| Published Application/Species/Sample/Dilution | Reference |
|---|
- western blot knockout validation; mouse; fig 6a
| Cheng K, Xiong S, Ye Z, Hong Z, Di A, Tsang K, et al. Caspase-11-mediated endothelial pyroptosis underlies endotoxemia-induced lung injury. J Clin Invest. 2017;127:4124-4135 pubmed publisher |
- western blot; mouse; loading ...; fig 3a
| Karki R, Sharma B, Tuladhar S, Williams E, Zalduondo L, Samir P, et al. Synergism of TNF-α and IFN-γ Triggers Inflammatory Cell Death, Tissue Damage, and Mortality in SARS-CoV-2 Infection and Cytokine Shock Syndromes. Cell. 2021;184:149-168.e17 pubmed publisher |
- western blot; mouse; fig s7a
| Li F, Li Y, Liang H, Xu T, Kong Y, Huang M, et al. HECTD3 mediates TRAF3 polyubiquitination and type I interferon induction during bacterial infection. J Clin Invest. 2018;128:4148-4162 pubmed publisher |
- western blot; mouse; loading ...; fig 4a
| Klaska I, Muckersie E, Martin Granados C, Christofi M, Forrester J. Lipopolysaccharide-primed heterotolerant dendritic cells suppress experimental autoimmune uveoretinitis by multiple mechanisms. Immunology. 2017;150:364-377 pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 2d
| Mortimer L, Moreau F, MacDonald J, Chadee K. NLRP3 inflammasome inhibition is disrupted in a group of auto-inflammatory disease CAPS mutations. Nat Immunol. 2016;17:1176-86 pubmed publisher |
- western blot; mouse; loading ...; fig s7d
| Kayagaki N, Stowe I, Lee B, O Rourke K, Anderson K, Warming S, et al. Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling. Nature. 2015;526:666-71 pubmed publisher |
- western blot; mouse; loading ...; fig s6b
| Shi J, Zhao Y, Wang K, Shi X, Wang Y, Huang H, et al. Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death. Nature. 2015;526:660-5 pubmed publisher |
| Diabate M, Munro P, Garcia E, Jacquel A, Michel G, Obba S, et al. Escherichia coli α-hemolysin counteracts the anti-virulence innate immune response triggered by the Rho GTPase activating toxin CNF1 during bacteremia. PLoS Pathog. 2015;11:e1004732 pubmed publisher |
| Youm Y, Nguyen K, Grant R, Goldberg E, Bodogai M, Kim D, et al. The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome-mediated inflammatory disease. Nat Med. 2015;21:263-9 pubmed publisher |
| Yuan Z, Syed M, Panchal D, Joo M, Colonna M, Brantly M, et al. Triggering receptor expressed on myeloid cells 1 (TREM-1)-mediated Bcl-2 induction prolongs macrophage survival. J Biol Chem. 2014;289:15118-29 pubmed publisher |
| Gurung P, Anand P, Malireddi R, Vande Walle L, Van Opdenbosch N, Dillon C, et al. FADD and caspase-8 mediate priming and activation of the canonical and noncanonical Nlrp3 inflammasomes. J Immunol. 2014;192:1835-46 pubmed publisher |
| Jin H, Oda H, Lai M, Skalsky R, Bethel K, Shepherd J, et al. MicroRNA-17~92 plays a causative role in lymphomagenesis by coordinating multiple oncogenic pathways. EMBO J. 2013;32:2377-91 pubmed publisher |
| Case C, Kohler L, Lima J, Strowig T, de Zoete M, Flavell R, et al. Caspase-11 stimulates rapid flagellin-independent pyroptosis in response to Legionella pneumophila. Proc Natl Acad Sci U S A. 2013;110:1851-6 pubmed publisher |
| Sun L, Wu Z, Hayashi Y, Peters C, Tsuda M, Inoue K, et al. Microglial cathepsin B contributes to the initiation of peripheral inflammation-induced chronic pain. J Neurosci. 2012;32:11330-42 pubmed |
| Kenneth N, Younger J, Hughes E, Marcotte D, Barker P, Saunders T, et al. An inactivating caspase 11 passenger mutation originating from the 129 murine strain in mice targeted for c-IAP1. Biochem J. 2012;443:355-9 pubmed publisher |
- immunohistochemistry; mouse
| Kang S, Wang S, Kuida K, Yuan J. Distinct downstream pathways of caspase-11 in regulating apoptosis and cytokine maturation during septic shock response. Cell Death Differ. 2002;9:1115-25 pubmed |
- immunoprecipitation; mouse
- immunohistochemistry; mouse
- western blot; mouse
| Kang S, Wang S, Hara H, Peterson E, Namura S, Amin Hanjani S, et al. Dual role of caspase-11 in mediating activation of caspase-1 and caspase-3 under pathological conditions. J Cell Biol. 2000;149:613-22 pubmed |
| Rui W, Wu Y, Yang Y, Xie W, Qin D, Ming J, et al. Myeloid gasdermin D drives early-stage T cell immunity and peripheral inflammation in a mouse model of Alzheimer's disease. J Neuroinflammation. 2024;21:266 pubmed publisher |
| Xu L, Peng F, Luo Q, Ding Y, Yuan F, Zheng L, et al. IRE1α silences dsRNA to prevent taxane-induced pyroptosis in triple-negative breast cancer. Cell. 2024;187:7248-7266.e34 pubmed publisher |
| Gao F, Xiong D, Sun Z, Shao J, Wei D, Nie S. ARC@DPBNPs suppress LPS-induced acute lung injury via inhibiting macrophage pyroptosis and M1 polarization by ERK pathway in mice. Int Immunopharmacol. 2024;131:111794 pubmed publisher |
| Han J, Karki R, Malireddi R, Mall R, Sarkar R, Sharma B, et al. NINJ1 mediates inflammatory cell death, PANoptosis, and lethality during infection conditions and heat stress. Nat Commun. 2024;15:1739 pubmed publisher |
| Ha J, Kim M, Park J, Lee Y, Lee J, Shin J, et al. SERTAD1 initiates NLRP3-mediated inflammasome activation through restricting NLRP3 polyubiquitination. Cell Rep. 2024;43:113752 pubmed publisher |
| Daily K, Badr A, Eltobgy M, Estfanous S, Whitham O, Tan M, et al. DNA hypomethylation promotes the expression of CASPASE-4 which exacerbates inflammation and amyloid-β deposition in Alzheimer's disease. Alzheimers Res Ther. 2024;16:29 pubmed publisher |
| Shim D, Eo J, Kim S, Hwang I, Nam B, Shin J, et al. Deficiency of circadian clock gene Bmal1 exacerbates noncanonical inflammasome-mediated pyroptosis and lethality via Rev-erbα-C/EBPβ-SAA1 axis. Exp Mol Med. 2024;56:370-382 pubmed publisher |
| Pandey A, Shen C, Feng S, Enosi Tuipulotu D, Ngo C, Liu C, et al. Ku70 senses cytosolic DNA and assembles a tumor-suppressive signalosome. Sci Adv. 2024;10:eadh3409 pubmed publisher |
| Yu Q, Yang Y, Xu T, Cai Y, Yang Z, Yuan F. Palmitoleic acid protects microglia from palmitate-induced neurotoxicity in vitro. PLoS ONE. 2024;19:e0297031 pubmed publisher |
| Ma C, Huang J, Jiang Y, Liu L, Wang N, Huang S, et al. Gasdermin D in macrophages drives orchitis by regulating inflammation and antigen presentation processes. EMBO Mol Med. 2024;16:361-385 pubmed publisher |
| Mazzarda F, Chittams Miles A, Pittaluga J, S xf6 zer E, Vernier P, Muratori C. Inflammasome Activation and IL-1β Release Triggered by Nanosecond Pulsed Electric Fields in Murine Innate Immune Cells and Skin. J Immunol. 2024;212:335-345 pubmed publisher |
| Exconde P, Hernandez Chavez C, Bourne C, Richards R, Bray M, Lopez J, et al. The tetrapeptide sequence of IL-18 and IL-1β regulates their recruitment and activation by inflammatory caspases. Cell Rep. 2023;42:113581 pubmed publisher |
| Watanabe N, Tamai R, Kiyoura Y. Alendronate augments lipid A‑induced IL‑1β release by ASC‑deficient RAW264 cells via AP‑1 activation. Exp Ther Med. 2023;26:577 pubmed publisher |
| Daily K, Badr A, Eltobgy M, Estfanous S, Whitham O, Tan M, et al. DNA hypomethylation promotes the expression of CASPASE-4 which exacerbates neuroinflammation and amyloid-β deposition in Alzheimer's disease The Ohio State University College of Medicine. bioRxiv. 2023;: pubmed publisher |
| Lin A, Guo Y, Zhang H, Lin P, Tao K, Jiang L, et al. GSDMD knockdown exacerbates hippocampal damage and seizure susceptibility by crosstalk between pyroptosis and apoptosis in kainic acid-induced temporal lobe epilepsy. Biochim Biophys Acta Mol Basis Dis. 2023;1869:166687 pubmed publisher |
| Exconde P, Hernandez Chavez C, Bray M, Lopez J, Srivastava T, Egan M, et al. The tetrapeptide sequence of IL-1β regulates its recruitment and activation by inflammatory caspases. bioRxiv. 2023;: pubmed publisher |
| Han J, Tweedell R, Kanneganti T. Evaluation of Caspase Activation to Assess Innate Immune Cell Death. J Vis Exp. 2023;: pubmed publisher |
| Wu Y, Mo S, Chen I, Hsieh F, Hsieh S, Zhang J, et al. Caspase-8 inactivation drives autophagy-dependent inflammasome activation in myeloid cells. Sci Adv. 2022;8:eabn9912 pubmed publisher |
| Gros M, Segura E, Rookhuizen D, Baudon B, Heurtebise Chr xe9 tien S, Burgdorf N, et al. Endocytic membrane repair by ESCRT-III controls antigen export to the cytosol during antigen cross-presentation. Cell Rep. 2022;40:111205 pubmed publisher |
| Jiang H, Niu C, Guo Y, Liu Z, Jiang Y. Wedelolactone induces apoptosis and pyroptosis in retinoblastoma through promoting ROS generation. Int Immunopharmacol. 2022;111:108855 pubmed publisher |
| Lin W, Li L, Hsiao Y, Wong W, Chiu H, Hsu H, et al. Repositioning of the Angiotensin II Receptor Antagonist Candesartan as an Anti-Inflammatory Agent With NLRP3 Inflammasome Inhibitory Activity. Front Immunol. 2022;13:870627 pubmed publisher |
| Wang Z, Yang X, Wang X, Liang F, Tang Y. Glycyrrhizin attenuates caspase-11-dependent immune responses and coagulopathy by targeting high mobility group box 1. Int Immunopharmacol. 2022;107:108713 pubmed publisher |
| Sundaram B, Karki R, Kanneganti T. NLRC4 Deficiency Leads to Enhanced Phosphorylation of MLKL and Necroptosis. Immunohorizons. 2022;6:243-252 pubmed publisher |
| Huang D, Chen P, Huang G, Sun H, Luo X, He C, et al. Salt-inducible kinases inhibitor HG-9-91-01 targets RIPK3 kinase activity to alleviate necroptosis-mediated inflammatory injury. Cell Death Dis. 2022;13:188 pubmed publisher |
| Guo Y, Mao R, Xie Q, Cheng X, Xu T, Wang X, et al. Francisella novicida Mutant XWK4 Triggers Robust Inflammasome Activation Favoring Infection. Front Cell Dev Biol. 2021;9:743335 pubmed publisher |
| Zheng M, Karki R, Kancharana B, Berns H, Pruett Miller S, Kanneganti T. Caspase-6 promotes activation of the caspase-11-NLRP3 inflammasome during gram-negative bacterial infections. J Biol Chem. 2021;297:101379 pubmed publisher |
| Karki R, Sundaram B, Sharma B, Lee S, Malireddi R, Nguyen L, et al. ADAR1 restricts ZBP1-mediated immune response and PANoptosis to promote tumorigenesis. Cell Rep. 2021;37:109858 pubmed publisher |
| Xiong S, Zhang L, Richner J, Class J, Rehman J, Malik A. Interleukin-1RA Mitigates SARS-CoV-2-Induced Inflammatory Lung Vascular Leakage and Mortality in Humanized K18-hACE-2 Mice. Arterioscler Thromb Vasc Biol. 2021;41:2773-2785 pubmed publisher |
| Fan R, Sui J, Dong X, Jing B, Gao Z. Wedelolactone alleviates acute pancreatitis and associated lung injury via GPX4 mediated suppression of pyroptosis and ferroptosis. Free Radic Biol Med. 2021;173:29-40 pubmed publisher |
| Shi H, Gao Y, Dong Z, Yang J, Gao R, Li X, et al. GSDMD-Mediated Cardiomyocyte Pyroptosis Promotes Myocardial I/R Injury. Circ Res. 2021;129:383-396 pubmed publisher |
| Wang X, Li Z, Bai Y, Zhang R, Meng R, Chen F, et al. A small molecule binding HMGB1 inhibits caspase-11-mediated lethality in sepsis. Cell Death Dis. 2021;12:402 pubmed publisher |
| Chen Q, Zheng J, Wang D, Liu Q, Kang L, Gao X, et al. Nitrosonisoldipine is a selective inhibitor of inflammatory caspases and protects against pyroptosis and related septic shock. Eur J Immunol. 2021;: pubmed publisher |
| Karki R, Sharma B, Tuladhar S, Williams E, Zalduondo L, Samir P, et al. Synergism of TNF-α and IFN-γ triggers inflammatory cell death, tissue damage, and mortality in SARS-CoV-2 infection and cytokine shock syndromes. bioRxiv. 2020;: pubmed publisher |
| Finethy R, Dockterman J, Kutsch M, Orench Rivera N, Wallace G, Piro A, et al. Dynamin-related Irgm proteins modulate LPS-induced caspase-11 activation and septic shock. EMBO Rep. 2020;21:e50830 pubmed publisher |
| Sakaguchi N, Sasai M, Bando H, Lee Y, Pradipta A, Ma J, et al. Role of Gate-16 and Gabarap in Prevention of Caspase-11-Dependent Excess Inflammation and Lethal Endotoxic Shock. Front Immunol. 2020;11:561948 pubmed publisher |
| Pereira L, Assis P, de Ara xfa jo N, Durso D, Junqueira C, Ata xed de M, et al. Caspase-8 mediates inflammation and disease in rodent malaria. Nat Commun. 2020;11:4596 pubmed publisher |
| Ma C, Yang D, Wang B, Wu C, Wu Y, Li S, et al. Gasdermin D in macrophages restrains colitis by controlling cGAS-mediated inflammation. Sci Adv. 2020;6:eaaz6717 pubmed publisher |
| Selkrig J, Li N, Hausmann A, Mangan M, Zietek M, Mateus A, et al. Spatiotemporal proteomics uncovers cathepsin-dependent macrophage cell death during Salmonella infection. Nat Microbiol. 2020;5:1119-1133 pubmed publisher |
| Wang J, Li X, Liu Y, Peng C, Zhu H, Tu G, et al. CircHIPK3 Promotes Pyroptosis in Acinar Cells Through Regulation of the miR-193a-5p/GSDMD Axis. Front Med (Lausanne). 2020;7:88 pubmed publisher |
| Karki R, Lee E, Sharma B, Banoth B, Kanneganti T. IRF8 Regulates Gram-Negative Bacteria-Mediated NLRP3 Inflammasome Activation and Cell Death. J Immunol. 2020;204:2514-2522 pubmed publisher |
| Huang L, Hong Z, Wu W, Xiong S, Zhong M, Gao X, et al. mtDNA Activates cGAS Signaling and Suppresses the YAP-Mediated Endothelial Cell Proliferation Program to Promote Inflammatory Injury. Immunity. 2020;52:475-486.e5 pubmed publisher |
| Wang C, Li Y, Wu X, Tian H, Jiang S, Xu T, et al. IRF3 and IRF7 contribute to diesel exhaust particles-induced pulmonary inflammation by mediating mTORC1 activation and restraining autophagy in mice. Eur J Immunol. 2020;: pubmed publisher |
| Wang K, Sun Q, Zhong X, Zeng M, Zeng H, Shi X, et al. Structural Mechanism for GSDMD Targeting by Autoprocessed Caspases in Pyroptosis. Cell. 2020;180:941-955.e20 pubmed publisher |
| Li S, Wu Y, Yang D, Wu C, Ma C, Liu X, et al. Gasdermin D in peripheral myeloid cells drives neuroinflammation in experimental autoimmune encephalomyelitis. J Exp Med. 2019;216:2562-2581 pubmed publisher |
| Wei Z, Wang J, Wang Y, Wang C, Liu X, Han Z, et al. Effects of Neutrophil Extracellular Traps on Bovine Mammary Epithelial Cells in vitro. Front Immunol. 2019;10:1003 pubmed publisher |
| Kayagaki N, Lee B, Stowe I, Kornfeld O, O Rourke K, Mirrashidi K, et al. IRF2 transcriptionally induces GSDMD expression for pyroptosis. Sci Signal. 2019;12: pubmed publisher |
| Pronin A, Pham D, An W, Dvoriantchikova G, Reshetnikova G, Qiao J, et al. Inflammasome Activation Induces Pyroptosis in the Retina Exposed to Ocular Hypertension Injury. Front Mol Neurosci. 2019;12:36 pubmed publisher |
| Liu Q, Zhang S, Sun Z, Guo X, Zhou H. E3 ubiquitin ligase Nedd4 is a key negative regulator for non-canonical inflammasome activation. Cell Death Differ. 2019;: pubmed publisher |
| Wang B, Lim J, Kajikawa T, Li X, Vallance B, Moutsopoulos N, et al. Macrophage β2-Integrins Regulate IL-22 by ILC3s and Protect from Lethal Citrobacter rodentium-Induced Colitis. Cell Rep. 2019;26:1614-1626.e5 pubmed publisher |
| Quach J, Moreau F, Sandall C, Chadee K. Entamoeba histolytica-induced IL-1β secretion is dependent on caspase-4 and gasdermin D. Mucosal Immunol. 2019;12:323-339 pubmed publisher |
| Chen J, Wang B, Lai J, Braunstein Z, He M, Ruan G, et al. Trimetazidine Attenuates Cardiac Dysfunction in Endotoxemia and Sepsis by Promoting Neutrophil Migration. Front Immunol. 2018;9:2015 pubmed publisher |
| Balakrishnan A, Karki R, Berwin B, Yamamoto M, Kanneganti T. Guanylate binding proteins facilitate caspase-11-dependent pyroptosis in response to type 3 secretion system-negative Pseudomonas aeruginosa. Cell Death Discov. 2018;4:3 pubmed publisher |
| Deigendesch N, Zychlinsky A, Meissner F. Copper Regulates the Canonical NLRP3 Inflammasome. J Immunol. 2018;200:1607-1617 pubmed publisher |
| Kerur N, Fukuda S, Banerjee D, Kim Y, Fu D, Apicella I, et al. cGAS drives noncanonical-inflammasome activation in age-related macular degeneration. Nat Med. 2018;24:50-61 pubmed publisher |
| Man S, Karki R, Briard B, Burton A, Gingras S, Pelletier S, et al. Differential roles of caspase-1 and caspase-11 in infection and inflammation. Sci Rep. 2017;7:45126 pubmed publisher |
| Jin H, Oda H, Chen P, Yang C, Zhou X, Kang S, et al. Differential Sensitivity of Target Genes to Translational Repression by miR-17~92. PLoS Genet. 2017;13:e1006623 pubmed publisher |
| Kolb R, Phan L, Borcherding N, Liu Y, Yuan F, Janowski A, et al. Obesity-associated NLRC4 inflammasome activation drives breast cancer progression. Nat Commun. 2016;7:13007 pubmed publisher |
| Man S, Karki R, Sasai M, Place D, Kesavardhana S, Temirov J, et al. IRGB10 Liberates Bacterial Ligands for Sensing by the AIM2 and Caspase-11-NLRP3 Inflammasomes. Cell. 2016;167:382-396.e17 pubmed publisher |
| Kim M, Bae S, Ryu J, Kwon Y, Oh J, Kwon J, et al. SESN2/sestrin2 suppresses sepsis by inducing mitophagy and inhibiting NLRP3 activation in macrophages. Autophagy. 2016;12:1272-91 pubmed publisher |
| Chung H, Vilaysane A, Lau A, Stahl M, Morampudi V, Bondzi Simpson A, et al. NLRP3 regulates a non-canonical platform for caspase-8 activation during epithelial cell apoptosis. Cell Death Differ. 2016;23:1331-46 pubmed publisher |
| Aachoui Y, Kajiwara Y, Leaf I, Mao D, Ting J, Coers J, et al. Canonical Inflammasomes Drive IFN-γ to Prime Caspase-11 in Defense against a Cytosol-Invasive Bacterium. Cell Host Microbe. 2015;18:320-32 pubmed publisher |
| Bonora M, Wieckowsk M, Chinopoulos C, Kepp O, Kroemer G, Galluzzi L, et al. Molecular mechanisms of cell death: central implication of ATP synthase in mitochondrial permeability transition. Oncogene. 2015;34:1608 pubmed publisher |
| Demon D, Kuchmiy A, Fossoul A, Zhu Q, Kanneganti T, Lamkanfi M. Caspase-11 is expressed in the colonic mucosa and protects against dextran sodium sulfate-induced colitis. Mucosal Immunol. 2014;7:1480-91 pubmed publisher |
| Van Opdenbosch N, Gurung P, Vande Walle L, Fossoul A, Kanneganti T, Lamkanfi M. Activation of the NLRP1b inflammasome independently of ASC-mediated caspase-1 autoproteolysis and speck formation. Nat Commun. 2014;5:3209 pubmed publisher |
| Kayagaki N, Warming S, Lamkanfi M, Vande Walle L, Louie S, Dong J, et al. Non-canonical inflammasome activation targets caspase-11. Nature. 2011;479:117-21 pubmed publisher |
