| Published Application/Species/Sample/Dilution | Reference |
|---|
- western blot; mouse; loading ...; fig 2d
| Yoon Y, Go G, Yoon S, Lim J, Lee G, Lee J, et al. Melatonin Treatment Improves Renal Fibrosis via miR-4516/SIAH3/PINK1 Axis. Cells. 2021;10: pubmed publisher |
- western blot; human; 1:1000; loading ...; fig 4e
| Swatek K, Usher J, Kueck A, Gladkova C, Mevissen T, Pruneda J, et al. Insights into ubiquitin chain architecture using Ub-clipping. Nature. 2019;572:533-537 pubmed publisher |
- western blot; human; loading ...; fig 7c
| Li L, Guturi K, Gautreau B, Patel P, Saad A, Morii M, et al. Ubiquitin ligase RNF8 suppresses Notch signaling to regulate mammary development and tumorigenesis. J Clin Invest. 2018;128:4525-4542 pubmed publisher |
- western blot; human; fig 1
| Damgaard R, Walker J, Marco Casanova P, Morgan N, Titheradge H, Elliott P, et al. The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity. Cell. 2016;166:1215-1230.e20 pubmed publisher |
- immunocytochemistry; human; fig 3
| Schwab A, Ebert A. Neurite Aggregation and Calcium Dysfunction in iPSC-Derived Sensory Neurons with Parkinson's Disease-Related LRRK2 G2019S Mutation. Stem Cell Reports. 2015;5:1039-1052 pubmed publisher |
- immunohistochemistry - frozen section; rat
| Begum G, Yan H, Li L, Singh A, Dixon C, Sun D. Docosahexaenoic acid reduces ER stress and abnormal protein accumulation and improves neuronal function following traumatic brain injury. J Neurosci. 2014;34:3743-55 pubmed publisher |
| Ejlerskov P, Rasmussen I, Nielsen T, Bergström A, Tohyama Y, Jensen P, et al. Tubulin polymerization-promoting protein (TPPP/p25?) promotes unconventional secretion of ?-synuclein through exophagy by impairing autophagosome-lysosome fusion. J Biol Chem. 2013;288:17313-35 pubmed publisher |
| Maroui M, Kheddache Atmane S, El Asmi F, Dianoux L, Aubry M, Chelbi Alix M. Requirement of PML SUMO interacting motif for RNF4- or arsenic trioxide-induced degradation of nuclear PML isoforms. PLoS ONE. 2012;7:e44949 pubmed publisher |
- immunohistochemistry; mouse
| Rosenfeldt M, Nixon C, Liu E, Mah L, Ryan K. Analysis of macroautophagy by immunohistochemistry. Autophagy. 2012;8:963-9 pubmed publisher |
- western blot; green plants
| Stuttmann J, Lechner E, Guerois R, Parker J, Nussaume L, Genschik P, et al. COP9 signalosome- and 26S proteasome-dependent regulation of SCFTIR1 accumulation in Arabidopsis. J Biol Chem. 2009;284:7920-30 pubmed publisher |
| Dayal S, Sparks A, Jacob J, Allende Vega N, Lane D, Saville M. Suppression of the deubiquitinating enzyme USP5 causes the accumulation of unanchored polyubiquitin and the activation of p53. J Biol Chem. 2009;284:5030-41 pubmed publisher |
- immunohistochemistry; fruit fly
| Watson M, Lagow R, Xu K, Zhang B, Bonini N. A drosophila model for amyotrophic lateral sclerosis reveals motor neuron damage by human SOD1. J Biol Chem. 2008;283:24972-81 pubmed publisher |
| Cripps D, Thomas S, Jeng Y, Yang F, Davies P, Yang A. Alzheimer disease-specific conformation of hyperphosphorylated paired helical filament-Tau is polyubiquitinated through Lys-48, Lys-11, and Lys-6 ubiquitin conjugation. J Biol Chem. 2006;281:10825-38 pubmed |
| Lichtenfels R, Kellner R, Atkins D, Bukur J, Ackermann A, Beck J, et al. Identification of metabolic enzymes in renal cell carcinoma utilizing PROTEOMEX analyses. Biochim Biophys Acta. 2003;1646:21-31 pubmed |
| Hamamoto K, Liang X, Ito A, Lanza M, Bui V, Zhang J, et al. Unveiling the physiological impact of ESCRT-dependent autophagosome closure by targeting the VPS37A ubiquitin E2 variant-like domain. Cell Rep. 2024;43:115016 pubmed publisher |
| Volik P, Zamaraev A, Egorshina A, Pervushin N, Kapusta A, Tyurin Kuzmin P, et al. Ally or traitor: the dual role of p62 in caspase-2 regulation. Cell Death Dis. 2024;15:827 pubmed publisher |
| Muhammad T, Edwards S, Morphis A, Johnson M, Oliveira V, Chamera T, et al. Non-cell-autonomous regulation of germline proteostasis by insulin/IGF-1 signaling-induced dietary peptide uptake via PEPT-1. EMBO J. 2024;43:4892-4921 pubmed publisher |
| Michel M, Scutts S, Komander D. Secondary interactions in ubiquitin-binding domains achieve linkage or substrate specificity. Cell Rep. 2024;43:114545 pubmed publisher |
| Xie Q, Hu B, Li H. Acetylation- and ubiquitination-regulated SFMBT2 acts as a tumor suppressor in clear cell renal cell carcinoma. Biol Direct. 2024;19:37 pubmed publisher |
| Hackerova L, Klusackova B, Zigo M, Zelenkova N, Havlikova K, Krejčířová R, et al. Modulatory effect of MG-132 proteasomal inhibition on boar sperm motility during in vitro capacitation. Front Vet Sci. 2023;10:1116891 pubmed publisher |
| Yang S, Xiang J, Ma C, Yang G, Wang X, Liu H, et al. Sp1-like protein KLF13 acts as a negative feedback regulator of TGF-β signaling and fibrosis. Cell Rep. 2023;42:112367 pubmed publisher |
| Phan J, Creekmore B, Nguyen A, Bershadskaya D, Darwich N, Lee E. Novel VCP activator reverses multisystem proteinopathy nuclear proteostasis defects and enhances TDP-43 aggregate clearance. bioRxiv. 2023;: pubmed publisher |
| Yonenobu Y, Beck G, Kido K, Maeda N, Yamashita R, Inoue K, et al. Neuropathology of spinocerebellar ataxia type 8: Common features and unique tauopathy. Neuropathology. 2023;: pubmed publisher |
| Guo Y, Chomiak A, Hong Y, Lowe C, Kopsidas C, Chan W, et al. Histone H2A ubiquitination resulting from Brap loss of function connects multiple aging hallmarks and accelerates neurodegeneration. iScience. 2022;25:104519 pubmed publisher |
| Chomiak A, Guo Y, Kopsidas C, McDaniel D, Lowe C, Pan H, et al. Nde1 is required for heterochromatin compaction and stability in neocortical neurons. iScience. 2022;25:104354 pubmed publisher |
| Kwon M, Oh T, Jang M, Kim G, Kim J, Ryu H, et al. Kurarinone induced p53-independent G0/G1 cell cycle arrest by degradation of K-RAS via WDR76 in human colorectal cancer cells. Eur J Pharmacol. 2022;923:174938 pubmed publisher |
| Aalto A, Mart xed nez Chac xf3 n G, Kietz C, Tsyganova N, Kreutzer J, Kallio P, et al. M1-linked ubiquitination facilitates NF-κB activation and survival during sterile inflammation. FEBS J. 2022;289:5180-5197 pubmed publisher |
| Zhang C, Tang Q, Xia H, Xu H, Bi F. PKM2 compensates for proteasome dysfunction by mediating the formation of the CHIP-HSP70-BAG3 complex and the aggregation of ubiquitinated proteins. FASEB J. 2022;36:e22121 pubmed publisher |
| Ito Y, Yamamoto T, Miyai K, Take J, Scherthan H, Rommel A, et al. Ascorbic acid-2 glucoside mitigates intestinal damage during pelvic radiotherapy in a rat bladder tumor model. Int J Radiat Biol. 2021;:1-16 pubmed publisher |
| Lu H, Lyu Y, Tran L, Lan J, Xie Y, Yang Y, et al. HIF-1 recruits NANOG as a coactivator for TERT gene transcription in hypoxic breast cancer stem cells. Cell Rep. 2021;36:109757 pubmed publisher |
| Jo J, Yang L, Tran H, Yu W, Sun A, Chang Y, et al. Lewy Body-like Inclusions in Human Midbrain Organoids Carrying Glucocerebrosidase and α-Synuclein Mutations. Ann Neurol. 2021;: pubmed publisher |
| Robichaud S, Fairman G, Vijithakumar V, Mak E, Cook D, Pelletier A, et al. Identification of novel lipid droplet factors that regulate lipophagy and cholesterol efflux in macrophage foam cells. Autophagy. 2021;17:3671-3689 pubmed publisher |
| Schwertheim S, Kälsch J, Jastrow H, Schaefer C, Theurer S, Ting S, et al. Characterization of two types of intranuclear hepatocellular inclusions in NAFLD. Sci Rep. 2020;10:16533 pubmed publisher |
| Thurner L, Hartmann S, Bewarder M, Fadle N, Regitz E, Schormann C, et al. Identification of the atypically modified autoantigen Ars2 as the target of B-cell receptors from activated B cell-type diffuse large B-cell lymphoma. Haematologica. 2020;: pubmed publisher |
| Chen Z, Wasney G, Picaud S, Filippakopoulos P, Vedadi M, D Angiolella V, et al. Identification of a PGXPP degron motif in dishevelled and structural basis for its binding to the E3 ligase KLHL12. Open Biol. 2020;10:200041 pubmed publisher |
| Yoon Y, Lee J, Song K, Noh H, Lee S. Melatonin-stimulated exosomes enhance the regenerative potential of chronic kidney disease-derived mesenchymal stem/stromal cells via cellular prion proteins. J Pineal Res. 2020;68:e12632 pubmed publisher |
| Schwertheim S, Theurer S, Jastrow H, Herold T, Ting S, Westerwick D, et al. New insights into intranuclear inclusions in thyroid carcinoma: Association with autophagy and with BRAFV600E mutation. PLoS ONE. 2019;14:e0226199 pubmed publisher |
| Sn S, Pandurangi J, Murumalla R, Dj V, Garimella L, Acharya A, et al. Small molecule modulator of aggrephagy regulates neuroinflammation to curb pathogenesis of neurodegeneration. EBioMedicine. 2019;50:260-273 pubmed publisher |
| Damgaard R, Elliott P, Swatek K, Maher E, Stepensky P, Elpeleg O, et al. OTULIN deficiency in ORAS causes cell type-specific LUBAC degradation, dysregulated TNF signalling and cell death. EMBO Mol Med. 2019;11: pubmed publisher |
| Aalto A, Mohan A, Schwintzer L, Kupka S, Kietz C, Walczak H, et al. M1-linked ubiquitination by LUBEL is required for inflammatory responses to oral infection in Drosophila. Cell Death Differ. 2019;26:860-876 pubmed publisher |
| Gladkova C, Maslen S, Skehel J, Komander D. Mechanism of parkin activation by PINK1. Nature. 2018;559:410-414 pubmed publisher |
| Gogoi M, Ravikumar V, Dixit N, Chakravortty D. Salmonella escapes antigen presentation through K63 ubiquitination mediated endosomal proteolysis of MHC II via modulation of endosomal acidification in dendritic cells. Pathog Dis. 2018;76: pubmed publisher |
| Deger S, Hung A, Gamboa J, Siew E, Ellis C, Booker C, et al. Systemic inflammation is associated with exaggerated skeletal muscle protein catabolism in maintenance hemodialysis patients. JCI Insight. 2017;2: pubmed publisher |
| Gersch M, Gladkova C, Schubert A, Michel M, Maslen S, Komander D. Mechanism and regulation of the Lys6-selective deubiquitinase USP30. Nat Struct Mol Biol. 2017;24:920-930 pubmed publisher |
| Michel M, Swatek K, Hospenthal M, Komander D. Ubiquitin Linkage-Specific Affimers Reveal Insights into K6-Linked Ubiquitin Signaling. Mol Cell. 2017;68:233-246.e5 pubmed publisher |
| Kaul Z, Chakrabarti O. Tumor susceptibility gene 101 regulates predisposition to apoptosis via ESCRT machinery accessory proteins. Mol Biol Cell. 2017;28:2106-2122 pubmed publisher |
| Pruneda J, Durkin C, Geurink P, Ovaa H, Santhanam B, Holden D, et al. The Molecular Basis for Ubiquitin and Ubiquitin-like Specificities in Bacterial Effector Proteases. Mol Cell. 2016;63:261-276 pubmed publisher |
| Ohmi K, Zhao H, Neufeld E. Defects in the medial entorhinal cortex and dentate gyrus in the mouse model of Sanfilippo syndrome type B. PLoS ONE. 2011;6:e27461 pubmed publisher |
| Guo J, Chen H, Mathew R, Fan J, Strohecker A, Karsli Uzunbas G, et al. Activated Ras requires autophagy to maintain oxidative metabolism and tumorigenesis. Genes Dev. 2011;25:460-70 pubmed publisher |
| Sun K, Johnson B, Gunn T. Mitochondrial dysfunction precedes neurodegeneration in mahogunin (Mgrn1) mutant mice. Neurobiol Aging. 2007;28:1840-52 pubmed |
| Ryazantsev S, Yu W, Zhao H, Neufeld E, Ohmi K. Lysosomal accumulation of SCMAS (subunit c of mitochondrial ATP synthase) in neurons of the mouse model of mucopolysaccharidosis III B. Mol Genet Metab. 2007;90:393-401 pubmed |
| Hawryluk M, Keyel P, Mishra S, Watkins S, Heuser J, Traub L. Epsin 1 is a polyubiquitin-selective clathrin-associated sorting protein. Traffic. 2006;7:262-81 pubmed |
| Chang L, Kamata H, Solinas G, Luo J, Maeda S, Venuprasad K, et al. The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP(L) turnover. Cell. 2006;124:601-13 pubmed |
