product summary
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company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
HIP1 Antibody (4B10)
catalog :
NB300-203
quantity :
0.1 ml (also 0.025 ml)
price :
409 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
4B10
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, chromatin immunoprecipitation, immunohistochemistry - paraffin section
more info or order :
citations: 14
Published Application/Species/Sample/DilutionReference
  • immunocytochemistry; human
  • western blot; human
Fontaine S, Bauer S, Lin X, Poorfarahani S, Ybe J. Replacement of charged and polar residues in the coiled-coiled interface of huntingtin-interacting protein 1 (HIP1) causes aggregation and cell death. FEBS Lett. 2012;586:3030-6 pubmed publisher
  • western blot; human
Barker B, Benovic J. G protein-coupled receptor kinase 5 phosphorylation of hip regulates internalization of the chemokine receptor CXCR4. Biochemistry. 2011;50:6933-41 pubmed publisher
  • immunohistochemistry - paraffin section; human
Bradley S, Holland E, Liu G, Thomas D, Hyun T, Ross T. Huntingtin interacting protein 1 is a novel brain tumor marker that associates with epidermal growth factor receptor. Cancer Res. 2007;67:3609-15 pubmed
  • chromatin immunoprecipitation; human
Mills I, Gaughan L, Robson C, Ross T, McCracken S, Kelly J, et al. Huntingtin interacting protein 1 modulates the transcriptional activity of nuclear hormone receptors. J Cell Biol. 2005;170:191-200 pubmed
  • western blot; mouse
  • western blot; human
Bradley S, Oravecz Wilson K, Bougeard G, Mizukami I, Li L, Munaco A, et al. Serum antibodies to huntingtin interacting protein-1: a new blood test for prostate cancer. Cancer Res. 2005;65:4126-33 pubmed
  • immunocytochemistry; human
Hyun T, Rao D, Saint Dic D, Michael L, Kumar P, Bradley S, et al. HIP1 and HIP1r stabilize receptor tyrosine kinases and bind 3-phosphoinositides via epsin N-terminal homology domains. J Biol Chem. 2004;279:14294-306 pubmed
  • immunoprecipitation; human
  • immunocytochemistry; human
  • western blot; human
  • immunoprecipitation; mouse
  • immunocytochemistry; mouse
  • western blot; mouse
Rao D, Chang J, Kumar P, Mizukami I, Smithson G, Bradley S, et al. Huntingtin interacting protein 1 Is a clathrin coat binding protein required for differentiation of late spermatogenic progenitors. Mol Cell Biol. 2001;21:7796-806 pubmed
Krzystek T, White J, Rathnayake R, Thurston L, Hoffmar Glennon H, Li Y, et al. HTT (huntingtin) and RAB7 co-migrate retrogradely on a signaling LAMP1-containing late endosome during axonal injury. Autophagy. 2023;19:1199-1220 pubmed publisher
Bettencourt C, Miki Y, Piras I, de Silva R, Foti S, Talboom J, et al. MOBP and HIP1 in multiple system atrophy: New α-synuclein partners in glial cytoplasmic inclusions implicated in the disease pathogenesis. Neuropathol Appl Neurobiol. 2021;47:640-652 pubmed publisher
Wang P, Liu B, Wu M, Wei X, Sheng S, You S, et al. Moderate prenatal alcohol exposure suppresses the TLR4-mediated innate immune response in the hippocampus of young rats. Neurosci Lett. 2019;699:77-83 pubmed publisher
Wei W, Wan H, Peng X, Zhou H, Lu Y, He Y. Antiviral effects of Ma Huang Tang against H1N1 influenza virus infection in vitro and in an ICR pneumonia mouse model. Biomed Pharmacother. 2018;102:1161-1175 pubmed publisher
Ye Y, Yang Y, Chen C, Li Z, Jia Y, Su X, et al. Electroacupuncture Improved Hippocampal Neurogenesis following Traumatic Brain Injury in Mice through Inhibition of TLR4 Signaling Pathway. Stem Cells Int. 2017;2017:5841814 pubmed publisher
Bradley S, Smith M, Hyun T, Lucas P, Li L, Antonuk D, et al. Aberrant Huntingtin interacting protein 1 in lymphoid malignancies. Cancer Res. 2007;67:8923-31 pubmed
Rao D, Hyun T, Kumar P, Mizukami I, Rubin M, Lucas P, et al. Huntingtin-interacting protein 1 is overexpressed in prostate and colon cancer and is critical for cellular survival. J Clin Invest. 2002;110:351-60 pubmed
product information
master code :
NB300-203
SKU :
NB300-203
product name :
HIP1 Antibody (4B10)
unit size :
0.1 ml (also 0.025 ml)
description :
The HIP1 Antibody (4B10) - BSA Free from Novus is a mouse monoclonal antibody to HIP1. This antibody reacts with human,mouse,rat (negative). The HIP1 Antibody (4B10) - BSA Free has been validated for the following applications: Immunoprecipitation,Western Blot,Immunocytochemistry/ Immunofluorescence,Immunohistochemistry,Chemotaxis,Immunohistochemistry-Paraffin,Chromatin Immunoprecipitation,Chromatin Immunoprecipitation (ChIP).
target :
HIP1
category :
Primary Antibodies
buffer :
Ascites
clonality :
Monoclonal
clone :
4B10
conjugate :
Unconjugated
host :
Mouse
immunogen :
Human 3'-HIP1 (~65 kDa)
isotype :
IgG1 Kappa
purity :
Unpurified
species :
Human,Mouse,Rat (Negative)
theoretical molecular weight :
115 kDa
gene symbol :
HIP1
accessionNumbers :
O00291
applications :
Immunohistochemistry,Chemotaxis,Immunoprecipitation,Western Blot,Immunohistochemistry-Paraffin,Immunocytochemistry/ Immunofluorescence,Chromatin Immunoprecipitation,Chromatin Immunoprecipitation (ChIP)
USD :
409 USD
alt names :
HIP-1, HIP-I, huntingtin interacting protein 1, huntingtin-interacting protein 1, Huntingtin-interacting protein I, ILWEQ, MGC126506
storage :
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
more info or order :
company information
Novus Biologicals
10771 E Easter Ave
Centennial, CO 80112
novus@novusbio.com
https://www.novusbio.com
3037301950
headquarters: USA
Novus Biologicals licenses, manufactures, and markets antibodies to over 20,000 unique targets to support a wide array of research areas. Novus is built on honesty, collaboration and strong relationships and continues to provide quality tools that accelerate research. Every product is backed by our 100% guarantee.