ER beta/NR3A2 Antibody (14C8) - Azide and BSA Free | Novus Biologicals NB200-305 product information

product summary

company name :

Novus Biologicals

other brands :

IMGENEX

product type :

antibody

product name :

ER beta/NR3A2 Antibody (14C8) - Azide and BSA Free

catalog :

NB200-305

quantity :

100 ul

price :

449 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

14C8

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, chromatin immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, dot blot

more info or order :

Novus Biologicals product webpage

citations: 78

Reference
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Navaratnam S, Skliris G, Qing G, Banerji S, Badiani K, Tu D, et al. Differential role of estrogen receptor beta in early versus metastatic non-small cell lung cancer. Horm Cancer. 2012;3:93-100 pubmed publisher
Choijamts B, Jimi S, Kondo T, Naganuma Y, Matsumoto T, Kuroki M, et al. CD133+ cancer stem cell-like cells derived from uterine carcinosarcoma (malignant mixed Müllerian tumor). Stem Cells. 2011;29:1485-95 pubmed publisher
Honma N, Saji S, Hirose M, Horiguchi S, Kuroi K, Hayashi S, et al. Sex steroid hormones in pairs of tumor and serum from breast cancer patients and pathobiological role of androstene-3β, 17β-diol. Cancer Sci. 2011;102:1848-54 pubmed publisher
Mehasseb M, Panchal R, Taylor A, Brown L, Bell S, Habiba M. Estrogen and progesterone receptor isoform distribution through the menstrual cycle in uteri with and without adenomyosis. Fertil Steril. 2011;95:2228-35, 2235.e1 pubmed publisher
Vouk K, Smuc T, Guggenberger C, Ribic Pucelj M, Sinkovec J, Husen B, et al. Novel estrogen-related genes and potential biomarkers of ovarian endometriosis identified by differential expression analysis. J Steroid Biochem Mol Biol. 2011;125:231-42 pubmed publisher
Miki Y, Abe K, Suzuki S, Suzuki T, Sasano H. Suppression of estrogen actions in human lung cancer. Mol Cell Endocrinol. 2011;340:168-74 pubmed publisher
Paruthiyil S, Cvoro A, Tagliaferri M, Cohen I, Shtivelman E, Leitman D. Estrogen receptor ? causes a G2 cell cycle arrest by inhibiting CDK1 activity through the regulation of cyclin B1, GADD45A, and BTG2. Breast Cancer Res Treat. 2011;129:777-84 pubmed publisher
Huang G, Gunter M, Arend R, Li M, Arias Pulido H, Prossnitz E, et al. Co-expression of GPR30 and ERbeta and their association with disease progression in uterine carcinosarcoma. Am J Obstet Gynecol. 2010;203:242.e1-5 pubmed publisher
Vivar O, Zhao X, Saunier E, Griffin C, Mayba O, Tagliaferri M, et al. Estrogen receptor beta binds to and regulates three distinct classes of target genes. J Biol Chem. 2010;285:22059-66 pubmed publisher
Mak P, Leav I, Pursell B, Bae D, Yang X, Taglienti C, et al. ERbeta impedes prostate cancer EMT by destabilizing HIF-1alpha and inhibiting VEGF-mediated snail nuclear localization: implications for Gleason grading. Cancer Cell. 2010;17:319-32 pubmed publisher
Vivar O, Saunier E, Leitman D, Firestone G, Bjeldanes L. Selective activation of estrogen receptor-beta target genes by 3,3'-diindolylmethane. Endocrinology. 2010;151:1662-7 pubmed publisher
Koyama S, Wada Hiraike O, Nakagawa S, Tanikawa M, Hiraike H, Miyamoto Y, et al. Repression of estrogen receptor beta function by putative tumor suppressor DBC1. Biochem Biophys Res Commun. 2010;392:357-62 pubmed publisher
Abe K, Miki Y, Ono K, Mori M, Kakinuma H, Kou Y, et al. Highly concordant coexpression of aromatase and estrogen receptor beta in non-small cell lung cancer. Hum Pathol. 2010;41:190-8 pubmed publisher
Wong M, Dobbins T, Tseung J, Tran N, Lee C, O BRIEN C, et al. Oestrogen receptor beta expression in pleomorphic adenomas of the parotid gland. J Clin Pathol. 2009;62:789-93 pubmed publisher
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Maehle B, Collett K, Tretli S, Akslen L, Grotmol T. Estrogen receptor beta--an independent prognostic marker in estrogen receptor alpha and progesterone receptor-positive breast cancer?. APMIS. 2009;117:644-50 pubmed publisher
Chakravarty D, Gupta N, Goda J, Srinivasan R, Patel F, Dhaliwal L. Steroid receptors, HER2/neu and Ki-67, in endometrioid type of endometrial carcinoma: Correlation with conventional histomorphological features of prognosis. Acta Histochem. 2010;112:355-63 pubmed publisher
Miki Y, Suzuki T, Nagasaki S, Hata S, Akahira J, Sasano H. Comparative effects of raloxifene, tamoxifen and estradiol on human osteoblasts in vitro: estrogen receptor dependent or independent pathways of raloxifene. J Steroid Biochem Mol Biol. 2009;113:281-9 pubmed publisher
Huang G, Arend R, Li M, Gunter M, Chiu L, Horwitz S, et al. Tissue microarray analysis of hormonal signaling pathways in uterine carcinosarcoma. Am J Obstet Gynecol. 2009;200:457.e1-5 pubmed publisher
Sato R, Suzuki T, Katayose Y, Miura K, Shiiba K, Tateno H, et al. Steroid sulfatase and estrogen sulfotransferase in colon carcinoma: regulators of intratumoral estrogen concentrations and potent prognostic factors. Cancer Res. 2009;69:914-22 pubmed publisher
Urbanska K, Pannizzo P, Lassak A, Gualco E, Surmacz E, Croul S, et al. Estrogen receptor beta-mediated nuclear interaction between IRS-1 and Rad51 inhibits homologous recombination directed DNA repair in medulloblastoma. J Cell Physiol. 2009;219:392-401 pubmed publisher
Belcher S, Ma X, Le H. Blockade of estrogen receptor signaling inhibits growth and migration of medulloblastoma. Endocrinology. 2009;150:1112-21 pubmed publisher
Chakravarty D, Srinivasan R, Ghosh S, Rajwanshi A, Gopalan S. Estrogen receptor beta (ERbeta) in endometrial simple hyperplasia and endometrioid carcinoma. Appl Immunohistochem Mol Morphol. 2008;16:535-42 pubmed publisher
Setlur S, Mertz K, Hoshida Y, Demichelis F, Lupien M, Perner S, et al. Estrogen-dependent signaling in a molecularly distinct subclass of aggressive prostate cancer. J Natl Cancer Inst. 2008;100:815-25 pubmed publisher
Ohata C, Tadokoro T, Itami S. Expression of estrogen receptor beta in normal skin, melanocytic nevi and malignant melanomas. J Dermatol. 2008;35:215-21 pubmed publisher
Dohi O, Hatori M, Suzuki T, Ono K, Hosaka M, Akahira J, et al. Sex steroid receptors expression and hormone-induced cell proliferation in human osteosarcoma. Cancer Sci. 2008;99:518-23 pubmed
Bukulmez O, Hardy D, Carr B, Word R, Mendelson C. Inflammatory status influences aromatase and steroid receptor expression in endometriosis. Endocrinology. 2008;149:1190-204 pubmed
Caiazza F, Galluzzo P, Lorenzetti S, Marino M. 17Beta-estradiol induces ERbeta up-regulation via p38/MAPK activation in colon cancer cells. Biochem Biophys Res Commun. 2007;359:102-7 pubmed
Gruvberger Saal S, Bendahl P, Saal L, Laakso M, Hegardt C, Edén P, et al. Estrogen receptor beta expression is associated with tamoxifen response in ERalpha-negative breast carcinoma. Clin Cancer Res. 2007;13:1987-94 pubmed
Galluzzo P, Caiazza F, Moreno S, Marino M. Role of ERbeta palmitoylation in the inhibition of human colon cancer cell proliferation. Endocr Relat Cancer. 2007;14:153-67 pubmed
Cvoro A, Paruthiyil S, Jones J, Tzagarakis Foster C, Clegg N, Tatomer D, et al. Selective activation of estrogen receptor-beta transcriptional pathways by an herbal extract. Endocrinology. 2007;148:538-47 pubmed
Al Dhaheri M, Rowan B. Protein kinase A exhibits selective modulation of estradiol-dependent transcription in breast cancer cells that is associated with decreased ligand binding, altered estrogen receptor alpha promoter interaction, and changes in receptor phosphorylation. Mol Endocrinol. 2007;21:439-56 pubmed
Skliris G, Lewis A, Emberley E, Peng B, Weebadda W, Kemp A, et al. Estrogen receptor-beta regulates psoriasin (S100A7) in human breast cancer. Breast Cancer Res Treat. 2007;104:75-85 pubmed
Dietrich W, Haitel A, Holzer G, Huber J, Kolbus A, Tschugguel W. Estrogen receptor-beta is the predominant estrogen receptor subtype in normal human synovia. J Soc Gynecol Investig. 2006;13:512-7 pubmed
Skliris G, Leygue E, Curtis Snell L, Watson P, Murphy L. Expression of oestrogen receptor-beta in oestrogen receptor-alpha negative human breast tumours. Br J Cancer. 2006;95:616-26 pubmed
Savinov A, Remacle A, Golubkov V, Krajewska M, Kennedy S, Duffy M, et al. Matrix metalloproteinase 26 proteolysis of the NH2-terminal domain of the estrogen receptor beta correlates with the survival of breast cancer patients. Cancer Res. 2006;66:2716-24 pubmed
Cvoro A, Tzagarakis Foster C, Tatomer D, Paruthiyil S, Fox M, Leitman D. Distinct roles of unliganded and liganded estrogen receptors in transcriptional repression. Mol Cell. 2006;21:555-64 pubmed
Poola I, Fuqua S, De Witty R, Abraham J, Marshallack J, Liu A. Estrogen receptor alpha-negative breast cancer tissues express significant levels of estrogen-independent transcription factors, ERbeta1 and ERbeta5: potential molecular targets for chemoprevention. Clin Cancer Res. 2005;11:7579-85 pubmed
Schwartz A, Prysak G, Murphy V, Lonardo F, Pass H, Schwartz J, et al. Nuclear estrogen receptor beta in lung cancer: expression and survival differences by sex. Clin Cancer Res. 2005;11:7280-7 pubmed
Poola I, Abraham J, Baldwin K, Saunders A, Bhatnagar R. Estrogen receptors beta4 and beta5 are full length functionally distinct ERbeta isoforms: cloning from human ovary and functional characterization. Endocrine. 2005;27:227-38 pubmed
Zheng F, Wu R, Smith C, O Malley B. Rapid estrogen-induced phosphorylation of the SRC-3 coactivator occurs in an extranuclear complex containing estrogen receptor. Mol Cell Biol. 2005;25:8273-84 pubmed
Ishibashi H, Suzuki T, Suzuki S, Niikawa H, Lu L, Miki Y, et al. Progesterone receptor in non-small cell lung cancer--a potent prognostic factor and possible target for endocrine therapy. Cancer Res. 2005;65:6450-8 pubmed
Helguero L, Faulds M, Gustafsson J, Haldosén L. Estrogen receptors alfa (ERalpha) and beta (ERbeta) differentially regulate proliferation and apoptosis of the normal murine mammary epithelial cell line HC11. Oncogene. 2005;24:6605-16 pubmed
Miki Y, Suzuki T, Tazawa C, Ishizuka M, Semba S, Gorai I, et al. Analysis of gene expression induced by diethylstilbestrol (DES) in human primitive Mullerian duct cells using microarray. Cancer Lett. 2005;220:197-210 pubmed
Jones L, Li M, Halama E, Ma Y, Lubet R, Grubbs C, et al. Promotion of mammary cancer development by tamoxifen in a mouse model of Brca1-mutation-related breast cancer. Oncogene. 2005;24:3554-62 pubmed
Hopp T, Weiss H, Parra I, Cui Y, Osborne C, Fuqua S. Low levels of estrogen receptor beta protein predict resistance to tamoxifen therapy in breast cancer. Clin Cancer Res. 2004;10:7490-9 pubmed
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Speirs V, Carder P, Lane S, Dodwell D, Lansdown M, Hanby A. Oestrogen receptor beta: what it means for patients with breast cancer. Lancet Oncol. 2004;5:174-81 pubmed
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Tee M, Rogatsky I, Tzagarakis Foster C, Cvoro A, An J, Christy R, et al. Estradiol and selective estrogen receptor modulators differentially regulate target genes with estrogen receptors alpha and beta. Mol Biol Cell. 2004;15:1262-72 pubmed
Tonetti D, Rubenstein R, DeLeon M, Zhao H, Pappas S, Bentrem D, et al. Stable transfection of an estrogen receptor beta cDNA isoform into MDA-MB-231 breast cancer cells. J Steroid Biochem Mol Biol. 2003;87:47-55 pubmed
Skliris G, Munot K, Bell S, Carder P, Lane S, Horgan K, et al. Reduced expression of oestrogen receptor beta in invasive breast cancer and its re-expression using DNA methyl transferase inhibitors in a cell line model. J Pathol. 2003;201:213-20 pubmed
Li X, Hisaoka M, Hashimoto H. Expression of estrogen receptors alpha and beta in soft tissue sarcomas: Immunohistochemical and molecular analysis. Pathol Int. 2003;53:671-9 pubmed
Omoto Y, Eguchi H, Yamamoto Yamaguchi Y, Hayashi S. Estrogen receptor (ER) beta1 and ERbetacx/beta2 inhibit ERalpha function differently in breast cancer cell line MCF7. Oncogene. 2003;22:5011-20 pubmed
Fuqua S, Schiff R, Parra I, Moore J, Mohsin S, Osborne C, et al. Estrogen receptor beta protein in human breast cancer: correlation with clinical tumor parameters. Cancer Res. 2003;63:2434-9 pubmed
Linja M, Savinainen K, Tammela T, Isola J, Visakorpi T. Expression of ERalpha and ERbeta in prostate cancer. Prostate. 2003;55:180-6 pubmed
Saji S, Omoto Y, Shimizu C, Warner M, Hayashi Y, Horiguchi S, et al. Expression of estrogen receptor (ER) (beta)cx protein in ER(alpha)-positive breast cancer: specific correlation with progesterone receptor. Cancer Res. 2002;62:4849-53 pubmed
Skliris G, Parkes A, Limer J, Burdall S, Carder P, Speirs V. Evaluation of seven oestrogen receptor beta antibodies for immunohistochemistry, western blotting, and flow cytometry in human breast tissue. J Pathol. 2002;197:155-62 pubmed
Speirs V, Skliris G, Burdall S, Carder P. Distinct expression patterns of ER alpha and ER beta in normal human mammary gland. J Clin Pathol. 2002;55:371-4 pubmed
Skliris G, Carder P, Lansdown M, Speirs V. Immunohistochemical detection of ERbeta in breast cancer: towards more detailed receptor profiling?. Br J Cancer. 2001;84:1095-8 pubmed

product information

master code :

NB200-305

SKU :

NB200-305

product name :

ER beta/NR3A2 Antibody (14C8) - Azide and BSA Free

unit size :

100 ul

description :

The ER beta/NR3A2 Antibody (14C8) - Azide and BSA Free from Novus is a mouse monoclonal antibody to ER beta/NR3A2. This antibody reacts with human,monkey,mouse,rabbit. The ER beta/NR3A2 Antibody (14C8) - Azide and BSA Free has been validated for the following applications: Simple Western,Chemotaxis,IF/IHC,Immunoprecipitation,Western Blot,Immunohistochemistry-Paraffin,Immunocytochemistry/ Immunofluorescence,Flow Cytometry,Immunohistochemistry,Immunohistochemistry-Frozen,Dot Blot,Chromatin Immunoprecipitation (ChIP).

target :

ER beta/NR3A2

category :

Primary Antibodies

buffer :

PBS

clonality :

Monoclonal

clone :

14C8

conjugate :

Unconjugated

host :

Mouse

immunogen :

Amino acids 1-153 of human ER-beta expressed in E. coli.

isotype :

IgG2b

purity :

Protein G purified

species :

Human,Monkey,Mouse,Rabbit

specificity :

Strong Erb staining in epithelial cell nuclei

theoretical molecular weight :

59 kDa

gene symbol :

ESR2

accessionNumbers :

Q92731

applications :

Simple Western,Chemotaxis,IF/IHC,Immunoprecipitation,Western Blot,Immunohistochemistry-Paraffin,Immunocytochemistry/ Immunofluorescence,Flow Cytometry,Immunohistochemistry,Immunohistochemistry-Frozen,Dot Blot,Chromatin Immunoprecipitation (ChIP)

USD :

449 USD

alt names :

Erb, ER-beta, ESR-BETA, ESTRB, estrogen receptor 2 (ER beta), estrogen receptor beta, estrogen receptor beta 4, NR3A2ESRB, Nuclear receptor subfamily 3 group A member 2

storage :

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

more info or order :

Novus Biologicals product webpage