product summary
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company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
ABCA1 Antibody - BSA Free
catalog :
NB400-105
quantity :
0.1 ml (also 0.025 ml)
price :
489 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
Alexa Fluor 532
clone name :
OTI2B3
reactivity :
human, mouse, rat, dogs, chicken, bovine
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, neutralization, immunoprecipitation, flow cytometry, EMSA, chromatin immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
citations: 186
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry; mouse; loading ...; fig 4d
  • western blot; mouse; loading ...; fig 4c
Brampton C, Pomozi V, Chen L, Apana A, McCurdy S, Zoll J, et al. ABCC6 deficiency promotes dyslipidemia and atherosclerosis. Sci Rep. 2021;11:3881 pubmed publisher
  • western blot; mouse; loading ...; fig 1f
Horie T, Nakao T, Miyasaka Y, Nishino T, Matsumura S, Nakazeki F, et al. microRNA-33 maintains adaptive thermogenesis via enhanced sympathetic nerve activity. Nat Commun. 2021;12:843 pubmed publisher
  • immunocytochemistry; mouse; loading ...; fig 7d
  • western blot; mouse; loading ...; fig 7b
Lv J, Wang H, Cui H, Liu Z, Zhang R, Lu M, et al. Blockade of Macrophage CD147 Protects Against Foam Cell Formation in Atherosclerosis. Front Cell Dev Biol. 2020;8:609090 pubmed publisher
  • western blot; mouse; loading ...; fig 5b
Casali B, Reed Geaghan E, Landreth G. Nuclear receptor agonist-driven modification of inflammation and amyloid pathology enhances and sustains cognitive improvements in a mouse model of Alzheimer's disease. J Neuroinflammation. 2018;15:43 pubmed publisher
  • western blot; human; loading ...; fig 5d
  • western blot; mouse; loading ...; fig 6d
Nelson J, Koenis D, Scheij S, Cook E, Moeton M, Santos A, et al. EEPD1 Is a Novel LXR Target Gene in Macrophages Which Regulates ABCA1 Abundance and Cholesterol Efflux. Arterioscler Thromb Vasc Biol. 2017;37:423-432 pubmed publisher
  • western blot; human; 1:500; fig 3a
Wang L, Palme V, Rotter S, Schilcher N, Cukaj M, Wang D, et al. Piperine inhibits ABCA1 degradation and promotes cholesterol efflux from THP-1-derived macrophages. Mol Nutr Food Res. 2017;61: pubmed publisher
  • western blot; bovine; 1:1000; loading ...; tbl 2
Ontsouka C, Huang X, Aliyev E, Albrecht C. In vitro characterization and endocrine regulation of cholesterol and phospholipid transport in the mammary gland. Mol Cell Endocrinol. 2017;439:35-45 pubmed publisher
  • western blot; mouse; loading ...; fig s5a
Conlon D, Thomas T, Fedotova T, Hernandez Ono A, Di Paolo G, Chan R, et al. Inhibition of apolipoprotein B synthesis stimulates endoplasmic reticulum autophagy that prevents steatosis. J Clin Invest. 2016;126:3852-3867 pubmed publisher
  • western blot; rat; fig 4
Zinkhan E, Zalla J, Carpenter J, Yu B, Yu X, Chan G, et al. Intrauterine growth restriction combined with a maternal high-fat diet increases hepatic cholesterol and low-density lipoprotein receptor activity in rats. Physiol Rep. 2016;4: pubmed publisher
  • western blot; mouse; loading ...; fig 1a
Hsieh J, Koseki M, Molusky M, Yakushiji E, Ichi I, Westerterp M, et al. TTC39B deficiency stabilizes LXR reducing both atherosclerosis and steatohepatitis. Nature. 2016;535:303-7 pubmed publisher
  • western blot; mouse; 1:1000; fig 3
  • western blot; human; 1:1000; fig 3
Fournier N, Tardivel S, Benoist J, Vedie B, Rousseau Ralliard D, Nowak M, et al. Eicosapentaenoic acid membrane incorporation impairs ABCA1-dependent cholesterol efflux via a protein kinase A signaling pathway in primary human macrophages. Biochim Biophys Acta. 2016;1861:331-41 pubmed publisher
Tsaousidou E, Chrzanowski J, Dran xe9 P, Lee G, Bahour N, Wang Z, et al. Endogenous p53 inhibitor TIRR dissociates systemic metabolic health from oncogenic activity. Cell Rep. 2024;43:114337 pubmed publisher
Vladimir de la Rosa J, Tabraue C, Huang Z, Orizaola M, Martin Rodr xed guez P, Steffensen K, et al. Reprogramming of the LXRα Transcriptome Sustains Macrophage Secondary Inflammatory Responses. Adv Sci (Weinh). 2024;11:e2307201 pubmed publisher
Steinbauer S, K xf6 nig A, Neuhauser C, Schwarzinger B, Stangl H, Iken M, et al. Elder (Sambucus nigra), identified by high-content screening, counteracts foam cell formation without promoting hepatic lipogenesis. Sci Rep. 2024;14:3547 pubmed publisher
Sheng R, Li Y, Wu Y, Liu C, Wang W, Han X, et al. A pan-PPAR agonist E17241 ameliorates hyperglycemia and diabetic dyslipidemia in KKAy mice via up-regulating ABCA1 in islet, liver, and white adipose tissue. Biomed Pharmacother. 2024;172:116220 pubmed publisher
Mao M, Deng Y, Wang L, Zhao G, Qi R, Gong H, et al. Chronic unpredictable mild stress promotes atherosclerosis via adipose tissue dysfunction in ApoE-/- mice. Peerj. 2023;11:e16029 pubmed publisher
Wiener J, Desire S, Garliyev V, Lyssenko Iii N, Pratic xf2 D, Lyssenko N. Down-Regulation of ABCA7 in Human Microglia, Astrocyte and THP-1 Cell Lines by Cholesterol Depletion, IL-1β and TNFα, or PMA. Cells. 2023;12: pubmed publisher
Resetar M, Tietcheu Galani B, Tsamo A, Chen Y, Schachner D, Stolzlechner S, et al. Flindissone, a Limonoid Isolated from Trichilia prieuriana, Is an LXR Agonist. J Nat Prod. 2023;86:1901-1909 pubmed publisher
Liu S, Zhang Y, Zheng X, Wang Z, Wang P, Zhang M, et al. Sulforaphane Inhibits Foam Cell Formation and Atherosclerosis via Mechanisms Involving the Modulation of Macrophage Cholesterol Transport and the Related Phenotype. Nutrients. 2023;15: pubmed publisher
Molina Gonzalez I, Holloway R, Jiwaji Z, Dando O, Kent S, Emelianova K, et al. Astrocyte-oligodendrocyte interaction regulates central nervous system regeneration. Nat Commun. 2023;14:3372 pubmed publisher
Miyagawa S, Horie T, Nishino T, Koyama S, Watanabe T, Baba O, et al. Inhibition of microRNA-33b in humanized mice ameliorates nonalcoholic steatohepatitis. Life Sci Alliance. 2023;6: pubmed publisher
Cao D, Khan Z, Li X, Saito S, Bernstein E, Victor A, et al. Macrophage angiotensin-converting enzyme reduces atherosclerosis by increasing peroxisome proliferator-activated receptor α and fundamentally changing lipid metabolism. Cardiovasc Res. 2023;119:1825-1841 pubmed publisher
Dragoljevic D, Lee M, Pernes G, Morgan P, Louis C, Shihata W, et al. Administration of an LXR agonist promotes atherosclerotic lesion remodelling in murine inflammatory arthritis. Clin Transl Immunology. 2023;12:e1446 pubmed publisher
Cashikar A, Toral Rios D, Timm D, Romero J, Strickland M, Long J, et al. Regulation of astrocyte lipid metabolism and ApoE secretionby the microglial oxysterol, 25-hydroxycholesterol. J Lipid Res. 2023;64:100350 pubmed publisher
Li Z, He M, Chen G, Worgall T, Jiang X. Effect of Total Sphingomyelin Synthase Activity on Low Density Lipoprotein Catabolism in Mice. bioRxiv. 2023;: pubmed publisher
Yalcınkaya M, Fotakis P, Liu W, Endo Umeda K, Dou H, Abramowicz S, et al. Cholesterol accumulation in macrophages drives NETosis in atherosclerotic plaques via IL-1β secretion. Cardiovasc Res. 2023;119:969-981 pubmed publisher
Wang H, Zheng A, Arias E, Cartee G. Prior AICAR induces elevated glucose uptake concomitant with greater γ3-AMPK activation and reduced membrane cholesterol in skeletal muscle from 26-month-old rats. Facets (Ott). 2022;7:774-791 pubmed publisher
Papotti B, Adorni M, Marchi C, Zimetti F, Ronda N, Panighel G, et al. PCSK9 Affects Astrocyte Cholesterol Metabolism and Reduces Neuron Cholesterol Supplying In Vitro: Potential Implications in Alzheimer's Disease. Int J Mol Sci. 2022;23: pubmed publisher
Cassim Bawa F, Gopoju R, Xu Y, Hu S, Zhu Y, Chen S, et al. Retinoic Acid Receptor Alpha (RARα) in Macrophages Protects from Diet-Induced Atherosclerosis in Mice. Cells. 2022;11: pubmed publisher
Cai Y, Wang Z, Li L, He L, Wu X, Zhang M, et al. Neuropeptide Y regulates cholesterol uptake and efflux in macrophages and promotes foam cell formation. J Cell Mol Med. 2022;26:5391-5402 pubmed publisher
Man B, Hu C, Yang G, Xiang J, Yang S, Ma C. Berberine attenuates diabetic atherosclerosis via enhancing the interplay between KLF16 and PPARα in ApoE-/- mice. Biochem Biophys Res Commun. 2022;624:59-67 pubmed publisher
Wang J, Li L, Hu A, Deng G, Wei J, Li Y, et al. Inhibition of ASGR1 decreases lipid levels by promoting cholesterol excretion. Nature. 2022;608:413-420 pubmed publisher
Perelroizen R, Philosof B, Budick Harmelin N, Chernobylsky T, Ron A, Katzir R, et al. Astrocyte immunometabolic regulation of the tumour microenvironment drives glioblastoma pathogenicity. Brain. 2022;145:3288-3307 pubmed publisher
Vaisar T, Wang S, Omer M, Irwin A, Storey C, Tang C, et al. 10,12-Conjugated linoleic acid supplementation improves HDL composition and function in mice. J Lipid Res. 2022;63:100241 pubmed publisher
Nguyen M, Hoang H, Rasheed A, Duchez A, Wyatt H, Cottee M, et al. miR-223 Exerts Translational Control of Proatherogenic Genes in Macrophages. Circ Res. 2022;131:42-58 pubmed publisher
Li J, Zhu Z, Li Y, Chen Y, Hu X, Liu Y, et al. D-4F, an apolipoprotein A-I mimetic, promotes the clearance of myelin debris and the reduction of foamy macrophages after spinal cord injury. Bioengineered. 2022;13:11794-11809 pubmed publisher
Picataggi A, Rodrigues A, Cromley D, Wang H, Wiener J, Garliyev V, et al. Specificity of ABCA7-mediated cell lipid efflux. Biochim Biophys Acta Mol Cell Biol Lipids. 2022;1867:159157 pubmed publisher
Yano H, Fujiwara Y, Horlad H, Pan C, Kai K, Niino D, et al. Blocking cholesterol efflux mechanism is a potential target for antilymphoma therapy. Cancer Sci. 2022;113:2129-2143 pubmed publisher
Peters F, Ebner L, Atac D, Maggi J, Berger W, den Hollander A, et al. Regulation of ABCA1 by AMD-Associated Genetic Variants and Hypoxia in iPSC-RPE. Int J Mol Sci. 2022;23: pubmed publisher
Yıldırım Z, Baboo S, Hamid S, Dogan A, Tufanlı Ö, Robichaud S, et al. Intercepting IRE1 kinase-FMRP signaling prevents atherosclerosis progression. EMBO Mol Med. 2022;14:e15344 pubmed publisher
Balamurugan K, Medishetti R, Kotha J, Behera P, Chandra K, Mavuduru V, et al. PHLPP1 promotes neutral lipid accumulation through AMPK/ChREBP-dependent lipid uptake and fatty acid synthesis pathways. iScience. 2022;25:103766 pubmed publisher
Wang W, Lokman N, Noye T, Macpherson A, Oehler M, Ricciardelli C. ABCA1 is associated with the development of acquired chemotherapy resistance and predicts poor ovarian cancer outcome. Cancer Drug Resist. 2021;4:485-502 pubmed publisher
Toma L, Barbalata T, Sanda G, Niculescu L, Sima A, Stancu C. CRISPR/dCas9 Transcriptional Activation of Endogenous Apolipoprotein AI and Paraoxonase 1 in Enterocytes Alleviates Endothelial Cell Dysfunction. Biomolecules. 2021;11: pubmed publisher
Kane J, Jansen M, Hendrix S, Bosmans L, Beckers L, Tiel C, et al. Anti-Galectin-2 Antibody Treatment Reduces Atherosclerotic Plaque Size and Alters Macrophage Polarity. Thromb Haemost. 2021;: pubmed publisher
Huuska N, Netti E, Tulamo R, Lehti S, Jahromi B, Kovanen P, et al. Serum Amyloid A Is Present in Human Saccular Intracranial Aneurysm Walls and Associates With Aneurysm Rupture. J Neuropathol Exp Neurol. 2021;80:966-974 pubmed publisher
Roberts L, Schwarz B, Speranza E, Leighton I, Wehrly T, Best S, et al. Pulmonary infection induces persistent, pathogen-specific lipidomic changes influencing trained immunity. iScience. 2021;24:103025 pubmed publisher
Casado M, Huerta L, Marcos Díaz A, Ortiz A, Kraemer F, Lasunción M, et al. Hormone-sensitive lipase deficiency affects the expression of SR-BI, LDLr, and ABCA1 receptors/transporters involved in cellular cholesterol uptake and efflux and disturbs fertility in mouse testis. Biochim Biophys Acta Mol Cell Biol Lipids. 2021;1866:159043 pubmed publisher
Han Y, Onufer E, Huang L, Sprung R, Davidson W, Czepielewski R, et al. Enterically derived high-density lipoprotein restrains liver injury through the portal vein. Science. 2021;373: pubmed publisher
Huang R, Hu Z, Chen X, Cao Y, Li H, Zhang H, et al. The Transcription Factor SUB1 Is a Master Regulator of the Macrophage TLR Response in Atherosclerosis. Adv Sci (Weinh). 2021;8:e2004162 pubmed publisher
Wright M, Varona Santos J, Kemmer C, Maugeais C, Carralot J, Roever S, et al. Compounds targeting OSBPL7 increase ABCA1-dependent cholesterol efflux preserving kidney function in two models of kidney disease. Nat Commun. 2021;12:4662 pubmed publisher
Mota A, Dominguez M, Weigert A, Snodgrass R, Namgaladze D, Brüne B. Lysosome-Dependent LXR and PPARδ Activation Upon Efferocytosis in Human Macrophages. Front Immunol. 2021;12:637778 pubmed publisher
Wang H, Lv J, Zhao Y, Wei H, Zhang T, Yang H, et al. Endothelial genetic deletion of CD147 induces changes in the dual function of the blood-brain barrier and is implicated in Alzheimer's disease. CNS Neurosci Ther. 2021;: pubmed publisher
Zhang S, Li Z, Zhang Y, Chen J, Li Y, Wu F, et al. Ketone Body 3-Hydroxybutyrate Ameliorates Atherosclerosis via Receptor Gpr109a-Mediated Calcium Influx. Adv Sci (Weinh). 2021;8:2003410 pubmed publisher
Navia Pelaez J, Choi S, Dos Santos Aggum Capettini L, Xia Y, Gonen A, Agatisa Boyle C, et al. Normalization of cholesterol metabolism in spinal microglia alleviates neuropathic pain. J Exp Med. 2021;218: pubmed publisher
Wang H, Arias E, Cartee G. Reduced membrane cholesterol content in skeletal muscle is not essential for greater insulin-stimulated glucose uptake after acute exercise by rats. Appl Physiol Nutr Metab. 2021;46:685-689 pubmed publisher
Alajbegovic A, Holmberg J, Daoud F, Rippe C, Kalliokoski G, Ekman M, et al. MRTFA overexpression promotes conversion of human coronary artery smooth muscle cells into lipid-laden foam cells. Vascul Pharmacol. 2021;:106837 pubmed publisher
Ma C, Feng K, Yang X, Yang Z, Wang Z, Shang Y, et al. Targeting macrophage liver X receptors by hydrogel-encapsulated T0901317 reduces atherosclerosis without effect on hepatic lipogenesis. Br J Pharmacol. 2021;178:1620-1638 pubmed publisher
Palafox Sánchez V, Ying Z, Royes L, Gomez Pinilla F. The interaction between brain and liver regulates lipid metabolism in the TBI pathology. Biochim Biophys Acta Mol Basis Dis. 2021;1867:166078 pubmed publisher
. E17241 as a Novel ABCA1 (ATP-Binding Cassette Transporter A1) Upregulator Ameliorates Atherosclerosis in Mice. Arterioscler Thromb Vasc Biol. 2021;:ATVBAHA120314156 pubmed publisher
Ma C, Zhang J, Yang S, Hua Y, Su J, Shang Y, et al. Astragalus Flavone Ameliorates Atherosclerosis and Hepatic Steatosis Via Inhibiting Lipid-Disorder and Inflammation in apoE-/- Mice. Front Pharmacol. 2020;11:610550 pubmed publisher
Ren Q, Xie X, Tang Y, Hu Q, Du Y. Methyl tertiary-butyl ether inhibits THP-1 macrophage cholesterol efflux in vitro and accelerates atherosclerosis in ApoE-deficient mice in vivo. J Environ Sci (China). 2021;101:236-247 pubmed publisher
Fu Y, Sun Y, Wang M, Hou Y, Huang W, Zhou D, et al. Elevation of JAML Promotes Diabetic Kidney Disease by Modulating Podocyte Lipid Metabolism. Cell Metab. 2020;32:1052-1062.e8 pubmed publisher
Mukherjee V, Ramakrishna P, Bora S, Kotteazeth S. Phytosteroid 28-homobrassinolide targets cholesterol and glucose homeostasis implicating ABCA1 and SREBP role in regulation. Steroids. 2021;165:108756 pubmed publisher
Dodge J, Jensen E, Yu J, Sardi S, Bialas A, Taksir T, et al. Neutral Lipid Cacostasis Contributes to Disease Pathogenesis in Amyotrophic Lateral Sclerosis. J Neurosci. 2020;40:9137-9147 pubmed publisher
Munir M, Ponce C, Santos J, Sufian H, Al Harrasi A, Gollahon L, et al. VD3 and LXR agonist (T0901317) combination demonstrated greater potency in inhibiting cholesterol accumulation and inducing apoptosis via ABCA1-CHOP-BCL-2 cascade in MCF-7 breast cancer cells. Mol Biol Rep. 2020;47:7771-7782 pubmed publisher
Zhao Y, Zeng C, Li X, Yang T, Kuang X, Du J. Klotho overexpression improves amyloid-β clearance and cognition in the APP/PS1 mouse model of Alzheimer's disease. Aging Cell. 2020;:e13239 pubmed publisher
Zhao D, Li J, Xue C, Feng K, Liu L, Zeng P, et al. TL1A inhibits atherosclerosis in apoE-deficient mice by regulating the phenotype of vascular smooth muscle cells. J Biol Chem. 2020;295:16314-16327 pubmed publisher
Shang Y, Ma C, Zhang J, Wang Z, Ren C, Luo X, et al. Bifunctional supramolecular nanofiber inhibits atherosclerosis by enhancing plaque stability and anti-inflammation in apoE-/- mice. Theranostics. 2020;10:10231-10244 pubmed publisher
Choi S, Kim K, Perkins G, Phan S, Edwards G, Xia Y, et al. AIBP protects retinal ganglion cells against neuroinflammation and mitochondrial dysfunction in glaucomatous neurodegeneration. Redox Biol. 2020;37:101703 pubmed publisher
Venkat P, Zacharek A, Landschoot Ward J, Wang F, Culmone L, Chen Z, et al. Exosomes derived from bone marrow mesenchymal stem cells harvested from type two diabetes rats promotes neurorestorative effects after stroke in type two diabetes rats. Exp Neurol. 2020;334:113456 pubmed publisher
Xia X, Xu Q, Liu M, Chen X, Liu X, He J, et al. Deubiquitination of CD36 by UCHL1 promotes foam cell formation. Cell Death Dis. 2020;11:636 pubmed publisher
Wu J, Yu X, Xue K, Wu J, Wang R, Xie X, et al. The Inhibition of miR-873 Provides Therapeutic Benefit in a Lipopolysaccharide-Induced Neuroinflammatory Model of Parkinson's Disease. Oxid Med Cell Longev. 2020;2020:8735249 pubmed publisher
Gao Q, Wei A, Chen F, Chen X, Ding W, Ding Z, et al. Enhancing PPARγ by HDAC inhibition reduces foam cell formation and atherosclerosis in ApoE deficient mice. Pharmacol Res. 2020;160:105059 pubmed publisher
Werkman I, Kövilein J, de Jonge J, Baron W. Impairing committed cholesterol biosynthesis in white matter astrocytes, but not grey matter astrocytes, enhances in vitro myelination. J Neurochem. 2020;: pubmed publisher
Wang D, Hiebl V, Schachner D, Ladurner A, Heiss E, Atanasov A, et al. Soraphen A enhances macrophage cholesterol efflux via indirect LXR activation and ABCA1 upregulation. Biochem Pharmacol. 2020;177:114022 pubmed publisher
Marshall J, Courage E, Elliott R, Fitzpatrick M, Kim A, Lopez Clavijo A, et al. THP-1 macrophage cholesterol efflux is impaired by palmitoleate through Akt activation. PLoS ONE. 2020;15:e0233180 pubmed publisher
Pathak P, Helsley R, Brown A, Buffa J, Choucair I, Nemet I, et al. Small molecule inhibition of gut microbial choline trimethylamine lyase activity alters host cholesterol and bile acid metabolism. Am J Physiol Heart Circ Physiol. 2020;318:H1474-H1486 pubmed publisher
Hiebl V, Schachner D, Ladurner A, Heiss E, Stangl H, Dirsch V. Caco-2 Cells for Measuring Intestinal Cholesterol Transport - Possibilities and Limitations. Biol Proced Online. 2020;22:7 pubmed publisher
Salonurmi T, Nabil H, Ronkainen J, Hyötyläinen T, Hautajärvi H, Savolainen M, et al. 4β-Hydroxycholesterol Signals From the Liver to Regulate Peripheral Cholesterol Transporters. Front Pharmacol. 2020;11:361 pubmed publisher
He Q, Wang F, Honda T, Greis K, Redington A. Ablation of miR-144 increases vimentin expression and atherosclerotic plaque formation. Sci Rep. 2020;10:6127 pubmed publisher
Fuenzalida B, Cantin C, Kallol S, Carvajal L, Past xe9 n V, Contreras Duarte S, et al. Cholesterol uptake and efflux are impaired in human trophoblast cells from pregnancies with maternal supraphysiological hypercholesterolemia. Sci Rep. 2020;10:5264 pubmed publisher
Koga M, Kanaoka Y, Inada K, Omine S, Kataoka Y, Yamauchi A. Hesperidin blocks varenicline-aggravated atherosclerotic plaque formation in apolipoprotein E knockout mice by downregulating net uptake of oxidized low-density lipoprotein in macrophages. J Pharmacol Sci. 2020;143:106-111 pubmed publisher
Bogie J, Grajchen E, Wouters E, Corrales A, Dierckx T, Vanherle S, et al. Stearoyl-CoA desaturase-1 impairs the reparative properties of macrophages and microglia in the brain. J Exp Med. 2020;217: pubmed publisher
Cipollari E, Szapary H, Picataggi A, Billheimer J, Lyssenko C, Ying G, et al. Correlates and Predictors of Cerebrospinal Fluid Cholesterol Efflux Capacity from Neural Cells, a Family of Biomarkers for Cholesterol Epidemiology in Alzheimer's Disease. J Alzheimers Dis. 2020;74:563-578 pubmed publisher
Matsuda J, Takahashi A, Takabatake Y, Sakai S, Minami S, Yamamoto T, et al. Metabolic effects of RUBCN/Rubicon deficiency in kidney proximal tubular epithelial cells. Autophagy. 2020;:1-16 pubmed publisher
Chen T, Yuan H, Sun Y, Song Y, Lü M, Ni X, et al. Metabolomics study of the prefrontal cortex in a rat model of attention deficit hyperactivity disorder reveals the association between cholesterol metabolism disorder and hyperactive behavior. Biochem Biophys Res Commun. 2020;523:315-321 pubmed publisher
Koga M, Kanaoka Y, Okamoto M, Nakao Y, Inada K, Takayama S, et al. Varenicline aggravates atherosclerotic plaque formation in nicotine-pretreated ApoE knockout mice due to enhanced oxLDL uptake by macrophages through downregulation of ABCA1 and ABCG1 expression. J Pharmacol Sci. 2020;142:9-15 pubmed publisher
Du Y, Li X, Su C, Xi M, Zhang X, Jiang Z, et al. Butyrate protects against high-fat diet-induced atherosclerosis via up-regulating ABCA1 expression in apolipoprotein E-deficiency mice. Br J Pharmacol. 2020;177:1754-1772 pubmed publisher
Pagano S, Magenta A, D Agostino M, Martino F, Barilla F, Satta N, et al. Anti-ApoA-1 IgGs in Familial Hypercholesterolemia Display Paradoxical Associations with Lipid Profile and Promote Foam Cell Formation. J Clin Med. 2019;8: pubmed publisher
Kaymak I, Maier C, Schmitz W, Campbell A, Dankworth B, Ade C, et al. Mevalonate Pathway Provides Ubiquinone to Maintain Pyrimidine Synthesis and Survival in p53-Deficient Cancer Cells Exposed to Metabolic Stress. Cancer Res. 2020;80:189-203 pubmed publisher
Xiao L, Luo G, Guo X, Jiang C, Zeng H, Zhou F, et al. Macrophage iron retention aggravates atherosclerosis: Evidence for the role of autocrine formation of hepcidin in plaque macrophages. Biochim Biophys Acta Mol Cell Biol Lipids. 2020;1865:158531 pubmed publisher
Smith T, Kahiel Z, LeBlond N, Ghorbani P, Farah E, Al Awosi R, et al. Characterization of Redox-Responsive LXR-Activating Nanoparticle Formulations in Primary Mouse Macrophages. Molecules. 2019;24: pubmed publisher
Xu Y, Xu Y, Zhu Y, Sun H, Juguilon C, Li F, et al. Macrophage miR-34a Is a Key Regulator of Cholesterol Efflux and Atherosclerosis. Mol Ther. 2020;28:202-216 pubmed publisher
Hennessy E, van Solingen C, Scacalossi K, Ouimet M, Afonso M, Prins J, et al. The long noncoding RNA CHROME regulates cholesterol homeostasis in primate. Nat Metab. 2019;1:98-110 pubmed publisher
Zhou Y, Bazick H, Miles J, Fethiere A, Salihi M, Fazio S, et al. A neutral lipid-enriched diet improves myelination and alleviates peripheral nerve pathology in neuropathic mice. Exp Neurol. 2019;321:113031 pubmed publisher
Paul A, Lydic T, Hogan R, Goo Y. Cholesterol Acceptors Regulate the Lipidome of Macrophage Foam Cells. Int J Mol Sci. 2019;20: pubmed publisher
Mukhamedova N, Hoang A, Dragoljevic D, Dubrovsky L, Pushkarsky T, Low H, et al. Exosomes containing HIV protein Nef reorganize lipid rafts potentiating inflammatory response in bystander cells. PLoS Pathog. 2019;15:e1007907 pubmed publisher
Koyama S, Horie T, Nishino T, Baba O, Sowa N, Miyasaka Y, et al. Identification of Differential Roles of MicroRNA-33a and -33b During Atherosclerosis Progression With Genetically Modified Mice. J Am Heart Assoc. 2019;8:e012609 pubmed publisher
Rege S, Royes L, Tsai B, Zhang G, Yang X, Gomez Pinilla F. Brain Trauma Disrupts Hepatic Lipid Metabolism: Blame It on Fructose?. Mol Nutr Food Res. 2019;63:e1801054 pubmed publisher
Zhou Y, Miles J, Tavori H, Lin M, Khoshbouei H, Borchelt D, et al. PMP22 regulates cholesterol trafficking and ABCA1-mediated cholesterol efflux. J Neurosci. 2019;: pubmed publisher
Tiwari P, Blank A, Cui C, Schoenfelt K, Zhou G, Xu Y, et al. Metabolically activated adipose tissue macrophages link obesity to triple-negative breast cancer. J Exp Med. 2019;216:1345-1358 pubmed publisher
Liao S, Zhou Q, Zhang Y. Elastic aortic wrap reduced aortic stiffness by partially alleviating the impairment of cholesterol efflux capacity in pigs. J Diabetes Metab Disord. 2018;17:101-109 pubmed publisher
Storti F, Klee K, Todorova V, Steiner R, Othman A, van der Velde Visser S, et al. Impaired ABCA1/ABCG1-mediated lipid efflux in the mouse retinal pigment epithelium (RPE) leads to retinal degeneration. elife. 2019;8: pubmed publisher
Margaryan N, Hazard Jenkins H, Salkeni M, Smolkin M, Coad J, Wen S, et al. The Stem Cell Phenotype of Aggressive Breast Cancer Cells. Cancers (Basel). 2019;11: pubmed publisher
Cabou C, Honorato P, Briceno L, Ghezali L, Duparc T, León M, et al. Pharmacological inhibition of the F1 -ATPase/P2Y1 pathway suppresses the effect of apolipoprotein A1 on endothelial nitric oxide synthesis and vasorelaxation. Acta Physiol (Oxf). 2019;226:e13268 pubmed publisher
Nakazeki F, Tsuge I, Horie T, Imamura K, Tsukita K, Hotta A, et al. MiR-33a is a therapeutic target in SPG4-related hereditary spastic paraplegia human neurons. Clin Sci (Lond). 2019;133:583-595 pubmed publisher
Tang S, Tabet F, Cochran B, Cuesta Torres L, Wu B, Barter P, et al. Apolipoprotein A-I enhances insulin-dependent and insulin-independent glucose uptake by skeletal muscle. Sci Rep. 2019;9:1350 pubmed publisher
Vaidya M, Jentsch J, Peters S, Keul P, Weske S, Gräler M, et al. Regulation of ABCA1-mediated cholesterol efflux by sphingosine-1-phosphate signaling in macrophages. J Lipid Res. 2019;60:506-515 pubmed publisher
Ramón Vázquez A, de la Rosa J, Tabraue C, Lopez F, Díaz Chico B, Bosca L, et al. Common and Differential Transcriptional Actions of Nuclear Receptors Liver X Receptors α and β in Macrophages. Mol Cell Biol. 2019;39: pubmed publisher
Moon S, Huang C, Houlihan S, Regunath K, Freed Pastor W, Morris J, et al. p53 Represses the Mevalonate Pathway to Mediate Tumor Suppression. Cell. 2019;176:564-580.e19 pubmed publisher
Torres Adorno A, Vitrac H, Qi Y, Tan L, Levental K, Fan Y, et al. Eicosapentaenoic acid in combination with EPHA2 inhibition shows efficacy in preclinical models of triple-negative breast cancer by disrupting cellular cholesterol efflux. Oncogene. 2019;38:2135-2150 pubmed publisher
Zinkhan E, Yu B, McKnight R. Uteroplacental Insufficiency Impairs Cholesterol Elimination in Adult Female Growth-Restricted Rat Offspring Fed a High-Fat Diet. Reprod Sci. 2019;26:1173-1180 pubmed publisher
Han Q, Yeung S, Ip M, Mak J. Dysregulation of cardiac lipid parameters in high-fat high-cholesterol diet-induced rat model. Lipids Health Dis. 2018;17:255 pubmed publisher
O Reilly M, Kajani S, Ralston J, Lenighan Y, Roche H, McGillicuddy F. Nutritionally Derived Metabolic Cues Typical of the Obese Microenvironment Increase Cholesterol Efflux Capacity of Adipose Tissue Macrophages. Mol Nutr Food Res. 2019;63:e1800713 pubmed publisher
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Pulakazhi Venu V, Adijiang A, Seibert T, Chen Y, Shi C, Batulan Z, et al. Heat shock protein 27-derived atheroprotection involves reverse cholesterol transport that is dependent on GM-CSF to maintain ABCA1 and ABCG1 expression in ApoE-/- mice. FASEB J. 2017;31:2364-2379 pubmed publisher
Cook E, Nelson J, Sorrentino V, Koenis D, Moeton M, Scheij S, et al. Identification of the ER-resident E3 ubiquitin ligase RNF145 as a novel LXR-regulated gene. PLoS ONE. 2017;12:e0172721 pubmed publisher
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Jiang M, Li X. Activation of PPAR? does not contribute to macrophage ABCA1 expression and ABCA1-mediated cholesterol efflux to apoAI. Biochem Biophys Res Commun. 2017;482:849-856 pubmed publisher
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product information
master code :
NB400-105
SKU :
NB400-105
product name :
ABCA1 Antibody - BSA Free
unit size :
0.1 ml (also 0.025 ml)
description :
The ABCA1 Antibody - BSA Free from Novus is a rabbit polyclonal antibody to ABCA1. This antibody reacts with avian - chicken,canine,chicken,chinese hamster,equine,hamster,human,mouse,mustelid,porcine,primate,rabbit,rat,hamster - cricetulus (chinese hamster). The ABCA1 Antibody - BSA Free has been validated for the following applications: Western Blot,Immunohistochemistry,Immunohistochemistry-Frozen,Block/Neutralize,Immunocytochemistry/ Immunofluorescence,Flow Cytometry,Chemotaxis,EMSA,IF/IHC,ELISA,Immunoprecipitation,Immunohistochemistry-Paraffin,Immunoblotting,Knockout Validated,Knockdown Validated,Chromatin Immunoprecipitation,Gel Super Shift Assays,Simple Western,Gel Supershift Assay,Chromatin Immunoprecipitation (ChIP),PCR,Dual RNAscope ISH-IHC.
target :
ABCA1
category :
Primary Antibodies
buffer :
PBS
clonality :
Polyclonal
concentration :
1 mg/ml
conjugate :
Unconjugated
host :
Rabbit
immunogen :
Partial peptide sequence (within residues 1100-1300) of human ABCA1 Antibody [UniProt# O95477]. Actual immunogen sequence is proprietary information.
isotype :
IgG
purity :
Immunogen affinity purified
species :
Avian - Chicken,Canine,Chicken,Chinese Hamster,Equine,Hamster,Human,Mouse,Mustelid,Porcine,Primate,Rabbit,Rat,Hamster - Cricetulus (Chinese Hamster)
theoretical molecular weight :
220 kDa
gene symbol :
ABCA1
Antibody validation :
Biological Validation
accessionNumbers :
O95477
applications :
Immunohistochemistry,Western Blot,Immunohistochemistry-Frozen,Block/Neutralize,Immunocytochemistry/ Immunofluorescence,Flow Cytometry,Chemotaxis,EMSA,IF/IHC,ELISA,Immunoprecipitation,Immunohistochemistry-Paraffin,Immunoblotting,Knockout Validated,Knockdown Validated,Chromatin Immunoprecipitation,Gel Super Shift Assays,Simple Western,Gel Supershift Assay,Chromatin Immunoprecipitation (ChIP),PCR,Dual RNAscope ISH-IHC
USD :
489 USD
alt names :
ABC-1, ABC1ATP-binding cassette transporter A1, ATP-binding cassette 1, ATP-binding cassette transporter 1, ATP-binding cassette, sub-family A (ABC1), member 1, CERP, Cholesterol efflux regulatory protein, EC 2.7.7.8, EC 2.8.1.8, EC 3.6.3, EC 3.6.3.41, FLJ14958, HDLDT1, membrane-bound, MGC164864, MGC165011, TGDATP-binding cassette sub-family A member 1
storage :
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
more info or order :
company information
Novus Biologicals
10771 E Easter Ave
Centennial, CO 80112
novus@novusbio.com
https://www.novusbio.com
3037301950
headquarters: USA
Novus Biologicals licenses, manufactures, and markets antibodies to over 20,000 unique targets to support a wide array of research areas. Novus is built on honesty, collaboration and strong relationships and continues to provide quality tools that accelerate research. Every product is backed by our 100% guarantee.