LRRK2 Antibody - BSA Free | Novus Biologicals NB300-268 product information

product summary

company name :

Novus Biologicals

other brands :

IMGENEX

product type :

antibody

product name :

LRRK2 Antibody - BSA Free

catalog :

NB300-268

quantity :

0.1 ml (also 0.025 ml)

price :

419 USD

clonality :

polyclonal

host :

domestic rabbit

conjugate :

HRP

clone name :

6C5cc

reactivity :

human, mouse, bovine

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

more info or order :

Novus Biologicals product webpage

citations: 15

Reference
Pajarillo E, Kim S, Digman A, Dutton M, Son D, Aschner M, et al. The role of microglial LRRK2 kinase in manganese-induced inflammatory neurotoxicity via NLRP3 inflammasome and RAB10-mediated autophagy dysfunction. J Biol Chem. 2023;299:104879 pubmed publisher
Pajarillo E, Kim S, Digman A, Dutton M, Son D, Aschner M, et al. The role of microglial LRRK2 in manganese-induced inflammatory neurotoxicity via NLRP3 inflammasome and RAB10-mediated autophagy dysfunction. bioRxiv. 2023;: pubmed publisher
Wang H, Li J, Tao L, Lv L, Sun J, Zhang T, et al. MiR-205 Regulates LRRK2 Expression in Dopamine Neurons in Parkinson's Disease through Methylation Modification. Iran J Public Health. 2022;51:1637-1647 pubmed publisher
Wallings R, Hughes L, Staley H, Simon Z, McFarland N, Alcalay R, et al. WHOPPA Enables Parallel Assessment of Leucine-Rich Repeat Kinase 2 and Glucocerebrosidase Enzymatic Activity in Parkinson's Disease Monocytes. Front Cell Neurosci. 2022;16:892899 pubmed publisher
Bharat V, Hsieh C, Wang X. Mitochondrial Defects in Fibroblasts of Pathogenic MAPT Patients. Front Cell Dev Biol. 2021;9:765408 pubmed publisher
Chen S, Luo Z, Ward C, Ibáñez D, Liu H, Zhong X, et al. Generation of two LRRK2 homozygous knockout human induced pluripotent stem cell lines using CRISPR/Cas9. Stem Cell Res. 2020;45:101804 pubmed publisher
Hsieh C, Li L, Vanhauwaert R, Nguyen K, Davis M, Bu G, et al. Miro1 Marks Parkinson's Disease Subset and Miro1 Reducer Rescues Neuron Loss in Parkinson's Models. Cell Metab. 2019;30:1131-1140.e7 pubmed publisher
Kim J, Pajarillo E, Rizor A, Son D, Lee J, Aschner M, et al. LRRK2 kinase plays a critical role in manganese-induced inflammation and apoptosis in microglia. PLoS ONE. 2019;14:e0210248 pubmed publisher
Bonello F, Hassoun S, Mouton Liger F, Shin Y, Muscat A, Tesson C, et al. LRRK2 impairs PINK1/Parkin-dependent mitophagy via its kinase activity: pathologic insights into Parkinson's disease. Hum Mol Genet. 2019;28:1645-1660 pubmed publisher
Takanashi M, Funayama M, Matsuura E, Yoshino H, Li Y, Tsuyama S, et al. Isolated nigral degeneration without pathological protein aggregation in autopsied brains with LRRK2 p.R1441H homozygous and heterozygous mutations. Acta Neuropathol Commun. 2018;6:105 pubmed publisher
Lim J, Bang Y, Choi J, Han A, Kwon M, Liu K, et al. LRRK2 G2019S Induces Anxiety/Depression-like Behavior before the Onset of Motor Dysfunction with 5-HT1A Receptor Upregulation in Mice. J Neurosci. 2018;38:1611-1621 pubmed publisher
Chen Z, Zhang W, Chua L, Chai C, Li R, Lin L, et al. Phosphorylation of amyloid precursor protein by mutant LRRK2 promotes AICD activity and neurotoxicity in Parkinson's disease. Sci Signal. 2017;10: pubmed publisher
Bliederhaeuser C, Zondler L, Grozdanov V, Ruf W, Brenner D, Melrose H, et al. LRRK2 contributes to monocyte dysregulation in Parkinson's disease. Acta Neuropathol Commun. 2016;4:123 pubmed
Nucifora F, Nucifora L, Ng C, Arbez N, Guo Y, Roby E, et al. Ubiqutination via K27 and K29 chains signals aggregation and neuronal protection of LRRK2 by WSB1. Nat Commun. 2016;7:11792 pubmed publisher
Vitte J, Traver S, Maués De Paula A, Lesage S, Rovelli G, Corti O, et al. Leucine-rich repeat kinase 2 is associated with the endoplasmic reticulum in dopaminergic neurons and accumulates in the core of Lewy bodies in Parkinson disease. J Neuropathol Exp Neurol. 2010;69:959-72 pubmed publisher

product information

master code :

NB300-268

SKU :

NB300-268

product name :

LRRK2 Antibody - BSA Free

unit size :

0.1 ml (also 0.025 ml)

description :

The LRRK2 Antibody - BSA Free from Novus is a rabbit polyclonal antibody to LRRK2. This antibody reacts with bovine,c. elegans,human,insect,mouse,plant,nematode - caenorhabditis elegans. The LRRK2 Antibody - BSA Free has been validated for the following applications: IF/IHC,ELISA,Flow Cytometry,Immunohistochemistry,Immunoprecipitation,Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunocytochemistry/ Immunofluorescence,Flow (Intracellular),Knockout Validated.

target :

LRRK2

category :

Primary Antibodies

buffer :

PBS

clonality :

Polyclonal

concentration :

1 mg/ml

conjugate :

Unconjugated

host :

Rabbit

immunogen :

A C-terminal synthetic peptide made to the human LRRK2 protein sequence (between residues 2500-2527). [UniProt# Q5S007]

isotype :

IgG

purity :

Immunogen affinity purified

species :

Bovine,C. elegans,Human,Insect,Mouse,Plant,Nematode - Caenorhabditis elegans

theoretical molecular weight :

286 kDa

gene symbol :

LRRK2

Antibody validation :

Independent Anitbodies

accessionNumbers :

Q5S007

applications :

IF/IHC,ELISA,Flow Cytometry,Immunohistochemistry,Immunoprecipitation,Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunocytochemistry/ Immunofluorescence,Flow (Intracellular),Knockout Validated

USD :

419 USD

alt names :

augmented in rheumatoid arthritis 17, AURA17, Dardarin, DKFZp434H2111, EC 2.7.11.1, FLJ45829, leucine-rich repeat kinase 2, leucine-rich repeat serine/threonine-protein kinase 2, PARK8DARDARIN, Parkinson disease (autosomal dominant) 8, RIPK7, ROCO2

storage :

Store at 4C short term. Store at -20C long term. Avoid freeze-thaw cycles.

more info or order :

Novus Biologicals product webpage