product summary
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company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
Niemann-Pick type C1 Like-1 Antibody - BSA Free
catalog :
NB400-128
quantity :
0.1 ml (also 0.025 ml)
price :
409 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunoprecipitation, immunohistochemistry - paraffin section
more info or order :
citations: 41
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; 1:1000; loading ...; fig s4a
Zhang Z, Wen H, Peng B, Weng J, Zeng F. HFD-induced TRAF6 upregulation promotes liver cholesterol accumulation and fatty liver development via EZH2-mediated miR-429/PPARα axis. Mol Ther Nucleic Acids. 2021;24:711-727 pubmed publisher
Toyoda Y, Takada T, Umezawa M, Tomura F, Yamanashi Y, Takeda K, et al. Identification of hepatic NPC1L1 as an NAFLD risk factor evidenced by ezetimibe-mediated steatosis prevention and recovery. FASEB Bioadv. 2019;1:283-295 pubmed publisher
Na Y, Jung D, Song J, Park J, Seok S. Pyruvate dehydrogenase kinase is a negative regulator of interleukin-10 production in macrophages. J Mol Cell Biol. 2020;: pubmed publisher
Toyoda Y, Takada T, Yamanashi Y, Suzuki H. Pathophysiological importance of bile cholesterol reabsorption: hepatic NPC1L1-exacerbated steatosis and decreasing VLDL-TG secretion in mice fed a high-fat diet. Lipids Health Dis. 2019;18:234 pubmed publisher
Jebessa Z, Shanmukha Kumar D, Dewenter M, Lehmann L, Xu C, Schreiter F, et al. The lipid droplet-associated protein ABHD5 protects the heart through proteolysis of HDAC4. Nat Metab. 2019;1:1157-1167 pubmed publisher
Lu H, Lu Y, Xie Y, Qiu S, Li X, Fan Z. Rational combination with PDK1 inhibition overcomes cetuximab resistance in head and neck squamous cell carcinoma. JCI Insight. 2019;4: pubmed publisher
Jiang H, Jin J, Duan Y, Xie Z, Li Y, Gao A, et al. Mitochondrial Uncoupling Coordinated With PDH Activation Safely Ameliorates Hyperglycemia via Promoting Glucose Oxidation. Diabetes. 2019;68:2197-2209 pubmed publisher
Li J, Zhu X, Wang H, Lee C, Chen S, Qian Y, et al. Akt1-mediated CPR cooling protection targets regulators of metabolism, inflammation and contractile function in mouse cardiac arrest. PLoS ONE. 2019;14:e0220604 pubmed publisher
Yamamoto H, Yamanashi Y, Takada T, Mu S, Tanaka Y, Komine T, et al. Hepatic Expression of Niemann-Pick C1-Like 1, a Cholesterol Reabsorber from Bile, Exacerbates Western Diet-Induced Atherosclerosis in LDL Receptor Mutant Mice. Mol Pharmacol. 2019;96:47-55 pubmed publisher
Thapa D, Zhang M, Manning J, Guimaraes D, Stoner M, Lai Y, et al. Loss of GCN5L1 in cardiac cells limits mitochondrial respiratory capacity under hyperglycemic conditions. Physiol Rep. 2019;7:e14054 pubmed publisher
Zhong W, Xu M, Li C, Zhu B, Cao X, Li D, et al. ORP4L Extracts and Presents PIP2 from Plasma Membrane for PLCβ3 Catalysis: Targeting It Eradicates Leukemia Stem Cells. Cell Rep. 2019;26:2166-2177.e9 pubmed publisher
Meng Z, Gwag T, Sui Y, Park S, Zhou X, Zhou C. The atypical antipsychotic quetiapine induces hyperlipidemia by activating intestinal PXR signaling. JCI Insight. 2019;4: pubmed publisher
Zhuang Y, Ly R, Frazier C, Yu J, Qin S, Fan X, et al. The novel function of tumor protein D54 in regulating pyruvate dehydrogenase and metformin cytotoxicity in breast cancer. Cancer Metab. 2019;7:1 pubmed publisher
Ontawong A, Duangjai A, Muanprasat C, Pasachan T, Pongchaidecha A, Amornlerdpison D, et al. Lipid-lowering effects of Coffea arabica pulp aqueous extract in Caco-2 cells and hypercholesterolemic rats. Phytomedicine. 2019;52:187-197 pubmed publisher
Kwong J, Huo J, Bround M, Boyer J, Schwanekamp J, Ghazal N, et al. The mitochondrial calcium uniporter underlies metabolic fuel preference in skeletal muscle. JCI Insight. 2018;3: pubmed publisher
Deng Y, Deng Z, Hao H, Wu X, Gao H, Tang S, et al. MicroRNA-23a promotes colorectal cancer cell survival by targeting PDK4. Exp Cell Res. 2018;373:171-179 pubmed publisher
Thapa D, Wu K, Stoner M, Xie B, Zhang M, Manning J, et al. The protein acetylase GCN5L1 modulates hepatic fatty acid oxidation activity via acetylation of the mitochondrial β-oxidation enzyme HADHA. J Biol Chem. 2018;293:17676-17684 pubmed publisher
Lemecha M, Morino K, Imamura T, Iwasaki H, Ohashi N, Ida S, et al. MiR-494-3p regulates mitochondrial biogenesis and thermogenesis through PGC1-α signalling in beige adipocytes. Sci Rep. 2018;8:15096 pubmed publisher
Gao Y, Zhou Z, Ren T, Kim S, He Y, Seo W, et al. Alcohol inhibits T-cell glucose metabolism and hepatitis in ALDH2-deficient mice and humans: roles of acetaldehyde and glucocorticoids. Gut. 2019;68:1311-1322 pubmed publisher
Ahn S, Jun D, Jang K, Lee B, Shin K. Duodenal Niemann-Pick C1-like 1 expression was negatively correlated with liver X receptor expression in nonalcoholic fatty liver disease. Korean J Intern Med. 2019;34:777-784 pubmed publisher
Menk A, Scharping N, Moreci R, Zeng X, Guy C, Salvatore S, et al. Early TCR Signaling Induces Rapid Aerobic Glycolysis Enabling Distinct Acute T Cell Effector Functions. Cell Rep. 2018;22:1509-1521 pubmed publisher
Xu S, Liu C, Xu W, Huang L, Zhao J, Zhao S. Butyrate induces apoptosis by activating PDC and inhibiting complex I through SIRT3 inactivation. Signal Transduct Target Ther. 2017;2:16035 pubmed publisher
Liu X, Zuo R, Bao Y, Qu X, Sun K, Ying H. Down-regulation of PDK4 is Critical for the Switch of Carbohydrate Catabolism during Syncytialization of Human Placental Trophoblasts. Sci Rep. 2017;7:8474 pubmed publisher
Gorga A, Rindone G, Regueira M, Pellizzari E, Camberos M, Cigorraga S, et al. PPARγ activation regulates lipid droplet formation and lactate production in rat Sertoli cells. Cell Tissue Res. 2017;369:611-624 pubmed publisher
Bhosale G, Sharpe J, Koh A, Kouli A, Szabadkai G, Duchen M. Pathological consequences of MICU1 mutations on mitochondrial calcium signalling and bioenergetics. Biochim Biophys Acta Mol Cell Res. 2017;1864:1009-1017 pubmed publisher
Jun J, Devera R, Unnikrishnan D, Shin M, Bevans Fonti S, Yao Q, et al. Adipose HIF-1α causes obesity by suppressing brown adipose tissue thermogenesis. J Mol Med (Berl). 2017;95:287-297 pubmed publisher
Zhong W, Yi Q, Xu B, Li S, Wang T, Liu F, et al. ORP4L is essential for T-cell acute lymphoblastic leukemia cell survival. Nat Commun. 2016;7:12702 pubmed publisher
Soayfane Z, Tercé F, Cantiello M, Robenek H, Nauze M, Bézirard V, et al. Exposure to dietary lipid leads to rapid production of cytosolic lipid droplets near the brush border membrane. Nutr Metab (Lond). 2016;13:48 pubmed publisher
Lu H, Li X, Lu Y, Qiu S, Fan Z. ASCT2 (SLC1A5) is an EGFR-associated protein that can be co-targeted by cetuximab to sensitize cancer cells to ROS-induced apoptosis. Cancer Lett. 2016;381:23-30 pubmed publisher
Rossi S, Windschüttl S, Matzkin M, Rey Ares V, Terradas C, Ponzio R, et al. Reactive oxygen species (ROS) production triggered by prostaglandin D2 (PGD2) regulates lactate dehydrogenase (LDH) expression/activity in TM4 Sertoli cells. Mol Cell Endocrinol. 2016;434:154-65 pubmed publisher
Kawase A, Hata S, Takagi M, Iwaki M. Pravastatin Modulate Niemann-Pick C1-Like 1 and ATP-Binding Cassette G5 and G8 to Influence Intestinal Cholesterol Absorption. J Pharm Pharm Sci. 2015;18:765-72 pubmed
Regueira M, Artagaveytia S, Galardo M, Pellizzari E, Cigorraga S, Meroni S, et al. Novel molecular mechanisms involved in hormonal regulation of lactate production in Sertoli cells. Reproduction. 2015;150:311-21 pubmed publisher
Zuo R, Gu X, Qi Q, Wang T, Zhao X, Liu J, et al. Warburg-like Glycolysis and Lactate Shuttle in Mouse Decidua during Early Pregnancy. J Biol Chem. 2015;290:21280-91 pubmed publisher
Hagopian K, Tomilov A, Kim K, Cortopassi G, Ramsey J. Key glycolytic enzyme activities of skeletal muscle are decreased under fed and fasted states in mice with knocked down levels of Shc proteins. PLoS ONE. 2015;10:e0124204 pubmed publisher
Sané A, Seidman E, Spahis S, Lamantia V, Garofalo C, Montoudis A, et al. New Insights In Intestinal Sar1B GTPase Regulation and Role in Cholesterol Homeostasis. J Cell Biochem. 2015;116:2270-82 pubmed publisher
Sui Y, Helsley R, Park S, Song X, Liu Z, Zhou C. Intestinal pregnane X receptor links xenobiotic exposure and hypercholesterolemia. Mol Endocrinol. 2015;29:765-76 pubmed publisher
Llorente Folch I, Rueda C, Pardo B, Szabadkai G, Duchen M, Satrustegui J. The regulation of neuronal mitochondrial metabolism by calcium. J Physiol. 2015;593:3447-62 pubmed publisher
Takada T, Yamanashi Y, Konishi K, Yamamoto T, Toyoda Y, Masuo Y, et al. NPC1L1 is a key regulator of intestinal vitamin K absorption and a modulator of warfarin therapy. Sci Transl Med. 2015;7:275ra23 pubmed publisher
Rellinger E, Romain C, Choi S, Qiao J, Chung D. Silencing gastrin-releasing peptide receptor suppresses key regulators of aerobic glycolysis in neuroblastoma cells. Pediatr Blood Cancer. 2015;62:581-6 pubmed publisher
Ho N, Coomber B. Pyruvate dehydrogenase kinase expression and metabolic changes following dichloroacetate exposure in anoxic human colorectal cancer cells. Exp Cell Res. 2015;331:73-81 pubmed publisher
Delaney L, Ho N, Morrison J, Farias N, Mosser D, Coomber B. Dichloroacetate affects proliferation but not survival of human colorectal cancer cells. Apoptosis. 2015;20:63-74 pubmed publisher
product information
master code :
NB400-128
SKU :
NB400-128
product name :
Niemann-Pick type C1 Like-1 Antibody - BSA Free
unit size :
0.1 ml (also 0.025 ml)
description :
The Niemann-Pick type C1 Like-1 Antibody - BSA Free from Novus is a rabbit polyclonal antibody to Niemann-Pick type C1 Like-1. This antibody reacts with human,mouse,rat. The Niemann-Pick type C1 Like-1 Antibody - BSA Free has been validated for the following applications: Immunoprecipitation,Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry.
target :
Niemann-Pick type C1 Like-1
category :
Primary Antibodies
buffer :
PBS
clonality :
Polyclonal
concentration :
1 mg/ml
conjugate :
Unconjugated
host :
Rabbit
immunogen :
A synthetic peptide made to an internal region of rat Niemann-Pick type C1 Like-1 (between residues 500-600). [Uniprot: Q6T3U3]
isotype :
IgG
purity :
Immunogen affinity purified
species :
Human,Mouse,Rat
theoretical molecular weight :
140 kDa
gene symbol :
NPC1L1
applications :
Immunoprecipitation,Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry
USD :
409 USD
alt names :
Niemann-Pick C1-like protein 1, NPC1 (Niemann-Pick disease, type C1, gene)-like 1, NPC11L1
storage :
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
more info or order :
company information
Novus Biologicals
10771 E Easter Ave
Centennial, CO 80112
novus@novusbio.com
https://www.novusbio.com
3037301950
headquarters: USA
Novus Biologicals licenses, manufactures, and markets antibodies to over 20,000 unique targets to support a wide array of research areas. Novus is built on honesty, collaboration and strong relationships and continues to provide quality tools that accelerate research. Every product is backed by our 100% guarantee.