alpha-Internexin Antibody (2E3) | Novus Biologicals NB300-140 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Novus Biologicals

other brands :

IMGENEX

product type :

antibody

product name :

alpha-Internexin Antibody (2E3)

catalog :

NB300-140

quantity :

0.025 ml

price :

129 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

2.00E+03

reactivity :

human, mouse, rat, bovine

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section

citations: 78

Reference
Bhatt T, Bhosale A, Bajantri B, Mathapathi M, Rizvi A, Scita G, et al. Sustained Secretion of the Antimicrobial Peptide S100A7 Is Dependent on the Downregulation of Caspase-8. Cell Rep. 2019;29:2546-2555.e4 pubmed publisher
Garcia M, Morello E, Garnier J, Barrault C, Garnier M, Burucoa C, et al. Pseudomonas aeruginosa flagellum is critical for invasion, cutaneous persistence and induction of inflammatory response of skin epidermis. Virulence. 2018;9:1163-1175 pubmed publisher
Li L, Cui Y, Ye L, Zhao Z, Jiang W, Ji J. Psoriasin overexpression confers drug resistance to cisplatin by activating ERK in gastric cancer. Int J Oncol. 2018;53:1171-1182 pubmed publisher
Bertelsen T, Iversen L, Johansen C. The human IL-17A/F heterodimer regulates psoriasis-associated genes through IκBζ. Exp Dermatol. 2018;27:1048-1052 pubmed publisher
Rosignoli C, Thibaut de Ménonville S, Orfila D, Béal M, Bertino B, Aubert J, et al. A topical treatment containing heat-treated Lactobacillus johnsonii NCC 533 reduces Staphylococcus aureus adhesion and induces antimicrobial peptide expression in an in vitro reconstructed human epidermis model. Exp Dermatol. 2018;27:358-365 pubmed publisher
Bielle F, Di Stefano A, Meyronet D, Picca A, Villa C, Bernier M, et al. Diffuse gliomas with FGFR3-TACC3 fusion have characteristic histopathological and molecular features. Brain Pathol. 2017;: pubmed publisher
Breton Q, Plouhinec H, Prunier Mirebeau D, Boisselier B, Michalak S, Menei P, et al. BRAF-V600E immunohistochemistry in a large series of glial and glial-neuronal tumors. Brain Behav. 2017;7:e00641 pubmed publisher
Tian T, Li X, Hua Z, Ma J, Wu X, Liu Z, et al. S100A7 promotes the migration, invasion and metastasis of human cervical cancer cells through epithelial-mesenchymal transition. Oncotarget. 2017;8:24964-24977 pubmed publisher
Bertelsen T, Ljungberg C, Boye Kjellerup R, Iversen L, Johansen C. IL-17F regulates psoriasis-associated genes through IÎºBÎ¶. Exp Dermatol. 2017;26:234-241 pubmed publisher
Bielle F, Ducray F, Mokhtari K, Dehais C, Adle Biassette H, Carpentier C, et al. Tumor cells with neuronal intermediate progenitor features define a subgroup of 1p/19q co-deleted anaplastic gliomas. Brain Pathol. 2017;27:567-579 pubmed publisher
Bianco K, Gormley M, Farrell J, Zhou Y, Oliverio O, Tilden H, et al. Placental transcriptomes in the common aneuploidies reveal critical regions on the trisomic chromosomes and genome-wide effects. Prenat Diagn. 2016;36:812-22 pubmed publisher
Koerdt S, Steinstraesser L, Stoeckelhuber M, Wales C, Rohleder N, Babaryka G, et al. Radiotherapy for oral cancer decreases the cutaneous expression of host defence peptides. J Craniomaxillofac Surg. 2016;44:882-9 pubmed publisher
Chu Y, Liu S, Cheng H, Huang S, Chang Y, Chiang C, et al. Opposing Effects of Zac1 and Curcumin on AP-1-Regulated Expressions of S100A7. PLoS ONE. 2015;10:e0144175 pubmed publisher
Matsumura N, Nobusawa S, Ikota H, Hirato J, Hirose T, Yokoo H, et al. Coexpression of cyclin D1 and alpha-internexin in oligodendroglial tumors. Brain Tumor Pathol. 2015;32:261-7 pubmed publisher
Dey K, Sarkar S, Pal I, Das S, Dey G, Bharti R, et al. Mechanistic attributes of S100A7 (psoriasin) in resistance of anoikis resulting tumor progression in squamous cell carcinoma of the oral cavity. Cancer Cell Int. 2015;15:74 pubmed publisher
Nagaishi M, Yokoo H, Nobusawa S, Fujii Y, Sugiura Y, Suzuki R, et al. Localized overexpression of alpha-internexin within nodules in multinodular and vacuolating neuronal tumors. Neuropathology. 2015;35:561-8 pubmed publisher
Zhao H, Wilkie T, Deol Y, Sneh A, Ganju A, Basree M, et al. miR-29b defines the pro-/anti-proliferative effects of S100A7 in breast cancer. Mol Cancer. 2015;14:11 pubmed publisher
de Castro A, Minty F, Hattinger E, Wolf R, Parkinson E. The secreted protein S100A7 (psoriasin) is induced by telomere dysfunction in human keratinocytes independently of a DNA damage response and cell cycle regulators. Longev Healthspan. 2014;3:8 pubmed publisher
Mcheik J, Barrault C, Pedretti N, Garnier J, Juchaux F, Levard G, et al. Study of proliferation and 3D epidermal reconstruction from foreskin, auricular and trunk keratinocytes in children. Burns. 2015;41:352-8 pubmed publisher
Rabeony H, Petit Paris I, Garnier J, Barrault C, Pedretti N, Guilloteau K, et al. Inhibition of keratinocyte differentiation by the synergistic effect of IL-17A, IL-22, IL-1?, TNF? and oncostatin M. PLoS ONE. 2014;9:e101937 pubmed publisher
Figarella Branger D, Mokhtari K, Dehais C, Jouvet A, Uro Coste E, Colin C, et al. Mitotic index, microvascular proliferation, and necrosis define 3 groups of 1p/19q codeleted anaplastic oligodendrogliomas associated with different genomic alterations. Neuro Oncol. 2014;16:1244-54 pubmed publisher
Teng X, Hu Z, Wei X, Wang Z, Guan T, Liu N, et al. IL-37 ameliorates the inflammatory process in psoriasis by suppressing proinflammatory cytokine production. J Immunol. 2014;192:1815-23 pubmed publisher
Reyes Botero G, Giry M, Mokhtari K, Labussiere M, Idbaih A, Delattre J, et al. Molecular analysis of diffuse intrinsic brainstem gliomas in adults. J Neurooncol. 2014;116:405-11 pubmed publisher
Nagaishi M, Suzuki A, Nobusawa S, Yokoo H, Nakazato Y. Alpha-internexin and altered CIC expression as a supportive diagnostic marker for oligodendroglial tumors with the 1p/19q co-deletion. Brain Tumor Pathol. 2014;31:257-64 pubmed publisher
Zhu L, Okano S, Takahara M, Chiba T, Tu Y, Oda Y, et al. Expression of S100 protein family members in normal skin and sweat gland tumors. J Dermatol Sci. 2013;70:211-9 pubmed publisher
Sneh A, Deol Y, Ganju A, Shilo K, Rosol T, Nasser M, et al. Differential role of psoriasin (S100A7) in estrogen receptor ? positive and negative breast cancer cells occur through actin remodeling. Breast Cancer Res Treat. 2013;138:727-39 pubmed publisher
Mcheik J, Barrault C, Pedretti N, Garnier J, Juchaux F, Levard G, et al. Foreskin-isolated keratinocytes provide successful extemporaneous autologous paediatric skin grafts. J Tissue Eng Regen Med. 2016;10:252-60 pubmed publisher
Vegfors J, Petersson S, Kovács A, Polyak K, Enerback C. The expression of Psoriasin (S100A7) and CD24 is linked and related to the differentiation of mammary epithelial cells. PLoS ONE. 2012;7:e53119 pubmed publisher
Ye L, Sun P, Martin T, Sanders A, Mason M, Jiang W. Psoriasin (S100A7) is a positive regulator of survival and invasion of prostate cancer cells. Urol Oncol. 2013;31:1576-83 pubmed publisher
Takano S, Kato Y, Yamamoto T, Kaneko M, Ishikawa E, Tsujimoto Y, et al. Immunohistochemical detection of IDH1 mutation, p53, and internexin as prognostic factors of glial tumors. J Neurooncol. 2012;108:361-73 pubmed publisher
Shubbar E, Vegfors J, Carlström M, Petersson S, Enerback C. Psoriasin (S100A7) increases the expression of ROS and VEGF and acts through RAGE to promote endothelial cell proliferation. Breast Cancer Res Treat. 2012;134:71-80 pubmed publisher
Nofech Mozes S, Spayne J, Rakovitch E, Kahn H, Seth A, Pignol J, et al. Biological Markers Predictive of Invasive Recurrence in DCIS. Clin Med Oncol. 2008;2:7-18 pubmed
Kesting M, Mueller C, Wagenpfeil S, Stoeckelhuber M, Steiner T, Bauer F, et al. Quantitative comparison of the expression of antimicrobial peptides in the oral mucosa and extraoral skin. Br J Oral Maxillofac Surg. 2012;50:447-53 pubmed publisher
Garreis F, Gottschalt M, Schlorf T, Gläser R, Harder J, Worlitzsch D, et al. Expression and regulation of antimicrobial peptide psoriasin (S100A7) at the ocular surface and in the lacrimal apparatus. Invest Ophthalmol Vis Sci. 2011;52:4914-22 pubmed publisher
Seilhean D, Le Ber I, Sarazin M, Lacomblez L, Millecamps S, Salachas F, et al. Fronto-temporal lobar degeneration: neuropathology in 60 cases. J Neural Transm (Vienna). 2011;118:753-64 pubmed publisher
Andresen E, Lange C, Strodthoff D, Goldmann T, Fischer N, Sahly H, et al. S100A7/psoriasin expression in the human lung: unchanged in patients with COPD, but upregulated upon positive S. aureus detection. BMC Pulm Med. 2011;11:10 pubmed publisher
Mokhtari K, Ducray F, Kros J, Gorlia T, Idbaih A, Taphoorn M, et al. Alpha-internexin expression predicts outcome in anaplastic oligodendroglial tumors and may positively impact the efficacy of chemotherapy: European organization for research and treatment of cancer trial 26951. Cancer. 2011;117:3014-26 pubmed publisher
Guilloteau K, Paris I, Pedretti N, Boniface K, Juchaux F, Huguier V, et al. Skin Inflammation Induced by the Synergistic Action of IL-17A, IL-22, Oncostatin M, IL-1{alpha}, and TNF-{alpha} Recapitulates Some Features of Psoriasis. J Immunol. 2010;184:5263-5270 pubmed publisher
San Millan B, Kaci R, Polivka M, Robert G, Heran F, Gueguen A, et al. [Gliomatosis cerebri: a biopsy and autopsy case report]. Ann Pathol. 2010;30:25-9 pubmed publisher
Hashiramoto A, Yamane T, Tsumiyama K, Yoshida K, Komai K, Yamada H, et al. Mammalian clock gene Cryptochrome regulates arthritis via proinflammatory cytokine TNF-alpha. J Immunol. 2010;184:1560-5 pubmed publisher
Kesting M, Sudhoff H, Hasler R, Nieberler M, Pautke C, Wolff K, et al. Psoriasin (S100A7) up-regulation in oral squamous cell carcinoma and its relation to clinicopathologic features. Oral Oncol. 2009;45:731-6 pubmed publisher
Wolf R, Voscopoulos C, Winston J, Dharamsi A, Goldsmith P, Gunsior M, et al. Highly homologous hS100A15 and hS100A7 proteins are distinctly expressed in normal breast tissue and breast cancer. Cancer Lett. 2009;277:101-7 pubmed publisher
Wolf R, Howard O, Dong H, Voscopoulos C, Boeshans K, Winston J, et al. Chemotactic activity of S100A7 (Psoriasin) is mediated by the receptor for advanced glycation end products and potentiates inflammation with highly homologous but functionally distinct S100A15. J Immunol. 2008;181:1499-506 pubmed
Pene J, Chevalier S, Preisser L, Venereau E, Guilleux M, Ghannam S, et al. Chronically inflamed human tissues are infiltrated by highly differentiated Th17 lymphocytes. J Immunol. 2008;180:7423-30 pubmed
Zhang H, Zhao Q, Chen Y, Wang Y, Gao S, Mao Y, et al. Selective expression of S100A7 in lung squamous cell carcinomas and large cell carcinomas but not in adenocarcinomas and small cell carcinomas. Thorax. 2008;63:352-9 pubmed publisher
Paruchuri V, Prasad A, McHugh K, Bhat H, Polyak K, Ganju R. S100A7-downregulation inhibits epidermal growth factor-induced signaling in breast cancer cells and blocks osteoclast formation. PLoS ONE. 2008;3:e1741 pubmed publisher
Petersson S, Bylander A, Yhr M, Enerback C. S100A7 (Psoriasin), highly expressed in ductal carcinoma in situ (DCIS), is regulated by IFN-gamma in mammary epithelial cells. BMC Cancer. 2007;7:205 pubmed
Zhang H, Wang Y, Chen Y, Sun S, Li N, Lv D, et al. Identification and validation of S100A7 associated with lung squamous cell carcinoma metastasis to brain. Lung Cancer. 2007;57:37-45 pubmed
Boniface K, Diveu C, Morel F, Pedretti N, Froger J, Ravon E, et al. Oncostatin M secreted by skin infiltrating T lymphocytes is a potent keratinocyte activator involved in skin inflammation. J Immunol. 2007;178:4615-22 pubmed
Sa S, Valdez P, Wu J, Jung K, Zhong F, Hall L, et al. The effects of IL-20 subfamily cytokines on reconstituted human epidermis suggest potential roles in cutaneous innate defense and pathogenic adaptive immunity in psoriasis. J Immunol. 2007;178:2229-40 pubmed
Mehul B, Bernard D, Brouard M, Delattre C, Schmidt R. Influence of calcium on the proteolytic degradation of the calmodulin-like skin protein (calmodulin-like protein 5) in psoriatic epidermis. Exp Dermatol. 2006;15:469-77 pubmed
Krop I, März A, Carlsson H, Li X, Bloushtain Qimron N, Hu M, et al. A putative role for psoriasin in breast tumor progression. Cancer Res. 2005;65:11326-34 pubmed
Kennedy R, Gorski J, Quinn J, Stewart G, James C, Moore S, et al. BRCA1 and c-Myc associate to transcriptionally repress psoriasin, a DNA damage-inducible gene. Cancer Res. 2005;65:10265-72 pubmed
Wang P, Wang S, Hsieh C, Chien C. Neural expression of alpha-internexin promoter in vitro and in vivo. J Cell Biochem. 2006;97:275-87 pubmed
Ko T, Chien C, Lu K. The expression of alpha-internexin and peripherin in the developing mouse pineal gland. J Biomed Sci. 2005;12:777-89 pubmed
Rauch U, Klotz M, Maas Omlor S, Wink E, Hänsgen A, Hagl C, et al. Expression of intermediate filament proteins and neuronal markers in the human fetal gut. J Histochem Cytochem. 2006;54:39-46 pubmed
Uchikado H, Shaw G, Wang D, Dickson D. Screening for neurofilament inclusion disease using alpha-internexin immunohistochemistry. Neurology. 2005;64:1658-9 pubmed
Chien C, Liu T, Ho C, Lu K. Overexpression of neuronal intermediate filament protein alpha-internexin in PC12 cells. J Neurosci Res. 2005;80:693-706 pubmed
Jing Ping Z, Tian Q, Sakagami H, Kondo H, Endo S, Suzuki T. p55 protein is a member of PSD scaffold proteins in the rat brain and interacts with various PSD proteins. Brain Res Mol Brain Res. 2005;135:204-16 pubmed
Josephs K, Uchikado H, McComb R, Bashir R, Wszolek Z, Swanson J, et al. Extending the clinicopathological spectrum of neurofilament inclusion disease. Acta Neuropathol. 2005;109:427-32 pubmed
Boniface K, Bernard F, Garcia M, Gurney A, Lecron J, Morel F. IL-22 inhibits epidermal differentiation and induces proinflammatory gene expression and migration of human keratinocytes. J Immunol. 2005;174:3695-702 pubmed
Martinsson H, Yhr M, Enerback C. Expression patterns of S100A7 (psoriasin) and S100A9 (calgranulin-B) in keratinocyte differentiation. Exp Dermatol. 2005;14:161-8 pubmed
Gläser R, Harder J, Lange H, Bartels J, Christophers E, Schroder J. Antimicrobial psoriasin (S100A7) protects human skin from Escherichia coli infection. Nat Immunol. 2005;6:57-64 pubmed
Cairns N, Grossman M, Arnold S, Burn D, Jaros E, Perry R, et al. Clinical and neuropathologic variation in neuronal intermediate filament inclusion disease. Neurology. 2004;63:1376-84 pubmed
Rajasalu T, Teesalu K, Janmey P, Uibo R. Demonstration of natural autoantibodies against the neurofilament protein alpha-internexin in sera of patients with endocrine autoimmunity and healthy individuals. Immunol Lett. 2004;94:153-60 pubmed
Cairns N, Uryu K, Bigio E, Mackenzie I, Gearing M, Duyckaerts C, et al. alpha-Internexin aggregates are abundant in neuronal intermediate filament inclusion disease (NIFID) but rare in other neurodegenerative diseases. Acta Neuropathol. 2004;108:213-23 pubmed
Cairns N, Zhukareva V, Uryu K, Zhang B, Bigio E, Mackenzie I, et al. alpha-internexin is present in the pathological inclusions of neuronal intermediate filament inclusion disease. Am J Pathol. 2004;164:2153-61 pubmed
Yuan A, Rao M, Kumar A, Julien J, Nixon R. Neurofilament transport in vivo minimally requires hetero-oligomer formation. J Neurosci. 2003;23:9452-8 pubmed
Ortino B, Inverardi F, Morante Oria J, Fairen A, Frassoni C. Substrates and routes of migration of early generated neurons in the developing rat thalamus. Eur J Neurosci. 2003;18:323-32 pubmed
Donner L, Teshima I. Peripheral medulloepithelioma: an immunohistochemical, ultrastructural, and cytogenetic study of a rare, chemotherapy-sensitive, pediatric tumor. Am J Surg Pathol. 2003;27:1008-12 pubmed
Porter D, Lahti Domenici J, Keshaviah A, Bae Y, Argani P, Marks J, et al. Molecular markers in ductal carcinoma in situ of the breast. Mol Cancer Res. 2003;1:362-75 pubmed
Stachowiak E, Fang X, Myers J, Dunham S, Stachowiak M. cAMP-induced differentiation of human neuronal progenitor cells is mediated by nuclear fibroblast growth factor receptor-1 (FGFR1). J Neurochem. 2003;84:1296-312 pubmed
Talbot N, Powell A, Garrett W. Spontaneous differentiation of porcine and bovine embryonic stem cells (epiblast) into astrocytes or neurons. In Vitro Cell Dev Biol Anim. 2002;38:191-7 pubmed
McGraw T, Mickle J, Shaw G, Streit W. Axonally transported peripheral signals regulate alpha-internexin expression in regenerating motoneurons. J Neurosci. 2002;22:4955-63 pubmed
Larivière R, Nguyen M, Ribeiro da Silva A, Julien J. Reduced number of unmyelinated sensory axons in peripherin null mice. J Neurochem. 2002;81:525-32 pubmed
Shaw G, Morse S, Ararat M, Graham F. Preferential transformation of human neuronal cells by human adenoviruses and the origin of HEK 293 cells. FASEB J. 2002;16:869-71 pubmed
Evans J, Sumners C, Moore J, Huentelman M, Deng J, Gelband C, et al. Characterization of mitotic neurons derived from adult rat hypothalamus and brain stem. J Neurophysiol. 2002;87:1076-85 pubmed
Enerback C, Porter D, Seth P, Sgroi D, Gaudet J, Weremowicz S, et al. Psoriasin expression in mammary epithelial cells in vitro and in vivo. Cancer Res. 2002;62:43-7 pubmed

product information

brand :

Novus

master code :

NB300-140

SKU :

NB300-140-0.025ml

product name :

alpha-Internexin Antibody (2E3)

description :

The alpha-Internexin Antibody (2E3) from Novus Biologicals is a mouse monoclonal antibody to alpha-Internexin. This antibody reacts with human, mouse, rat, porcine, bovine. The alpha-Internexin Antibody (2E3) has been validated for the following applications: Western Blot, Simple Western, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin.

target :

alpha-Internexin

category :

Primary Antibodies

unit size :

0.025 ml

buffer :

50% PBS, 50% Glycerol

clonality :

Monoclonal

clone :

2.00E+03

concentration :

1 mg/ml

conjugate :

Unconjugated

host :

Mouse

immunogen :

Purified recombinant rat alpha Internexin expressed in and purified from E. coli [UniProt# P23565]

isotype :

IgG1

purity :

Affinity purified

species :

Human, Mouse, Rat, Porcine, Bovine

theoretical molecular weight :

66 kDa

gene symbol :

INA

catalog number base :

NB300-140

accessionNumbers :

P23565

applications :

Western Blot, Simple Western, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin

2020 USD :

129

2021 USD :

129 USD

alt names :

66 kDa neurofilament protein, alpha-Inx, FLJ18662, FLJ57501, internexin neuronal intermediate filament protein, alpha, MGC12702, NEF5, Neurofilament 5, neurofilament 5 (66kD), Neurofilament-66, neurofilament-66, tax-binding protein, NF-66alpha-internexin, TXBP-1

storage :

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.