LANA2 Antibody (CM-A807) - BSA Free | Novus Biologicals NB200-167 product information

product summary

company name :

Novus Biologicals

other brands :

IMGENEX

product type :

antibody

product name :

LANA2 Antibody (CM-A807) - BSA Free

catalog :

NB200-167

quantity :

0.1 ml (also 0.025 ml)

price :

409 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

CM-A807

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

more info or order :

Novus Biologicals product webpage

citations: 13

Reference
Choi U, Lee J, Park A, Jung K, Lee S, Choi Y, et al. Herpesvirus-induced spermidine synthesis and eIF5A hypusination for viral episomal maintenance. Cell Rep. 2022;40:111234 pubmed publisher
Moodad S, El Hajj R, Hleihel R, Hajjar L, Tawil N, Karam M, et al. Lenalidomide in Combination with Arsenic Trioxide: an Effective Therapy for Primary Effusion Lymphoma. Cancers (Basel). 2020;12: pubmed publisher
Golas G, Jang S, Naik N, Alonso J, Papp B, Toth Z. Comparative analysis of the viral interferon regulatory factors of KSHV for their requisite for virus production and inhibition of the type I interferon pathway. Virology. 2020;541:160-173 pubmed publisher
Chen J, Dai L, Goldstein A, Zhang H, Tang W, Forrest J, et al. Identification of new antiviral agents against Kaposi's sarcoma-associated herpesvirus (KSHV) by high-throughput drug screening reveals the role of histamine-related signaling in promoting viral lytic reactivation. PLoS Pathog. 2019;15:e1008156 pubmed publisher
Xiang Q, Ju H, Li Q, Mei S, Chen D, Choi Y, et al. Human Herpesvirus 8 Interferon Regulatory Factors 1 and 3 Mediate Replication and Latency Activities via Interactions with USP7 Deubiquitinase. J Virol. 2018;92: pubmed publisher
Lee H, Li F, Choi U, Yu H, Aldrovandi G, Feng P, et al. Deregulation of HDAC5 by Viral Interferon Regulatory Factor 3 Plays an Essential Role in Kaposi's Sarcoma-Associated Herpesvirus-Induced Lymphangiogenesis. MBio. 2018;9: pubmed publisher
Liang Q, Chang B, Lee P, Brulois K, Ge J, Shi M, et al. Identification of the Essential Role of Viral Bcl-2 for Kaposi's Sarcoma-Associated Herpesvirus Lytic Replication. J Virol. 2015;89:5308-17 pubmed publisher
Zuo J, Hislop A, Leung C, Sabbah S, Rowe M. Kaposi's sarcoma-associated herpesvirus-encoded viral IRF3 modulates major histocompatibility complex class II (MHC-II) antigen presentation through MHC-II transactivator-dependent and -independent mechanisms: implications for oncogenesis. J Virol. 2013;87:5340-50 pubmed publisher
Marcos Villar L, Gallego P, Munoz Fontela C, de la Cruz Herrera C, Campagna M, Gonzalez D, et al. Kaposi's sarcoma-associated herpesvirus lana2 protein interacts with the pocket proteins and inhibits their sumoylation. Oncogene. 2014;33:495-503 pubmed publisher
Marcos Villar L, Campagna M, Lopitz Otsoa F, Gallego P, González Santamaría J, Gonzalez D, et al. Covalent modification by SUMO is required for efficient disruption of PML oncogenic domains by Kaposi's sarcoma-associated herpesvirus latent protein LANA2. J Gen Virol. 2011;92:188-94 pubmed publisher
Sarek G, Järviluoma A, Moore H, Tojkander S, Vartia S, Biberfeld P, et al. Nucleophosmin phosphorylation by v-cyclin-CDK6 controls KSHV latency. PLoS Pathog. 2010;6:e1000818 pubmed publisher
Marcos Villar L, Lopitz Otsoa F, Gallego P, Munoz Fontela C, González Santamaría J, Campagna M, et al. Kaposi's sarcoma-associated herpesvirus protein LANA2 disrupts PML oncogenic domains and inhibits PML-mediated transcriptional repression of the survivin gene. J Virol. 2009;83:8849-58 pubmed publisher
Shin Y, Joo C, Gack M, Lee H, Jung J. Kaposi's sarcoma-associated herpesvirus viral IFN regulatory factor 3 stabilizes hypoxia-inducible factor-1 alpha to induce vascular endothelial growth factor expression. Cancer Res. 2008;68:1751-9 pubmed publisher

image

image 1 :

Western Blot: LANA2 Antibody (CM-A807) [NB200-167] - Detection of LANA2 in infected lysates (30 ug) using 2 ug/ml of NB 200-167. ECL detection 1.5 minutes. Lane 1: BCBL-1 (KSHV+) Lane 2: BC-1 (KSHV+/EBV+) Lane 3: BCP-1 (KSHV+)

product information

brand :

Novus Biologicals, a Bio-Techne brand

catalog number base :

NB200-167

SKU :

NB200-167

product name :

LANA2 Antibody (CM-A807) - BSA Free

description :

The LANA2 Antibody (CM-A807) - BSA Free from Novus Biologicals is a mouse monoclonal antibody to LANA2. This antibody reacts with human,mouse,virus. The LANA2 Antibody (CM-A807) - BSA Free has been validated for the following applications: ELISA,Immunohistochemistry,Immunoprecipitation,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Knockout Validated,Western Blot,Immunocytochemistry/ Immunofluorescence.

target :

LANA2

unit size :

0.1 ml (also 0.025 ml)

category :

Primary Antibodies

buffer :

PBS

clonality :

Monoclonal

clone :

CM-A807

concentration :

2.0 mg/ml

conjugate :

Unconjugated

host :

Mouse

immunogen :

Recombinant LANA2 fusion protein.

isotype :

IgG1 Kappa

purity :

Protein G purified

species :

Human,Mouse,Virus

specificity :

This is specific for KSHV LANA2 (residues 143-310 epitope recognition)

storage :

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

applications :

ELISA,Immunohistochemistry,Immunoprecipitation,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Knockout Validated,Western Blot,Immunocytochemistry/ Immunofluorescence

USD :

399

USD 2025 :

409 USD

alt names :

LANA 2, LANA-2, Latency-associated nuclear antigen 2, vIRF 3, vIRF3, vIRF-3

more info or order :

Novus Biologicals product webpage