product summary
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company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
DNA/RNA Damage Antibody (15A3) - BSA Free
catalog :
NB110-96878
quantity :
0.1 mg (also 0.025 mg)
price :
479 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
15A3
application :
ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, dot blot
more info or order :
citations: 25
Reference
Tang J, Lu X, Zhang T, Feng Y, Xu Q, Li J, et al. Shiga toxin 2 A-subunit induces mitochondrial damage, mitophagy and apoptosis via the interaction of Tom20 in Caco-2 cells. Heliyon. 2023;9:e20012 pubmed publisher
Fraser B, Wilkins A, De Iuliis G, Rebourcet D, Nixon B, Aitken R. Development of a model for studying the developmental consequences of oxidative sperm DNA damage by targeting redox-cycling naphthoquinones to the Sertoli cell population. Free Radic Biol Med. 2023;206:50-62 pubmed publisher
Langford M, Srur L, Redens T, Byrd W. Conjunctival epitheliopathy induced by topical exposure to bacterial peptidoglycan, muramyl dipeptide. Exp Eye Res. 2023;227:109383 pubmed publisher
Soria Meneses P, Jurado Campos A, G xf3 mez Rubio V, S xe1 nchez Ajofr xed n I, Soler A, Garde J, et al. Determination of Ram (Ovis aries) Sperm DNA Damage Due to Oxidative Stress: 8-OHdG Immunodetection Assay vs. SCSA®. Animals (Basel). 2022;12: pubmed publisher
Shrestha S, Erikson G, Lyon J, Spigelman A, Bautista A, Manning Fox J, et al. Aging compromises human islet beta cell function and identity by decreasing transcription factor activity and inducing ER stress. Sci Adv. 2022;8:eabo3932 pubmed publisher
González M, Prashar T, Connaughton H, Barry M, ROBKER R, Rose R. Restoring Sperm Quality Post-Cryopreservation Using Mitochondrial-Targeted Compounds. Antioxidants (Basel). 2022;11: pubmed publisher
Sadeghi N, Tavalaee M, Kiani Esfahani A, Moazamian A, Gharagozloo P, Aitken R, et al. Apoptotic M540 bodies present in human semen interfere with flow cytometry-assisted assessment of sperm DNA fragmentation and oxidation. Basic Clin Androl. 2021;31:23 pubmed publisher
Berby B, Bichara C, Rives Feraille A, Jumeau F, Pizio P, Setif V, et al. Oxidative Stress Is Associated with Telomere Interaction Impairment and Chromatin Condensation Defects in Spermatozoa of Infertile Males. Antioxidants (Basel). 2021;10: pubmed publisher
Zhao F, Whiting S, Lambourne S, Aitken R, Sun Y. Melatonin alleviates heat stress-induced oxidative stress and apoptosis in human spermatozoa. Free Radic Biol Med. 2021;164:410-416 pubmed publisher
Aitken R, Whiting S, Connaughton H, Curry B, Reinheimer T, van Duin M. A novel pathway for the induction of DNA damage in human spermatozoa involving extracellular cell-free DNA. Mutat Res. 2020;821:111722 pubmed publisher
Champroux A, Goubely C, Henry Berger J, Drevet J, Kocer A. Three-Dimensional Confocal Analysis of Chromosome Positioning Coupled with Immunofluorescence in Mouse Sperm Nuclei. Methods Mol Biol. 2021;2198:255-268 pubmed publisher
Alissafi T, Kalafati L, Lazari M, Filia A, Kloukina I, Manifava M, et al. Mitochondrial Oxidative Damage Underlies Regulatory T Cell Defects in Autoimmunity. Cell Metab. 2020;32:591-604.e7 pubmed publisher
Noblanc A, Klaassen A, Robaire B. The Exacerbation of Aging and Oxidative Stress in the Epididymis of Sod1 Null Mice. Antioxidants (Basel). 2020;9: pubmed publisher
Soria Meneses P, Jurado Campos A, Montoro V, Soler A, Garde J, Fernández Santos M. Ovine sperm DNA oxidation quantification using an 8-OHdG immunodetection assay. Reprod Domest Anim. 2019;54 Suppl 4:59-64 pubmed publisher
Youngson N, Uddin G, Das A, Martinez C, Connaughton H, Whiting S, et al. Impacts of obesity, maternal obesity and nicotinamide mononucleotide supplementation on sperm quality in mice. Reproduction. 2019;158:171-181 pubmed publisher
Moloney C, Rayaprolu S, Howard J, Fromholt S, Brown H, Collins M, et al. Analysis of spinal and muscle pathology in transgenic mice overexpressing wild-type and ALS-linked mutant MATR3. Acta Neuropathol Commun. 2018;6:137 pubmed publisher
Vorilhon S, Brugnon F, Kocer A, Dollet S, Bourgne C, Berger M, et al. Accuracy of human sperm DNA oxidation quantification and threshold determination using an 8-OHdG immuno-detection assay. Hum Reprod. 2018;33:553-562 pubmed publisher
Xavier M, Nixon B, Roman S, Aitken R. Improved methods of DNA extraction from human spermatozoa that mitigate experimentally-induced oxidative DNA damage. PLoS ONE. 2018;13:e0195003 pubmed publisher
Oblette A, Rives N, Dumont L, Rives A, Verhaeghe F, Jumeau F, et al. Assessment of sperm nuclear quality after in vitro maturation of fresh or frozen/thawed mouse pre-pubertal testes. Mol Hum Reprod. 2017;23:674-684 pubmed publisher
Marangi G, Lattante S, Doronzio P, Conte A, Tasca G, Monforte M, et al. Matrin 3 variants are frequent in Italian ALS patients. Neurobiol Aging. 2017;49:218.e1-218.e7 pubmed publisher
Rayaprolu S, D Alton S, Crosby K, Moloney C, Howard J, Duffy C, et al. Heterogeneity of Matrin 3 in the developing and aging murine central nervous system. J Comp Neurol. 2016;524:2740-52 pubmed publisher
Yarosh C, Tapescu I, Thompson M, Qiu J, Mallory M, Fu X, et al. TRAP150 interacts with the RNA-binding domain of PSF and antagonizes splicing of numerous PSF-target genes in T cells. Nucleic Acids Res. 2015;43:9006-16 pubmed publisher
Moldovan J, Moran J. The Zinc-Finger Antiviral Protein ZAP Inhibits LINE and Alu Retrotransposition. PLoS Genet. 2015;11:e1005121 pubmed publisher
Depreux F, Puckelwartz M, Augustynowicz A, Wolfgeher D, Labno C, Pierre Louis D, et al. Disruption of the lamin A and matrin-3 interaction by myopathic LMNA mutations. Hum Mol Genet. 2015;24:4284-95 pubmed publisher
Noblanc A, Peltier M, Damon Soubeyrand C, Kerchkove N, Chabory E, Vernet P, et al. Epididymis response partly compensates for spermatozoa oxidative defects in snGPx4 and GPx5 double mutant mice. PLoS ONE. 2012;7:e38565 pubmed publisher
product information
master code :
NB110-96878
SKU :
NB110-96878
product name :
DNA/RNA Damage Antibody (15A3) - BSA Free
unit size :
0.1 mg (also 0.025 mg)
description :
The DNA/RNA Damage Antibody (15A3) - BSA Free from Novus is a mouse monoclonal antibody to DNA/RNA Damage. This antibody reacts with human,mouse,non-species specific,rabbit. The DNA/RNA Damage Antibody (15A3) - BSA Free has been validated for the following applications: Immunohistochemistry,Flow Cytometry,IF/IHC,Immunoprecipitation,Immunohistochemistry-Paraffin,Immunoassay,Immunocytochemistry/ Immunofluorescence,ELISA,Dot Blot,Functional Assay.
target :
DNA/RNA Damage
category :
Primary Antibodies
buffer :
PBS, 50% Glycerol
clonality :
Monoclonal
clone :
15A3
concentration :
1 mg/ml
conjugate :
Unconjugated
host :
Mouse
immunogen :
8-hydroxy-guanosine-BSA and-casein conjugates
isotype :
IgG2b
purity :
Protein G purified
species :
Human,Mouse,Non-species specific,Rabbit
specificity :
Recognizes markers of oxidative damage to DNA (8-hydroxy-2'-deoxyguanosine, 8-hydroxyguanine and 8-hydroxyguanosine)
applications :
Flow Cytometry,IF/IHC,Immunohistochemistry,Immunoprecipitation,Immunohistochemistry-Paraffin,Immunoassay,Immunocytochemistry/ Immunofluorescence,ELISA,Dot Blot,Functional Assay
USD :
479 USD
alt names :
DNA/RNA Oxidative Damage Markers Monoclonal
storage :
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
more info or order :
company information
Novus Biologicals
10771 E Easter Ave
Centennial, CO 80112
novus@novusbio.com
https://www.novusbio.com
3037301950
headquarters: USA
Novus Biologicals licenses, manufactures, and markets antibodies to over 20,000 unique targets to support a wide array of research areas. Novus is built on honesty, collaboration and strong relationships and continues to provide quality tools that accelerate research. Every product is backed by our 100% guarantee.