product summary
request information :
company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
Rabbit Polyclonal Histone H3 Antibody
catalog :
NB21-1253R
quantity :
0.05 mg
price :
219.00 USD
clonality :
polyclonal
host :
rabbit
conjugate :
DyLight 550
reactivity :
human, mouse
application :
western blot
more info or order :
Novus Biologicals product webpage
product information
Catalog Number :
NB21-1253R
Product Name :
Rabbit Polyclonal Histone H3 Antibody
List Price :
219.00 USD
Product Type :
Primary Antibodies
Package Size :
0.05 mg
AltNames :
H3 histone, family 3A, H3.3AH3F3H3F3B, H3.3B, histone H3.3, MGC87782, MGC87783
Background :
The histone modification H3K36me3 is important in the differentiation and maintenance of specialized cells derived from stem cell progenitors. The presence and abundance of H3K36me3 is correlated to the downstream transcription of those pathway components important for cellular functions that differentiate cells from each other. The polycomb repressive complex 2 (PRC2) represses transcription by methylation of H3 lysine 27, but this methylation is inhibited by the presence of the H3K36me3 mark. SETD2 is the main methyltransferase responsible for methylating the H3K36me3. Once methylated, H3K36me3 is highly associated with active transcription factors, and the generation of integral downstream pathways, which move stem cells towards differentiation.
Buffer :
50 mM sodium borate
Clonality :
Polyclonal
Conjugate :
DyLight 550
Application Summary :
Western Blot, Dot Blot
Host :
Rabbit
Immunogen :
Synthetic trimethylated peptide surrounding Lysine 36 of human Histone H3.2 [Swiss Prot Q71DI3].
Marker :
Nuclear Marker
Modification :
Trimethyl Lys36
Notes :
Epi-Plus antibody production in collaboration with Rockland Immunochemicals Inc.
Preservative :
No Preservative
Purity :
Affinity purified
CrossReactivity :
Human, mouse, and C. elegans. Predicted to react with many species including rat, chicken, Xenopus, Drosophila, and plant based on 100% sequence homology.
Storage :
Store at 4C in the dark.
Swissprot Human :
Q71DI3
Uses :
This Histone H3 K36me3 antibody is useful for dot blot and Western blot, where a band is seen ~15 kDa.
Research Area :
Chromatin Modifiers, Chromatin Research, Epigenetics, Histones and Modified Histones
more info or order :
Novus Biologicals product webpage
company information
Novus Biologicals
8100 Southpark Way, A-8
Littleton, CO 80120
novus@novusbio.com
www.novusbio.com
3037301950
headquarters: USA
The mission of Novus Biologicals, LLC is to accelerate scientific discovery by developing and marketing unique products in the forefront of science. Novus Biologicals was organized to provide the biological research community with a mechanism for commercializing unique biological materials. We also focus on continually monitoring scientific trends and supply materials to serve these trends. By making these products widely available to institutional and commercial researchers, Novus Biologicals plays an important role in furthering biological research. All of Novus Biologicals products are supplied with detailed technical information and ongoing support. By serving niche and emerging markets, Novus Biologicals has become specialists in markets and has formed and will continue to form ongoing partnerships with our customers.