product summary
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company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
GAP-43 Antibody - BSA Free
catalog :
NB300-143
quantity :
0.1 ml (also 0.025 ml)
price :
419 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
DyLight 650
clone name :
6H12
reactivity :
human, mouse, rat, dogs, chicken, bovine
application :
western blot, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
citations: 74
Published Application/Species/Sample/DilutionReference
  • immunocytochemistry; human; 1:40; tbl 1
de Souza C, Nivison Smith L, Christie D, Polkinghorne P, McGhee C, Kalloniatis M, et al. Macromolecular markers in normal human retina and applications to human retinal disease. Exp Eye Res. 2016;150:135-48 pubmed publisher
  • western blot; dogs; 1:2000; fig 7
  • western blot; bovine
Smolek T, Madari A, Farbáková J, Kandrac O, Jadhav S, Cente M, et al. Tau hyperphosphorylation in synaptosomes and neuroinflammation are associated with canine cognitive impairment. J Comp Neurol. 2016;524:874-95 pubmed publisher
Hara Y, Jha M, Huang J, Han Y, Langohr I, Gaglia G, et al. The IL-4-IL-4Rα axis modulates olfactory neuroimmune signaling to induce loss of smell. Allergy. 2025;80:440-461 pubmed publisher
Cavarischia Rega C, Sharma K, Fitzgerald J, Macek B. Proteome Dynamics in iPSC-Derived Human Dopaminergic Neurons. Mol Cell Proteomics. 2024;23:100838 pubmed publisher
Blaszkiewicz M, Tao T, Mensah Arhin K, Willows J, Bates R, Huang W, et al. Gene therapy approaches for obesity-induced adipose neuropathy: Device-targeted AAV-mediated neurotrophic factor delivery to adipocytes in subcutaneous adipose. Mol Ther. 2024;32:1407-1424 pubmed publisher
Cain M, Klein N, Jiang X, Salimi H, Wu Q, Miller M, et al. Post-exposure intranasal IFNα suppresses replication and neuroinvasion of Venezuelan Equine Encephalitis virus within olfactory sensory neurons. J Neuroinflammation. 2024;21:24 pubmed publisher
Cain M, Klein N, Jiang X, Klein R. Post-exposure intranasal IFNα suppresses replication and neuroinvasion of Venezuelan Equine Encephalitis virus within olfactory sensory neurons. bioRxiv. 2023;: pubmed publisher
Tamaru T, Kobayakawa K, Saiwai H, Konno D, Kijima K, Yoshizaki S, et al. Glial scar survives until the chronic phase by recruiting scar-forming astrocytes after spinal cord injury. Exp Neurol. 2023;359:114264 pubmed publisher
Ueha R, Ito T, Ueha S, Furukawa R, Kitabatake M, Ouji Sageshima N, et al. Evidence for the spread of SARS-CoV-2 and olfactory cell lineage impairment in close-contact infection Syrian hamster models. Front Cell Infect Microbiol. 2022;12:1019723 pubmed publisher
Huang J, Kunkhyen T, Rangel A, Brechbill T, Gregory J, Winson Bushby E, et al. Immature olfactory sensory neurons provide behaviourally relevant sensory input to the olfactory bulb. Nat Commun. 2022;13:6194 pubmed publisher
Efraim Y, Chen F, Cheong K, Gaylord E, McNamara N, Knox S. A synthetic tear protein resolves dry eye through promoting corneal nerve regeneration. Cell Rep. 2022;40:111307 pubmed publisher
Ueha R, Ito T, Furukawa R, Kitabatake M, Ouji Sageshima N, Ueha S, et al. Oral SARS-CoV-2 Inoculation Causes Nasal Viral Infection Leading to Olfactory Bulb Infection: An Experimental Study. Front Cell Infect Microbiol. 2022;12:924725 pubmed publisher
Mohanta S, Peng L, Li Y, Lu S, Sun T, Carnevale L, et al. Neuroimmune cardiovascular interfaces control atherosclerosis. Nature. 2022;605:152-159 pubmed publisher
Ching K, Wang J, Stearns T. Long-range migration of centrioles to the apical surface of the olfactory epithelium. elife. 2022;11: pubmed publisher
Mazuelas H, Magall xf3 n Lorenz M, Fern xe1 ndez Rodr xed guez J, Uriarte Arrazola I, Richaud Patin Y, Terribas E, et al. Modeling iPSC-derived human neurofibroma-like tumors in mice uncovers the heterogeneity of Schwann cells within plexiform neurofibromas. Cell Rep. 2022;38:110385 pubmed publisher
Pototskiy E, Vinokuroff K, Ojeda A, Major C, Sharma D, Anderson T, et al. Downregulation of CD40L-CD40 attenuates seizure susceptibility and severity of seizures. Sci Rep. 2021;11:17262 pubmed publisher
Mori E, Ueha R, Kondo K, Funada S, Shimmura H, Kanemoto K, et al. Squamous and Respiratory Metaplasia After Olfactory Mucosal Resection. Front Neurosci. 2021;15:695653 pubmed publisher
Paramos de Carvalho D, Martins I, Cristóvão A, Dias A, Neves Silva D, Pereira T, et al. Targeting senescent cells improves functional recovery after spinal cord injury. Cell Rep. 2021;36:109334 pubmed publisher
Li F, Lo T, Miles L, Wang Q, Noristani H, Li D, et al. The Atr-Chek1 pathway inhibits axon regeneration in response to Piezo-dependent mechanosensation. Nat Commun. 2021;12:3845 pubmed publisher
Zhu Y, Zhang Q, Xie H, Yu K, Xu G, Li S, et al. Environmental enrichment combined with fasudil promotes motor function recovery and axonal regeneration after stroke. Neural Regen Res. 2021;16:2512-2520 pubmed publisher
Deng W, Wu G, Min L, Feng Z, Chen H, Tan M, et al. Optogenetic Neuronal Stimulation Promotes Functional Recovery After Spinal Cord Injury. Front Neurosci. 2021;15:640255 pubmed publisher
Cao W, Zhang C, Chen R, Wu Q, Xu R, Zhang L, et al. A Novel Cerebroprotein Hydrolysate, CH1, Ameliorates Chronic Focal Cerebral Ischemia Injury by Promoting White Matter Integrity via the Shh/Ptch-1/Gli-1 Signaling Pathway. Neuropsychiatr Dis Treat. 2020;16:3209-3224 pubmed publisher
Rousset F, B C Kokje V, Sipione R, Schmidbauer D, Nacher Soler G, Ilmj xe4 rv S, et al. Intrinsically Self-renewing Neuroprogenitors From the A/J Mouse Spiral Ganglion as Virtually Unlimited Source of Mature Auditory Neurons. Front Cell Neurosci. 2020;14:395 pubmed publisher
Zhang C, Cui L, He W, Zhang X, Liu H. Dl-3-n-butylphthalide promotes neurite outgrowth of primary cortical neurons by Sonic Hedgehog signaling via upregulating Gap43. Exp Cell Res. 2021;398:112420 pubmed publisher
Niu J, Sanders S, Jeong H, Holland S, Sun Y, Collura K, et al. Coupled Control of Distal Axon Integrity and Somal Responses to Axonal Damage by the Palmitoyl Acyltransferase ZDHHC17. Cell Rep. 2020;33:108365 pubmed publisher
Sanders S, Hernandez L, Soh H, Karnam S, Walikonis R, Tzingounis A, et al. The palmitoyl acyltransferase ZDHHC14 controls Kv1-family potassium channel clustering at the axon initial segment. elife. 2020;9: pubmed publisher
Collura K, Niu J, Sanders S, Montersino A, Holland S, Thomas G. The palmitoyl acyltransferases ZDHHC5 and ZDHHC8 are uniquely present in DRG axons and control retrograde signaling via the Gp130/JAK/STAT3 pathway. J Biol Chem. 2020;295:15427-15437 pubmed publisher
Pal Ghosh S, Tadvalkar G, Karpinski B, Stepp M. Diurnal Control of Sensory Axon Growth and Shedding in the Mouse Cornea. Invest Ophthalmol Vis Sci. 2020;61:1 pubmed publisher
Liu Y, Hall B, Lwin N, Teo E, Yam G, Hipsley A, et al. Tissue Responses and Wound Healing following Laser Scleral Microporation for Presbyopia Therapy. Transl Vis Sci Technol. 2020;9:6 pubmed publisher
Lemons K, Fu Z, Ogura T, Lin W. TRPM5-expressing Microvillous Cells Regulate Region-specific Cell Proliferation and Apoptosis During Chemical Exposure. Neuroscience. 2020;434:171-190 pubmed publisher
Hasegawa Ishii S, Imamura F, Nagayama S, Murata M, Shimada A. Differential Effects of Nasal Inflammation and Odor Deprivation on Layer-Specific Degeneration of the Mouse Olfactory Bulb. Eneuro. 2020;7: pubmed publisher
Merino P, Diaz A, Torre E, Yepes M. Urokinase-type plasminogen activator (uPA) regulates the expression and function of growth-associated protein 43 (GAP-43) in the synapse. J Biol Chem. 2020;295:619-630 pubmed publisher
Bandeira F, Yam G, Liu Y, Devarajan K, Mehta J. Three-Dimensional Neurite Characterization of Small Incision Lenticule Extraction Derived Lenticules. Invest Ophthalmol Vis Sci. 2019;60:4408-4415 pubmed publisher
Blaszkiewicz M, Willows J, Dubois A, Waible S, DiBello K, Lyons L, et al. Neuropathy and neural plasticity in the subcutaneous white adipose depot. PLoS ONE. 2019;14:e0221766 pubmed publisher
Azmi S, Jeziorska M, Ferdousi M, Petropoulos I, Ponirakis G, Marshall A, et al. Early nerve fibre regeneration in individuals with type 1 diabetes after simultaneous pancreas and kidney transplantation. Diabetologia. 2019;: pubmed publisher
Culjat M, Milosevic N. Callosal septa express guidance cues and are paramedian guideposts for human corpus callosum development. J Anat. 2019;235:670-686 pubmed publisher
Sanders S, De Simone F, Thomas G. mTORC1 Signaling Is Palmitoylation-Dependent in Hippocampal Neurons and Non-neuronal Cells and Involves Dynamic Palmitoylation of LAMTOR1 and mTOR. Front Cell Neurosci. 2019;13:115 pubmed publisher
Song Y, Li D, Farrelly O, Miles L, Li F, Kim S, et al. The Mechanosensitive Ion Channel Piezo Inhibits Axon Regeneration. Neuron. 2019;102:373-389.e6 pubmed publisher
Carrio M, Mazuelas H, Richaud Patin Y, Gel B, Terribas E, Rosas I, et al. Reprogramming Captures the Genetic and Tumorigenic Properties of Neurofibromatosis Type 1 Plexiform Neurofibromas. Stem Cell Reports. 2019;12:411-426 pubmed publisher
Wang W, Jiang Z, Lu R, Liu H, Ma N, Cai J, et al. Effects of Renal Denervation via Renal Artery Adventitial Cryoablation on Atrial Fibrillation and Cardiac Neural Remodeling. Cardiol Res Pract. 2018;2018:2603025 pubmed publisher
Ueha R, Kondo K, Ueha S, Yamasoba T. Dose-Dependent Effects of Insulin-Like Growth Factor 1 in the Aged Olfactory Epithelium. Front Aging Neurosci. 2018;10:385 pubmed publisher
Wu Y, Ma L, Duyck K, Long C, Moran A, Scheerer H, et al. A Population of Navigator Neurons Is Essential for Olfactory Map Formation during the Critical Period. Neuron. 2018;: pubmed publisher
Renziehausen A, Wang H, Rao B, Weir L, Nigro C, Lattanzio L, et al. The renin angiotensin system (RAS) mediates bifunctional growth regulation in melanoma and is a novel target for therapeutic intervention. Oncogene. 2019;38:2320-2336 pubmed publisher
Perry R, Hezroni H, Goldrich M, Ulitsky I. Regulation of Neuroregeneration by Long Noncoding RNAs. Mol Cell. 2018;72:553-567.e5 pubmed publisher
Zhang X, Huang Y, Cong X, Qu L, Zhang K, Wu L, et al. Parasympathectomy increases resting secretion of the submandibular gland in minipigs in the long term. J Cell Physiol. 2019;234:9515-9524 pubmed publisher
Sahoo P, Lee S, Jaiswal P, Alber S, Kar A, Miller Randolph S, et al. Axonal G3BP1 stress granule protein limits axonal mRNA translation and nerve regeneration. Nat Commun. 2018;9:3358 pubmed publisher
Wei Y, Hua J, Liu X, Hua X, Sun C, Bai J, et al. LncNEN885 inhibits epithelial-mesenchymal transition by partially regulation of Wnt/β-catenin signalling in gastroenteropancreatic neuroendocrine neoplasms. Cancer Sci. 2018;109:3139-3148 pubmed publisher
Ueha R, Ueha S, Kondo K, Kikuta S, Yamasoba T. Cigarette Smoke-Induced Cell Death Causes Persistent Olfactory Dysfunction in Aged Mice. Front Aging Neurosci. 2018;10:183 pubmed publisher
Xiong L, Liu Y, Zhou M, Wang G, Quan D, Shuai W, et al. Targeted ablation of cardiac sympathetic neurons attenuates adverse postinfarction remodelling and left ventricular dysfunction. Exp Physiol. 2018;103:1221-1229 pubmed publisher
Boboila S, Lopez G, Yu J, Banerjee D, Kadenhe Chiweshe A, Connolly E, et al. Transcription factor activating protein 4 is synthetically lethal and a master regulator of MYCN-amplified neuroblastoma. Oncogene. 2018;37:5451-5465 pubmed publisher
Schmitd L, Beesley L, Russo N, Bellile E, Inglehart R, Liu M, et al. Redefining Perineural Invasion: Integration of Biology With Clinical Outcome. Neoplasia. 2018;20:657-667 pubmed publisher
Zechel S, Fernández Suárez D, Ibanez C. Cell-autonomous role of GFR?1 in the development of olfactory bulb GABAergic interneurons. Biol Open. 2018;7: pubmed publisher
Ueha R, Shichino S, Ueha S, Kondo K, Kikuta S, Nishijima H, et al. Reduction of Proliferating Olfactory Cells and Low Expression of Extracellular Matrix Genes Are Hallmarks of the Aged Olfactory Mucosa. Front Aging Neurosci. 2018;10:86 pubmed publisher
Cui Y, Yao Y, Zhao Y, Xiao Z, Cao Z, Han S, et al. Functional collagen conduits combined with human mesenchymal stem cells promote regeneration after sciatic nerve transection in dogs. J Tissue Eng Regen Med. 2018;12:1285-1296 pubmed publisher
Hines T, Gao X, Sahu S, Lange M, Turner J, Twiss J, et al. An Essential Postdevelopmental Role for Lis1 in Mice. Eneuro. 2018;5: pubmed publisher
Kosi N, Alić I, Salamon I, Mitrecic D. Stroke promotes survival of nearby transplanted neural stem cells by decreasing their activation of caspase 3 while not affecting their differentiation. Neurosci Lett. 2018;666:111-119 pubmed publisher
Pal Ghosh S, Tadvalkar G, Stepp M. Alterations in Corneal Sensory Nerves During Homeostasis, Aging, and After Injury in Mice Lacking the Heparan Sulfate Proteoglycan Syndecan-1. Invest Ophthalmol Vis Sci. 2017;58:4959-4975 pubmed publisher
Gu Y, Shi Y, Yang Q, Gu W, He Y, Zheng H, et al. miR-3074-5p Promotes the Apoptosis but Inhibits the Invasiveness of Human Extravillous Trophoblast-Derived HTR8/SVneo Cells In Vitro. Reprod Sci. 2018;25:690-699 pubmed publisher
Hara M, Kobayakawa K, Ohkawa Y, Kumamaru H, Yokota K, Saito T, et al. Interaction of reactive astrocytes with type I collagen induces astrocytic scar formation through the integrin-N-cadherin pathway after spinal cord injury. Nat Med. 2017;23:818-828 pubmed publisher
Lemons K, Fu Z, Aoudé I, Ogura T, Sun J, Chang J, et al. Lack of TRPM5-Expressing Microvillous Cells in Mouse Main Olfactory Epithelium Leads to Impaired Odor-Evoked Responses and Olfactory-Guided Behavior in a Challenging Chemical Environment. Eneuro. 2017;4: pubmed publisher
Fang Y, Huang X, Wan Y, Tian H, Tian Y, Wang W, et al. Deficiency of TREK-1 potassium channel exacerbates secondary injury following spinal cord injury in mice. J Neurochem. 2017;141:236-246 pubmed publisher
Akins M, Berk Rauch H, Kwan K, Mitchell M, Shepard K, Korsak L, et al. Axonal ribosomes and mRNAs associate with fragile X granules in adult rodent and human brains. Hum Mol Genet. 2017;26:192-209 pubmed publisher
Lopes C, Gonçalves N, Gomes C, Saraiva M, Pêgo A. BDNF gene delivery mediated by neuron-targeted nanoparticles is neuroprotective in peripheral nerve injury. Biomaterials. 2017;121:83-96 pubmed publisher
Cheng N, Jiao S, Gumaste A, Bai L, Belluscio L. APP Overexpression Causes A?-Independent Neuronal Death through Intrinsic Apoptosis Pathway. Eneuro. 2016;3: pubmed publisher
Ku J, Park K, Lee J, Cho K, Nam Y, Jeong D, et al. Discovery, Optimization, and Biological Evaluation of Sulfonamidoacetamides as an Inducer of Axon Regeneration. J Med Chem. 2016;59:4676-87 pubmed publisher
Ueha R, Ueha S, Sakamoto T, Kanaya K, Suzukawa K, Nishijima H, et al. Cigarette Smoke Delays Regeneration of the Olfactory Epithelium in Mice. Neurotox Res. 2016;30:213-24 pubmed publisher
Janmaat C, de Rooij K, Locher H, de Groot S, de Groot J, Frijns J, et al. Human Dermal Fibroblasts Demonstrate Positive Immunostaining for Neuron- and Glia- Specific Proteins. PLoS ONE. 2015;10:e0145235 pubmed publisher
Ceber M, Sener U, Mihmanli A, Kilic U, Topcu B, Karakas M. The relationship between changes in the expression of growth associated protein-43 and functional recovery of the injured inferior alveolar nerve following transection without repair in adult rats. J Craniomaxillofac Surg. 2015;43:1906-13 pubmed publisher
Nakano H, Iida Y, Suzuki M, Aoki M, Umemura M, Takahashi S, et al. Activating transcription factor 5 (ATF5) is essential for the maturation and survival of mouse basal vomeronasal sensory neurons. Cell Tissue Res. 2016;363:621-33 pubmed publisher
Ibrahim D, Taniguchi K, Yamamoto Y, Taniguchi K, Nakamuta N. Immunohistochemical and lectin histochemical studies on the developing olfactory organs of fetal camel. Microsc Res Tech. 2015;78:613-9 pubmed publisher
Rousselle S, Brants I, Sakaoka A, Hubbard B, Jackson N, Wicks J, et al. Neuromatous regeneration as a nerve response after catheter-based renal denervation therapy in a large animal model: immunohistochemical study. Circ Cardiovasc Interv. 2015;8: pubmed publisher
Baldo G, Lorenzini D, Santos D, Mayer F, Vitry S, Bigou S, et al. Shotgun proteomics reveals possible mechanisms for cognitive impairment in Mucopolysaccharidosis I mice. Mol Genet Metab. 2015;114:138-45 pubmed publisher
Nakamuta S, Nakamuta N, Yamamoto Y, Onodera N, Araki I. Transient appearance of the epithelial invagination in the olfactory pit of chick embryos. J Vet Med Sci. 2015;77:89-93 pubmed publisher
Smith T, Muchlinski M, Bhatnagar K, Durham E, Bonar C, Burrows A. The vomeronasal organ of Lemur catta. Am J Primatol. 2015;77:229-38 pubmed publisher
product information
master code :
NB300-143
SKU :
NB300-143
product name :
GAP-43 Antibody - BSA Free
unit size :
0.1 ml (also 0.025 ml)
description :
The GAP-43 Antibody - BSA Free from Novus is a rabbit polyclonal antibody to GAP-43. This antibody reacts with avian - chicken,bovine,canine,chicken,drosophila,equine,human,insect - drosophila,insect - drosophila melanogaster,mouse,porcine,primate,rat. The GAP-43 Antibody - BSA Free has been validated for the following applications: Immunocytochemistry/ Immunofluorescence,Immunohistochemistry,IF/IHC,Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Flow Cytometry.
target :
GAP-43
category :
Primary Antibodies
buffer :
50% PBS, 50% glycerol
clonality :
Polyclonal
concentration :
1 mg/ml
conjugate :
Unconjugated
host :
Rabbit
immunogen :
C-terminal peptide of rodent GAP43, KEDPEADQEHA coupled to KLH.
purity :
Immunogen affinity purified
species :
Avian - Chicken,Bovine,Canine,Chicken,Drosophila,Equine,Human,Insect - Drosophila,Insect - Drosophila melanogaster,Mouse,Porcine,Primate,Rat
theoretical molecular weight :
43 kDa
gene symbol :
GAP43
applications :
Immunohistochemistry,Immunocytochemistry/ Immunofluorescence,IF/IHC,Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Flow Cytometry
USD :
419 USD
alt names :
Axonal membrane protein GAP-43, B-50, calmodulin-binding protein P-57, growth associated protein 43, Growth-associated protein 43, nerve growth-related peptide GAP43, Neural phosphoprotein B-50, neuromodulin, neuron growth-associated protein 43, PP46, protein F1
storage :
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
more info or order :
company information
Novus Biologicals
10771 E Easter Ave
Centennial, CO 80112
novus@novusbio.com
https://www.novusbio.com
3037301950
headquarters: USA
Novus Biologicals licenses, manufactures, and markets antibodies to over 20,000 unique targets to support a wide array of research areas. Novus is built on honesty, collaboration and strong relationships and continues to provide quality tools that accelerate research. Every product is backed by our 100% guarantee.