product summary
request information :
company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
Rabbit Polyclonal Survivin Antibody
catalog :
NB110-92717H
quantity :
0.1 ml
price :
269.00 USD
clonality :
polyclonal
host :
rabbit
conjugate :
HRP
reactivity :
human, rat
application :
western blot
more info or order :
Novus Biologicals product webpage
product information
Catalog Number :
NB110-92717H
Product Name :
Rabbit Polyclonal Survivin Antibody
List Price :
269.00 USD
Product Type :
Primary Antibodies
Package Size :
0.1 ml
AltNames :
EPR-1, IAP4, API4 survivin variant 3 alpha, Apoptosis inhibitor 4 baculoviral IAP repeat-containing protein 5, Apoptosis inhibitor survivin, baculoviral IAP repeat-containing 5, BIRC5
Background :
Survivin is a structurally unique inhibitor of apoptosis (IAP) that has been linked to protection from apoptosis, control of cell division, and cellular adaptation to stress. In order for survivin to provide this cytoprotection an interaction with at least one other IAP, such as XIAP, is necessary. It has recently been shown that Survivin is phosphorylated at Ser20 by protein kinase A (PKA) in the cytosol but not in the mitochondria. This phosphorylation on Ser20 disrupts the binding of cytosolic survivin to XIAP and therefore diminishes survivin's cytoprotective properties.
Buffer :
PBS
Clonality :
Polyclonal
Conjugate :
HRP
Application Summary :
Western Blot
Host :
Rabbit
Immunogen :
A synthetic peptide surrounding the phosphorylated serine 20 of the human Survivin protein. [Swiss-Prot #O15392]
Localization :
Cytoplasm and Mitochondria.
Modification :
p Ser20
Preservative :
No Preservative
Purity :
Immunogen affinity purified
CrossReactivity :
Human and Rat.
Storage :
Store at 4C in the dark.
Swissprot Human :
O15392
TMW :
16.5 kDa
Uses :
This Survivin antibody is useful for Immunocytochemistry/Immunofluorescence and Western blot, where a band is seen at ~16.5 kDa. In ICC/IF staining was observed in the spindle midzone, centrosome and intercellular bridge.
Research Area :
Angiogenesis, Apoptosis, Astrocyte Markers, Cancer, Cellular Markers, Core ESC Like Genes, Glia Markers, Growth and Development, Mitotic Regulators, Neurodegeneration, Neuronal Cell Markers, Neuroscience, Stem Cell Markers, Tumor Suppressors
more info or order :
Novus Biologicals product webpage
company information
Novus Biologicals
8100 Southpark Way, A-8
Littleton, CO 80120
novus@novusbio.com
www.novusbio.com
3037301950
headquarters: USA
The mission of Novus Biologicals, LLC is to accelerate scientific discovery by developing and marketing unique products in the forefront of science. Novus Biologicals was organized to provide the biological research community with a mechanism for commercializing unique biological materials. We also focus on continually monitoring scientific trends and supply materials to serve these trends. By making these products widely available to institutional and commercial researchers, Novus Biologicals plays an important role in furthering biological research. All of Novus Biologicals products are supplied with detailed technical information and ongoing support. By serving niche and emerging markets, Novus Biologicals has become specialists in markets and has formed and will continue to form ongoing partnerships with our customers.