product summary
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company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
Ki67/MKI67 Antibody - BSA Free
catalog :
NB110-89719
quantity :
0.1 ml (also 0.025 ml)
price :
399 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
clone name :
31A1067
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
citations: 172
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 9f
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Mu N, Lei Y, Wang Y, Wang Y, Duan Q, Ma G, et al. Inhibition of SIRT1/2 upregulates HSPA5 acetylation and induces pro-survival autophagy via ATF4-DDIT4-mTORC1 axis in human lung cancer cells. Apoptosis. 2019;24:798-811 pubmed publisher
Wang Y, Su G, Huang Z, Fan J, Wang Y. Cepharanthine hydrochloride degrades polyglutamine-expanded androgen receptor proteins through an autophagy pathway in neuron cells. Eur J Pharmacol. 2019;861:172534 pubmed publisher
Akiyama N, Yamamoto Fukuda T, Yoshikawa M, Kojima H. Regulation of DNA methylation levels in the process of oral mucosal regeneration in a rat oral ulcer model. Histol Histopathol. 2019;:18147 pubmed publisher
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Wu M, Chien C, Chang J, Chen Y. Pro-apoptotic effect of haem oxygenase-1 in human colorectal carcinoma cells via endoplasmic reticular stress. J Cell Mol Med. 2019;23:5692-5704 pubmed publisher
Chao M, Chang L, Tu H, Chang C, Lai M, Chen Y, et al. Combination treatment strategy for pancreatic cancer involving the novel HDAC inhibitor MPT0E028 with a MEK inhibitor beyond K-Ras status. Clin Epigenetics. 2019;11:85 pubmed publisher
Jia R, Jia N, Yang F, Liu Z, Li R, Jiang Y, et al. Hydrogen Alleviates Necroptosis and Cognitive Deficits in Lithium-Pilocarpine Model of Status Epilepticus. Cell Mol Neurobiol. 2019;39:857-869 pubmed publisher
An W, Yao S, Sun X, Hou Z, Lin Y, Su L, et al. Glucocorticoid modulatory element-binding protein 1 (GMEB1) interacts with the de-ubiquitinase USP40 to stabilize CFLARL and inhibit apoptosis in human non-small cell lung cancer cells. J Exp Clin Cancer Res. 2019;38:181 pubmed publisher
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Owonikoko T, Zhang G, Lallani S, Chen Z, Martinson D, Khuri F, et al. Evaluation of preclinical efficacy of everolimus and pasireotide in thyroid cancer cell lines and xenograft models. PLoS ONE. 2019;14:e0206309 pubmed publisher
Chou C, Huang H, Yang C, Dahms H, Liang S, Wang T, et al. Reduced camptothecin sensitivity of estrogen receptor-positive human breast cancer cells following exposure to di(2-ethylhexyl)phthalate (DEHP) is associated with DNA methylation changes. Environ Toxicol. 2019;34:401-414 pubmed publisher
Jaworski S, Strojny B, Sawosz E, Wierzbicki M, Grodzik M, Kutwin M, et al. Degradation of Mitochondria and Oxidative Stress as the Main Mechanism of Toxicity of Pristine Graphene on U87 Glioblastoma Cells and Tumors and HS-5 Cells. Int J Mol Sci. 2019;20: pubmed publisher
Li X, Song H, Kong F, Guo Y, Chen Y, Zhang L, et al. Pemetrexed exerts anticancer effects by inducing G0/G1-phase cell cycle arrest and activating the NOXA/Mcl-1 axis in human esophageal squamous cell carcinoma cells. Oncol Lett. 2019;17:1851-1858 pubmed publisher
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Chang Y, Fong Y, Tsai E, Chang Y, Chou H, Wu C, et al. Exogenous C₈-Ceramide Induces Apoptosis by Overproduction of ROS and the Switch of Superoxide Dismutases SOD1 to SOD2 in Human Lung Cancer Cells. Int J Mol Sci. 2018;19: pubmed publisher
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Chou C, Liu W, Hong Y, Dahms H, Chiu C, Chang W, et al. Ethyl Acetate Extract of Scindapsus cf. hederaceus Exerts the Inhibitory Bioactivity on Human Non-Small Cell Lung Cancer Cells through Modulating ER Stress. Int J Mol Sci. 2018;19: pubmed publisher
Krishnamoorthy V, Khanna R, Parnaik V. E3 ubiquitin ligase HECW2 targets PCNA and lamin B1. Biochim Biophys Acta Mol Cell Res. 2018;1865:1088-1104 pubmed publisher
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Zhao L, Zhu Z, Yao C, Huang Y, Zhi E, Chen H, et al. VEGFC/VEGFR3 Signaling Regulates Mouse Spermatogonial Cell Proliferation via the Activation of AKT/MAPK and Cyclin D1 Pathway and Mediates the Apoptosis by affecting Caspase 3/9 and Bcl-2. Cell Cycle. 2018;17:225-239 pubmed publisher
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Chang W, Liu W, Chiu Y, Chen B, Chuang S, Chen Y, et al. A 4-Phenoxyphenol Derivative Exerts Inhibitory Effects on Human Hepatocellular Carcinoma Cells through Regulating Autophagy and Apoptosis Accompanied by Downregulating α-Tubulin Expression. Molecules. 2017;22: pubmed publisher
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Chao M, Huang H, HuangFu W, Hsu K, Liu Y, Wu Y, et al. An oral quinoline derivative, MPT0B392, causes leukemic cells mitotic arrest and overcomes drug resistant cancer cells. Oncotarget. 2017;8:27772-27785 pubmed publisher
Nepali K, Lee H, Lai M, Ojha R, Wu T, Wu G, et al. Ring-opened tetrahydro-?-carbolines display cytotoxicity and selectivity with histone deacetylase isoforms. Eur J Med Chem. 2017;127:115-127 pubmed publisher
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Liu X, Lv Z, Zou J, Liu X, Ma J, Wang J, et al. Afatinib down-regulates MCL-1 expression through the PERK-eIF2α-ATF4 axis and leads to apoptosis in head and neck squamous cell carcinoma. Am J Cancer Res. 2016;6:1708-19 pubmed
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Ren H, Guo H, Thakur A, Zhang S, Wang T, Liang Y, et al. Blockade efficacy of MEK/ERK-dependent autophagy enhances PI3K/Akt inhibitor NVP-BKM120's therapeutic effectiveness in lung cancer cells. Oncotarget. 2016;7:67277-67287 pubmed publisher
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Huang H, Chao M, Li Y, Chang L, Chen C, Chen M, et al. MPT0G066, a novel anti-mitotic drug, induces JNK-independent mitotic arrest, JNK-mediated apoptosis, and potentiates antineoplastic effect of cisplatin in ovarian cancer. Sci Rep. 2016;6:31664 pubmed publisher
Huang X, Huang R, Gou S, Wang Z, Liao Z, Wang H. Combretastatin A-4 Analogue: A Dual-Targeting and Tubulin Inhibitor Containing Antitumor Pt(IV) Moiety with a Unique Mode of Action. Bioconjug Chem. 2016;27:2132-48 pubmed publisher
Shi P, Oh Y, Zhang G, Yao W, Yue P, Li Y, et al. Met gene amplification and protein hyperactivation is a mechanism of resistance to both first and third generation EGFR inhibitors in lung cancer treatment. Cancer Lett. 2016;380:494-504 pubmed publisher
Repsold L, Pretorius E, Joubert A. Ex vivo apoptotic and autophagic influence of an estradiol analogue on platelets. Exp Hematol Oncol. 2015;5:18 pubmed publisher
Chen N, Chyau C, Lee Y, Tseng H, Chou F. Promotion of mitotic catastrophe via activation of PTEN by paclitaxel with supplement of mulberry water extract in bladder cancer cells. Sci Rep. 2016;6:20417 pubmed publisher
Lai Y, Chuang Y, Chang C, Yeh T. Macrophage migration inhibitory factor has a permissive role in concanavalin A-induced cell death of human hepatoma cells through autophagy. Cell Death Dis. 2015;6:e2008 pubmed publisher
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Oliver Metzig M, Fuchs D, Tagscherer K, Gröne H, Schirmacher P, Roth W. Inhibition of caspases primes colon cancer cells for 5-fluorouracil-induced TNF-α-dependent necroptosis driven by RIP1 kinase and NF-κB. Oncogene. 2016;35:3399-409 pubmed publisher
Fassl A, Tagscherer K, Richter J, De Castro Arce J, Savini C, Rösl F, et al. Inhibition of Notch1 signaling overcomes resistance to the death ligand Trail by specificity protein 1-dependent upregulation of death receptor 5. Cell Death Dis. 2015;6:e1921 pubmed publisher
Liu X, Guo S, Liu X, Su L. Chaetocin induces endoplasmic reticulum stress response and leads to death receptor 5-dependent apoptosis in human non-small cell lung cancer cells. Apoptosis. 2015;20:1499-507 pubmed publisher
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Liou J, Teng M, Tsai Y, Lin E, Chen B. UV-blocking spectacle lens protects against UV-induced decline of visual performance. Mol Vis. 2015;21:846-56 pubmed
Gkouskou K, Ioannou M, Pavlopoulos G, Georgila K, Siganou A, Nikolaidis G, et al. Apolipoprotein A-I inhibits experimental colitis and colitis-propelled carcinogenesis. Oncogene. 2016;35:2496-505 pubmed publisher
He S, Zhao Z, Yang Y, O Connell D, Zhang X, Oh S, et al. Truncating mutation in the autophagy gene UVRAG confers oncogenic properties and chemosensitivity in colorectal cancers. Nat Commun. 2015;6:7839 pubmed publisher
Lu J, Lin Y, Lai Y, Chen C, Hu C, Tien H, et al. MK-2206 induces apoptosis of AML cells and enhances the cytotoxicity of cytarabine. Med Oncol. 2015;32:206 pubmed publisher
Rodriguez M, Siwko S, Zeng L, Li J, Yi Z, Liu M. Prostate-specific G-protein-coupled receptor collaborates with loss of PTEN to promote prostate cancer progression. Oncogene. 2016;35:1153-62 pubmed publisher
Li J, Sharkey C, King M. Piperlongumine and immune cytokine TRAIL synergize to promote tumor death. Sci Rep. 2015;5:9987 pubmed publisher
Jaworski S, Sawosz E, Kutwin M, Wierzbicki M, Hinzmann M, Grodzik M, et al. In vitro and in vivo effects of graphene oxide and reduced graphene oxide on glioblastoma. Int J Nanomedicine. 2015;10:1585-96 pubmed publisher
Talaber G, Tuckermann J, Okret S. ACTH controls thymocyte homeostasis independent of glucocorticoids. FASEB J. 2015;29:2526-34 pubmed publisher
Kato S, Hayashi S, Kitahara Y, Nagasawa K, Aono H, Shibata J, et al. Saireito (TJ-114), a Japanese traditional herbal medicine, reduces 5-fluorouracil-induced intestinal mucositis in mice by inhibiting cytokine-mediated apoptosis in intestinal crypt cells. PLoS ONE. 2015;10:e0116213 pubmed publisher
Roobol A, Roobol J, Bastide A, Knight J, Willis A, Smales C. p58IPK is an inhibitor of the eIF2α kinase GCN2 and its localization and expression underpin protein synthesis and ER processing capacity. Biochem J. 2015;465:213-25 pubmed publisher
Liu T, Lo H, Wei L, Hsiao H, Yang P. S-Adenosyl-L-methionine-competitive inhibitors of the histone methyltransferase EZH2 induce autophagy and enhance drug sensitivity in cancer cells. Anticancer Drugs. 2015;26:139-47 pubmed publisher
Owonikoko T, Zhang G, Deng X, Rossi M, Switchenko J, Doho G, et al. Poly (ADP) ribose polymerase enzyme inhibitor, veliparib, potentiates chemotherapy and radiation in vitro and in vivo in small cell lung cancer. Cancer Med. 2014;3:1579-94 pubmed publisher
Xia M, Meng G, Jiang A, Chen A, Dahlhaus M, Gonzalez P, et al. Mitophagy switches cell death from apoptosis to necrosis in NSCLC cells treated with oncolytic measles virus. Oncotarget. 2014;5:3907-18 pubmed
Yan J, Zhong N, Liu G, Chen K, Liu X, Su L, et al. Usp9x- and Noxa-mediated Mcl-1 downregulation contributes to pemetrexed-induced apoptosis in human non-small-cell lung cancer cells. Cell Death Dis. 2014;5:e1316 pubmed publisher
Tsai A, Wang C, Liou J, Pai H, Hsiao C, Chang J, et al. Orally active microtubule-targeting agent, MPT0B271, for the treatment of human non-small cell lung cancer, alone and in combination with erlotinib. Cell Death Dis. 2014;5:e1162 pubmed publisher
Yi L, Zongyuan Y, Cheng G, Lingyun Z, Guilian Y, Wei G. Quercetin enhances apoptotic effect of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in ovarian cancer cells through reactive oxygen species (ROS) mediated CCAAT enhancer-binding protein homologous protein (CHOP)-death receptor 5 pa. Cancer Sci. 2014;105:520-7 pubmed publisher
Lin W, Tsai H, Liao H, Tang C, Wu Y, Hsu P, et al. Helicobacter pylori sensitizes TNF-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis in human gastric epithelial cells through regulation of FLIP. Cell Death Dis. 2014;5:e1109 pubmed publisher
Chen C, Chen M, Wang J, Tsai A, Chen C, Liou J, et al. Synergistic interaction between the HDAC inhibitor, MPT0E028, and sorafenib in liver cancer cells in vitro and in vivo. Clin Cancer Res. 2014;20:1274-1287 pubmed publisher
Mukherjee S, Chowdhury D, Kotcherlakota R, Patra S, B V, Bhadra M, et al. Potential theranostics application of bio-synthesized silver nanoparticles (4-in-1 system). Theranostics. 2014;4:316-35 pubmed publisher
Wang H, Lewsadder M, Dorn E, Xu S, Lakshmana M. RanBP9 overexpression reduces dendritic arbor and spine density. Neuroscience. 2014;265:253-62 pubmed publisher
Galvez Contreras A, Gonzalez Castañeda R, Luquin S, Guzmán Muñiz J, Moy Lopez N, Ramos Zúñiga R, et al. Diphenylhydantoin promotes proliferation in the subventricular zone and dentate gyrus. Am J Neurosci. 2012;3:1-9 pubmed
Zhao X, Liu X, Su L. Parthenolide induces apoptosis via TNFRSF10B and PMAIP1 pathways in human lung cancer cells. J Exp Clin Cancer Res. 2014;33:3 pubmed publisher
Paul S, Kundu R. Antiproliferative activity of methanolic extracts from two green algae, Enteromorpha intestinalis and Rizoclonium riparium on HeLa cells. Daru. 2013;21:72 pubmed publisher
Aulakh G, Balachandran Y, Liu L, Singh B. Angiostatin inhibits activation and migration of neutrophils. Cell Tissue Res. 2014;355:375-96 pubmed publisher
Hristova N, Tagscherer K, Fassl A, Kopitz J, Roth W. Notch1-dependent regulation of p27 determines cell fate in colorectal cancer. Int J Oncol. 2013;43:1967-75 pubmed publisher
Tsai A, Pai H, Wang C, Liou J, Teng C, Wang J, et al. In vitro and in vivo anti-tumour effects of MPT0B014, a novel derivative aroylquinoline, and in combination with erlotinib in human non-small-cell lung cancer cells. Br J Pharmacol. 2014;171:122-33 pubmed publisher
Weissinger D, Tagscherer K, Macher Göppinger S, Haferkamp A, Wagener N, Roth W. The soluble Decoy Receptor 3 is regulated by a PI3K-dependent mechanism and promotes migration and invasion in renal cell carcinoma. Mol Cancer. 2013;12:120 pubmed publisher
Kant S, Kumar A, Singh S. Tumor growth retardation and chemosensitizing action of fatty acid synthase inhibitor orlistat on T cell lymphoma: implication of reconstituted tumor microenvironment and multidrug resistance phenotype. Biochim Biophys Acta. 2014;1840:294-302 pubmed publisher
Huang C, Yang C, Jeng Y, Chen C, Wu H, Chang Y, et al. Autocrine/paracrine mechanism of interleukin-17B receptor promotes breast tumorigenesis through NF-?B-mediated antiapoptotic pathway. Oncogene. 2014;33:2968-77 pubmed publisher
Palavicini J, Lloyd B, Hayes C, Bianchi E, Kang D, Dawson Scully K, et al. RanBP9 Plays a Critical Role in Neonatal Brain Development in Mice. PLoS ONE. 2013;8:e66908 pubmed publisher
Wallace M, Russell A. Striated muscle activator of Rho signaling is required for myotube survival but does not influence basal protein synthesis or degradation. Am J Physiol Cell Physiol. 2013;305:C414-26 pubmed publisher
Chiu C, Haung J, Chang F, Huang K, Huang H, Huang H, et al. Golden berry-derived 4?-hydroxywithanolide E for selectively killing oral cancer cells by generating ROS, DNA damage, and apoptotic pathways. PLoS ONE. 2013;8:e64739 pubmed publisher
Saha T. LAMP2A overexpression in breast tumors promotes cancer cell survival via chaperone-mediated autophagy. Autophagy. 2012;8:1643-56 pubmed publisher
Hossain A, Radwan F, Doonan B, God J, Zhang L, Bell P, et al. A possible cross-talk between autophagy and apoptosis in generating an immune response in melanoma. Apoptosis. 2012;17:1066-78 pubmed publisher
Schultz C, Golembieski W, King D, Brown S, Brodie C, Rempel S. Inhibition of HSP27 alone or in combination with pAKT inhibition as therapeutic approaches to target SPARC-induced glioma cell survival. Mol Cancer. 2012;11:20 pubmed publisher
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Gonzalez Perez O, Chavez Casillas O, Jauregui Huerta F, Lopez Virgen V, Guzmán Muñiz J, Moy Lopez N, et al. Stress by noise produces differential effects on the proliferation rate of radial astrocytes and survival of neuroblasts in the adult subgranular zone. Neurosci Res. 2011;70:243-50 pubmed publisher
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product information
master code :
NB110-89719
SKU :
NB110-89719
product name :
Ki67/MKI67 Antibody - BSA Free
unit size :
0.1 ml (also 0.025 ml)
description :
The Ki67/MKI67 Antibody - BSA Free from Novus is a rabbit polyclonal antibody to Ki67/MKI67. This antibody reacts with human,mouse,rat. The Ki67/MKI67 Antibody - BSA Free has been validated for the following applications: Immunohistochemistry-Frozen,Immunocytochemistry/ Immunofluorescence,IF/IHC,Flow Cytometry,Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry.
target :
Ki67/MKI67
category :
Primary Antibodies
buffer :
PBS
clonality :
Polyclonal
concentration :
1 mg/ml
conjugate :
Unconjugated
host :
Rabbit
immunogen :
The immunogen for this KI67/MKI67 Antibody was made using a synthetic peptide from the internal region of Mouse KI67/MKI67, between aminoacids 2000-2050 (2021-2036) Uniprot# E9PVX6.
isotype :
IgG
purity :
Immunogen affinity purified
species :
Human,Mouse,Rat
theoretical molecular weight :
351 kDa
gene symbol :
MKI67
Antibody validation :
Biological Validation
accessionNumbers :
P46013
applications :
IF/IHC,Flow Cytometry,Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunocytochemistry/ Immunofluorescence,Immunohistochemistry
USD :
399 USD
alt names :
antigen identified by monoclonal Ki-67, antigen KI-67, Antigen Ki67, Ki67, Ki-67, KIA, Marker Of Proliferation Ki-67, MIB-, MIB-1, PPP1R105, Proliferation Marker Protein Ki-67, proliferation-related Ki-67 antigen, Protein Phosphatase 1, Regulatory Subunit 105
storage :
Store at 4C. Do not freeze.
more info or order :
company information
Novus Biologicals
10771 E Easter Ave
Centennial, CO 80112
novus@novusbio.com
https://www.novusbio.com
3037301950
headquarters: USA
Novus Biologicals licenses, manufactures, and markets antibodies to over 20,000 unique targets to support a wide array of research areas. Novus is built on honesty, collaboration and strong relationships and continues to provide quality tools that accelerate research. Every product is backed by our 100% guarantee.