product summary
request information :
company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
Rabbit Polyclonal FXR/NR1H4 Antibody
catalog :
NB400-153R
quantity :
0.1 ml
price :
329.00 USD
clonality :
polyclonal
host :
rabbit
conjugate :
DyLight 550
reactivity :
human
application :
western blot
more info or order :
Novus Biologicals product webpage
product information
Catalog Number :
NB400-153R
Product Name :
Rabbit Polyclonal FXR/NR1H4 Antibody
List Price :
329.00 USD
Product Type :
Primary Antibodies
Package Size :
0.1 ml
AltNames :
farnesoid X receptor, Farnesoid X-activated receptor, Farnesol receptor HRR-1, FXRBAR, HRR-1, HRR1MGC163445, Nuclear receptor subfamily 1 group H member 4, nuclear receptor subfamily 1, group H, member 4, Retinoid X receptor-interacting protein 14, RIP14RXR-interacting protein 14, bile acid receptor
Background :
The steroid receptor superfamily acts through direct association with DNA sequences known as hormone response elements (HREs) and bind DNA as either homo- or heterodimers. The promiscuous mediator of heterodimerization, RXR, is the receptor for 9-cis retinoic acid, and dimerizes with VDR, TR, PPAR, as well as several novel receptors including LXR (also referred to as RLD-1) and FXR. FXR and LXR fall into a category of proteins termed "orphan receptors" because of their lack of a defined function, and in the case of LXR, the lack of a defined ligand. FXR has been shown to bind a class of lipid molecules called farnesoids. LXR/RXR heterodimers have highest affinity for DR-4 DNA elements while FXR/RXR heterodimers bind IR-1 elements. Both LXR/RXR and FXR/RXR heterodimers retain their responsiveness to 9-cis retinoic acid.
Buffer :
50mM sodium borate
Clonality :
Polyclonal
Conjugate :
DyLight 550
Application Summary :
Western Blot
Host :
Rabbit
Immunogen :
A synthetic peptide made to the C-terminus of the human FXR protein. [UniProt# Q96RI1]
Localization :
Cytoplasmic, nuclear
Preservative :
No Preservative
Purity :
Immunogen affinity purified
CrossReactivity :
Human
Storage :
Store at 4C in the dark.
TMW :
66 kDa
Uses :
This FXR antibody is useful for Immunocytochemistry/Immunofluorescence and Western blot analysis, where a band is seen at ~66 kDa. In ICC/IF nuclear and cytoplasmic staining was observed.
Research Area :
Cancer, Chromatin Research, Lipid and Metabolism, Signal Transduction
more info or order :
Novus Biologicals product webpage
company information
Novus Biologicals
8100 Southpark Way, A-8
Littleton, CO 80120
novus@novusbio.com
www.novusbio.com
3037301950
headquarters: USA
The mission of Novus Biologicals, LLC is to accelerate scientific discovery by developing and marketing unique products in the forefront of science. Novus Biologicals was organized to provide the biological research community with a mechanism for commercializing unique biological materials. We also focus on continually monitoring scientific trends and supply materials to serve these trends. By making these products widely available to institutional and commercial researchers, Novus Biologicals plays an important role in furthering biological research. All of Novus Biologicals products are supplied with detailed technical information and ongoing support. By serving niche and emerging markets, Novus Biologicals has become specialists in markets and has formed and will continue to form ongoing partnerships with our customers.