This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
TfR (Transferrin R) Antibody (OX26)
catalog :
NB200-585
quantity :
0.1 mg (also 0.025 mg)
price :
299 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
OX26
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
citations: 51
Reference
Chen X, Zhang B, Liu T, Feng M, Zhang Y, Zhang C, et al. Liproxstatin-1 Attenuates Morphine Tolerance through Inhibiting Spinal Ferroptosis-like Cell Death. ACS Chem Neurosci. 2019;10:4824-4833 pubmed publisher
Del Duca E, Pavel A, Dubin C, Song T, Wallace E, Peng X, et al. Major Differences in Expression of Inflammatory Pathways in Skin from Different Body Sites of Healthy Individuals. J Invest Dermatol. 2019;139:2228-2232.e10 pubmed publisher
Sanyal R, Pavel A, Glickman J, Chan T, Zheng X, Zhang N, et al. Atopic dermatitis in African American patients is TH2/TH22-skewed with TH1/TH17 attenuation. Ann Allergy Asthma Immunol. 2019;122:99-110.e6 pubmed publisher
Reinartz S, van Tongeren J, van Egmond D, de Groot E, Fokkens W, van Drunen C. Dendritic Cell Subsets in Oral Mucosa of Allergic and Healthy Subjects. PLoS ONE. 2016;11:e0154409 pubmed publisher
Fehres C, Bruijns S, Sotthewes B, Kalay H, Schaffer L, Head S, et al. Phenotypic and Functional Properties of Human Steady State CD14+ and CD1a+ Antigen Presenting Cells and Epidermal Langerhans Cells. PLoS ONE. 2015;10:e0143519 pubmed publisher
Ng W, Londrigan S, Nasr N, Cunningham A, Turville S, Brooks A, et al. The C-type Lectin Langerin Functions as a Receptor for Attachment and Infectious Entry of Influenza A Virus. J Virol. 2016;90:206-21 pubmed publisher
van den Berg L, Ribeiro C, Zijlstra Willems E, de Witte L, Fluitsma D, Tigchelaar W, et al. Caveolin-1 mediated uptake via langerin restricts HIV-1 infection in human Langerhans cells. Retrovirology. 2014;11:123 pubmed publisher
Schaeffer E, Flacher V, Papageorgiou V, Decossas M, Fauny J, Krämer M, et al. Dermal CD14(+) Dendritic Cell and Macrophage Infection by Dengue Virus Is Stimulated by Interleukin-4. J Invest Dermatol. 2015;135:1743-1751 pubmed publisher
Bigley V, McGovern N, Milne P, Dickinson R, Pagan S, Cookson S, et al. Langerin-expressing dendritic cells in human tissues are related to CD1c+ dendritic cells and distinct from Langerhans cells and CD141high XCR1+ dendritic cells. J Leukoc Biol. 2015;97:627-34 pubmed publisher
Milne P, Bigley V, Gunawan M, Haniffa M, Collin M. CD1c+ blood dendritic cells have Langerhans cell potential. Blood. 2015;125:470-3 pubmed publisher
Stoitzner P, Schaffenrath S, Tripp C, Reider D, Komenda K, Del Frari B, et al. Human skin dendritic cells can be targeted in situ by intradermal injection of antibodies against lectin receptors. Exp Dermatol. 2014;23:909-15 pubmed publisher
Flacher V, Tripp C, Mairhofer D, Steinman R, Stoitzner P, Idoyaga J, et al. Murine Langerin+ dermal dendritic cells prime CD8+ T cells while Langerhans cells induce cross-tolerance. EMBO Mol Med. 2014;6:1191-204 pubmed publisher
Nasr N, Lai J, Botting R, Mercier S, Harman A, Kim M, et al. Inhibition of two temporal phases of HIV-1 transfer from primary Langerhans cells to T cells: the role of langerin. J Immunol. 2014;193:2554-64 pubmed publisher
Larbi A, Mitjavila Garcia M, Flamant S, Valogne Y, Clay D, Usunier B, et al. Generation of multipotent early lymphoid progenitors from human embryonic stem cells. Stem Cells Dev. 2014;23:2983-95 pubmed publisher
Gulati N, Suárez Fariñas M, Fuentes Duculan J, Gilleaudeau P, Sullivan Whalen M, Correa Da Rosa J, et al. Molecular characterization of human skin response to diphencyprone at peak and resolution phases: therapeutic insights. J Invest Dermatol. 2014;134:2531-2540 pubmed publisher
Stoll P, Heinz A, Bratke K, Bier A, Garbe K, Kuepper M, et al. Impact of smoking on dendritic cell phenotypes in the airway lumen of patients with COPD. Respir Res. 2014;15:48 pubmed publisher
Schuster C, Mildner M, Mairhofer M, Bauer W, Fiala C, Prior M, et al. Human embryonic epidermis contains a diverse Langerhans cell precursor pool. Development. 2014;141:807-15 pubmed publisher
Lommatzsch M, Kraeft U, Troebs L, Garbe K, Bier A, Stoll P, et al. Fluticasone impact on airway dendritic cells in smokers: a randomized controlled trial. Respir Res. 2013;14:114 pubmed publisher
Debeer S, Le Luduec J, Kaiserlian D, Laurent P, Nicolas J, Dubois B, et al. Comparative histology and immunohistochemistry of porcine versus human skin. Eur J Dermatol. 2013;23:456-66 pubmed publisher
Welty N, Staley C, Ghilardi N, Sadowsky M, Igyarto B, Kaplan D. Intestinal lamina propria dendritic cells maintain T cell homeostasis but do not affect commensalism. J Exp Med. 2013;210:2011-24 pubmed publisher
Bonetti M, Bacci S, Santosuosso M, Mazzanti B, Aldinucci A, Ballerini C, et al. Rosiglitazone promotes the differentiation of Langerhans cells and inhibits that of other dendritic cell types from CD133 positive hematopoietic precursors. Histol Histopathol. 2014;29:323-32 pubmed publisher
Tjomsland V, Ellegård R, Kjölhede P, Wodlin N, Hinkula J, Lifson J, et al. Blocking of integrins inhibits HIV-1 infection of human cervical mucosa immune cells with free and complement-opsonized virions. Eur J Immunol. 2013;43:2361-72 pubmed publisher
Lenormand C, Spiegelhalter C, Cinquin B, Bardin S, Bausinger H, Angenieux C, et al. Birbeck granule-like "organized smooth endoplasmic reticulum" resulting from the expression of a cytoplasmic YFP-tagged langerin. PLoS ONE. 2013;8:e60813 pubmed publisher
Luckashenak N, Wähe A, Breit K, Brakebusch C, Brocker T. Rho-family GTPase Cdc42 controls migration of Langerhans cells in vivo. J Immunol. 2013;190:27-35 pubmed publisher
Mayumi N, Watanabe E, Norose Y, Watari E, Kawana S, Geijtenbeek T, et al. E-cadherin interactions are required for Langerhans cell differentiation. Eur J Immunol. 2013;43:270-80 pubmed publisher
Hitzler M, Majdic O, Heine G, Worm M, Ebert G, Luch A, et al. Human Langerhans cells control Th cells via programmed death-ligand 1 in response to bacterial stimuli and nickel-induced contact allergy. PLoS ONE. 2012;7:e46776 pubmed publisher
Iram N, Mildner M, Prior M, Petzelbauer P, Fiala C, Hacker S, et al. Age-related changes in expression and function of Toll-like receptors in human skin. Development. 2012;139:4210-9 pubmed publisher
Haniffa M, Shin A, Bigley V, McGovern N, Teo P, See P, et al. Human tissues contain CD141hi cross-presenting dendritic cells with functional homology to mouse CD103+ nonlymphoid dendritic cells. Immunity. 2012;37:60-73 pubmed publisher
Schwingshackl P, Obermoser G, Nguyen V, Fritsch P, Sepp N, Romani N. Distribution and maturation of skin dendritic cell subsets in two forms of cutaneous T-cell lymphoma: mycosis fungoides and Sézary syndrome. Acta Derm Venereol. 2012;92:269-75 pubmed publisher
Segura E, Valladeau Guilemond J, Donnadieu M, Sastre Garau X, Soumelis V, Amigorena S. Characterization of resident and migratory dendritic cells in human lymph nodes. J Exp Med. 2012;209:653-60 pubmed publisher
van der Vlist M, de Witte L, de Vries R, Litjens M, de Jong M, Fluitsma D, et al. Human Langerhans cells capture measles virus through Langerin and present viral antigens to CD4? T cells but are incapable of cross-presentation. Eur J Immunol. 2011;41:2619-31 pubmed publisher
Fujita H, Shemer A, Suárez Fariñas M, Johnson Huang L, Tintle S, Cardinale I, et al. Lesional dendritic cells in patients with chronic atopic dermatitis and psoriasis exhibit parallel ability to activate T-cell subsets. J Allergy Clin Immunol. 2011;128:574-82.e1-12 pubmed publisher
Ouwehand K, Spiekstra S, Waaijman T, Scheper R, de Gruijl T, Gibbs S. Technical advance: Langerhans cells derived from a human cell line in a full-thickness skin equivalent undergo allergen-induced maturation and migration. J Leukoc Biol. 2011;90:1027-33 pubmed publisher
Eisenwort G, Jurkin J, Yasmin N, Bauer T, Gesslbauer B, Strobl H. Identification of TROP2 (TACSTD2), an EpCAM-like molecule, as a specific marker for TGF-?1-dependent human epidermal Langerhans cells. J Invest Dermatol. 2011;131:2049-57 pubmed publisher
Bigley V, Haniffa M, Doulatov S, Wang X, Dickinson R, McGovern N, et al. The human syndrome of dendritic cell, monocyte, B and NK lymphoid deficiency. J Exp Med. 2011;208:227-34 pubmed publisher
Stary G, Klein I, Bauer W, Koszik F, Reininger B, Kohlhofer S, et al. Glucocorticosteroids modify Langerhans cells to produce TGF-? and expand regulatory T cells. J Immunol. 2011;186:103-12 pubmed publisher
Peressin M, Holl V, Schmidt S, Decoville T, Mirisky D, Lederle A, et al. HIV-1 replication in Langerhans and interstitial dendritic cells is inhibited by neutralizing and Fc-mediated inhibitory antibodies. J Virol. 2011;85:1077-85 pubmed publisher
van de Laar L, van den Bosch A, van der Kooij S, Janssen H, Coffer P, van Kooten C, et al. A nonredundant role for canonical NF-?B in human myeloid dendritic cell development and function. J Immunol. 2010;185:7252-61 pubmed publisher
Bobr A, Olvera Gomez I, Igyarto B, Haley K, Hogquist K, Kaplan D. Acute ablation of Langerhans cells enhances skin immune responses. J Immunol. 2010;185:4724-8 pubmed publisher
de Jong M, de Witte L, Taylor M, Geijtenbeek T. Herpes simplex virus type 2 enhances HIV-1 susceptibility by affecting Langerhans cell function. J Immunol. 2010;185:1633-41 pubmed publisher
Huch J, Cunningham A, Arvin A, Nasr N, Santegoets S, Slobedman E, et al. Impact of varicella-zoster virus on dendritic cell subsets in human skin during natural infection. J Virol. 2010;84:4060-72 pubmed publisher
Schuster C, Vaculik C, Fiala C, Meindl S, Brandt O, Imhof M, et al. HLA-DR+ leukocytes acquire CD1 antigens in embryonic and fetal human skin and contain functional antigen-presenting cells. J Exp Med. 2009;206:169-81 pubmed publisher
Mayer W, Irschick U, Moser P, Wurm M, Huemer H, Romani N, et al. Characterization of antigen-presenting cells in fresh and cultured human corneas using novel dendritic cell markers. Invest Ophthalmol Vis Sci. 2007;48:4459-67 pubmed
Couty J, Rampon C, Leveque M, Laran Chich M, Bourdoulous S, Greenwood J, et al. PECAM-1 engagement counteracts ICAM-1-induced signaling in brain vascular endothelial cells. J Neurochem. 2007;103:793-801 pubmed
Gosk S, Vermehren C, Storm G, Moos T. Targeting anti-transferrin receptor antibody (OX26) and OX26-conjugated liposomes to brain capillary endothelial cells using in situ perfusion. J Cereb Blood Flow Metab. 2004;24:1193-204 pubmed
Cox J, Lamb J, Bal V, Butcher G, Howard J, Owen M, et al. The phenotypic and molecular characterization of Nb2 lymphoma cells activated with IL-2 and human growth hormone. Immunology. 1989;66:83-9 pubmed
Movassagh M, Spatz A, Davoust J, Lebecque S, Romero P, Pittet M, et al. Selective accumulation of mature DC-Lamp+ dendritic cells in tumor sites is associated with efficient T-cell-mediated antitumor response and control of metastatic dissemination in melanoma. Cancer Res. 2004;64:2192-8 pubmed
Moos T, Morgan E. Restricted transport of anti-transferrin receptor antibody (OX26) through the blood-brain barrier in the rat. J Neurochem. 2001;79:119-29 pubmed
Valladeau J, Ravel O, Dezutter Dambuyant C, Moore K, Kleijmeer M, Liu Y, et al. Langerin, a novel C-type lectin specific to Langerhans cells, is an endocytic receptor that induces the formation of Birbeck granules. Immunity. 2000;12:71-81 pubmed
Valladeau J, Duvert Frances V, Pin J, Dezutter Dambuyant C, Vincent C, Massacrier C, et al. The monoclonal antibody DCGM4 recognizes Langerin, a protein specific of Langerhans cells, and is rapidly internalized from the cell surface. Eur J Immunol. 1999;29:2695-704 pubmed
Ito T, Inaba M, Inaba K, Toki J, Sogo S, Iguchi T, et al. A CD1a+/CD11c+ subset of human blood dendritic cells is a direct precursor of Langerhans cells. J Immunol. 1999;163:1409-19 pubmed
product information
brand :
Novus
master code :
NB200-585
SKU :
NB200-585-0.1mg
product name :
TfR (Transferrin R) Antibody (OX26)
description :
The TfR (Transferrin R) Antibody (OX26) from Novus Biologicals is a mouse monoclonal antibody to TfR (Transferrin R). This antibody reacts with mouse, rat. The TfR (Transferrin R) Antibody (OX26) has been validated for the following applications: Western Blot, Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen, Flow (Intracellular), CyTOF-ready.
target :
TfR (Transferrin R)
category :
Primary Antibodies
unit size :
0.1 mg (also 0.025 mg)
buffer :
PBS
clonality :
Monoclonal
clone :
OX26
concentration :
1.0 mg/ml
conjugate :
Unconjugated
host :
Mouse
immunogen :
PHA activated rat lymphocytes.
isotype :
IgG2a
purity :
Protein G purified
species :
Mouse, Rat
specificity :
Labels dividing cells of various types but also binds to a number of non-dividing normal tissues and endothelium of brain capillaries.
gene symbol :
TFRC
catalog number base :
NB200-585
accessionNumbers :
Q99376
applications :
Western Blot, Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen, Flow (Intracellular), CyTOF-ready
2020 USD :
299
2021 USD :
299 USD
alt names :
CD71 antigen, CD71TRFR, OX26 monoclonal, OX26 transferrin receptor, p90, T9, TfR, TfR1, TR, transferrin receptor (p90, CD71), transferrin receptor protein 1, Trfr
storage :
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
company information
Novus Biologicals
8100 Southpark Way, A-8
Littleton, CO 80120
novus@novusbio.com
https://www.novusbio.com
3037301950
headquarters: USA
Novus Biologicals licenses, manufactures, and markets antibodies to over 20,000 unique targets to support a wide array of research areas. Novus is built on honesty, collaboration and strong relationships and continues to provide quality tools that accelerate research. Every product is backed by our 100% guarantee.