product summary
request information :
company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
Rat Monoclonal ABCA7 Antibody
catalog :
NB400-163PE
quantity :
0.1 ml
price :
309.00 USD
clonality :
monoclonal
host :
rat
conjugate :
PE
reactivity :
human, mouse
application :
flow cytometry
more info or order :
Novus Biologicals product webpage
product information
Catalog Number :
NB400-163PE
Product Name :
Rat Monoclonal ABCA7 Antibody
List Price :
309.00 USD
Product Type :
Primary Antibodies
Package Size :
0.1 ml
AltNames :
EC 2.2.1.1, EC 3.6.3, EC 3.6.3.41, FLJ40025, Macrophage ABC transporter, ABCA-SSN, ABCXATP-binding cassette sub-family A member 7, ATP-binding cassette, sub-family A (ABC1), member 7, Autoantigen SS-N
Background :
ABCA7 (ATP-binding cassette sub-family A member 7) belongs to "A" subfamily of ABC transporters that predominantly transport lipids and other lipophilic molecules across membranes. ABCA7 shows higher expression in brain, lung, adrenal gland and spleen as well as hematopoietic tissues. It localizes to cell membrane ruffles/phagocytic cups of activated macrophages; to cytoplasm (Golgi and endosomes) of resting macrophages, and to the apical brush border of cells in the proximal tubules of kidney. It is also detected in both the plasma membrane and in intracellular compartments in myelo-lymphatic tissues (peripheral leukocytes, thymus, spleen, and bone marrow). ABCA7 facilitates the transport of phospholipids and, to a lesser extent, cholesterol, across cell membranes to extracellular apoAI and apoE discoidal lipoprotein complexes. Moreover, it implicates in macrophages mediated phagocytosis of apoptotic cells, and binds APOA1 for involving in apolipoprotein-mediated phospholipid efflux from cells. ABCA7 also mediate cholesterol efflux, and can regulate the cellular ceramide homeostasis during keratinocytes differentiation.
Buffer :
PBS
Clonality :
Monoclonal
Clone :
7A1-144
Conjugate :
PE
Application Summary :
Flow Cytometry
Host :
Rat
Immunogen :
Mouse ABCA7 stably-transfected HeLa cells. [UniProt# Q91V24]
Isotype :
IgG2a Kappa
Localization :
Cell Membrane and Cytoplasmic
Preservative :
No Preservative
Purity :
Protein G purified
CrossReactivity :
Mouse
Storage :
Store at 4C in the dark.
TMW :
240 kDa
Uses :
This ABCA7 antibody is useful for Flow Cytometry and Western Blot, where a band is observed at ~240 kDa. This ABCA7 antibody is not reactive in ELISA.
Research Area :
ABC Transporters, Astrocyte Markers, Cellular Markers, Cholesterol Metabolism, Glia Markers, Golgi Apparatus Markers, Lipid and Metabolism, Neuroscience, Plasma Membrane Markers, Signal Transduction
more info or order :
Novus Biologicals product webpage
company information
Novus Biologicals
8100 Southpark Way, A-8
Littleton, CO 80120
novus@novusbio.com
www.novusbio.com
3037301950
headquarters: USA
The mission of Novus Biologicals, LLC is to accelerate scientific discovery by developing and marketing unique products in the forefront of science. Novus Biologicals was organized to provide the biological research community with a mechanism for commercializing unique biological materials. We also focus on continually monitoring scientific trends and supply materials to serve these trends. By making these products widely available to institutional and commercial researchers, Novus Biologicals plays an important role in furthering biological research. All of Novus Biologicals products are supplied with detailed technical information and ongoing support. By serving niche and emerging markets, Novus Biologicals has become specialists in markets and has formed and will continue to form ongoing partnerships with our customers.