SCP3/SYCP3 Antibody | Novus Biologicals NB300-230 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Novus Biologicals

other brands :

IMGENEX

product type :

antibody

product name :

SCP3/SYCP3 Antibody

catalog :

NB300-230

quantity :

0.1 ml (also 0.025 ml)

price :

299 USD

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

2.30E+06

reactivity :

human, mouse, bovine

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

citations: 40

Published Application/Species/Sample/Dilution	Reference
immunocytochemistry; mouse; 1:500; loading ...; fig 1d	McNicoll F, Kühnel A, Biswas U, Hempel K, Whelan G, Eichele G, et al. Meiotic sex chromosome cohesion and autosomal synapsis are supported by Esco2. Life Sci Alliance. 2020;3: pubmed publisher
immunohistochemistry - frozen section; mouse; 1:500; loading ...; fig 2a	Biswas U, Hempel K, Llano E, Pendas A, Jessberger R. Distinct Roles of Meiosis-Specific Cohesin Complexes in Mammalian Spermatogenesis. PLoS Genet. 2016;12:e1006389 pubmed publisher
	Huang L, Peng Z, Lu C, Chen Y, Lv J, Qin M, et al. Ginsenoside Rg1 alleviates repeated alcohol exposure-induced psychomotor and cognitive deficits. Chin Med. 2020;15:44 pubmed publisher
	Hu P, Liu J, Maita I, Kwok C, Gu E, Gergues M, et al. Chronic Stress Induces Maladaptive Behaviors by Activating Corticotropin-Releasing Hormone Signaling in the Mouse Oval Bed Nucleus of the Stria Terminalis. J Neurosci. 2020;40:2519-2537 pubmed publisher
	Tian C, Liu L, Ye X, Fu H, Sheng X, Wang L, et al. Functional Oocytes Derived from Granulosa Cells. Cell Rep. 2019;29:4256-4267.e9 pubmed publisher
	Evans C, Thomas R, Freeman T, Hvoslef Eide M, Good M, Kidd E. Selective reduction of APP-BACE1 activity improves memory via NMDA-NR2B receptor-mediated mechanisms in aged PDAPP mice. Neurobiol Aging. 2019;75:136-149 pubmed publisher
	Carvajal F, Mira R, Rovegno M, Minniti A, Cerpa W. Age-related NMDA signaling alterations in SOD2 deficient mice. Biochim Biophys Acta Mol Basis Dis. 2018;1864:2010-2020 pubmed publisher
	Zhou Z, Wang L, Ge F, Gong P, Wang H, Wang F, et al. Pold3 is required for genomic stability and telomere integrity in embryonic stem cells and meiosis. Nucleic Acids Res. 2018;46:3468-3486 pubmed publisher
	Biswas B, Batista F, Sundaram S, Stanley P. MGAT1 and Complex N-Glycans Regulate ERK Signaling During Spermatogenesis. Sci Rep. 2018;8:2022 pubmed publisher
	Biswas U, Stevense M, Jessberger R. SMC1α Substitutes for Many Meiotic Functions of SMC1β but Cannot Protect Telomeres from Damage. Curr Biol. 2018;28:249-261.e4 pubmed publisher
	Pose Utrilla J, Garcia Guerra L, del Puerto A, Martin A, Jurado Arjona J, De León Reyes N, et al. Excitotoxic inactivation of constitutive oxidative stress detoxification pathway in neurons can be rescued by PKD1. Nat Commun. 2017;8:2275 pubmed publisher
	Wang N, Satirapod C, Ohguchi Y, Park E, Woods D, Tilly J. Genetic studies in mice directly link oocytes produced during adulthood to ovarian function and natural fertility. Sci Rep. 2017;7:10011 pubmed publisher
	Yeo A, Becherel O, Luff J, Graham M, Richard D, Lavin M. Senataxin controls meiotic silencing through ATR activation and chromatin remodeling. Cell Discov. 2015;1:15025 pubmed publisher
	Won S, Incontro S, Nicoll R, Roche K. PSD-95 stabilizes NMDA receptors by inducing the degradation of STEP61. Proc Natl Acad Sci U S A. 2016;113:E4736-44 pubmed publisher
	Rajagopal S, Deb I, Poddar R, Paul S. Aging is associated with dimerization and inactivation of the brain-enriched tyrosine phosphatase STEP. Neurobiol Aging. 2016;41:25-38 pubmed publisher
	Poddar R, Rajagopal S, Shuttleworth C, Paul S. Zn2+-dependent Activation of the Trk Signaling Pathway Induces Phosphorylation of the Brain-enriched Tyrosine Phosphatase STEP: MOLECULAR BASIS FOR ZN2+-INDUCED ERK MAPK ACTIVATION. J Biol Chem. 2016;291:813-25 pubmed publisher
	Kim H, Jang J, Choi B. A single fraction from Uncaria sinensis exerts neuroprotective effects against glutamate-induced neurotoxicity in primary cultured cortical neurons. Anat Cell Biol. 2015;48:95-103 pubmed publisher
	Wang Y, Briz V, Chishti A, Bi X, Baudry M. Distinct roles for ?-calpain and m-calpain in synaptic NMDAR-mediated neuroprotection and extrasynaptic NMDAR-mediated neurodegeneration. J Neurosci. 2013;33:18880-92 pubmed publisher
	Deb I, Manhas N, Poddar R, Rajagopal S, Allan A, Lombroso P, et al. Neuroprotective role of a brain-enriched tyrosine phosphatase, STEP, in focal cerebral ischemia. J Neurosci. 2013;33:17814-26 pubmed publisher
	Kim H, Kim Y, Jang J, Choi Y, Baek J, Hong J, et al. Neuroprotective effects of Polygonum multiflorum extract against glutamate-induced oxidative toxicity in HT22 hippocampal cells. J Ethnopharmacol. 2013;150:108-15 pubmed publisher
	Sun W, Zelek Molik A, McGinty J. Short and long access to cocaine self-administration activates tyrosine phosphatase STEP and attenuates GluN expression but differentially regulates GluA expression in the prefrontal cortex. Psychopharmacology (Berl). 2013;229:603-13 pubmed publisher
	Shinohara Y, Hosoya A, Yahagi K, Ferecskó A, Yaguchi K, Sik A, et al. Hippocampal CA3 and CA2 have distinct bilateral innervation patterns to CA1 in rodents. Eur J Neurosci. 2012;35:702-10 pubmed publisher
	Farooq M, Kaswala R, Kleiman N, Kasinathan C, Frederikse P. GluA2 AMPA glutamate receptor subunit exhibits codon 607 Q/R RNA editing in the lens. Biochem Biophys Res Commun. 2012;418:273-7 pubmed publisher
	Davis M, Olausson P, Greengard P, Taylor J, Nairn A. Regulator of calmodulin signaling knockout mice display anxiety-like behavior and motivational deficits. Eur J Neurosci. 2012;35:300-8 pubmed publisher
	Mukherjee S, Poddar R, Deb I, Paul S. Dephosphorylation of specific sites in the kinase-specificity sequence domain leads to ubiquitin-mediated degradation of the tyrosine phosphatase STEP. Biochem J. 2011;440:115-25 pubmed publisher
	Poddar R, Deb I, Mukherjee S, Paul S. NR2B-NMDA receptor mediated modulation of the tyrosine phosphatase STEP regulates glutamate induced neuronal cell death. J Neurochem. 2010;115:1350-62 pubmed publisher
	Zhang Y, Kurup P, Xu J, Carty N, Fernandez S, Nygaard H, et al. Genetic reduction of striatal-enriched tyrosine phosphatase (STEP) reverses cognitive and cellular deficits in an Alzheimer's disease mouse model. Proc Natl Acad Sci U S A. 2010;107:19014-9 pubmed publisher
	Kurup P, Zhang Y, Xu J, Venkitaramani D, Haroutunian V, Greengard P, et al. Abeta-mediated NMDA receptor endocytosis in Alzheimer's disease involves ubiquitination of the tyrosine phosphatase STEP61. J Neurosci. 2010;30:5948-57 pubmed publisher
	DiRocco D, Scheiner Z, Sindreu C, Chan G, Storm D. A role for calmodulin-stimulated adenylyl cyclases in cocaine sensitization. J Neurosci. 2009;29:2393-403 pubmed publisher
	Goebel Goody S, Davies K, Alvestad Linger R, Freund R, Browning M. Phospho-regulation of synaptic and extrasynaptic N-methyl-d-aspartate receptors in adult hippocampal slices. Neuroscience. 2009;158:1446-59 pubmed publisher
	Zhang Y, Venkitaramani D, Gladding C, Zhang Y, Kurup P, Molnar E, et al. The tyrosine phosphatase STEP mediates AMPA receptor endocytosis after metabotropic glutamate receptor stimulation. J Neurosci. 2008;28:10561-6 pubmed publisher
	Zhao M, Choi Y, Obrietan K, Dudek S. Synaptic plasticity (and the lack thereof) in hippocampal CA2 neurons. J Neurosci. 2007;27:12025-32 pubmed
	Hu Y, Zhang Y, Venkitaramani D, Lombroso P. Translation of striatal-enriched protein tyrosine phosphatase (STEP) after beta1-adrenergic receptor stimulation. J Neurochem. 2007;103:531-41 pubmed
	Choi Y, Lin S, Lee B, Kurup P, Cho H, Naegele J, et al. Status epilepticus-induced somatostatinergic hilar interneuron degeneration is regulated by striatal enriched protein tyrosine phosphatase. J Neurosci. 2007;27:2999-3009 pubmed
	Paul S, Nairn A, Wang P, Lombroso P. NMDA-mediated activation of the tyrosine phosphatase STEP regulates the duration of ERK signaling. Nat Neurosci. 2003;6:34-42 pubmed
	Nguyen T, Liu J, Lombroso P. Striatal enriched phosphatase 61 dephosphorylates Fyn at phosphotyrosine 420. J Biol Chem. 2002;277:24274-9 pubmed
	Pelkey K, Askalan R, Paul S, Kalia L, Nguyen T, Pitcher G, et al. Tyrosine phosphatase STEP is a tonic brake on induction of long-term potentiation. Neuron. 2002;34:127-38 pubmed
	Paul S, Snyder G, Yokakura H, Picciotto M, Nairn A, Lombroso P. The Dopamine/D1 receptor mediates the phosphorylation and inactivation of the protein tyrosine phosphatase STEP via a PKA-dependent pathway. J Neurosci. 2000;20:5630-8 pubmed
	Nguyen T, Paul S, Xu Y, Gurd J, Lombroso P. Calcium-dependent cleavage of striatal enriched tyrosine phosphatase (STEP). J Neurochem. 1999;73:1995-2001 pubmed
	Gurd J, Bissoon N, Nguyen T, Lombroso P, Rider C, Beesley P, et al. Hypoxia-ischemia in perinatal rat brain induces the formation of a low molecular weight isoform of striatal enriched tyrosine phosphatase (STEP). J Neurochem. 1999;73:1990-4 pubmed

product information

brand :

Novus

SKU :

NB300-230

product name :

SCP3/SYCP3 Antibody

unit sizes :

0.1 ml (also 0.025 ml)

description :

The SCP3/SYCP3 Antibody from Novus is a rabbit polyclonal antibody to SCP3/SYCP3. This antibody reacts with human, mouse, porcine, bovine. The SCP3/SYCP3 Antibody has been validated for the following applications: Western Blot, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin.

target :

SCP3 /SYCP3

category :

Primary Antibodies

buffer :

Tris-Citrate/Phosphate (pH 7.0 - 8.0)

clonality :

Polyclonal

concentration :

1 mg/ml

conjugate :

Unconjugated

host :

Rabbit

immunogen :

A synthetic peptide made to the N-terminal region of the mouse SCP3 protein. [UniProt# P70281]

isotype :

IgG

purity :

Immunogen affinity purified

species :

Human, Mouse, Porcine, Bovine

storage :

Store at 4C. Do not freeze.

uses :

Western Blot usage reported in scientific literature (PMID: 27462424).

gene symbol :

SYCP3

catalog number base :

NB300-230

applications :

Western Blot, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin

USD :

299 USD

default size :

TRUE

alt names :

MGC71888, SCP3, SCP-3, SCP3 chromosome 3 open reading frame 8, SCP3 COR1, synaptonemal complex protein 3