wang R, Ma Z, Wang H, et al. Competing endogenous RNA network analysis of CD274, IL‑10 and FOXP3 co‑expression in laryngeal squamous cell carcinoma. Mol Med Rep. 2018;17:3859-3869 pubmed publisher
Hueschen C, Kenny S, Xu K, Dumont S. NuMA recruits dynein activity to microtubule minus-ends at mitosis. elife. 2017;6: pubmed publisher
D Arrigo P, Russo M, Rea A, Tufano M, Guadagno E, Del Basso De Caro M, et al. A regulatory role for the co-chaperone FKBP51s in PD-L1 expression in glioma. Oncotarget. 2017;8:68291-68304 pubmed publisher
di Pietro F, Valon L, Li Y, Goïame R, Genovesio A, Morin X. An RNAi Screen in a Novel Model of Oriented Divisions Identifies the Actin-Capping Protein Z ? as an Essential Regulator of Spindle Orientation. Curr Biol. 2017;27:2452-2464.e8 pubmed publisher
Elting M, Prakash M, Udy D, Dumont S. Mapping Load-Bearing in the Mammalian Spindle Reveals Local Kinetochore Fiber Anchorage that Provides Mechanical Isolation and Redundancy. Curr Biol. 2017;27:2112-2122.e5 pubmed publisher
Gravelle P, Burroni B, Péricart S, Rossi C, Bezombes C, Tosolini M, et al. Mechanisms of PD-1/PD-L1 expression and prognostic relevance in non-Hodgkin lymphoma: a summary of immunohistochemical studies. Oncotarget. 2017;8:44960-44975 pubmed publisher
Decarreau J, Wagenbach M, Lynch E, Halpern A, Vaughan J, KOLLMAN J, et al. The tetrameric kinesin Kif25 suppresses pre-mitotic centrosome separation to establish proper spindle orientation. Nat Cell Biol. 2017;19:384-390 pubmed publisher
Bronchud M, Tresserra F, Xu W, Warren S, Cusidó M, Zantop B, et al. Placental immune editing switch (PIES): learning about immunomodulatory pathways from a unique case report. Oncotarget. 2016;7:83817-83827 pubmed publisher
Serçin Ã, Larsimont J, Karambelas A, Marthiens V, Moers V, Boeckx B, et al. Transient PLK4 overexpression accelerates tumorigenesis in p53-deficient epidermis. Nat Cell Biol. 2016;18:100-10 pubmed publisher
Kaneko Y, Suenaga Y, Islam S, Matsumoto D, Nakamura Y, Ohira M, et al. Functional interplay between MYCN, NCYM, and OCT4 promotes aggressiveness of human neuroblastomas. Cancer Sci. 2015;106:840-7 pubmed publisher
Aguilar L, Shirley L, Chung V, Marsh C, Walker J, Coyle W, et al. Gene-mediated cytotoxic immunotherapy as adjuvant to surgery or chemoradiation for pancreatic adenocarcinoma. Cancer Immunol Immunother. 2015;64:727-36 pubmed publisher
product information
brand :
Novus Biologicals, a Bio-Techne Brand
catalog number base :
NB500-174
SKU :
NB500-174
product name :
NuMA Antibody
Description :
The NuMA Antibody from Novus is a rabbit polyclonal antibody to NuMA. This antibody reacts with human, mouse, rat, mammal, marsupial, primate. The NuMA Antibody has been validated for the following applications: Western Blot, Simple Western, Immunohistochemistry, Immunocytochemistry/ Immunofluorescence, Immunoprecipitation, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen.
target :
NuMA
category :
Primary Antibodies
unit size :
0.1 ml (also 0.025 ml)
buffer :
Whole antisera
clonality :
Polyclonal
conjugate :
Unconjugated
host :
Rabbit
immunogen :
Full-length recombinant human NuMA expressed in insect Sf9 cells using baculovirus expression system, then purified to near homogeneity prior to immunization.
isotype :
IgG
purity :
Unpurified
species :
Human, Mouse, Rat, Mammal, Marsupial, Primate
gene symbol :
NUMA1
accessionNumbers :
Q14980
applications :
Western Blot, Simple Western, Immunohistochemistry, Immunocytochemistry/ Immunofluorescence, Immunoprecipitation, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen
USD :
399 USD
alt names :
centrophilin stabilizes mitotic spindle in mitotic cells, nuclear mitotic apparatus protein 1, NUMA, NuMA protein, SP-H antigen, structural nuclear protein
storage :
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
more info or order :
company information
Novus Biologicals
10771 E Easter Ave
Centennial, CO 80112
novus@novusbio.com
https://www.novusbio.com
3037301950
headquarters: USA
Novus Biologicals licenses, manufactures, and markets antibodies to over 20,000 unique targets to support a wide array of research areas. Novus is built on honesty, collaboration and strong relationships and continues to provide quality tools that accelerate research. Every product is backed by our 100% guarantee.