product summary
request information :
company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
Mouse Monoclonal Insulin R/CD220 Antibody
catalog :
NB400-142F
quantity :
0.1 ml
price :
299 USD
clonality :
monoclonal
host :
mouse
conjugate :
FITC
reactivity :
human, rat, mouse
application :
ELISA, western blot, immunoprecipitation, neutralization
more info or order :
Novus Biologicals product webpage
product information
Catalog Number :
NB400-142F
Product Name :
Mouse Monoclonal Insulin R/CD220 Antibody
List Price :
299 USD
Product Type :
Primary Antibodies
Package Size :
0.1 ml
AltNames :
CD 220, CD220, CD220 antigen, EC 2.7.10, EC 2.7.10.1, HHF5, insulin receptor, IR
Background :
Insulin receptor (INSR) is a receptor tyrosine kinase which is well known for its regulatory role in peripheral glucose metabolism. INSR contain disulfide bridged 135-kD alpha subunits (extracellular ligand binding portion) and 95-kD beta subunit (an extracellular, a single transmembrane, and an intracellular kinase domain). During signaling, ligand binding to alpha subunits activates the intrinsic kinase activity located in the beta subunits and subsequently initiates a cascade of phosphorylation events leading to various biological functions. Unlike other RTKs, INSR's most activities require accessory molecules called insulin receptor substrates (IRSs) e.g. example IRS1-4 is required to engage multiple downstream signaling. INSR kinase can activate two major cellular signaling pathways, PI3K/Akt and Ras/MAPK, which regulate diverse cellular processes including gene expression, protein synthesis, and vesicle trafficking, which result in the regulation of glucose, lipid and protein metabolism, cell growth and differentiation. Defects in INSR have been linked to several pathologies including Rabson-Mendenhall syndrome (RMS), leprechaunism (LEPRCH), noninsulin-dependent diabetes mellitus (NIDDM), familial hyperinsulinemic hypoglycemia type 5 (HHF5) and insulin-resistant diabetes mellitus with acanthosis nigricans type A (IRAN type A).
Buffer :
50mM sodium borate
Clonality :
Monoclonal
Clone :
MA-20
Concentration :
1.2 mg/ml
Conjugate :
FITC
Application Summary :
Western Blot, Blocking/Neutralizing, ELISA, Immunoprecipitation
Host :
Mouse
Immunogen :
Highly purified Insulin Receptor (alpha-subunit) from human term placentas. [UniProt# P06213]
Isotype :
IgG2b
Localization :
Membrane; single pass type I membrane protein.
Preservative :
No Preservative
Purity :
Protein G purified
CrossReactivity :
Human and rat. Mouse reactivity reported in scientific literature (PMID: 24389353)
Storage :
Store at 4C in the dark.
Swissprot Human :
P06213
Uses :
This Insulin Receptor (MA-20) antibody is useful for ELISA, Immunoprecipitation, Western blot and Blocking/Neutralizing assays.
Research Area :
Diabetes Research, Lipid and Metabolism, Neuroscience, Nutrient Sensing in the Brain, Phospho Specific, Protein Kinase, Signal Transduction, Tyrosine Kinases
more info or order :
Novus Biologicals product webpage
company information
Novus Biologicals
8100 Southpark Way, A-8
Littleton, CO 80120
novus@novusbio.com
www.novusbio.com
3037301950
headquarters: USA
The mission of Novus Biologicals, LLC is to accelerate scientific discovery by developing and marketing unique products in the forefront of science. Novus Biologicals was organized to provide the biological research community with a mechanism for commercializing unique biological materials. We also focus on continually monitoring scientific trends and supply materials to serve these trends. By making these products widely available to institutional and commercial researchers, Novus Biologicals plays an important role in furthering biological research. All of Novus Biologicals products are supplied with detailed technical information and ongoing support. By serving niche and emerging markets, Novus Biologicals has become specialists in markets and has formed and will continue to form ongoing partnerships with our customers.