product summary
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company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
IGF-II R/IGF2R Antibody (2G11) - BSA Free
catalog :
NB300-514
quantity :
0.1 ml (also 0.025 ml)
price :
409 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
2G11
reactivity :
human, mouse, rat, bovine
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section
more info or order :
citations: 31
Published Application/Species/Sample/DilutionReference
  • immunocytochemistry; human
  • western blot; human
Ganley I, Carroll K, Bittova L, Pfeffer S. Rab9 GTPase regulates late endosome size and requires effector interaction for its stability. Mol Biol Cell. 2004;15:5420-30 pubmed
  • immunocytochemistry; human
Arighi C, Hartnell L, Aguilar R, Haft C, Bonifacino J. Role of the mammalian retromer in sorting of the cation-independent mannose 6-phosphate receptor. J Cell Biol. 2004;165:123-33 pubmed
  • immunocytochemistry; human
Valdez A, Cabaniols J, Brown M, Roche P. Syntaxin 11 is associated with SNAP-23 on late endosomes and the trans-Golgi network. J Cell Sci. 1999;112 ( Pt 6):845-54 pubmed
  • immunocytochemistry; mouse
Barker L, George K, Falkow S, Small P. Differential trafficking of live and dead Mycobacterium marinum organisms in macrophages. Infect Immun. 1997;65:1497-504 pubmed
  • immunocytochemistry; human
Heinzen R, Scidmore M, Rockey D, Hackstadt T. Differential interaction with endocytic and exocytic pathways distinguish parasitophorous vacuoles of Coxiella burnetii and Chlamydia trachomatis. Infect Immun. 1996;64:796-809 pubmed
Calcagnì A, Staiano L, Zampelli N, Minopoli N, Herz N, Di Tullio G, et al. Loss of the batten disease protein CLN3 leads to mis-trafficking of M6PR and defective autophagic-lysosomal reformation. Nat Commun. 2023;14:3911 pubmed publisher
Aguilar Gonz xe1 lez A, Gonz xe1 lez Correa J, Barriocanal Casado E, Ramos Hern xe1 ndez I, Lerma Ju xe1 rez M, Greco S, et al. Isogenic GAA-KO Murine Muscle Cell Lines Mimicking Severe Pompe Mutations as Preclinical Models for the Screening of Potential Gene Therapy Strategies. Int J Mol Sci. 2022;23: pubmed publisher
Choi W, Kim S, Aurass P, Huo W, Creasey E, Edwards M, et al. SdhA blocks disruption of the Legionella-containing vacuole by hijacking the OCRL phosphatase. Cell Rep. 2021;37:109894 pubmed publisher
Wang Q, Tao C, Hannan A, Yoon S, Min X, Peregrin J, et al. Lacrimal gland budding requires PI3K-dependent suppression of EGF signaling. Sci Adv. 2021;7: pubmed publisher
Muzio L, Sirtori R, Gornati D, Eleuteri S, Fossaghi A, Brancaccio D, et al. Retromer stabilization results in neuroprotection in a model of Amyotrophic Lateral Sclerosis. Nat Commun. 2020;11:3848 pubmed publisher
Rutledge E, Parvez R, Short K, Smyth I, McMahon A. Morphogenesis of the kidney and lung requires branch-tip directed activity of the Adamts18 metalloprotease. Dev Biol. 2019;454:156-169 pubmed publisher
Cheng J, Hu L, Yang Z, Suo C, Wang Y, Gao P, et al. 2-Oxonanonoidal Antibiotic Actinolactomycin Inhibits Cancer Progression by Suppressing HIF-1α. Cells. 2019;8: pubmed publisher
Kakegawa W, Katoh A, Narumi S, Miura E, Motohashi J, Takahashi A, et al. Optogenetic Control of Synaptic AMPA Receptor Endocytosis Reveals Roles of LTD in Motor Learning. Neuron. 2018;99:985-998.e6 pubmed publisher
Takahashi K, Mashima H, Miura K, Maeda D, Goto A, Goto T, et al. Disruption of Small GTPase Rab7 Exacerbates the Severity of Acute Pancreatitis in Experimental Mouse Models. Sci Rep. 2017;7:2817 pubmed publisher
Martins F, Aguila M, Mandarim de Lacerda C. Impaired steroidogenesis in the testis of leptin-deficient mice (ob/ob -/-). Acta Histochem. 2017;119:508-515 pubmed publisher
Graus Nunes F, Marinho T, Barbosa da Silva S, Aguila M, Mandarim de Lacerda C, Souza Mello V. Differential effects of angiotensin receptor blockers on pancreatic islet remodelling and glucose homeostasis in diet-induced obese mice. Mol Cell Endocrinol. 2017;439:54-64 pubmed publisher
Kim H, Lee K, Park I, Chung Y, Im S, Noh D, et al. Expression of SIRT1 and apoptosis-related proteins is predictive for lymph node metastasis and disease-free survival in luminal A breast cancer. Virchows Arch. 2015;467:563-70 pubmed publisher
Shibayama Y, Kondo T, Ohya H, Fujisawa S, Teshima T, Iseki K. Upregulation of microRNA-126-5p is associated with drug resistance to cytarabine and poor prognosis in AML patients. Oncol Rep. 2015;33:2176-82 pubmed publisher
Hsuan S, Chyau C, Hung H, Chen J, Chou F. The induction of apoptosis and autophagy by Wasabia japonica extract in colon cancer. Eur J Nutr. 2016;55:491-503 pubmed publisher
Hu H, Takano N, Xiang L, Gilkes D, Luo W, Semenza G. Hypoxia-inducible factors enhance glutamate signaling in cancer cells. Oncotarget. 2014;5:8853-68 pubmed
Chien S, Kuo S, Chen D, Su C. Sann-Joong-Kuey-Jian-Tang decreases the protein expression of Mcl?1 and TCTP and increases that of TNF-? and Bax in BxPC?3 pancreatic carcinoma cells. Int J Mol Med. 2013;32:85-92 pubmed publisher
Chen Y, Yan M, Chien S, Kuo S, Chen D, Cheng C, et al. Sann-Joong-Kuey-Jian-Tang inhibits hepatocellular carcinoma Hep-G2 cell proliferation by increasing TNF-?, Caspase-8, Caspase- 3 and Bax but by decreasing TCTP and Mcl-1 expression in vitro. Mol Med Rep. 2013;7:1487-93 pubmed publisher
Fuzio P, Ditonno P, Rutigliano M, Battaglia M, Bettocchi C, Loverre A, et al. Regulation of TGF-?1 expression by androgen deprivation therapy of prostate cancer. Cancer Lett. 2012;318:135-44 pubmed publisher
Hsu L, Hsu Y, Liang Y, Liaw C, Kuo Y, Pan T. Induction of apoptosis in human breast adenocarcinoma cells MCF-7 by monapurpyridine A, a new azaphilone derivative from Monascus purpureus NTU 568. Molecules. 2012;17:664-73 pubmed publisher
Dash R, Azab B, Quinn B, Shen X, Wang X, Das S, et al. Apogossypol derivative BI-97C1 (Sabutoclax) targeting Mcl-1 sensitizes prostate cancer cells to mda-7/IL-24-mediated toxicity. Proc Natl Acad Sci U S A. 2011;108:8785-90 pubmed publisher
Hsu L, Hsu Y, Liang Y, Kuo Y, Pan T. Anti-tumor and anti-inflammatory properties of ankaflavin and monaphilone A from monascus purpureus NTU 568. J Agric Food Chem. 2011;59:1124-30 pubmed publisher
Gould Rothberg B, Bracken M, Rimm D. Tissue biomarkers for prognosis in cutaneous melanoma: a systematic review and meta-analysis. J Natl Cancer Inst. 2009;101:452-74 pubmed publisher
Kulkarni A, Kingsbury S, Tudzarova S, Hong H, Loddo M, Rashid M, et al. Cdc7 kinase is a predictor of survival and a novel therapeutic target in epithelial ovarian carcinoma. Clin Cancer Res. 2009;15:2417-25 pubmed publisher
Nikiforov M, Riblett M, Tang W, Gratchouck V, Zhuang D, Fernandez Y, et al. Tumor cell-selective regulation of NOXA by c-MYC in response to proteasome inhibition. Proc Natl Acad Sci U S A. 2007;104:19488-93 pubmed
Rodriguez J, Lazebnik Y. Caspase-9 and APAF-1 form an active holoenzyme. Genes Dev. 1999;13:3179-84 pubmed
Dintzis S, Velculescu V, Pfeffer S. Receptor extracellular domains may contain trafficking information. Studies of the 300-kDa mannose 6-phosphate receptor. J Biol Chem. 1994;269:12159-66 pubmed
product information
master code :
NB300-514
SKU :
NB300-514
product name :
IGF-II R/IGF2R Antibody (2G11) - BSA Free
unit size :
0.1 ml (also 0.025 ml)
description :
The IGF-II R/IGF2R Antibody (2G11) - BSA Free from Novus is a mouse monoclonal antibody to IGF-II R/IGF2R. This antibody reacts with bovine,human,mouse,primate,rat. The IGF-II R/IGF2R Antibody (2G11) - BSA Free has been validated for the following applications: Flow Cytometry,Immunohistochemistry,Immunocytochemistry/ Immunofluorescence,IF/IHC,Western Blot,ELISA,Immunoprecipitation,Immunohistochemistry-Paraffin,CyTOF-ready.
target :
IGF-II R/IGF2R
category :
Primary Antibodies
buffer :
PBS
clonality :
Monoclonal
clone :
2G11
concentration :
1.0 mg/ml
conjugate :
Unconjugated
host :
Mouse
immunogen :
Purified bovine Mannose 6 Phosphate Receptor (Cation independent) [UniProt# P08169]
isotype :
IgG2a Kappa
purity :
Protein A purified
species :
Bovine,Human,Mouse,Primate,Rat
gene symbol :
IGF2R
accessionNumbers :
P08169
applications :
Flow Cytometry,Immunohistochemistry,Immunocytochemistry/ Immunofluorescence,IF/IHC,Western Blot,ELISA,Immunoprecipitation,Immunohistochemistry-Paraffin,CyTOF-ready
USD :
409 USD
alt names :
300 kDa mannose 6-phosphate receptor, cation-independent mannose-6 phosphate receptor, cation-independent mannose-6-phosphate receptor, CD222, CD222 antigen, CI Man-6-P receptor, CIMPR, CI-MPR, IGF-II receptor, insulin-like growth factor 2 receptorM6P/IGF2R, Insulin-like growth factor II receptor, M6P/IGF2 receptor, M6PR, M6P-R, MPR 300, MPR1, MPRIM6PR
storage :
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
more info or order :
company information
Novus Biologicals
10771 E Easter Ave
Centennial, CO 80112
novus@novusbio.com
https://www.novusbio.com
3037301950
headquarters: USA
Novus Biologicals licenses, manufactures, and markets antibodies to over 20,000 unique targets to support a wide array of research areas. Novus is built on honesty, collaboration and strong relationships and continues to provide quality tools that accelerate research. Every product is backed by our 100% guarantee.