NQO-1 Antibody (A180) - BSA Free | Novus Biologicals NB200-209 product information

product summary

company name :

Novus Biologicals

other brands :

IMGENEX

product type :

antibody

product name :

NQO-1 Antibody (A180) - BSA Free

catalog :

NB200-209

quantity :

0.1 ml (also 0.025 ml)

price :

409 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

A180

reactivity :

human, mouse, rat, dogs

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

more info or order :

Novus Biologicals product webpage

citations: 51

Published Application/Species/Sample/Dilution	Reference
western blot; human; fig 7a	Moore T, Cheng L, Wolf D, Ngo J, Segawa M, Zhu X, et al. Parkin regulates adiposity by coordinating mitophagy with mitochondrial biogenesis in white adipocytes. Nat Commun. 2022;13:6661 pubmed publisher
	Lapak K, Saeidi S, Bok I, Wamsley N, Plutzer I, Bhatt D, et al. Proximity proteomic analysis of the NRF family reveals the Parkinson's disease protein ZNF746/PARIS as a co-complexed repressor of NRF2. Sci Signal. 2023;16:eadi9018 pubmed publisher
	Meister M, Feresin R. Blackberry consumption protects against e-cigarette-induced vascular oxidative stress in mice. Food Funct. 2023;14:10709-10730 pubmed publisher
	Zarcone G, Lenski M, MARTINEZ T, Talahari S, Simonin O, Gar xe7 on G, et al. Impact of Electronic Cigarettes, Heated Tobacco Products and Conventional Cigarettes on the Generation of Oxidative Stress and Genetic and Epigenetic Lesions in Human Bronchial Epithelial BEAS-2B Cells. Toxics. 2023;11: pubmed publisher
	Liu X, Yan C, Chang C, Meng F, Shen W, Wang S, et al. FOXA2 Suppression by TRIM36 Exerts Anti-Tumor Role in Colorectal Cancer Via Inducing NRF2/GPX4-Regulated Ferroptosis. Adv Sci (Weinh). 2023;10:e2304521 pubmed publisher
	Wu D, Sun Q, Wei W, Bai Y, Zhai L, Jia L. Nrf2-mediated protective effect of alpha-lipoic acid on synaptic oxidative damage and inhibition of PKC/ERK/CREB pathway in bisphenol A-exposed HT-22 cells. Food Chem Toxicol. 2023;181:114112 pubmed publisher
	Wamsley N, Wilkerson E, Guan L, Lapak K, Schrank T, Holmes B, et al. Targeted Proteomic Quantitation of NRF2 Signaling and Predictive Biomarkers in HNSCC. Mol Cell Proteomics. 2023;22:100647 pubmed publisher
	Wang X, Wang W, Zhang R, Ma B, Ni L, Feng H, et al. Melatonin attenuates high glucose‑induced endothelial cell pyroptosis by activating the Nrf2 pathway to inhibit NLRP3 inflammasome activation. Mol Med Rep. 2023;27: pubmed publisher
	Meister M, Najjar R, Danh J, Knapp D, Wanders D, Feresin R. Berry consumption mitigates the hypertensive effects of a high-fat, high-sucrose diet via attenuation of renal and aortic AT1R expression resulting in improved endothelium-derived NO bioavailability. J Nutr Biochem. 2023;112:109225 pubmed publisher
	Petrillo S, D Amico J, Nicita F, Torda C, Vasco G, Bertini E, et al. Antioxidant Response in Human X-Linked Adrenoleukodystrophy Fibroblasts. Antioxidants (Basel). 2022;11: pubmed publisher
	Li Q, Fadoul G, Ikonomovic M, Yang T, Zhang F. Sulforaphane promotes white matter plasticity and improves long-term neurological outcomes after ischemic stroke via the Nrf2 pathway. Free Radic Biol Med. 2022;193:292-303 pubmed publisher
	Watzky M, Huard S, Juricek L, Dairou J, Chauvet C, Coumoul X, et al. Hexokinase 2 is a transcriptional target and a positive modulator of AHR signalling. Nucleic Acids Res. 2022;50:5545-5564 pubmed publisher
	Xirouchaki C, Jia Y, McGrath M, Greatorex S, Tran M, Merry T, et al. Skeletal muscle NOX4 is required for adaptive responses that prevent insulin resistance. Sci Adv. 2021;7:eabl4988 pubmed publisher
	Giovannucci T, Salomons F, Haraldsson M, Elfman L, Wickström M, Young P, et al. Inhibition of the ubiquitin-proteasome system by an NQO1-activatable compound. Cell Death Dis. 2021;12:914 pubmed publisher
	Siegel D, Bersie S, Harris P, Di Francesco A, Armstrong M, Reisdorph N, et al. A redox-mediated conformational change in NQO1 controls binding to microtubules and α-tubulin acetylation. Redox Biol. 2021;39:101840 pubmed publisher
	Sekiguchi M, Seki M, Kawai T, Yoshida K, Yoshida M, Isobe T, et al. Integrated multiomics analysis of hepatoblastoma unravels its heterogeneity and provides novel druggable targets. NPJ Precis Oncol. 2020;4:20 pubmed publisher
	Chatterjee A, Kosmacek E, Shrishrimal S, McDonald J, Oberley Deegan R. MnTE-2-PyP, a manganese porphyrin, reduces cytotoxicity caused by irradiation in a diabetic environment through the induction of endogenous antioxidant defenses. Redox Biol. 2020;34:101542 pubmed publisher
	Shrishrimal S, Chatterjee A, Kosmacek E, Davis P, McDonald J, Oberley Deegan R. Manganese porphyrin, MnTE-2-PyP, treatment protects the prostate from radiation-induced fibrosis (RIF) by activating the NRF2 signaling pathway and enhancing SOD2 and sirtuin activity. Free Radic Biol Med. 2020;152:255-270 pubmed publisher
	Serafini M, Catanzaro M, Fagiani F, Simoni E, Caporaso R, Dacrema M, et al. Modulation of Keap1/Nrf2/ARE Signaling Pathway by Curcuma- and Garlic-Derived Hybrids. Front Pharmacol. 2019;10:1597 pubmed publisher
	Petrillo S, D Amico J, La Rosa P, Bertini E, Piemonte F. Targeting NRF2 for the Treatment of Friedreich's Ataxia: A Comparison among Drugs. Int J Mol Sci. 2019;20: pubmed publisher
	La Rosa P, Russo M, D Amico J, Petrillo S, Aquilano K, Lettieri Barbato D, et al. Nrf2 Induction Re-establishes a Proper Neuronal Differentiation Program in Friedreich's Ataxia Neural Stem Cells. Front Cell Neurosci. 2019;13:356 pubmed publisher
	Jeong J, Ji S, Lee H, Hong S, Kim G, Park C, et al. Fermented Sea Tangle (Laminaria japonica Aresch) Suppresses RANKL-Induced Osteoclastogenesis by Scavenging ROS in RAW 264.7 Cells. Foods. 2019;8: pubmed publisher
	Yim S, Clish C, Gladyshev V. Selenium Deficiency Is Associated with Pro-longevity Mechanisms. Cell Rep. 2019;27:2785-2797.e3 pubmed publisher
	Peng J, Zhou F, Wang Y, Xu Y, Zhang H, Zou F, et al. Differential response to lead toxicity in rat primary microglia and astrocytes. Toxicol Appl Pharmacol. 2018;363:64-71 pubmed publisher
	Wang Y, Feng F, Liu M, Xue J, Huang H. Resveratrol ameliorates sepsis-induced acute kidney injury in a pediatric rat model via Nrf2 signaling pathway. Exp Ther Med. 2018;16:3233-3240 pubmed publisher
	Bricambert J, Alves Guerra M, Esteves P, Prip Buus C, Bertrand Michel J, Guillou H, et al. The histone demethylase Phf2 acts as a molecular checkpoint to prevent NAFLD progression during obesity. Nat Commun. 2018;9:2092 pubmed publisher
	Chen C, Chen Y, Sung P, Sun C, Chen K, Chen Y, et al. Effective protection against acute respiratory distress syndrome/sepsis injury by combined adipose-derived mesenchymal stem cells and preactivated disaggregated platelets. Oncotarget. 2017;8:82415-82429 pubmed publisher
	Shrishrimal S, Kosmacek E, Chatterjee A, Tyson M, Oberley Deegan R. The SOD Mimic, MnTE-2-PyP, Protects from Chronic Fibrosis and Inflammation in Irradiated Normal Pelvic Tissues. Antioxidants (Basel). 2017;6: pubmed publisher
	Petrillo S, Piermarini E, Pastore A, Vasco G, Schirinzi T, Carrozzo R, et al. Nrf2-Inducers Counteract Neurodegeneration in Frataxin-Silenced Motor Neurons: Disclosing New Therapeutic Targets for Friedreich's Ataxia. Int J Mol Sci. 2017;18: pubmed publisher
	Simoni E, Serafini M, Caporaso R, Marchetti C, Racchi M, Minarini A, et al. Targeting the Nrf2/Amyloid-Beta Liaison in Alzheimer's Disease: A Rational Approach. ACS Chem Neurosci. 2017;8:1618-1627 pubmed publisher
	Kim J, Lim J, Kang B, Jung K, Choi H. Capillarisin augments anti-oxidative and anti-inflammatory responses by activating Nrf2/HO-1 signaling. Neurochem Int. 2017;105:11-20 pubmed publisher
	Zhang T, Hu Q, Shi L, Qin L, Zhang Q, Mi M. Equol Attenuates Atherosclerosis in Apolipoprotein E-Deficient Mice by Inhibiting Endoplasmic Reticulum Stress via Activation of Nrf2 in Endothelial Cells. PLoS ONE. 2016;11:e0167020 pubmed publisher
	Qin T, Yin S, Yang J, Zhang Q, Liu Y, Huang F, et al. Sinomenine attenuates renal fibrosis through Nrf2-mediated inhibition of oxidative stress and TGF? signaling. Toxicol Appl Pharmacol. 2016;304:1-8 pubmed publisher
	Qin T, Du R, Huang F, Yin S, Yang J, Qin S, et al. Sinomenine activation of Nrf2 signaling prevents hyperactive inflammation and kidney injury in a mouse model of obstructive nephropathy. Free Radic Biol Med. 2016;92:90-99 pubmed publisher
	BouÅ¡ovÃ¡ I, BÃ¡rtÃkovÃ¡ H, MatouÅ¡kovÃ¡ P, LnÄ›niÄkovÃ¡ K, Zappe L, ValentovÃ¡ K, et al. Cranberry extract-enriched diets increase NAD(P)H:quinone oxidoreductase and catalase activities in obese but not in nonobese mice. Nutr Res. 2015;35:901-9 pubmed publisher
	Qin S, Du R, Yin S, Liu X, Xu G, Cao W. Nrf2 is essential for the anti-inflammatory effect of carbon monoxide in LPS-induced inflammation. Inflamm Res. 2015;64:537-48 pubmed publisher
	Suyama K, Watanabe M, Sakabe K, Otomo A, Okada Y, Terayama H, et al. GRP78 suppresses lipid peroxidation and promotes cellular antioxidant levels in glial cells following hydrogen peroxide exposure. PLoS ONE. 2014;9:e86951 pubmed publisher
	Zhang T, Liang X, Shi L, Wang L, Chen J, Kang C, et al. Estrogen receptor and PI3K/Akt signaling pathway involvement in S-(-)equol-induced activation of Nrf2/ARE in endothelial cells. PLoS ONE. 2013;8:e79075 pubmed publisher
	Wang B, Zhu X, Kim Y, Li J, Huang S, Saleem S, et al. Histone deacetylase inhibition activates transcription factor Nrf2 and protects against cerebral ischemic damage. Free Radic Biol Med. 2012;52:928-36 pubmed publisher
	Gao M, Singh A, Macri K, Reynolds C, Singhal V, Biswal S, et al. Antioxidant components of naturally-occurring oils exhibit marked anti-inflammatory activity in epithelial cells of the human upper respiratory system. Respir Res. 2011;12:92 pubmed publisher
	Solis L, Behrens C, Dong W, Suraokar M, Ozburn N, Moran C, et al. Nrf2 and Keap1 abnormalities in non-small cell lung carcinoma and association with clinicopathologic features. Clin Cancer Res. 2010;16:3743-53 pubmed publisher
	Li C, Kim M, Godoy L, Thiantanawat A, Trudel L, Wogan G. Nitric oxide activation of Keap1/Nrf2 signaling in human colon carcinoma cells. Proc Natl Acad Sci U S A. 2009;106:14547-51 pubmed publisher
	Salama S, Kamel M, Diaz Arrastia C, Xu X, Veenstra T, Salih S, et al. Effect of tumor necrosis factor-alpha on estrogen metabolism and endometrial cells: potential physiological and pathological relevance. J Clin Endocrinol Metab. 2009;94:285-93 pubmed publisher
	Cho H, Imani F, Miller DeGraff L, Walters D, Melendi G, Yamamoto M, et al. Antiviral activity of Nrf2 in a murine model of respiratory syncytial virus disease. Am J Respir Crit Care Med. 2009;179:138-50 pubmed publisher
	Lee J, Bhora F, Sun J, Cheng G, Arguiri E, Solomides C, et al. Dietary flaxseed enhances antioxidant defenses and is protective in a mouse model of lung ischemia-reperfusion injury. Am J Physiol Lung Cell Mol Physiol. 2008;294:L255-65 pubmed
	Dehn D, Siegel D, Zafar K, Reigan P, Swann E, Moody C, et al. 5-Methoxy-1,2-dimethyl-3-[(4-nitrophenoxy)methyl]indole-4,7-dione, a mechanism-based inhibitor of NAD(P)H:quinone oxidoreductase 1, exhibits activity against human pancreatic cancer in vitro and in vivo. Mol Cancer Ther. 2006;5:1702-9 pubmed
	Slitt A, Cherrington N, Dieter M, Aleksunes L, Scheffer G, Huang W, et al. trans-Stilbene oxide induces expression of genes involved in metabolism and transport in mouse liver via CAR and Nrf2 transcription factors. Mol Pharmacol. 2006;69:1554-63 pubmed
	Zhang J, Schulz W, Li Y, Wang R, Zotz R, Wen D, et al. Association of NAD(P)H: quinone oxidoreductase 1 (NQO1) C609T polymorphism with esophageal squamous cell carcinoma in a German Caucasian and a northern Chinese population. Carcinogenesis. 2003;24:905-9 pubmed
	Anwar A, Dehn D, Siegel D, Kepa J, Tang L, Pietenpol J, et al. Interaction of human NAD(P)H:quinone oxidoreductase 1 (NQO1) with the tumor suppressor protein p53 in cells and cell-free systems. J Biol Chem. 2003;278:10368-73 pubmed
	Siegel D, Anwar A, Winski S, Kepa J, Zolman K, Ross D. Rapid polyubiquitination and proteasomal degradation of a mutant form of NAD(P)H:quinone oxidoreductase 1. Mol Pharmacol. 2001;59:263-8 pubmed
	Siegel D, Ross D. Immunodetection of NAD(P)H:quinone oxidoreductase 1 (NQO1) in human tissues. Free Radic Biol Med. 2000;29:246-53 pubmed

product information

master code :

NB200-209

SKU :

NB200-209

product name :

NQO-1 Antibody (A180) - BSA Free

unit size :

0.1 ml (also 0.025 ml)

description :

The NQO-1 Antibody (A180) - BSA Free from Novus is a mouse monoclonal antibody to NQO-1. This antibody reacts with canine,human,mouse,primate,rat. The NQO-1 Antibody (A180) - BSA Free has been validated for the following applications: IF/IHC,Immunoprecipitation,Western Blot,Immunohistochemistry-Paraffin,Immunocytochemistry/ Immunofluorescence,Flow Cytometry,Immunohistochemistry,Immunohistochemistry-Frozen,Flow (Intracellular),Simple Western.

target :

NQO-1

category :

Primary Antibodies

buffer :

PBS

clonality :

Monoclonal

clone :

A180

concentration :

1.0 mg/ml

conjugate :

Unconjugated

host :

Mouse

immunogen :

Full length recombinant NQO1 from human lung [UniProt# P15559]

isotype :

IgG1

purity :

Protein G purified

species :

Canine,Human,Mouse,Primate,Rat

specificity :

Does not cross-react with NQO2

theoretical molecular weight :

31 kDa

gene symbol :

NQO1

Antibody validation :

Biological Validation

applications :

IF/IHC,Immunoprecipitation,Western Blot,Immunohistochemistry-Paraffin,Immunocytochemistry/ Immunofluorescence,Flow Cytometry,Immunohistochemistry,Immunohistochemistry-Frozen,Flow (Intracellular),Simple Western

USD :

409 USD

alt names :

Azoreductase, DHQU, DIA4azoreductase, diaphorase (NADH/NADPH) (cytochrome b-5 reductase), dioxin-inducible 1, DTDEC 1.6.5.2, DT-diaphorase, Menadione reductase, NAD(P)H dehydrogenase [quinone] 1, NAD(P)H dehydrogenase, quinone 1, NAD(P)H:menadione oxidoreductase 1, NAD(P)H:Quinone acceptor oxidoreductase type 1, NAD(P)H:quinone oxidoreductase 1, NAD(P)H:quinone oxireductase, NMOR1diaphorase-4, Phylloquinone reductase, QR1NMORI, Quinone reductase 1

storage :

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

more info or order :

Novus Biologicals product webpage