product summary
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company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
PPAR alpha/NR1C1 Antibody (3B6/PPAR) - BSA Free
catalog :
NB300-537
quantity :
100 ug (also 0.025 mg)
price :
449 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
3B6/PPAR
reactivity :
human, mouse, rat, bovine
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, EMSA, chromatin immunoprecipitation, immunohistochemistry - paraffin section
more info or order :
citations: 39
Reference
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Zhang F, Liu L, Xie Y, Wang J, Chen X, Zheng S, et al. Cardiac contractility modulation ameliorates myocardial metabolic remodeling in a rabbit model of chronic heart failure through activation of AMPK and PPAR-α pathway. Open Med (Wars). 2022;17:365-374 pubmed publisher
Zhao X, Jin C, Dong T, Sun Z, Zheng X, Feng B, et al. Characterization of promoters for adeno-associated virus mediated efficient Cas9 activation in adult Cas9 knock-in murine cochleae. Hear Res. 2020;394:107999 pubmed publisher
Alix E, Godlee C, Cerny O, Blundell S, Tocci R, Matthews S, et al. The Tumour Suppressor TMEM127 Is a Nedd4-Family E3 Ligase Adaptor Required by Salmonella SteD to Ubiquitinate and Degrade MHC Class II Molecules. Cell Host Microbe. 2020;28:54-68.e7 pubmed publisher
Liu Y, Chen J, Crisante D, Jaramillo Lopez J, Mahadevan R. Dynamic Cell Programming with Quorum Sensing-Controlled CRISPRi Circuit. ACS Synth Biol. 2020;9:1284-1291 pubmed publisher
Yu Y, Leete T, Born D, Young L, Barrera L, Lee S, et al. Cytosine base editors with minimized unguided DNA and RNA off-target events and high on-target activity. Nat Commun. 2020;11:2052 pubmed publisher
Yang Q, Sun S, Liu W, Liu Q, Wang J. Hypoxia training improves hepatic steatosis partly by downregulation of CB1 receptor in obese mice. Biochem Biophys Res Commun. 2020;525:639-645 pubmed publisher
Kang W, Zhao X, Sun Z, Dong T, Jin C, Tong L, et al. Adeno-associated virus vector enables safe and efficient Cas9 activation in neonatal and adult Cas9 knockin murine cochleae. Gene Ther. 2020;: pubmed publisher
Wu Y, Yang L, Chang T, Kandeel F, Yee J. A Small Molecule-Controlled Cas9 Repressible System. Mol Ther Nucleic Acids. 2020;19:922-932 pubmed publisher
Wilk A, Hayat F, Cunningham R, Li J, Garavaglia S, Zamani L, et al. Extracellular NAD+ enhances PARP-dependent DNA repair capacity independently of CD73 activity. Sci Rep. 2020;10:651 pubmed publisher
Li X. Gap junction protein connexin43 and tunneling nanotubes in human trabecular meshwork cells. Int J Physiol Pathophysiol Pharmacol. 2019;11:212-219 pubmed
Schick S, Rendeiro A, Runggatscher K, Ringler A, Boidol B, Hinkel M, et al. Systematic characterization of BAF mutations provides insights into intracomplex synthetic lethalities in human cancers. Nat Genet. 2019;51:1399-1410 pubmed publisher
Johnston R, Seamon K, Saada E, Podlevsky J, Branda S, Timlin J, et al. Use of anti-CRISPR protein AcrIIA4 as a capture ligand for CRISPR/Cas9 detection. Biosens Bioelectron. 2019;141:111361 pubmed publisher
Savage A, Kurusamy S, Chen Y, Jiang Z, Chhabria K, MacDonald R, et al. tmem33 is essential for VEGF-mediated endothelial calcium oscillations and angiogenesis. Nat Commun. 2019;10:732 pubmed publisher
Qiang J, Ma Z, Xie X, Shi L, Geng Y, Hu J, et al. Multi-omic Analyses Reveal Minimal Impact of the CRISPR-Cas9 Nuclease on Cultured Human Cells. J Proteome Res. 2019;18:1054-1063 pubmed publisher
Oakes B, Fellmann C, Rishi H, Taylor K, Ren S, Nadler D, et al. CRISPR-Cas9 Circular Permutants as Programmable Scaffolds for Genome Modification. Cell. 2019;176:254-267.e16 pubmed publisher
Kumar S, Rani R, Karns R, Gandhi C. Augmenter of liver regeneration protein deficiency promotes hepatic steatosis by inducing oxidative stress and microRNA-540 expression. FASEB J. 2019;33:3825-3840 pubmed publisher
Melnik S, Dvornikov D, Muller Decker K, Depner S, Stannek P, Meister M, et al. Cancer cell specific inhibition of Wnt/?-catenin signaling by forced intracellular acidification. Cell Discov. 2018;4:37 pubmed publisher
Charpentier M, Khedher A, Menoret S, Brion A, Lamribet K, Dardillac E, et al. CtIP fusion to Cas9 enhances transgene integration by homology-dependent repair. Nat Commun. 2018;9:1133 pubmed publisher
Li L, He M, Xiao H, Liu X, Wang K, Zhang Y. Acetic Acid Influences BRL-3A Cell Lipid Metabolism via the AMPK Signalling Pathway. Cell Physiol Biochem. 2018;45:2021-2030 pubmed publisher
Sykora P, Witt K, Revanna P, Smith Roe S, Dismukes J, Lloyd D, et al. Next generation high throughput DNA damage detection platform for genotoxic compound screening. Sci Rep. 2018;8:2771 pubmed publisher
Basila M, Kelley M, Smith A. Minimal 2'-O-methyl phosphorothioate linkage modification pattern of synthetic guide RNAs for increased stability and efficient CRISPR-Cas9 gene editing avoiding cellular toxicity. PLoS ONE. 2017;12:e0188593 pubmed publisher
Rogers Z, McFarland C, Winters I, Naranjo S, Chuang C, Petrov D, et al. A quantitative and multiplexed approach to uncover the fitness landscape of tumor suppression in vivo. Nat Methods. 2017;14:737-742 pubmed publisher
El Fatimy R, Subramanian S, Uhlmann E, Krichevsky A. Genome Editing Reveals Glioblastoma Addiction to MicroRNA-10b. Mol Ther. 2017;25:368-378 pubmed publisher
Sun Q, Zhang W, Zhong W, Sun X, Zhou Z. Pharmacological inhibition of NOX4 ameliorates alcohol-induced liver injury in mice through improving oxidative stress and mitochondrial function. Biochim Biophys Acta Gen Subj. 2017;1861:2912-2921 pubmed publisher
Chew W, Tabebordbar M, Cheng J, Mali P, Wu E, Ng A, et al. A multifunctional AAV-CRISPR-Cas9 and its host response. Nat Methods. 2016;13:868-74 pubmed publisher
Choi J, Dang Y, Abraham S, Ma H, Zhang J, Guo H, et al. Lentivirus pre-packed with Cas9 protein for safer gene editing. Gene Ther. 2016;23:627-33 pubmed publisher
Rotondi S, Modarelli A, Oliva M, Rostomyan L, Sanità P, Ventura L, et al. Expression of Peroxisome Proliferator-Activated Receptor alpha (PPARα) in somatotropinomas: Relationship with Aryl hydrocarbon receptor Interacting Protein (AIP) and in vitro effects of fenofibrate in GH3 cells. Mol Cell Endocrinol. 2016;426:61-72 pubmed publisher
Chu V, Weber T, Graf R, Sommermann T, Petsch K, Sack U, et al. Efficient generation of Rosa26 knock-in mice using CRISPR/Cas9 in C57BL/6 zygotes. BMC Biotechnol. 2016;16:4 pubmed publisher
Tatone C, Benedetti E, Vitti M, Di Emidio G, Ciriminna R, Vento M, et al. Modulating Intrafollicular Hormonal Milieu in Controlled Ovarian Stimulation: Insights From PPAR Expression in Human Granulosa Cells. J Cell Physiol. 2016;231:908-14 pubmed publisher
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Cao H, Wen G, Li H. Role of peroxisome proliferator-activated receptor α in atherosclerosis. Mol Med Rep. 2014;9:1755-60 pubmed publisher
Gao W, Xu W, Li H. The expression and role of peroxisome proliferator-activated receptor α in atherosclerosis. Mol Med Rep. 2013;7:862-8 pubmed publisher
Crespillo A, Suarez J, Bermudez Silva F, Rivera P, Vida M, Alonso M, et al. Expression of the cannabinoid system in muscle: effects of a high-fat diet and CB1 receptor blockade. Biochem J. 2011;433:175-85 pubmed publisher
Liu Y, Heymann R, Moatamed F, Schultz J, Sobel D, Brent G. A mutant thyroid hormone receptor alpha antagonizes peroxisome proliferator-activated receptor alpha signaling in vivo and impairs fatty acid oxidation. Endocrinology. 2007;148:1206-17 pubmed
Alwayn I, Andersson C, Lee S, Arsenault D, Bistrian B, Gura K, et al. Inhibition of matrix metalloproteinases increases PPAR-alpha and IL-6 and prevents dietary-induced hepatic steatosis and injury in a murine model. Am J Physiol Gastrointest Liver Physiol. 2006;291:G1011-9 pubmed
Sumanasekera W, Tien E, Turpey R, Vanden Heuvel J, Perdew G. Evidence that peroxisome proliferator-activated receptor alpha is complexed with the 90-kDa heat shock protein and the hepatitis virus B X-associated protein 2. J Biol Chem. 2003;278:4467-73 pubmed
product information
master code :
NB300-537
SKU :
NB300-537
product name :
PPAR alpha/NR1C1 Antibody (3B6/PPAR) - BSA Free
unit size :
100 ug (also 0.025 mg)
description :
The PPAR alpha/NR1C1 Antibody (3B6/PPAR) - BSA Free from Novus is a mouse monoclonal antibody to PPAR alpha/NR1C1. This antibody reacts with bovine,human,mouse,rabbit,rat. The PPAR alpha/NR1C1 Antibody (3B6/PPAR) - BSA Free has been validated for the following applications: Immunoprecipitation,Western Blot,Simple Western,IF/IHC,Immunohistochemistry-Paraffin,Flow Cytometry,Immunohistochemistry,Gel Super Shift Assays,Chromatin Immunoprecipitation (ChIP),Knockdown Validated,Immunocytochemistry/ Immunofluorescence.
target :
PPAR alpha/NR1C1
category :
Primary Antibodies
buffer :
PBS
clonality :
Monoclonal
clone :
3B6/PPAR
concentration :
1 mg/ml
conjugate :
Unconjugated
host :
Mouse
immunogen :
Purified recombinant PPAR alpha protein.
isotype :
IgG2b
purity :
Immunogen affinity purified
species :
Bovine,Human,Mouse,Rabbit,Rat
specificity :
PPAR alpha (3B6/PPAR)
gene symbol :
PPARA
Antibody validation :
Knockout/Knockdown
accessionNumbers :
Q07869
applications :
Western Blot,Simple Western,IF/IHC,Immunoprecipitation,Immunohistochemistry-Paraffin,Flow Cytometry,Immunohistochemistry,Gel Super Shift Assays,Chromatin Immunoprecipitation (ChIP),Knockdown Validated,Immunocytochemistry/ Immunofluorescence
USD :
449 USD
alt names :
alpha, hPPAR, NR1C1MGC2237, Nuclear receptor subfamily 1 group C member 1, peroxisome proliferator-activated receptor alpha, PPARalpha, PPAR-alpha, PPARMGC2452
storage :
Store at -20C. Avoid freeze-thaw cycles.
more info or order :
company information
Novus Biologicals
10771 E Easter Ave
Centennial, CO 80112
novus@novusbio.com
https://www.novusbio.com
3037301950
headquarters: USA
Novus Biologicals licenses, manufactures, and markets antibodies to over 20,000 unique targets to support a wide array of research areas. Novus is built on honesty, collaboration and strong relationships and continues to provide quality tools that accelerate research. Every product is backed by our 100% guarantee.