xCT Antibody - BSA Free | Novus Biologicals NB300-317 product information

product summary

company name :

Novus Biologicals

other brands :

IMGENEX

product type :

antibody

product name :

xCT Antibody - BSA Free

catalog :

NB300-317

quantity :

0.1 ml (also 0.025 ml)

price :

419 USD

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

14D5

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

more info or order :

Novus Biologicals product webpage

citations: 21

Reference
Wang J, Wang Y, Liu Y, Cai X, Huang X, Fu W, et al. Ferroptosis, a new target for treatment of renal injury and fibrosis in a 5/6 nephrectomy-induced CKD rat model. Cell Death Discov. 2022;8:127 pubmed publisher
Zhang H, Hughes C, Li W, He J, Surdez D, El Naggar A, et al. Proteomic Screens for Suppressors of Anoikis Identify IL1RAP as a Promising Surface Target in Ewing Sarcoma. Cancer Discov. 2021;11:2884-2903 pubmed publisher
Martinez R, Huang W, Samadani R, Mackowiak B, Centola G, Chen L, et al. Mechanistic Analysis of an Extracellular Signal-Regulated Kinase 2-Interacting Compound that Inhibits Mutant BRAF-Expressing Melanoma Cells by Inducing Oxidative Stress. J Pharmacol Exp Ther. 2021;376:84-97 pubmed publisher
Klinger S. Segment-specific effects of resveratrol on porcine small intestinal dipeptide absorption depend on the mucosal pH and are due to different mechanisms: potential roles of different transport proteins and protein kinases. J Nutr Biochem. 2020;85:108467 pubmed publisher
Long Y, Tao H, Karachi A, Grippin A, Jin L, Chang Y, et al. Dysregulation of Glutamate Transport Enhances Treg Function That Promotes VEGF Blockade Resistance in Glioblastoma. Cancer Res. 2020;80:499-509 pubmed publisher
Koizumi M, Ueda K, Niimura F, Nishiyama A, Yanagita M, Saito A, et al. Podocyte Injury Augments Intrarenal Angiotensin II Generation and Sodium Retention in a Megalin-Dependent Manner. Hypertension. 2019;74:509-517 pubmed publisher
Hayasaki T, Ishimoto T, Doke T, Hirayama A, Soga T, Furuhashi K, et al. Fructose increases the activity of sodium hydrogen exchanger in renal proximal tubules that is dependent on ketohexokinase. J Nutr Biochem. 2019;71:54-62 pubmed publisher
Huang M, Lin Y, Chang C, Lei F, Ho E, Liu R, et al. RGS4 deficit in prefrontal cortex contributes to the behaviors related to schizophrenia via system xc--mediated glutamatergic dysfunction in mice. Theranostics. 2018;8:4781-4794 pubmed publisher
Masuda T, Watanabe Y, Fukuda K, Watanabe M, Onishi A, Ohara K, et al. Unmasking a sustained negative effect of SGLT2 inhibition on body fluid volume in the rat. Am J Physiol Renal Physiol. 2018;315:F653-F664 pubmed publisher
Klinger S, Breves G. Resveratrol Inhibits Porcine Intestinal Glucose and Alanine Transport: Potential Roles of Na?/K?-ATPase Activity, Protein Kinase A, AMP-Activated Protein Kinase and the Association of Selected Nutrient Transport Proteins with Detergent Resistant Memb. Nutrients. 2018;10: pubmed publisher
Fenton R, Poulsen S, de la Mora Chavez S, Soleimani M, Dominguez Rieg J, Rieg T. Renal tubular NHE3 is required in the maintenance of water and sodium chloride homeostasis. Kidney Int. 2017;92:397-414 pubmed publisher
Chew S, Okazaki Y, Akatsuka S, Wang S, Jiang L, Ohara Y, et al. Rheostatic CD44 isoform expression and its association with oxidative stress in human malignant mesothelioma. Free Radic Biol Med. 2017;106:91-99 pubmed publisher
Linher Melville K, Haftchenary S, Gunning P, Singh G. Signal transducer and activator of transcription 3 and 5 regulate system Xc- and redox balance in human breast cancer cells. Mol Cell Biochem. 2015;405:205-21 pubmed publisher
Ozkucur N, Song B, Bola S, Zhang L, Reid B, Fu G, et al. NHE3 phosphorylation via PKC? marks the polarity and orientation of directionally migrating cells. Cell Mol Life Sci. 2014;71:4653-4663 pubmed publisher
Perike S, Ozkucur N, Sharma P, Staroske W, Bläsche R, Barth K, et al. Phospho-NHE3 forms membrane patches and interacts with beta-actin to sense and maintain constant direction during cell migration. Exp Cell Res. 2014;324:13-29 pubmed publisher
Liu T, Jose P. Gastrin induces sodium-hydrogen exchanger 3 phosphorylation and mTOR activation via a phosphoinositide 3-kinase-/protein kinase C-dependent but AKT-independent pathway in renal proximal tubule cells derived from a normotensive male human. Endocrinology. 2013;154:865-75 pubmed publisher
Rieg T, Gerasimova M, Murray F, Masuda T, Tang T, Rose M, et al. Natriuretic effect by exendin-4, but not the DPP-4 inhibitor alogliptin, is mediated via the GLP-1 receptor and preserved in obese type 2 diabetic mice. Am J Physiol Renal Physiol. 2012;303:F963-71 pubmed publisher
Ozkucur N, Perike S, Sharma P, Funk R. Persistent directional cell migration requires ion transport proteins as direction sensors and membrane potential differences in order to maintain directedness. BMC Cell Biol. 2011;12:4 pubmed publisher
Dynia D, Steinmetz A, Kocinsky H. NHE3 function and phosphorylation are regulated by a calyculin A-sensitive phosphatase. Am J Physiol Renal Physiol. 2010;298:F745-53 pubmed publisher
Kocinsky H, Dynia D, Wang T, Aronson P. NHE3 phosphorylation at serines 552 and 605 does not directly affect NHE3 activity. Am J Physiol Renal Physiol. 2007;293:F212-8 pubmed
Kocinsky H, Girardi A, Biemesderfer D, Nguyen T, Mentone S, Orlowski J, et al. Use of phospho-specific antibodies to determine the phosphorylation of endogenous Na+/H+ exchanger NHE3 at PKA consensus sites. Am J Physiol Renal Physiol. 2005;289:F249-58 pubmed

product information

master code :

NB300-317

SKU :

NB300-317

product name :

xCT Antibody - BSA Free

unit size :

0.1 ml (also 0.025 ml)

description :

The xCT Antibody - BSA Free from Novus is a rabbit polyclonal antibody to xCT. This antibody reacts with human,mouse,rat. The xCT Antibody - BSA Free has been validated for the following applications: Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Flow Cytometry,Immunohistochemistry,Immunoblotting,Simple Western,Immunocytochemistry/ Immunofluorescence.

target :

xCT

category :

Primary Antibodies

buffer :

PBS

clonality :

Polyclonal

concentration :

1 mg/ml

conjugate :

Unconjugated

host :

Rabbit

immunogen :

This xCT Antibody was prepared from a synthetic peptide made to a region within the N-terminus of the mouse xCT protein (between residues 1-50). [Uniprot: Q9WTR6]

isotype :

IgG

purity :

Immunogen affinity purified

species :

Human,Mouse,Rat

theoretical molecular weight :

55 kDa

gene symbol :

SLC7A11

Antibody validation :

Biological Validation

applications :

Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Flow Cytometry,Immunohistochemistry,Immunoblotting,Simple Western,Immunocytochemistry/ Immunofluorescence

USD :

419 USD

alt names :

Amino acid transport system xc-, Calcium channel blocker resistance protein CCBR1, CCBR1, cystine/glutamate transporter, SLC7A11, solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11, Solute carrier family 7 member 11, solute carrier family 7, (cationic amino acid transporter, y+ system) member 11, xCT

storage :

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

more info or order :

Novus Biologicals product webpage