product summary
request information :
company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
Rabbit Polyclonal Histone H3 Antibody
catalog :
NB21-1091F
quantity :
0.05 mg
price :
209.00 USD
clonality :
polyclonal
host :
rabbit
conjugate :
FITC
reactivity :
human, mouse
application :
western blot
more info or order :
Novus Biologicals product webpage
product information
Catalog Number :
NB21-1091F
Product Name :
Rabbit Polyclonal Histone H3 Antibody
List Price :
209.00 USD
Product Type :
Primary Antibodies
Package Size :
0.05 mg
AltNames :
H3 histone, family 3A, H3.3AH3F3H3F3B, H3.3B, histone H3.3, MGC87782, MGC87783
Background :
H3 pS10 is typically associated with activation of transcription of genes associated with histone H3. This modification is linked to the initiation of chromatin condensation in G(2). During mitosis, H3pS10 is required for proper chromosome segregation. Formation of the H3pS10 modification seems to be regulated in part by p53, which interacts with histone modifying complexes. In development of the retina, the presence of H3pS10 is linked to the abundance of eye defects. This developmental effect of H3pS10 seems to be related to Psf2 and GPR84. The human Timeless protein (Tim) regulates the global H3pS10 phosphorylation in G2/M phase. VASP concentrations peak during mitosis in HeLa cells at the same time as H3pS10, indicating that co-responsibility for transition of G2/M phases. AURKB promotes the phosphorylation of histone H3 at pS10.
Buffer :
50mM sodium borate
Clonality :
Polyclonal
Conjugate :
FITC
Application Summary :
Western Blot, Dot Blot
Host :
Rabbit
Immunogen :
Synthetic phosphorylated peptide surrounding Serine 10 of human Histone H3.2 [Swiss Prot Q71DI3].
Localization :
Nucleus. Chromosome
Marker :
Nuclear Marker
Modification :
p Ser10
Preservative :
No Preservative
Purity :
Immunogen affinity purified
CrossReactivity :
Human, mouse, and C. elegans. Predicted to react with many species including rat, chicken, Xenopus, Drosophila, and plant based on 100% sequence homology.
Storage :
Store at 4C in the dark.
Swissprot Human :
Q71DI3
Uses :
This H3 pS10 antibody is useful for ICC/IF, Dot Blot, and Western Blot where a band is observed ~15 kDa in HeLa histone prep and C. elegans embryo lysate.
Research Area :
Chromatin Modifiers, Chromatin Research, Epigenetics, Histones and Modified Histones, Phospho Specific
more info or order :
Novus Biologicals product webpage
company information
Novus Biologicals
8100 Southpark Way, A-8
Littleton, CO 80120
novus@novusbio.com
www.novusbio.com
3037301950
headquarters: USA
The mission of Novus Biologicals, LLC is to accelerate scientific discovery by developing and marketing unique products in the forefront of science. Novus Biologicals was organized to provide the biological research community with a mechanism for commercializing unique biological materials. We also focus on continually monitoring scientific trends and supply materials to serve these trends. By making these products widely available to institutional and commercial researchers, Novus Biologicals plays an important role in furthering biological research. All of Novus Biologicals products are supplied with detailed technical information and ongoing support. By serving niche and emerging markets, Novus Biologicals has become specialists in markets and has formed and will continue to form ongoing partnerships with our customers.