product summary
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company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
SCP3/SYCP3 Antibody - BSA Free
catalog :
NB300-232
quantity :
0.1 ml (also 0.025 ml)
price :
469 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat, chicken, bovine, zebrafish
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
citations: 60
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry; mouse; loading ...; fig 3a
Hinch A, Becker P, Li T, Moralli D, Zhang G, Bycroft C, et al. The Configuration of RPA, RAD51, and DMC1 Binding in Meiosis Reveals the Nature of Critical Recombination Intermediates. Mol Cell. 2020;79:689-701.e10 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 2c
  • immunocytochemistry; mouse; loading ...; fig 3a
Huang G, Liu L, Wang H, Gou M, Gong P, Tian C, et al. Tet1 Deficiency Leads to Premature Reproductive Aging by Reducing Spermatogonia Stem Cells and Germ Cell Differentiation. iScience. 2020;23:100908 pubmed publisher
  • immunocytochemistry; mouse; 1:100; loading ...; fig 3e
Pan H, Jiang N, Sun S, Jiang H, Xu J, Jiang X, et al. UHRF1-repressed 5'-hydroxymethylcytosine is essential for the male meiotic prophase I. Cell Death Dis. 2020;11:142 pubmed publisher
  • immunohistochemistry; mouse; 1:500; loading ...; fig 1a
  • immunohistochemistry; human; 1:500; fig 4b
Heeren A, He N, de Souza A, Goercharn Ramlal A, van Iperen L, Roost M, et al. On the development of extragonadal and gonadal human germ cells. Biol Open. 2016;5:185-94 pubmed publisher
Davies B, Zhang G, Moralli D, Alghadban S, Biggs D, Preece C, et al. Characterization of meiotic recombination intermediates through gene knockouts in founder hybrid mice. Genome Res. 2023;33:2018-2027 pubmed publisher
He J, Yan A, Chen B, Huang J, Kee K. 3D genome remodeling and homologous pairing during meiotic prophase of mouse oogenesis and spermatogenesis. Dev Cell. 2023;58:3009-3027.e6 pubmed publisher
Wu D, Huang H, Chen T, Gai X, Li Q, Wang C, et al. The BRCA1/BARD1 complex recognizes pre-ribosomal RNA to facilitate homologous recombination. Cell Discov. 2023;9:99 pubmed publisher
Younis N, Caldeira Brant A, Chu T, Abdalla S, Orwig K. Human immature testicular tissue organ culture: a step towards fertility preservation and restoration. Front Endocrinol (Lausanne). 2023;14:1242263 pubmed publisher
Islam K, Ajao A, Venkataramani K, Rivera J, Pathania S, Henke K, et al. The RNA-binding protein Adad1 is necessary for germ cell maintenance and meiosis in zebrafish. PLoS Genet. 2023;19:e1010589 pubmed publisher
Dil S, Ye J, Ma H, Unar A, Khan I, Ali A, et al. Cornichon protein CNIH4 is not essential for mice gametogenesis and fertility. Dev Biol. 2023;496:15-23 pubmed publisher
Abdallah S, Jampy A, Moison D, Wieckowski M, Messiaen S, Martini E, et al. Foetal exposure to the bisphenols BADGE and BPAF impairs meiosis through DNA oxidation in mouse ovaries. Environ Pollut. 2023;317:120791 pubmed publisher
Abe H, Yeh Y, Munakata Y, Ishiguro K, Andreassen P, Namekawa S. Active DNA damage response signaling initiates and maintains meiotic sex chromosome inactivation. Nat Commun. 2022;13:7212 pubmed publisher
Yan X, Feng Y, Hao Y, Zhong R, Jiang Y, Tang X, et al. Gut-Testis Axis: Microbiota Prime Metabolome To Increase Sperm Quality in Young Type 2 Diabetes. Microbiol Spectr. 2022;10:e0142322 pubmed publisher
Hu M, Yeh Y, Munakata Y, Abe H, Sakashita A, Maezawa S, et al. PRC1-mediated epigenetic programming is required to generate the ovarian reserve. Nat Commun. 2022;13:4510 pubmed publisher
Ali H, Unar A, Dil S, Ali I, Khan K, Khan I, et al. Testis-specific fascin component FSCN3 is dispensable for mouse spermatogenesis and fertility. Mol Biol Rep. 2022;49:6261-6268 pubmed publisher
Hao Y, Feng Y, Yan X, Chen L, Ma X, Tang X, et al. Gut Microbiota-Testis Axis: FMT Mitigates High-Fat Diet-Diminished Male Fertility via Improving Systemic and Testicular Metabolome. Microbiol Spectr. 2022;10:e0002822 pubmed publisher
Li Y, Meng R, Li S, Gu B, Xu X, Zhang H, et al. The ZFP541-KCTD19 complex is essential for pachytene progression by activating meiotic genes during mouse spermatogenesis. J Genet Genomics. 2022;49:1029-1041 pubmed publisher
Tseng H, Liu Y, Lu B, Chen C. Immature Testicular Tissue Engineered from Weaned Mice to Adults for Prepubertal Fertility Preservation-An In Vivo Translational Study. Int J Mol Sci. 2022;23: pubmed publisher
Gai X, Xin D, Wu D, Wang X, Chen L, Wang Y, et al. Pre-ribosomal RNA reorganizes DNA damage repair factors in nucleus during meiotic prophase and DNA damage response. Cell Res. 2022;32:254-268 pubmed publisher
Islam K, Modi M, Siegfried K. The Zebrafish Meiotic Cohesin Complex Protein Smc1b Is Required for Key Events in Meiotic Prophase I. Front Cell Dev Biol. 2021;9:714245 pubmed publisher
Hassold T, Maylor Hagen H, Wood A, Gruhn J, Hoffmann E, Broman K, et al. Failure to recombine is a common feature of human oogenesis. Am J Hum Genet. 2021;108:16-24 pubmed publisher
Shioda K, Odajima J, Kobayashi M, Kobayashi M, Cordazzo B, Isselbacher K, et al. Transcriptomic and Epigenetic Preservation of Genetic Sex Identity in Estrogen-feminized Male Chicken Embryonic Gonads. Endocrinology. 2021;162: pubmed publisher
Zaman Q, Khan R, Hameed U, Shah W, Waqas A, Zubair M, et al. Exonuclease 5 is dispensable for meiotic progression and male fertility in mouse. Gene. 2020;:145254 pubmed publisher
Yousaf A, Wu Y, Khan R, Shah W, Khan I, Shi Q, et al. Normal spermatogenesis and fertility in Ddi1 (DNA damage inducible 1) mutant mice. Reprod Biol. 2020;20:520-524 pubmed publisher
Larose H, Kent T, Ma Q, Shami A, Harerimana N, Li J, et al. Regulation of meiotic progression by Sertoli-cell androgen signaling. Mol Biol Cell. 2020;31:2841-2862 pubmed publisher
Yun Y, Ito M, Sandhu S, Hunter N. Cytological Monitoring of Meiotic Crossovers in Spermatocytes and Oocytes. Methods Mol Biol. 2021;2153:267-286 pubmed publisher
Wells D, Bitoun E, Moralli D, Zhang G, Hinch A, Jankowska J, et al. ZCWPW1 is recruited to recombination hotspots by PRDM9 and is essential for meiotic double strand break repair. elife. 2020;9: pubmed publisher
Khan R, Ye J, Yousaf A, Shah W, Aftab A, Shah B, et al. Evolutionarily conserved and testis-specific gene, 4930524B15Rik, is not essential for mouse spermatogenesis and fertility. Mol Biol Rep. 2020;47:5207-5213 pubmed publisher
Zwettler F, Spindler M, Reinhard S, Klein T, Kurz A, Benavente R, et al. Tracking down the molecular architecture of the synaptonemal complex by expansion microscopy. Nat Commun. 2020;11:3222 pubmed publisher
Petrillo C, Barroca V, Ribeiro J, Lailler N, Livera G, Keeney S, et al. shani mutation in mouse affects splicing of Spata22 and leads to impaired meiotic recombination. Chromosoma. 2020;129:161-179 pubmed publisher
Ge W, Wang J, Zhang R, Tan S, Zhang F, Liu W, et al. Dissecting the initiation of female meiosis in the mouse at single-cell resolution. Cell Mol Life Sci. 2021;78:695-713 pubmed publisher
Zhao Y, Zhang P, Ge W, Feng Y, Li L, Sun Z, et al. Alginate oligosaccharides improve germ cell development and testicular microenvironment to rescue busulfan disrupted spermatogenesis. Theranostics. 2020;10:3308-3324 pubmed publisher
Che L, Alavattam K, Stambrook P, Namekawa S, Du C. BRUCE preserves genomic stability in the male germline of mice. Cell Death Differ. 2020;: pubmed publisher
Guioli S, Zhao D, Nandi S, Clinton M, Lovell Badge R. Oestrogen in the chick embryo can induce chromosomally male ZZ left gonad epithelial cells to form an ovarian cortex that can support oogenesis. Development. 2020;147: pubmed publisher
Abe H, Alavattam K, Hu Y, Pang Q, Andreassen P, Hegde R, et al. The Initiation of Meiotic Sex Chromosome Inactivation Sequesters DNA Damage Signaling from Autosomes in Mouse Spermatogenesis. Curr Biol. 2019;: pubmed publisher
Harpelunde Poulsen K, Nielsen J, Frederiksen H, Melau C, Juul Hare K, Langhoff Thuesen L, et al. Dysregulation of FGFR signalling by a selective inhibitor reduces germ cell survival in human fetal gonads of both sexes and alters the somatic niche in fetal testes. Hum Reprod. 2019;34:2228-2243 pubmed publisher
Xie Y, Khan R, Wahab F, Hussain H, Ali A, Ma H, et al. The testis-specifically expressed Dpep3 is not essential for male fertility in mice. Gene. 2019;: pubmed publisher
Gorence G, Pulcastro H, Lawson C, Gerona R, Friesen M, Horan T, et al. Chemical Contaminants from Plastics in the Animal Environment. J Am Assoc Lab Anim Sci. 2019;58:190-196 pubmed publisher
Sun Z, Zhang P, Wang J, Liu J, Li L, Shen W, et al. Melatonin alleviates meiotic defects in fetal mouse oocytes induced by Di (2-ethylhexyl) phthalate in vitro. Aging (Albany NY). 2018;10:4175-4187 pubmed publisher
Jørgensen A, Macdonald J, Nielsen J, Kilcoyne K, Perlman S, Lundvall L, et al. Nodal Signaling Regulates Germ Cell Development and Establishment of Seminiferous Cords in the Human Fetal Testis. Cell Rep. 2018;25:1924-1937.e4 pubmed publisher
Mu X, Wen J, Chen Q, Wang Z, Wang Y, Guo M, et al. Retinoic acid-induced CYP51 nuclear translocation promotes meiosis prophase I process and is correlated to the expression of REC8 and STAG3 in mice. Biol Open. 2018;7: pubmed publisher
Horan T, Pulcastro H, Lawson C, Gerona R, Martin S, Gieske M, et al. Replacement Bisphenols Adversely Affect Mouse Gametogenesis with Consequences for Subsequent Generations. Curr Biol. 2018;28:2948-2954.e3 pubmed publisher
Mary N, Villagómez D, Revay T, Rezaei S, Donaldson B, Pinton A, et al. Meiotic Synapsis and Gene Expression Altered by a Balanced Y-Autosome Reciprocal Translocation in an Azoospermic Pig. Sex Dev. 2018;12: pubmed publisher
Zhai Q, Ge W, Wang J, Sun X, Ma J, Liu J, et al. Exposure to Zinc oxide nanoparticles during pregnancy induces oocyte DNA damage and affects ovarian reserve of mouse offspring. Aging (Albany NY). 2018;10:2170-2189 pubmed publisher
Cheng S, Qin X, Han Z, Sun X, Feng Y, Yang F, et al. Nicotine exposure impairs germ cell development in human fetal ovaries cultured in vitro. Aging (Albany NY). 2018;10:1556-1574 pubmed publisher
Fouquet B, Pawlikowska P, Caburet S, Guigon C, Mäkinen M, Tanner L, et al. A homozygous FANCM mutation underlies a familial case of non-syndromic primary ovarian insufficiency. elife. 2017;6: pubmed publisher
Cheng P, Wu H, Li C, Chen C, Cheng H. Characterization of the testicular regeneration potential in premature cockerels. J Reprod Dev. 2017;63:563-570 pubmed publisher
Pang J, Zhou Q, Sun X, Li L, Zhou B, Zeng F, et al. Effect of low-dose zearalenone exposure on reproductive capacity of male mice. Toxicol Appl Pharmacol. 2017;333:60-67 pubmed publisher
Liu J, Lai F, Li L, Sun X, Cheng S, Ge W, et al. Di (2-ethylhexyl) phthalate exposure impairs meiotic progression and DNA damage repair in fetal mouse oocytes in vitro. Cell Death Dis. 2017;8:e2966 pubmed publisher
Jung D, Xiong J, Ye M, Qin X, Li L, Cheng S, et al. In vitro differentiation of human embryonic stem cells into ovarian follicle-like cells. Nat Commun. 2017;8:15680 pubmed publisher
Liu K, Sun X, Feng Y, Cheng S, Li B, Li Y, et al. The impact of Zearalenone on the meiotic progression and primordial follicle assembly during early oogenesis. Toxicol Appl Pharmacol. 2017;329:9-17 pubmed publisher
Vallot C, Patrat C, Collier A, Huret C, Casanova M, Liyakat Ali T, et al. XACT Noncoding RNA Competes with XIST in the Control of X Chromosome Activity during Human Early Development. Cell Stem Cell. 2017;20:102-111 pubmed publisher
Zhuang X, Tang W, Feng X, Liu C, Zhu J, Yan J, et al. Trim27 interacts with Slx2, is associated with meiotic processes during spermatogenesis. Cell Cycle. 2016;15:2576-2584 pubmed
Tang X, Xu S, Li R, Zhang H, Chen Q, Wu W, et al. Polycomb repressive complex 1 (PRC1) regulates meiotic initiation of ovarian germ cells in chick embryos. Mol Cell Endocrinol. 2016;437:171-182 pubmed publisher
Hanna R, Moffett D, Forster F, Trudgett A, Brennan G, Fairweather I. Fasciola hepatica: a light and electron microscope study of the ovary and of the development of oocytes within eggs in the uterus provides an insight into reproductive strategy. Vet Parasitol. 2016;221:93-103 pubmed publisher
Lambeth L, Morris K, Ayers K, Wise T, O Neil T, Wilson S, et al. Overexpression of Anti-Müllerian Hormone Disrupts Gonadal Sex Differentiation, Blocks Sex Hormone Synthesis, and Supports Cell Autonomous Sex Development in the Chicken. Endocrinology. 2016;157:1258-75 pubmed publisher
Ge W, Ma H, Cheng S, Sun Y, Sun L, Sun X, et al. Differentiation of early germ cells from human skin-derived stem cells without exogenous gene integration. Sci Rep. 2015;5:13822 pubmed publisher
Cadalbert L, Ghaffar F, Stevenson D, Bryson S, Vaz F, Gottlieb E, et al. Mouse Tafazzin Is Required for Male Germ Cell Meiosis and Spermatogenesis. PLoS ONE. 2015;10:e0131066 pubmed publisher
De Melo Bernardo A, Heeren A, van Iperen L, Fernandes M, He N, Anjie S, et al. Meiotic wave adds extra asymmetry to the development of female chicken gonads. Mol Reprod Dev. 2015;82:774-86 pubmed publisher
Liang G, Zhang X, Wang J, Sun Y, Sun X, Cheng S, et al. Activin A accelerates the progression of fetal oocytes throughout meiosis and early oogenesis in the mouse. Stem Cells Dev. 2015;24:2455-65 pubmed publisher
product information
master code :
NB300-232
SKU :
NB300-232
product name :
SCP3/SYCP3 Antibody - BSA Free
unit size :
0.1 ml (also 0.025 ml)
description :
The SCP3/SYCP3 Antibody - BSA Free from Novus is a rabbit polyclonal antibody to SCP3/SYCP3. This antibody reacts with avian - chicken,bovine,chicken,feline,human,mouse,parasite,porcine,rat,fish - danio rerio (zebrafish). The SCP3/SYCP3 Antibody - BSA Free has been validated for the following applications: Immunocytochemistry/ Immunofluorescence,Immunohistochemistry,Western Blot,IF/IHC,Immunoprecipitation,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunoblotting.
target :
SCP3/SYCP3
category :
Primary Antibodies
buffer :
PBS
clonality :
Polyclonal
concentration :
1 mg/ml
conjugate :
Unconjugated
host :
Rabbit
immunogen :
A synthetic peptide made to the C-terminal region of the human SCP3 protein. [UniProt# Q8IZU3]
isotype :
IgG
purity :
Immunogen affinity purified
species :
Avian - Chicken,Bovine,Chicken,Feline,Human,Mouse,Parasite,Porcine,Rat,Fish - Danio rerio (Zebrafish)
gene symbol :
SYCP3
accessionNumbers :
Q8IZU3
applications :
Immunocytochemistry/ Immunofluorescence,Immunohistochemistry,Western Blot,IF/IHC,Immunoprecipitation,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunoblotting
USD :
469 USD
alt names :
anti-SCP3, MGC71888, SCP3, SCP-3, SCP3 chromosome 3 open reading frame 8, SCP3 COR1, synaptonemal complex protein 3
storage :
Store at 4C. Do not freeze.
more info or order :
company information
Novus Biologicals
10771 E Easter Ave
Centennial, CO 80112
novus@novusbio.com
https://www.novusbio.com
3037301950
headquarters: USA
Novus Biologicals licenses, manufactures, and markets antibodies to over 20,000 unique targets to support a wide array of research areas. Novus is built on honesty, collaboration and strong relationships and continues to provide quality tools that accelerate research. Every product is backed by our 100% guarantee.