| Published Application/Species/Sample/Dilution | Reference |
|---|
- immunohistochemistry; mouse; 1:200; loading ...; fig 5a
| Ku C, Wuputra K, Kato K, Pan J, Li C, Tsai M, et al. Deletion of Jdp2 enhances Slc7a11 expression in Atoh-1 positive cerebellum granule cell progenitors in vivo. Stem Cell Res Ther. 2021;12:369 pubmed publisher |
- western blot; mouse; 1:3000; loading ...
| Wang Q, Bin C, Xue Q, Gao Q, Huang A, Wang K, et al. GSTZ1 sensitizes hepatocellular carcinoma cells to sorafenib-induced ferroptosis via inhibition of NRF2/GPX4 axis. Cell Death Dis. 2021;12:426 pubmed publisher |
- western blot; mouse; fig 2
| Van Liefferinge J, Bentea E, Demuyser T, Albertini G, Follin Arbelet V, Holmseth S, et al. Comparative analysis of antibodies to xCT (Slc7a11): Forewarned is forearmed. J Comp Neurol. 2016;524:1015-32 pubmed publisher |
| Shi J, Wang Q, Wei X, Huo B, Ye J, Yi X, et al. Histone acetyltransferase P300 deficiency promotes ferroptosis of vascular smooth muscle cells by activating the HIF-1α/HMOX1 axis. Mol Med. 2023;29:91 pubmed publisher |
| Yan Y, Teng H, Hang Q, Kondiparthi L, Lei G, Horbath A, et al. SLC7A11 expression level dictates differential responses to oxidative stress in cancer cells. Nat Commun. 2023;14:3673 pubmed publisher |
| Ma Z, Fan Y, Peng Y, Bian L, Zhou J, Wang L, et al. miR-6315 silencing protects against spinal cord injury through the Smo and anti-ferroptosis pathway. Biosci Rep. 2023;43: pubmed publisher |
| Bao X, Luo X, Bai X, Lv Y, Weng X, Zhang S, et al. Cigarette tar mediates macrophage ferroptosis in atherosclerosis through the hepcidin/FPN/SLC7A11 signaling pathway. Free Radic Biol Med. 2023;201:76-88 pubmed publisher |
| Zhou Y, Qian W, Li X, Wei W. NF-κB Inhibitor Myrislignan Induces Ferroptosis of Glioblastoma Cells via Regulating Epithelial-Mesenchymal Transformation in a Slug-Dependent Manner. Oxid Med Cell Longev. 2023;2023:7098313 pubmed publisher |
| Xie Z, Wang X, Luo X, Yan J, Zhang J, Sun R, et al. Activated AMPK mitigates diabetes-related cognitive dysfunction by inhibiting hippocampal ferroptosis. Biochem Pharmacol. 2023;207:115374 pubmed publisher |
| Park M, Cho Y, Choi Y, Min J, Park Y, Yoon S, et al. Particulate matter induces ferroptosis by accumulating iron and dysregulating the antioxidant system. BMB Rep. 2023;56:96-101 pubmed |
| Mi Y, Wei C, Sun L, Liu H, Zhang J, Luo J, et al. Melatonin inhibits ferroptosis and delays age-related cataract by regulating SIRT6/p-Nrf2/GPX4 and SIRT6/NCOA4/FTH1 pathways. Biomed Pharmacother. 2023;157:114048 pubmed publisher |
| Ishii T, Mimura I, Nagaoka K, Naito A, Sugasawa T, Kuroda R, et al. Effect of M2-like macrophages of the injured-kidney cortex on kidney cancer progression. Cell Death Discov. 2022;8:480 pubmed publisher |
| Sketriené D, Battista D, Lalert L, Kraiwattanapirom N, Thai H, Leeboonngam T, et al. Compulsive-like eating of high-fat high-sugar food is associated with 'addiction-like' glutamatergic dysfunction in obesity prone rats. Addict Biol. 2022;27:e13206 pubmed publisher |
| Li N, Yi X, He Y, Huo B, Chen Y, Zhang Z, et al. Targeting Ferroptosis as a Novel Approach to Alleviate Aortic Dissection. Int J Biol Sci. 2022;18:4118-4134 pubmed publisher |
| Lee J, Chang Chien G, Lin S, Hsiao Y, Ke M, Chen A, et al. 5-Lipoxygenase Inhibition Protects Retinal Pigment Epithelium from Sodium Iodate-Induced Ferroptosis and Prevents Retinal Degeneration. Oxid Med Cell Longev. 2022;2022:1792894 pubmed publisher |
| Yuan F, Sun Q, Zhang S, Ye L, Xu Y, Deng G, et al. The dual role of p62 in ferroptosis of glioblastoma according to p53 status. Cell Biosci. 2022;12:20 pubmed publisher |
| Chen Y, Yi X, Huo B, He Y, Guo X, Zhang Z, et al. BRD4770 functions as a novel ferroptosis inhibitor to protect against aortic dissection. Pharmacol Res. 2022;177:106122 pubmed publisher |
| Seo M, Kim Y, Ye B, Park S, Kim S, Jung J, et al. PET Imaging of System xC - in Immune Cells for Assessment of Disease Activity in Mice and Patients with Inflammatory Bowel Disease. J Nucl Med. 2022;63:1586-1591 pubmed publisher |
| Akusjärvi S, Ambikan A, Krishnan S, Gupta S, Sperk M, Vegvari A, et al. Integrative proteo-transcriptomic and immunophenotyping signatures of HIV-1 elite control phenotype: A cross-talk between glycolysis and HIF signaling. iScience. 2022;25:103607 pubmed publisher |
| Yuan F, Sun Q, Zhang S, Ye L, Xu Y, Xu Z, et al. HSP27 protects against ferroptosis of glioblastoma cells. Hum Cell. 2022;35:238-249 pubmed publisher |
| Cheng Z, Akatsuka S, Li G, Mori K, Takahashi T, Toyokuni S. Ferroptosis resistance determines high susceptibility of murine A/J strain to iron-induced renal carcinogenesis. Cancer Sci. 2022;113:65-78 pubmed publisher |
| Tang Y, Luo H, Xiao Q, Li L, Zhong X, Zhang J, et al. Isoliquiritigenin attenuates septic acute kidney injury by regulating ferritinophagy-mediated ferroptosis. Ren Fail. 2021;43:1551-1560 pubmed publisher |
| Kim H, Choi Y, Kim S, Kim H, Jun D, Yoon K, et al. Auranofin prevents liver fibrosis by system Xc-mediated inhibition of NLRP3 inflammasome. Commun Biol. 2021;4:824 pubmed publisher |
| Sharbeen G, McCarroll J, Akerman A, Kopecky C, Youkhana J, Kokkinos J, et al. Cancer-Associated Fibroblasts in Pancreatic Ductal Adenocarcinoma Determine Response to SLC7A11 Inhibition. Cancer Res. 2021;81:3461-3479 pubmed publisher |
| Zhao X, Gao M, Liang J, Chen Y, Wang Y, Wang Y, et al. SLC7A11 Reduces Laser-Induced Choroidal Neovascularization by Inhibiting RPE Ferroptosis and VEGF Production. Front Cell Dev Biol. 2021;9:639851 pubmed publisher |
| Kim S, Kang S, Joo J, Han S, Shin H, Nam B, et al. Characterization of ferroptosis in kidney tubular cell death under diabetic conditions. Cell Death Dis. 2021;12:160 pubmed publisher |
| Kazama M, Kato Y, Kakita A, Noguchi N, Urano Y, Masui K, et al. Astrocytes release glutamate via cystine/glutamate antiporter upregulated in response to increased oxidative stress related to sporadic amyotrophic lateral sclerosis. Neuropathology. 2020;40:587-598 pubmed publisher |
| Healey K, Kibble S, Bell A, Hodges S, Swartzwelder H. Effects of adolescent intermittent ethanol on hippocampal expression of glutamate homeostasis and astrocyte-neuronal tethering proteins in male and female rats. J Neurosci Res. 2020;: pubmed publisher |
| Krys D, Mattingly S, Glubrecht D, Wuest M, Wuest F. PET Imaging of L-Type Amino Acid Transporter (LAT1) and Cystine-Glutamate Antiporter (xc-) with [18F]FDOPA and [18F]FSPG in Breast Cancer Models. Mol Imaging Biol. 2020;22:1562-1571 pubmed publisher |
| Park S, Na S, Kumar M, Mosci C, Wardak M, Koglin N, et al. Clinical Evaluation of (4S)-4-(3-[18F]Fluoropropyl)-L-glutamate (18F-FSPG) for PET/CT Imaging in Patients with Newly Diagnosed and Recurrent Prostate Cancer. Clin Cancer Res. 2020;26:5380-5387 pubmed publisher |
| Gao M, Liu H, Xiao Y, Guo Y, Wan X, Li X, et al. xCT regulates redox homeostasis and promotes photoreceptor survival after retinal detachment. Free Radic Biol Med. 2020;158:32-43 pubmed publisher |
| Long Y, Tao H, Karachi A, Grippin A, Jin L, Chang Y, et al. Dysregulation of Glutamate Transport Enhances Treg Function That Promotes VEGF Blockade Resistance in Glioblastoma. Cancer Res. 2020;80:499-509 pubmed publisher |
| Wu W, Sun H, Chen J, OuYang H, Yu X, Chen H, et al. Immunosuppressive Immature Myeloid Cell Generation Is Controlled by Glutamine Metabolism in Human Cancer. Cancer Immunol Res. 2019;7:1605-1618 pubmed publisher |
| Pitman K, Alluri S, Kristian A, Aarnes E, Lyng H, Riss P, et al. Influx rate of 18F-fluoroaminosuberic acid reflects cystine/glutamate antiporter expression in tumour xenografts. Eur J Nucl Med Mol Imaging. 2019;46:2190-2198 pubmed publisher |
| Isobe S, Kataoka M, Endo J, Moriyama H, Okazaki S, Tsuchihashi K, et al. Endothelial-Mesenchymal Transition Drives Expression of CD44 Variant and xCT in Pulmonary Hypertension. Am J Respir Cell Mol Biol. 2019;: pubmed publisher |
| Ungard R, Linher Melville K, Nashed M, Sharma M, Wen J, Singh G. xCT knockdown in human breast cancer cells delays onset of cancer-induced bone pain. Mol Pain. 2019;15:1744806918822185 pubmed publisher |
| Li C, Chen H, Lan Z, He S, Chen R, Wang F, et al. mTOR-dependent upregulation of xCT blocks melanin synthesis and promotes tumorigenesis. Cell Death Differ. 2019;: pubmed publisher |
| Greenwood H, McCormick P, Gendron T, Glaser M, Pereira R, Maddocks O, et al. Measurement of Tumor Antioxidant Capacity and Prediction of Chemotherapy Resistance in Preclinical Models of Ovarian Cancer by Positron Emission Tomography. Clin Cancer Res. 2019;25:2471-2482 pubmed publisher |
| Mi D, Dixit S, Warner T, Kennard J, Scharf D, Kessler E, et al. Altered glutamate clearance in ascorbate deficient mice increases seizure susceptibility and contributes to cognitive impairment in APP/PSEN1 mice. Neurobiol Aging. 2018;71:241-254 pubmed publisher |
| Miladinovic T, Ungard R, Linher Melville K, Popovic S, Singh G. Functional effects of TrkA inhibition on system xC--mediated glutamate release and cancer-induced bone pain. Mol Pain. 2018;14:1744806918776467 pubmed publisher |
| Logan C, Lacrosse A, Knackstedt L. Nucleus accumbens GLT-1a overexpression reduces glutamate efflux during reinstatement of cocaine-seeking but is not sufficient to attenuate reinstatement. Neuropharmacology. 2018;135:297-307 pubmed publisher |
| Hoehne A, James M, Alam I, Ronald J, Schneider B, D Souza A, et al. [18F]FSPG-PET reveals increased cystine/glutamate antiporter (xc-) activity in a mouse model of multiple sclerosis. J Neuroinflammation. 2018;15:55 pubmed publisher |
| Bechard A, Hamor P, Schwendt M, Knackstedt L. The effects of ceftriaxone on cue-primed reinstatement of cocaine-seeking in male and female rats: estrous cycle effects on behavior and protein expression in the nucleus accumbens. Psychopharmacology (Berl). 2018;235:837-848 pubmed publisher |
| Nasca C, Bigio B, Zelli D, De Angelis P, Lau T, Okamoto M, et al. Role of the Astroglial Glutamate Exchanger xCT in Ventral Hippocampus in Resilience to Stress. Neuron. 2017;96:402-413.e5 pubmed publisher |
| Sayin V, LeBoeuf S, Singh S, Davidson S, Biancur D, Guzelhan B, et al. Activation of the NRF2 antioxidant program generates an imbalance in central carbon metabolism in cancer. elife. 2017;6: pubmed publisher |
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| Lacrosse A, O Donovan S, Sepulveda Orengo M, McCullumsmith R, Reissner K, Schwendt M, et al. Contrasting the Role of xCT and GLT-1 Upregulation in the Ability of Ceftriaxone to Attenuate the Cue-Induced Reinstatement of Cocaine Seeking and Normalize AMPA Receptor Subunit Expression. J Neurosci. 2017;37:5809-5821 pubmed publisher |
| Suárez Pozos E, MartÃnez Lozada Z, Méndez Flores O, Guillem A, Hernández Kelly L, Castelán F, et al. Characterization of the cystine/glutamate antiporter in cultured Bergmann glia cells. Neurochem Int. 2017;108:52-59 pubmed publisher |
| Martin C, Patel M, Melendez Ferro M, Sims B. Erythropoietin-induced cytoprotection in intestinal epithelial cells is linked to system Xc. Exp Cell Res. 2017;352:202-206 pubmed publisher |
| Merckx E, Albertini G, Paterka M, Jensen C, Albrecht P, Dietrich M, et al. Absence of system xc- on immune cells invading the central nervous system alleviates experimental autoimmune encephalitis. J Neuroinflammation. 2017;14:9 pubmed publisher |
| Kavanaugh G, Williams J, Morris A, Nickels M, Walker R, Koglin N, et al. Utility of [18F]FSPG PET to Image Hepatocellular Carcinoma: First Clinical Evaluation in a US Population. Mol Imaging Biol. 2016;18:924-934 pubmed |
| Polewski M, Reveron Thornton R, Cherryholmes G, Marinov G, Cassady K, Aboody K. Increased Expression of System xc- in Glioblastoma Confers an Altered Metabolic State and Temozolomide Resistance. Mol Cancer Res. 2016;14:1229-1242 pubmed |
| Linher Melville K, Nashed M, Ungard R, Haftchenary S, Rosa D, Gunning P, et al. Chronic Inhibition of STAT3/STAT5 in Treatment-Resistant Human Breast Cancer Cell Subtypes: Convergence on the ROS/SUMO Pathway and Its Effects on xCT Expression and System xc- Activity. PLoS ONE. 2016;11:e0161202 pubmed publisher |
| Slosky L, Bassirirad N, Symons A, Thompson M, Doyle T, Forte B, et al. The cystine/glutamate antiporter system xc- drives breast tumor cell glutamate release and cancer-induced bone pain. Pain. 2016;157:2605-2616 pubmed |
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| Pati D, Kelly K, Stennett B, Frazier C, Knackstedt L. Alcohol consumption increases basal extracellular glutamate in the nucleus accumbens core of Sprague-Dawley rats without increasing spontaneous glutamate release. Eur J Neurosci. 2016;44:1896-905 pubmed publisher |
| Lu H, Samanta D, Xiang L, Zhang H, Hu H, Chen I, et al. Chemotherapy triggers HIF-1-dependent glutathione synthesis and copper chelation that induces the breast cancer stem cell phenotype. Proc Natl Acad Sci U S A. 2015;112:E4600-9 pubmed publisher |
| Merckx E, Demuyser T, Bentea E, Van Liefferinge J, Albertini G, Deneyer L, et al. Lack of effect of Theiler's murine encephalomyelitis virus infection on system xcâ». Neurosci Lett. 2015;593:124-8 pubmed publisher |
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| Aal Aaboda M, Alhaddad H, Osowik F, Nauli S, Sari Y. Effects of (R)-(-)-5-methyl-1-nicotinoyl-2-pyrazoline on glutamate transporter 1 and cysteine/glutamate exchanger as well as ethanol drinking behavior in male, alcohol-preferring rats. J Neurosci Res. 2015;93:930-7 pubmed publisher |
| Martin L, Gardner L. Stress-induced inhibition of nonsense-mediated RNA decay regulates intracellular cystine transport and intracellular glutathione through regulation of the cystine/glutamate exchanger SLC7A11. Oncogene. 2015;34:4211-8 pubmed publisher |
