product summary
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company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
hnRNP L Antibody (4D11) - BSA Free
catalog :
NB120-6106
quantity :
0.1 ml (also 0.025 ml)
price :
409 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
4D11
reactivity :
human, mouse, rat, bovine
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - frozen section
more info or order :
citations: 23
Published Application/Species/Sample/DilutionReference
  • western blot; human
Yao P, Potdar A, Ray P, Eswarappa S, Flagg A, Willard B, et al. The HILDA complex coordinates a conditional switch in the 3'-untranslated region of the VEGFA mRNA. PLoS Biol. 2013;11:e1001635 pubmed publisher
  • western blot; human
Hung L, Heiner M, Hui J, Schreiner S, Benes V, Bindereif A. Diverse roles of hnRNP L in mammalian mRNA processing: a combined microarray and RNAi analysis. RNA. 2008;14:284-96 pubmed
  • western blot; human
Hui J, Stangl K, Lane W, Bindereif A. HnRNP L stimulates splicing of the eNOS gene by binding to variable-length CA repeats. Nat Struct Biol. 2003;10:33-7 pubmed
  • immunoprecipitation; mouse
Soderberg M, Raffalli Mathieu F, Lang M. Inflammation modulates the interaction of heterogeneous nuclear ribonucleoprotein (hnRNP) I/polypyrimidine tract binding protein and hnRNP L with the 3'untranslated region of the murine inducible nitric-oxide synthase mRNA. Mol Pharmacol. 2002;62:423-31 pubmed
  • immunoprecipitation; human
  • western blot; human
Shih S, Claffey K. Regulation of human vascular endothelial growth factor mRNA stability in hypoxia by heterogeneous nuclear ribonucleoprotein L. J Biol Chem. 1999;274:1359-65 pubmed
  • western blot; human
Hahm B, Kim Y, Kim J, Kim T, Jang S. Heterogeneous nuclear ribonucleoprotein L interacts with the 3' border of the internal ribosomal entry site of hepatitis C virus. J Virol. 1998;72:8782-8 pubmed
  • immunoprecipitation; human
Liu X, Mertz J. HnRNP L binds a cis-acting RNA sequence element that enables intron-dependent gene expression. Genes Dev. 1995;9:1766-80 pubmed
Sun C, Liu M, Chang J, Yang D, Zhao B, Wang H, et al. Heterogeneous Nuclear Ribonucleoprotein L Negatively Regulates Foot-and-Mouth Disease Virus Replication through Inhibition of Viral RNA Synthesis by Interacting with the Internal Ribosome Entry Site in the 5' Untranslated Region. J Virol. 2020;94: pubmed publisher
Juste Y, Cuervo A. Analysis of Chaperone-Mediated Autophagy. Methods Mol Biol. 2019;1880:703-727 pubmed publisher
Seki T, Sato M, Kibe Y, Ohta T, Oshima M, Konno A, et al. Lysosomal dysfunction and early glial activation are involved in the pathogenesis of spinocerebellar ataxia type 21 caused by mutant transmembrane protein 240. Neurobiol Dis. 2018;120:34-50 pubmed publisher
Pajares M, Rojo A, Arias E, Díaz Carretero A, Cuervo A, Cuadrado A. Transcription factor NFE2L2/NRF2 modulates chaperone-mediated autophagy through the regulation of LAMP2A. Autophagy. 2018;14:1310-1322 pubmed publisher
Gong Z, Tasset I, Díaz A, Anguiano J, Tas E, Cui L, et al. Humanin is an endogenous activator of chaperone-mediated autophagy. J Cell Biol. 2018;217:635-647 pubmed publisher
Yao P, Wu J, Lindner D, Fox P. Interplay between miR-574-3p and hnRNP L regulates VEGFA mRNA translation and tumorigenesis. Nucleic Acids Res. 2017;45:7950-7964 pubmed publisher
Zhang S, Eitan E, Mattson M. Early involvement of lysosome dysfunction in the degeneration of cerebral cortical neurons caused by the lipid peroxidation product 4-hydroxynonenal. J Neurochem. 2017;140:941-954 pubmed publisher
Ganesan S, Reynolds C, Hollinger K, Pearce S, Gabler N, Baumgard L, et al. Twelve hours of heat stress induces inflammatory signaling in porcine skeletal muscle. Am J Physiol Regul Integr Comp Physiol. 2016;310:R1288-96 pubmed publisher
Li Y, Collins M, An J, Geiser R, Tegeler T, Tsantilas K, et al. Immunoprecipitation and mass spectrometry defines an extensive RBM45 protein-protein interaction network. Brain Res. 2016;1647:79-93 pubmed publisher
Park C, Suh Y, Cuervo A. Regulated degradation of Chk1 by chaperone-mediated autophagy in response to DNA damage. Nat Commun. 2015;6:6823 pubmed publisher
Kett L, Stiller B, Bernath M, Tasset I, Blesa J, Jackson Lewis V, et al. α-Synuclein-independent histopathological and motor deficits in mice lacking the endolysosomal Parkinsonism protein Atp13a2. J Neurosci. 2015;35:5724-42 pubmed publisher
Ferreira J, Fôfo H, Bejarano E, Bento C, Ramalho J, Girao H, et al. STUB1/CHIP is required for HIF1A degradation by chaperone-mediated autophagy. Autophagy. 2013;9:1349-66 pubmed publisher
Hubbi M, Hu H, Kshitiz -, Ahmed I, Levchenko A, Semenza G. Chaperone-mediated autophagy targets hypoxia-inducible factor-1? (HIF-1?) for lysosomal degradation. J Biol Chem. 2013;288:10703-14 pubmed publisher
Orenstein S, Kuo S, Tasset I, Arias E, Koga H, Fernandez Carasa I, et al. Interplay of LRRK2 with chaperone-mediated autophagy. Nat Neurosci. 2013;16:394-406 pubmed publisher
Koga H, Kaushik S, Cuervo A. Altered lipid content inhibits autophagic vesicular fusion. FASEB J. 2010;24:3052-65 pubmed publisher
Guerrero C, Bouyssounade D, Zárate S, Isa P, López T, Espinosa R, et al. Heat shock cognate protein 70 is involved in rotavirus cell entry. J Virol. 2002;76:4096-102 pubmed
product information
brand :
Novus Biologicals, a Bio-Techne brand
catalog number base :
NB120-6106
SKU :
NB120-6106
product name :
hnRNP L Antibody (4D11) - BSA Free
description :
The hnRNP L Antibody (4D11) - BSA Free from Novus Biologicals is a mouse monoclonal antibody to hnRNP L. This antibody reacts with amphibian,bovine,chicken,human,mouse,primate,rat. The hnRNP L Antibody (4D11) - BSA Free has been validated for the following applications: ELISA,Immunohistochemistry,Immunohistochemistry-Frozen,Immunoprecipitation,Western Blot,Immunocytochemistry/ Immunofluorescence.
target :
hnRNP L
unit size :
0.1 ml (also 0.025 ml)
category :
Primary Antibodies
buffer :
PBS
clonality :
Monoclonal
clone :
4D11
concentration :
1.0 mg/ml
conjugate :
Unconjugated
host :
Mouse
immunogen :
Human hnRNP proteins from HeLa cells purified by affinity chromatography on ssDNA agarose.
isotype :
IgG1
purity :
Protein G purified
species :
Amphibian,Bovine,Chicken,Human,Mouse,Primate,Rat
storage :
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
gene symbol :
HNRNPL
accessionNumbers :
P14866, Q8R081
applications :
ELISA,Immunohistochemistry,Immunohistochemistry-Frozen,Immunoprecipitation,Western Blot,Immunocytochemistry/ Immunofluorescence
USD :
399
USD 2025 :
409 USD
alt names :
FLJ35509, heterogeneous nuclear ribonucleoprotein L, hnRNP L, hnRNP-L, HNRPL
more info or order :
company information
Novus Biologicals
10771 E Easter Ave
Centennial, CO 80112
novus@novusbio.com
https://www.novusbio.com
3037301950
headquarters: USA
Novus Biologicals licenses, manufactures, and markets antibodies to over 20,000 unique targets to support a wide array of research areas. Novus is built on honesty, collaboration and strong relationships and continues to provide quality tools that accelerate research. Every product is backed by our 100% guarantee.