product summary
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company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
Tyrosine Hydroxylase Antibody - Azide Free
catalog :
NB300-110
quantity :
0.1 ml (also 0.025 ml)
price :
479 USD
clonality :
polyclonal
host :
domestic sheep
conjugate :
DyLight 405
clone name :
6H12
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
citations: 65
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry; mouse; 1:2000; loading ...; fig 6b
Furlan A, Dyachuk V, Kastriti M, Calvo Enrique L, Abdo H, Hadjab S, et al. Multipotent peripheral glial cells generate neuroendocrine cells of the adrenal medulla. Science. 2017;357: pubmed publisher
  • immunohistochemistry; mouse; fig 5
  • immunohistochemistry; human; fig 5
La Manno G, Gyllborg D, Codeluppi S, Nishimura K, Salto C, Zeisel A, et al. Molecular Diversity of Midbrain Development in Mouse, Human, and Stem Cells. Cell. 2016;167:566-580.e19 pubmed publisher
  • immunohistochemistry; rat; 1:2000; loading ...; fig 1a
Rodionova K, Fiedler C, Guenther F, Grouzmann E, Neuhuber W, Fischer M, et al. Complex reinnervation pattern after unilateral renal denervation in rats. Am J Physiol Regul Integr Comp Physiol. 2016;310:R806-18 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:1000; loading ...; fig 1a
van der Keylen P, Garreis F, Steigleder R, Sommer D, Neuhuber W, Wörl J. Involvement of catecholaminergic neurons in motor innervation of striated muscle in the mouse esophagus. Histochem Cell Biol. 2016;145:573-85 pubmed publisher
Carreras Mascaro A, Grochowska M, Boumeester V, Dits N, Bilgi x4ab E, Breedveld G, et al. LRP10 and α-synuclein transmission in Lewy body diseases. Cell Mol Life Sci. 2024;81:75 pubmed publisher
Jo A, Deniz S, Cherian S, Xu J, Futagi D, DeVries S, et al. Modular interneuron circuits control motion sensitivity in the mouse retina. Nat Commun. 2023;14:7746 pubmed publisher
Globig A, Zhao S, Roginsky J, Maltez V, Güiza J, Avina Ochoa N, et al. The β1-adrenergic receptor links sympathetic nerves to T cell exhaustion. Nature. 2023;622:383-392 pubmed publisher
Runkel M, Tarabishi A, Shay Winkler K, Emmert M, Goh Q, Cornwall R. The role of sympathetic innervation in neonatal muscle growth and neuromuscular contractures. FEBS J. 2023;290:4877-4898 pubmed publisher
Garc xed a Revilla J, Boza Serrano A, Jin Y, Vadukul D, Sold xe1 n Hidalgo J, Camprub xed Ferrer L, et al. Galectin-3 shapes toxic alpha-synuclein strains in Parkinson's disease. Acta Neuropathol. 2023;146:51-75 pubmed publisher
Pértile R, Brigden R, Raman V, Cui X, Du Z, Eyles D. Vitamin D: A potent regulator of dopaminergic neuron differentiation and function. J Neurochem. 2023;: pubmed publisher
Lai J, Porcu A, Romoli B, Keisler M, Manfredsson F, Powell S, et al. Nicotine-Mediated Recruitment of GABAergic Neurons to a Dopaminergic Phenotype Attenuates Motor Deficits in an Alpha-Synuclein Parkinson's Model. Int J Mol Sci. 2023;24: pubmed publisher
Xu P, He H, Gao Q, Zhou Y, Wu Z, Zhang X, et al. Human midbrain dopaminergic neuronal differentiation markers predict cell therapy outcomes in a Parkinson's disease model. J Clin Invest. 2022;132: pubmed publisher
Brandon A, Cui X, Luan W, Ali A, Pértile R, Alexander S, et al. Prenatal hypoxia alters the early ontogeny of dopamine neurons. Transl Psychiatry. 2022;12:238 pubmed publisher
Alekseenko Z, Dias J, Adler A, Kozhevnikova M, van Lunteren J, Nolbrant S, et al. Robust derivation of transplantable dopamine neurons from human pluripotent stem cells by timed retinoic acid delivery. Nat Commun. 2022;13:3046 pubmed publisher
Aparecida Nedel Pertile R, Kiltschewskij D, Geaghan M, Barnett M, Cui X, Cairns M, et al. Developmental vitamin D-deficiency increases the expression of microRNAs involved in dopamine neuron development. Brain Res. 2022;1789:147953 pubmed publisher
Kameneva P, Melnikova V, Kastriti M, Kurtova A, Kryukov E, Murtazina A, et al. Serotonin limits generation of chromaffin cells during adrenal organ development. Nat Commun. 2022;13:2901 pubmed publisher
Arotcarena M, Soria F, Cunha A, Doudnikoff E, Pr xe9 vot G, Daniel J, et al. Acidic nanoparticles protect against α-synuclein-induced neurodegeneration through the restoration of lysosomal function. Aging Cell. 2022;21:e13584 pubmed publisher
Kabelik D, Julien A, Waddell B, Batschelett M, O Connell L. Aggressive but not reproductive boldness in male green anole lizards correlates with baseline vasopressin activity. Horm Behav. 2022;140:105109 pubmed publisher
Barr H, Wall E, Woolley S. Dopamine in the songbird auditory cortex shapes auditory preference. Curr Biol. 2021;31:4547-4559.e5 pubmed publisher
Xiang C, Chen P, Zhang Q, Li Y, Pan Y, Xie W, et al. Intestinal microbiota modulates adrenomedullary response through Nod1 sensing in chromaffin cells. iScience. 2021;24:102849 pubmed publisher
Kameneva P, Artemov A, Kastriti M, Faure L, Olsen T, Otte J, et al. Single-cell transcriptomics of human embryos identifies multiple sympathoblast lineages with potential implications for neuroblastoma origin. Nat Genet. 2021;53:694-706 pubmed publisher
Hong J, Adam R, Gao L, Hahka T, Xia Z, Wang D, et al. Macrophage activation in stellate ganglia contributes to lung injury-induced arrhythmogenesis in male rats. Acta Physiol (Oxf). 2021;232:e13657 pubmed publisher
Etxeberria Rekalde E, Alzola Aldamizetxebarria S, Flunkert S, Hable I, Daurer M, Neddens J, et al. Quantification of Huntington's Disease Related Markers in the R6/2 Mouse Model. Front Mol Neurosci. 2020;13:617229 pubmed publisher
Milanese C, Gabriels S, Barnhoorn S, Cerri S, Ulusoy A, Gornati S, et al. Gender biased neuroprotective effect of Transferrin Receptor 2 deletion in multiple models of Parkinson's disease. Cell Death Differ. 2020;: pubmed publisher
Morarach K, Mikhailova A, Knoflach V, Memic F, Kumar R, Li W, et al. Diversification of molecularly defined myenteric neuron classes revealed by single-cell RNA sequencing. Nat Neurosci. 2021;24:34-46 pubmed publisher
Evans R, Twedell E, Zhu M, Ascencio J, Zhang R, Khaliq Z. Functional Dissection of Basal Ganglia Inhibitory Inputs onto Substantia Nigra Dopaminergic Neurons. Cell Rep. 2020;32:108156 pubmed publisher
García Domínguez I, Suárez Pereira I, Santiago M, Pérez Villegas E, Bravo L, López Martín C, et al. Selective deletion of Caspase-3 gene in the dopaminergic system exhibits autistic-like behaviour. Prog Neuropsychopharmacol Biol Psychiatry. 2021;104:110030 pubmed publisher
Le J, Park J, Ha V, Luong A, Branciamore S, Rodin A, et al. Single-Cell RNA-Seq Mapping of Human Thymopoiesis Reveals Lineage Specification Trajectories and a Commitment Spectrum in T Cell Development. Immunity. 2020;52:1105-1118.e9 pubmed publisher
Romanov R, Tretiakov E, Kastriti M, Zupancic M, Häring M, Korchynska S, et al. Molecular design of hypothalamus development. Nature. 2020;582:246-252 pubmed publisher
Ysselstein D, Nguyen M, Young T, Severino A, Schwake M, Merchant K, et al. LRRK2 kinase activity regulates lysosomal glucocerebrosidase in neurons derived from Parkinson's disease patients. Nat Commun. 2019;10:5570 pubmed publisher
Xie M, Kamenev D, Kaucka M, Kastriti M, Zhou B, Artemov A, et al. Schwann cell precursors contribute to skeletal formation during embryonic development in mice and zebrafish. Proc Natl Acad Sci U S A. 2019;116:15068-15073 pubmed publisher
Shah S, Maric D, Denaro F, Ibrahim W, MASON R, Kumar A, et al. Nitrosative Stress Is Associated with Dopaminergic Dysfunction in the HIV-1 Transgenic Rat. Am J Pathol. 2019;189:1375-1385 pubmed publisher
Kastriti M, Kameneva P, Kamenev D, Dyachuk V, Furlan A, Hampl M, et al. Schwann Cell Precursors Generate the Majority of Chromaffin Cells in Zuckerkandl Organ and Some Sympathetic Neurons in Paraganglia. Front Mol Neurosci. 2019;12:6 pubmed publisher
Theofilopoulos S, Abreu de Oliveira W, Yang S, Yutuc E, Saeed A, Abdel Khalik J, et al. 24(S),25-Epoxycholesterol and cholesterol 24S-hydroxylase (CYP46A1) overexpression promote midbrain dopaminergic neurogenesis in vivo. J Biol Chem. 2019;294:4169-4176 pubmed publisher
García Domínguez I, Veselá K, García Revilla J, Carrillo Jimenez A, Roca Ceballos M, Santiago M, et al. Peripheral Inflammation Enhances Microglia Response and Nigral Dopaminergic Cell Death in an in vivo MPTP Model of Parkinson's Disease. Front Cell Neurosci. 2018;12:398 pubmed publisher
Kabelik D, Weitekamp C, Choudhury S, Hartline J, Smith A, Hofmann H. Neural activity in the social decision-making network of the brown anole during reproductive and agonistic encounters. Horm Behav. 2018;106:178-188 pubmed publisher
Yang S, Toledo E, Rosmaninho P, Peng C, Uhlen P, Castro D, et al. A Zeb2-miR-200c loop controls midbrain dopaminergic neuron neurogenesis and migration. Commun Biol. 2018;1:75 pubmed publisher
Barr H, Woolley S. Developmental auditory exposure shapes responses of catecholaminergic neurons to socially-modulated song. Sci Rep. 2018;8:11717 pubmed publisher
Milanese C, Cerri S, Ulusoy A, Gornati S, Plat A, Gabriels S, et al. Activation of the DNA damage response in vivo in synucleinopathy models of Parkinson's disease. Cell Death Dis. 2018;9:818 pubmed publisher
Okawa S, Salto C, Ravichandran S, Yang S, Toledo E, Arenas E, et al. Transcriptional synergy as an emergent property defining cell subpopulation identity enables population shift. Nat Commun. 2018;9:2595 pubmed publisher
Luan W, Hammond L, Vuillermot S, Meyer U, Eyles D. Maternal Vitamin D Prevents Abnormal Dopaminergic Development and Function in a Mouse Model of Prenatal Immune Activation. Sci Rep. 2018;8:9741 pubmed publisher
Shaltouki A, Hsieh C, Kim M, Wang X. Alpha-synuclein delays mitophagy and targeting Miro rescues neuron loss in Parkinson's models. Acta Neuropathol. 2018;136:607-620 pubmed publisher
Dai J, Chen Y, Sakata J. EGR-1 Expression in Catecholamine-synthesizing Neurons Reflects Auditory Learning and Correlates with Responses in Auditory Processing Areas. Neuroscience. 2018;379:415-427 pubmed publisher
Van Ruijssevelt L, Chen Y, von Eugen K, Hamaide J, De Groof G, Verhoye M, et al. fMRI Reveals a Novel Region for Evaluating Acoustic Information for Mate Choice in a Female Songbird. Curr Biol. 2018;28:711-721.e6 pubmed publisher
Abdellah N, Van Remoortel S, Mohey Elsaeed O, Mustafa M, Ahmed Y, Timmermans J, et al. Neuropeptide AF Induces Piecemeal Degranulation in Murine Mucosal Mast Cells: A New Mediator in Neuro-Immune Communication in the Intestinal Lamina Propria?. Anat Rec (Hoboken). 2018;301:1103-1114 pubmed publisher
Friend L, Weed J, Sandoval P, Nufer T, Ostlund I, Edwards J. CB1-Dependent Long-Term Depression in Ventral Tegmental Area GABA Neurons: A Novel Target for Marijuana. J Neurosci. 2017;37:10943-10954 pubmed publisher
Sinharay S, Lee D, Shah S, Muthusamy S, Papadakis G, Zhang X, et al. Cross-sectional and longitudinal small animal PET shows pre and post-synaptic striatal dopaminergic deficits in an animal model of HIV. Nucl Med Biol. 2017;55:27-33 pubmed publisher
Kim H, Kang H, Lee Y, Park C, Jo A, Khang R, et al. Identification of transketolase as a target of PARIS in substantia nigra. Biochem Biophys Res Commun. 2017;493:1050-1056 pubmed publisher
Dulcis D, Lippi G, Stark C, Do L, Berg D, Spitzer N. Neurotransmitter Switching Regulated by miRNAs Controls Changes in Social Preference. Neuron. 2017;95:1319-1333.e5 pubmed publisher
Chen Y, Clark O, Woolley S. Courtship song preferences in female zebra finches are shaped by developmental auditory experience. Proc Biol Sci. 2017;284: pubmed publisher
Skrzypecki J, Gawlak M, Huc T, Szulczyk P, Ufnal M. Renal denervation decreases blood pressure and renal tyrosine hydroxylase but does not augment the effect of hypotensive drugs. Clin Exp Hypertens. 2017;39:290-294 pubmed publisher
Rivetti di Val Cervo P, Romanov R, Spigolon G, Masini D, Martín Montañez E, Toledo E, et al. Induction of functional dopamine neurons from human astrocytes in vitro and mouse astrocytes in a Parkinson's disease model. Nat Biotechnol. 2017;35:444-452 pubmed publisher
Jalewa J, Sharma M, Gengler S, Holscher C. A novel GLP-1/GIP dual receptor agonist protects from 6-OHDA lesion in a rat model of Parkinson's disease. Neuropharmacology. 2017;117:238-248 pubmed publisher
Villaescusa J, Li B, Toledo E, Rivetti di Val Cervo P, Yang S, Stott S, et al. A PBX1 transcriptional network controls dopaminergic neuron development and is impaired in Parkinson's disease. EMBO J. 2016;35:1963-78 pubmed publisher
Schubloom H, Woolley S. Variation in social relationships relates to song preferences and EGR1 expression in a female songbird. Dev Neurobiol. 2016;76:1029-40 pubmed publisher
Buckinx R, Van Remoortel S, Gijsbers R, Waddington S, Timmermans J. Proof-of-concept: neonatal intravenous injection of adeno-associated virus vectors results in successful transduction of myenteric and submucosal neurons in the mouse small and large intestine. Neurogastroenterol Motil. 2016;28:299-305 pubmed publisher
Merrill C, Friend L, Newton S, Hopkins Z, Edwards J. Ventral tegmental area dopamine and GABA neurons: Physiological properties and expression of mRNA for endocannabinoid biosynthetic elements. Sci Rep. 2015;5:16176 pubmed publisher
Hodson E, Nicholls L, Turner P, Llyr R, Fielding J, Douglas G, et al. Regulation of ventilatory sensitivity and carotid body proliferation in hypoxia by the PHD2/HIF-2 pathway. J Physiol. 2016;594:1179-95 pubmed publisher
Matheson L, Sun H, Sakata J. Forebrain circuits underlying the social modulation of vocal communication signals. Dev Neurobiol. 2016;76:47-63 pubmed publisher
Matheson L, Sakata J. Catecholaminergic contributions to vocal communication signals. Eur J Neurosci. 2015;41:1180-94 pubmed publisher
Mansley M, Neuhuber W, Korbmacher C, Bertog M. Norepinephrine stimulates the epithelial Na+ channel in cortical collecting duct cells via α2-adrenoceptors. Am J Physiol Renal Physiol. 2015;308:F450-8 pubmed publisher
Kelly A, Goodson J. Functional interactions of dopamine cell groups reflect personality, sex, and social context in highly social finches. Behav Brain Res. 2015;280:101-12 pubmed publisher
Usoskin D, Furlan A, Islam S, Abdo H, Lönnerberg P, Lou D, et al. Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing. Nat Neurosci. 2015;18:145-53 pubmed publisher
Buckinx R, Bagyánszki M, Avula L, Adriaensen D, Van Nassauw L, Timmermans J. Expression of corticotropin-releasing factor and urocortins in the normal and Schistosoma mansoni-infected mouse ileum. Cell Tissue Res. 2015;359:453-463 pubmed publisher
Contini M, Raviola E. GABAergic synapses made by a retinal dopaminergic neuron. Proc Natl Acad Sci U S A. 2003;100:1358-63 pubmed
product information
master code :
NB300-110
SKU :
NB300-110
product name :
Tyrosine Hydroxylase Antibody - Azide Free
unit size :
0.1 ml (also 0.025 ml)
description :
The Tyrosine Hydroxylase Antibody - Azide Free from Novus is a sheep polyclonal antibody to Tyrosine Hydroxylase. This antibody reacts with amphibian,avian,finch,human,mammal,mouse,rabbit,rat,reptile. The Tyrosine Hydroxylase Antibody - Azide Free has been validated for the following applications: Immunohistochemistry,IF/IHC,Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunohistochemistry Free-Floating,Immunocytochemistry/ Immunofluorescence,Single Cell Western.
target :
Tyrosine Hydroxylase
category :
Primary Antibodies
buffer :
10 mM HEPES (pH 7.5), 0.15 M NaCl, 0.1 mg/mL BSA, 50% Glycerol
clonality :
Polyclonal
conjugate :
Unconjugated
host :
Sheep
immunogen :
SDS-denatured, native rat tyrosine hydroxylase purified from pheochromocytoma.
isotype :
IgG
purity :
Antigen Affinity-purified
species :
Amphibian,Avian,Finch,Human,Mammal,Mouse,Rabbit,Rat,Reptile
specificity :
Specific for the ~60 kDa tyrosine hydroxylase protein
theoretical molecular weight :
60 kDa
gene symbol :
TH
accessionNumbers :
P04177
applications :
Immunohistochemistry,IF/IHC,Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunohistochemistry Free-Floating,Immunocytochemistry/ Immunofluorescence,Single Cell Western
USD :
479 USD
alt names :
DYT14, DYT5b, EC 1.14.16, EC 1.14.16.2, TH, TYH dystonia 14, Tyrosine 3-hydroxylase, tyrosine 3-monooxygenase, tyrosine hydroxylase
storage :
Store at -20C. Avoid freeze-thaw cycles.
more info or order :
company information
Novus Biologicals
10771 E Easter Ave
Centennial, CO 80112
novus@novusbio.com
https://www.novusbio.com
3037301950
headquarters: USA
Novus Biologicals licenses, manufactures, and markets antibodies to over 20,000 unique targets to support a wide array of research areas. Novus is built on honesty, collaboration and strong relationships and continues to provide quality tools that accelerate research. Every product is backed by our 100% guarantee.