product summary
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company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
Osteopontin/OPN Antibody (1B20) - BSA Free
catalog :
NB110-89062
quantity :
0.1 ml (also 0.025 ml)
price :
399 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
1B20
reactivity :
human, mouse, rat, bovine, domestic rabbit
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
citations: 106
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - paraffin section; domestic rabbit; loading ...; fig 7b
Cheng M, Wahafu T, Jiang G, Liu W, Qiao Y, Peng X, et al. A novel open-porous magnesium scaffold with controllable microstructures and properties for bone regeneration. Sci Rep. 2016;6:24134 pubmed publisher
  • immunohistochemistry - paraffin section; human
Di Bartolomeo M, Pietrantonio F, Pellegrinelli A, Martinetti A, Mariani L, Daidone M, et al. Osteopontin, E-cadherin, and β-catenin expression as prognostic biomarkers in patients with radically resected gastric cancer. Gastric Cancer. 2016;19:412-420 pubmed publisher
  • immunohistochemistry - paraffin section; human
Magro C, Momtahen S, Hagen J. Osteopontin expression in biopsies of calciphylaxis. Eur J Dermatol. 2015;25:20-5 pubmed publisher
  • immunohistochemistry - paraffin section; domestic rabbit
Nguyen T, Min Y, Lee B. Nanoparticle biphasic calcium phosphate loading on gelatin-pectin scaffold for improved bone regeneration. Tissue Eng Part A. 2015;21:1376-87 pubmed publisher
  • immunohistochemistry - paraffin section; rat
Fujita K, Fukuda M, Fukui H, Horie M, Endoh S, Uchida K, et al. Intratracheal instillation of single-wall carbon nanotubes in the rat lung induces time-dependent changes in gene expression. Nanotoxicology. 2015;9:290-301 pubmed publisher
  • immunohistochemistry - frozen section; human
  • western blot; human
Goswami R, Millo T, Mishra S, Das M, Kapoor M, Tomar N, et al. Expression of osteogenic molecules in the caudate nucleus and gray matter and their potential relevance for Basal Ganglia calcification in hypoparathyroidism. J Clin Endocrinol Metab. 2014;99:1741-8 pubmed publisher
  • immunohistochemistry - paraffin section; domestic rabbit; 1:100
  • immunocytochemistry; domestic rabbit; 1:200
Nguyen T, Lee B. A combination of biphasic calcium phosphate scaffold with hyaluronic acid-gelatin hydrogel as a new tool for bone regeneration. Tissue Eng Part A. 2014;20:1993-2004 pubmed publisher
  • immunohistochemistry - frozen section; rat
  • immunocytochemistry; rat
Nikodemova M, Small A, Smith S, Mitchell G, Watters J. Spinal but not cortical microglia acquire an atypical phenotype with high VEGF, galectin-3 and osteopontin, and blunted inflammatory responses in ALS rats. Neurobiol Dis. 2014;69:43-53 pubmed publisher
  • immunohistochemistry - paraffin section; domestic rabbit
Bondarenko A, Angrisani N, Meyer Lindenberg A, Seitz J, Waizy H, Reifenrath J. Magnesium-based bone implants: immunohistochemical analysis of peri-implant osteogenesis by evaluation of osteopontin and osteocalcin expression. J Biomed Mater Res A. 2014;102:1449-57 pubmed publisher
  • immunohistochemistry; human
Rui Y, Lui P, Rolf C, Wong Y, Lee Y, Chan K. Expression of chondro-osteogenic BMPs in clinical samples of patellar tendinopathy. Knee Surg Sports Traumatol Arthrosc. 2012;20:1409-17 pubmed publisher
  • western blot; human
Kon S, Yokosaki Y, Maeda M, Segawa T, Horikoshi Y, Tsukagoshi H, et al. Mapping of functional epitopes of osteopontin by monoclonal antibodies raised against defined internal sequences. J Cell Biochem. 2002;84:420-32 pubmed
Zhao L, Wang Z, Tan Y, Ma J, Huang W, Zhang X, et al. IL-17A/CEBPβ/OPN/LYVE-1 axis inhibits anti-tumor immunity by promoting tumor-associated tissue-resident macrophages. Cell Rep. 2024;43:115039 pubmed publisher
Anerillas L, Wiberg M, Kingham P, Kelk P. Platelet lysate for expansion or osteogenic differentiation of bone marrow mesenchymal stem cells for 3D tissue constructs. Regen Ther. 2023;24:298-310 pubmed publisher
Abou Rjeileh U, Dos Santos Neto J, Chirivi M, O Boyle N, Salcedo D, Prom C, et al. Oleic acid abomasal infusion limits lipolysis and improves insulin sensitivity in adipose tissue from periparturient dairy cows. J Dairy Sci. 2023;106:4306-4323 pubmed publisher
Li J, Li W, Kong M, Li Z, Yang T, Wang Q, et al. Self-healing hybrid hydrogels with sustained bioactive components release for guided bone regeneration. J Nanobiotechnology. 2023;21:62 pubmed publisher
Liao H, Zou Z, Liu W, Guo X, Xie J, Li L, et al. Osteopontin-integrin signaling positively regulates neuroplasticity through enhancing neural autophagy in the peri-infarct area after ischemic stroke. Am J Transl Res. 2022;14:7726-7743 pubmed
Shen J, Fan Z, Wu C, Qi G, Cao Q, Xu F. Sacubitril Valsartan Enhances Cardiac Function and Alleviates Myocardial Infarction in Rats through a SUV39H1/SPP1 Axis. Oxid Med Cell Longev. 2022;2022:5009289 pubmed publisher
Fan C, Li Z, Ji Q, Sun H, Liang Y, Yang P. Carboxymethyl chitin or chitosan for osteoinduction effect on the human periodontal ligament stem cells. Dent Mater J. 2022;41:392-401 pubmed publisher
Park S, Park M, Lee B. Autologous stromal vascular fraction-loaded hyaluronic acid/gelatin-biphasic calcium phosphate scaffold for bone tissue regeneration. Mater Sci Eng C Mater Biol Appl. 2022;132:112533 pubmed publisher
Oliveros Anerillas L, Kingham P, Lammi M, Wiberg M, Kelk P. Three-Dimensional Osteogenic Differentiation of Bone Marrow Mesenchymal Stem Cells Promotes Matrix Metallopeptidase 13 (MMP13) Expression in Type I Collagen Hydrogels. Int J Mol Sci. 2021;22: pubmed publisher
V x103 ru x163 R, Melinte P, P xee rvu A, G xee ngu O, Sima G, Oancea C, et al. Calcium fructoborate coating of titanium-hydroxyapatite implants by chemisorption deposition improves implant osseointegration in the femur of New Zealand White rabbit experimental model. Rom J Morphol Embryol. 2020;61:1235-1247 pubmed publisher
Acharya T, Kumar S, Tiwari N, Ghosh A, Tiwari A, Pal S, et al. TRPM8 channel inhibitor-encapsulated hydrogel as a tunable surface for bone tissue engineering. Sci Rep. 2021;11:3730 pubmed publisher
Padalhin A, Ventura R, Kim B, Sultana T, Park C, Lee B. Boosting osteogenic potential and bone regeneration by co-cultured cell derived extracellular matrix incorporated porous electrospun scaffold. J Biomater Sci Polym Ed. 2021;:1-20 pubmed publisher
Kerns M, Miller R, Mazhar M, Byrd A, Archer N, Pinkser B, et al. Pathogenic and therapeutic role for NRF2 signaling in ultraviolet light-induced skin pigmentation. JCI Insight. 2020;5: pubmed publisher
Shang L, Deng D, Roffel S, Gibbs S. Differential influence of Streptococcus mitis on host response to metals in reconstructed human skin and oral mucosa. Contact Dermatitis. 2020;83:347-360 pubmed publisher
Yu J, Berga S, Zou W, Rajakumar A, Man M, Sidell N, et al. Human Endometrial Stromal Cell Differentiation is Stimulated by PPARβ/δ Activation: New Targets for Infertility?. J Clin Endocrinol Metab. 2020;105: pubmed publisher
Kang H, Makkar P, Padalhin A, Lee G, Im S, Lee B. Comparative study on biodegradation and biocompatibility of multichannel calcium phosphate based bone substitutes. Mater Sci Eng C Mater Biol Appl. 2020;110:110694 pubmed publisher
Scimeca M, Anemona L, Granaglia A, Bonfiglio R, Urbano N, Toschi N, et al. Plaque calcification is driven by different mechanisms of mineralization associated with specific cardiovascular risk factors. Nutr Metab Cardiovasc Dis. 2019;29:1330-1336 pubmed publisher
Igase M, Shousu K, Fujiki N, Sakurai M, Bonkobara M, Hwang C, et al. Anti-tumour activity of oncolytic reovirus against canine histiocytic sarcoma cells. Vet Comp Oncol. 2019;17:184-193 pubmed publisher
Gao X, Gao S, Guan Y, Huang L, Huang J, Lin L, et al. Toll-like receptor 3 controls QT interval on the electrocardiogram by targeting the degradation of Kv4.2/4.3 channels in the endoplasmic reticulum. FASEB J. 2019;33:6197-6208 pubmed publisher
Regel I, Raulefs S, Benitz S, Mihaljevic C, Rieder S, Leinenkugel G, et al. Loss of TLR3 and its downstream signaling accelerates acinar cell damage in the acute phase of pancreatitis. Pancreatology. 2019;19:149-157 pubmed publisher
Zhu J, Message S, Mallia P, Kebadze T, Contoli M, Ward C, et al. Bronchial mucosal IFN-α/β and pattern recognition receptor expression in patients with experimental rhinovirus-induced asthma exacerbations. J Allergy Clin Immunol. 2019;143:114-125.e4 pubmed publisher
Alyessary A, Yap A, Othman S, Rahman M, Al Namnam N, Radzi Z. Is there an optimal initial amount of activation for midpalatal suture expansion? : A histomorphometric and immunohistochemical study in a rabbit model. J Orofac Orthop. 2018;79:169-179 pubmed publisher
Gu R, Ding M, Shi D, Huang T, Guo M, Yu L, et al. Calcium/Calmodulin-Dependent Protein Kinase IV Mediates IFN-γ-Induced Immune Behaviors in Skeletal Muscle Cells. Cell Physiol Biochem. 2018;46:351-364 pubmed publisher
Zou H, Su R, Ruan J, Shao H, Qian K, Ye J, et al. Toll-like receptor 3 pathway restricts Marek's disease virus infection. Oncotarget. 2017;8:70847-70853 pubmed publisher
Auger J, Santinón A, Roy D, Mossman K, Xu J, Segura M, et al. Type I Interferon Induced by Streptococcus suis Serotype 2 is Strain-Dependent and May Be Beneficial for Host Survival. Front Immunol. 2017;8:1039 pubmed publisher
Jayash S, Hashim N, Misran M, Baharuddin N. Local application of osteoprotegerin-chitosan gel in critical-sized defects in a rabbit model. Peerj. 2017;5:e3513 pubmed publisher
Wada S, Kanzaki H, Narimiya T, Nakamura Y. Novel device for application of continuous mechanical tensile strain to mammalian cells. Biol Open. 2017;6:518-524 pubmed publisher
Larsson O, Tengroth L, Xu Y, Uddman R, Kumlien Georén S, Cardell L. Substance P represents a novel first-line defense mechanism in the nose. J Allergy Clin Immunol. 2018;141:128-136.e3 pubmed publisher
Brempelis K, Yuen S, Schwarz N, Mohar I, Crispe I. Central role of the TIR-domain-containing adaptor-inducing interferon-β (TRIF) adaptor protein in murine sterile liver injury. Hepatology. 2017;65:1336-1351 pubmed publisher
Helminen O, Huhta H, Kauppila J, Lehenkari P, Saarnio J, Karttunen T. Localization of nucleic acid-sensing toll-like receptors in human and mouse pancreas. APMIS. 2017;125:85-92 pubmed publisher
Wu Y, Su W, Wu P, Shen P, Jou I. Degradation of elastic fiber and elevated elastase expression in long head of biceps tendinopathy. J Orthop Res. 2017;35:1919-1926 pubmed publisher
Jayash S, Hashim N, Misran M, Baharuddin N. In vitro evaluation of osteoprotegerin in chitosan for potential bone defect applications. Peerj. 2016;4:e2229 pubmed publisher
Huhta H, Helminen O, Kauppila J, Salo T, Porvari K, Saarnio J, et al. The Expression of Toll-like Receptors in Normal Human and Murine Gastrointestinal Organs and the Effect of Microbiome and Cancer. J Histochem Cytochem. 2016;64:470-82 pubmed publisher
Silva Barrios S, Smans M, Duerr C, Qureshi S, Fritz J, Descoteaux A, et al. Innate Immune B Cell Activation by Leishmania donovani Exacerbates Disease and Mediates Hypergammaglobulinemia. Cell Rep. 2016;15:2427-37 pubmed publisher
Evangelista M, Castro S, Alves C, Dias A, Souza V, Reis L, et al. Early IFN-? production together with decreased expression of TLR3 and TLR9 characterizes EAE development conditional on the presence of myelin. Autoimmunity. 2016;49:258-67 pubmed publisher
Yang Y, Wang S, Huang Z, Zou H, Yan B, Luo W, et al. The RNA-binding protein Mex3B is a coreceptor of Toll-like receptor 3 in innate antiviral response. Cell Res. 2016;26:288-303 pubmed publisher
Reins R, Baidouri H, McDermott A. Vitamin D Activation and Function in Human Corneal Epithelial Cells During TLR-Induced Inflammation. Invest Ophthalmol Vis Sci. 2015;56:7715-27 pubmed publisher
Jamin A, Dehoux L, Dossier C, Fila M, Heming N, Monteiro R, et al. Toll-like receptor 3 expression and function in childhood idiopathic nephrotic syndrome. Clin Exp Immunol. 2015;182:332-45 pubmed publisher
Wang K, Xiao J, Peng B, Xing F, So K, Tipoe G, et al. Retinal structure and function preservation by polysaccharides of wolfberry in a mouse model of retinal degeneration. Sci Rep. 2014;4:7601 pubmed publisher
Addison J, Koontz C, Fugett J, Creighton C, Chen D, Farrugia M, et al. KAP1 promotes proliferation and metastatic progression of breast cancer cells. Cancer Res. 2015;75:344-55 pubmed publisher
Tengroth L, Arebro J, Kumlien Geor n S, Winqvist O, Cardell L. Deprived TLR9 expression in apparently healthy nasal mucosa might trigger polyp-growth in chronic rhinosinusitis patients. PLoS ONE. 2014;9:e105618 pubmed publisher
Li J, Setiawan M, Wu H, Beuerman R, Zhao P. Regulation of Toll-like receptor expression in human conjunctival epithelial cells. Mediators Inflamm. 2014;2014:493596 pubmed publisher
Chatterjee P, Chiasson V, Seerangan G, Tobin R, Kopriva S, Newell Rogers M, et al. Cotreatment with interleukin 4 and interleukin 10 modulates immune cells and prevents hypertension in pregnant mice. Am J Hypertens. 2015;28:135-42 pubmed publisher
Tengroth L, Millrud C, Kvarnhammar A, Kumlien Georén S, Latif L, Cardell L. Functional effects of Toll-like receptor (TLR)3, 7, 9, RIG-I and MDA-5 stimulation in nasal epithelial cells. PLoS ONE. 2014;9:e98239 pubmed publisher
Green T, Santos M, Ejaeidi A, Craft B, Lewis R, Cruse J. Toll-like receptor (TLR) expression of immune system cells from metastatic breast cancer patients with circulating tumor cells. Exp Mol Pathol. 2014;97:44-8 pubmed publisher
Ichikawa T, Sugiura H, Koarai A, Minakata Y, Kikuchi T, Morishita Y, et al. TLR3 activation augments matrix metalloproteinase production through reactive nitrogen species generation in human lung fibroblasts. J Immunol. 2014;192:4977-88 pubmed publisher
Pohar J, Pirher N, Bencina M, Mancek Keber M, Jerala R. The ectodomain of TLR3 receptor is required for its plasma membrane translocation. PLoS ONE. 2014;9:e92391 pubmed publisher
Hamidi S, Schäfer Korting M, Weindl G. TLR2/1 and sphingosine 1-phosphate modulate inflammation, myofibroblast differentiation and cell migration in fibroblasts. Biochim Biophys Acta. 2014;1841:484-94 pubmed publisher
Anagandula M, Richardson S, Oberste M, Sioofy Khojine A, Hyoty H, Morgan N, et al. Infection of human islets of Langerhans with two strains of Coxsackie B virus serotype 1: assessment of virus replication, degree of cell death and induction of genes involved in the innate immunity pathway. J Med Virol. 2014;86:1402-11 pubmed publisher
Fadnis P, Ravi V, Desai A, Turtle L, Solomon T. Innate immune mechanisms in Japanese encephalitis virus infection: effect on transcription of pattern recognition receptors in mouse neuronal cells and brain tissue. Viral Immunol. 2013;26:366-77 pubmed publisher
Østvik A, Granlund A, Torp S, Flatberg A, Beisvag V, Waldum H, et al. Expression of Toll-like receptor-3 is enhanced in active inflammatory bowel disease and mediates the excessive release of lipocalin 2. Clin Exp Immunol. 2013;173:502-11 pubmed publisher
Abdi J, Mutis T, Garssen J, Redegeld F. Characterization of the Toll-like receptor expression profile in human multiple myeloma cells. PLoS ONE. 2013;8:e60671 pubmed publisher
Yan K, Zhu W, Yu L, Li N, Zhang X, Liu P, et al. Toll-like receptor 3 and RIG-I-like receptor activation induces innate antiviral responses in mouse ovarian granulosa cells. Mol Cell Endocrinol. 2013;372:73-85 pubmed publisher
Pohar J, Pirher N, Bencina M, Mancek Keber M, Jerala R. The role of UNC93B1 protein in surface localization of TLR3 receptor and in cell priming to nucleic acid agonists. J Biol Chem. 2013;288:442-54 pubmed publisher
Yamashita M, Chattopadhyay S, Fensterl V, Saikia P, Wetzel J, Sen G. Epidermal growth factor receptor is essential for Toll-like receptor 3 signaling. Sci Signal. 2012;5:ra50 pubmed publisher
Xu L, Song C, Ni M, Meng F, Xie H, Li G. Cellular retinol-binding protein 1 (CRBP-1) regulates osteogenenesis and adipogenesis of mesenchymal stem cells through inhibiting RXR?-induced ?-catenin degradation. Int J Biochem Cell Biol. 2012;44:612-9 pubmed publisher
Kleinman M, Kaneko H, Cho W, Dridi S, Fowler B, Blandford A, et al. Short-interfering RNAs induce retinal degeneration via TLR3 and IRF3. Mol Ther. 2012;20:101-8 pubmed publisher
Menendez D, Shatz M, Azzam K, Garantziotis S, Fessler M, Resnick M. The Toll-like receptor gene family is integrated into human DNA damage and p53 networks. PLoS Genet. 2011;7:e1001360 pubmed publisher
Kuznik A, Bencina M, Svajger U, Jeras M, Rozman B, Jerala R. Mechanism of endosomal TLR inhibition by antimalarial drugs and imidazoquinolines. J Immunol. 2011;186:4794-804 pubmed publisher
Dasgupta G, Chentoufi A, You S, Falatoonzadeh P, Urbano L, Akhtarmalik A, et al. Engagement of TLR2 reverses the suppressor function of conjunctiva CD4+CD25+ regulatory T cells and promotes herpes simplex virus epitope-specific CD4+CD25- effector T cell responses. Invest Ophthalmol Vis Sci. 2011;52:3321-33 pubmed publisher
Peltier D, Simms A, Farmer J, Miller D. Human neuronal cells possess functional cytoplasmic and TLR-mediated innate immune pathways influenced by phosphatidylinositol-3 kinase signaling. J Immunol. 2010;184:7010-21 pubmed publisher
Taura M, Fukuda R, Suico M, Eguma A, Koga T, Shuto T, et al. TLR3 induction by anticancer drugs potentiates poly I:C-induced tumor cell apoptosis. Cancer Sci. 2010;101:1610-7 pubmed publisher
Johnston M, Wang A, Catarino M, Ball L, Phan V, MacDonald J, et al. Extracts of the rat tapeworm, Hymenolepis diminuta, suppress macrophage activation in vitro and alleviate chemically induced colitis in mice. Infect Immun. 2010;78:1364-75 pubmed publisher
Ménager P, Roux P, Mégret F, Bourgeois J, Le Sourd A, Danckaert A, et al. Toll-like receptor 3 (TLR3) plays a major role in the formation of rabies virus Negri Bodies. PLoS Pathog. 2009;5:e1000315 pubmed publisher
Sacre S, Lo A, Gregory B, Simmonds R, Williams L, Feldmann M, et al. Inhibitors of TLR8 reduce TNF production from human rheumatoid synovial membrane cultures. J Immunol. 2008;181:8002-9 pubmed
Taura M, Eguma A, Suico M, Shuto T, Koga T, Komatsu K, et al. p53 regulates Toll-like receptor 3 expression and function in human epithelial cell lines. Mol Cell Biol. 2008;28:6557-67 pubmed publisher
Cohen P, Koski G, Czerniecki B, Bunting K, Fu X, Wang Z, et al. STAT3- and STAT5-dependent pathways competitively regulate the pan-differentiation of CD34pos cells into tumor-competent dendritic cells. Blood. 2008;112:1832-43 pubmed publisher
Fukuda K, Watanabe T, Tokisue T, Tsujita T, Nishikawa S, Hasegawa T, et al. Modulation of double-stranded RNA recognition by the N-terminal histidine-rich region of the human toll-like receptor 3. J Biol Chem. 2008;283:22787-94 pubmed publisher
Burgener I, Jungi T. Antibodies specific for human or murine Toll-like receptors detect canine leukocytes by flow cytometry. Vet Immunol Immunopathol. 2008;124:184-91 pubmed publisher
Kleinman M, Yamada K, Takeda A, Chandrasekaran V, Nozaki M, Baffi J, et al. Sequence- and target-independent angiogenesis suppression by siRNA via TLR3. Nature. 2008;452:591-7 pubmed publisher
Kim H, Yang E, Lee J, Kim S, Shin J, Park J, et al. Double-stranded RNA mediates interferon regulatory factor 3 activation and interleukin-6 production by engaging Toll-like receptor 3 in human brain astrocytes. Immunology. 2008;124:480-8 pubmed publisher
Duffy K, Lamb R, San Mateo L, Jordan J, Canziani G, Brigham Burke M, et al. Down modulation of human TLR3 function by a monoclonal antibody. Cell Immunol. 2007;248:103-14 pubmed
Morikawa T, Sugiyama A, Kume H, Ota S, Kashima T, Tomita K, et al. Identification of Toll-like receptor 3 as a potential therapeutic target in clear cell renal cell carcinoma. Clin Cancer Res. 2007;13:5703-9 pubmed
Lundberg A, Drexler S, Monaco C, Williams L, Sacre S, Feldmann M, et al. Key differences in TLR3/poly I:C signaling and cytokine induction by human primary cells: a phenomenon absent from murine cell systems. Blood. 2007;110:3245-52 pubmed
Ranjith Kumar C, Miller W, Sun J, Xiong J, Santos J, Yarbrough I, et al. Effects of single nucleotide polymorphisms on Toll-like receptor 3 activity and expression in cultured cells. J Biol Chem. 2007;282:17696-705 pubmed
Wong C, Cheung P, Ip W, Lam C. Intracellular signaling mechanisms regulating toll-like receptor-mediated activation of eosinophils. Am J Respir Cell Mol Biol. 2007;37:85-96 pubmed
Ranjith Kumar C, Miller W, Xiong J, Russell W, Lamb R, Santos J, et al. Biochemical and functional analyses of the human Toll-like receptor 3 ectodomain. J Biol Chem. 2007;282:7668-78 pubmed
Xu S, Koldovsky U, Xu M, Wang D, Fitzpatrick E, Son G, et al. High-avidity antitumor T-cell generation by toll receptor 8-primed, myeloid- derived dendritic cells is mediated by IL-12 production. Surgery. 2006;140:170-8 pubmed
Johnsen I, Nguyen T, Ringdal M, Tryggestad A, Bakke O, Lien E, et al. Toll-like receptor 3 associates with c-Src tyrosine kinase on endosomes to initiate antiviral signaling. EMBO J. 2006;25:3335-46 pubmed
Yang X, Murthy V, Schultz K, Tatro J, Fitzgerald K, Beasley D. Toll-like receptor 3 signaling evokes a proinflammatory and proliferative phenotype in human vascular smooth muscle cells. Am J Physiol Heart Circ Physiol. 2006;291:H2334-43 pubmed
Sun J, Duffy K, Ranjith Kumar C, Xiong J, Lamb R, Santos J, et al. Structural and functional analyses of the human Toll-like receptor 3. Role of glycosylation. J Biol Chem. 2006;281:11144-51 pubmed
LeBouder E, Rey Nores J, Raby A, Affolter M, Vidal K, Thornton C, et al. Modulation of neonatal microbial recognition: TLR-mediated innate immune responses are specifically and differentially modulated by human milk. J Immunol. 2006;176:3742-52 pubmed
Mansson A, Adner M, Cardell L. Toll-like receptors in cellular subsets of human tonsil T cells: altered expression during recurrent tonsillitis. Respir Res. 2006;7:36 pubmed
Groskreutz D, Monick M, Powers L, Yarovinsky T, Look D, Hunninghake G. Respiratory syncytial virus induces TLR3 protein and protein kinase R, leading to increased double-stranded RNA responsiveness in airway epithelial cells. J Immunol. 2006;176:1733-40 pubmed
Qi H, Shelhamer J. Toll-like receptor 4 signaling regulates cytosolic phospholipase A2 activation and lipid generation in lipopolysaccharide-stimulated macrophages. J Biol Chem. 2005;280:38969-75 pubmed
de Bouteiller O, Merck E, Hasan U, Hubac S, Benguigui B, Trinchieri G, et al. Recognition of double-stranded RNA by human toll-like receptor 3 and downstream receptor signaling requires multimerization and an acidic pH. J Biol Chem. 2005;280:38133-45 pubmed
Furrie E, Macfarlane S, Thomson G, Macfarlane G. Toll-like receptors-2, -3 and -4 expression patterns on human colon and their regulation by mucosal-associated bacteria. Immunology. 2005;115:565-74 pubmed
Schneeman T, Bruno M, Schjerven H, Johansen F, Chady L, Kaetzel C. Regulation of the polymeric Ig receptor by signaling through TLRs 3 and 4: linking innate and adaptive immune responses. J Immunol. 2005;175:376-84 pubmed
Ueta M, Hamuro J, Kiyono H, Kinoshita S. Triggering of TLR3 by polyI:C in human corneal epithelial cells to induce inflammatory cytokines. Biochem Biophys Res Commun. 2005;331:285-94 pubmed
Francois S, El Benna J, Dang P, Pedruzzi E, Gougerot Pocidalo M, Elbim C. Inhibition of neutrophil apoptosis by TLR agonists in whole blood: involvement of the phosphoinositide 3-kinase/Akt and NF-kappaB signaling pathways, leading to increased levels of Mcl-1, A1, and phosphorylated Bad. J Immunol. 2005;174:3633-42 pubmed
Li K, Chen Z, Kato N, Gale M, Lemon S. Distinct poly(I-C) and virus-activated signaling pathways leading to interferon-beta production in hepatocytes. J Biol Chem. 2005;280:16739-47 pubmed
Harii N, Lewis C, Vasko V, McCall K, Benavides Peralta U, Sun X, et al. Thyrocytes express a functional toll-like receptor 3: overexpression can be induced by viral infection and reversed by phenylmethimazole and is associated with Hashimoto's autoimmune thyroiditis. Mol Endocrinol. 2005;19:1231-50 pubmed
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Wen L, Peng J, Li Z, Wong F. The effect of innate immunity on autoimmune diabetes and the expression of Toll-like receptors on pancreatic islets. J Immunol. 2004;172:3173-80 pubmed
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product information
master code :
NB110-89062
SKU :
NB110-89062
product name :
Osteopontin/OPN Antibody (1B20) - BSA Free
unit size :
0.1 ml (also 0.025 ml)
description :
The Osteopontin/OPN Antibody (1B20) - BSA Free from Novus is a mouse monoclonal antibody to Osteopontin/OPN. This antibody reacts with bovine,human,mouse,rabbit,rat. The Osteopontin/OPN Antibody (1B20) - BSA Free has been validated for the following applications: Western Blot,Immunohistochemistry,IF/IHC,Simple Western,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunocytochemistry/ Immunofluorescence,Immunoprecipitation.
target :
Osteopontin/OPN
category :
Primary Antibodies
buffer :
PBS pH 7.4
clonality :
Monoclonal
clone :
1B20
concentration :
1 mg/ml
conjugate :
Unconjugated
host :
Mouse
immunogen :
Synthetic peptide corresponding to the C-terminus of human Osteopontin [Swiss-Prot# P10451].
isotype :
IgG1
purity :
Protein G purified
species :
Bovine,Human,Mouse,Rabbit,Rat
gene symbol :
SPP1
accessionNumbers :
p10451, P08721
applications :
Immunohistochemistry,IF/IHC,Simple Western,Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunocytochemistry/ Immunofluorescence,Immunoprecipitation
USD :
399 USD
alt names :
BNSP, Bone sialoprotein 1, MGC110940, Nephropontin, osteopontin, secreted phosphoprotein 1bone sialoprotein I, early T-lymphocyteactivation 1), secreted phosphoprotein-1 (osteopontin, bone sialoprotein), SPP-1, SPP1/CALPHA1 fusion, Urinary stone protein, uropontin
storage :
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
more info or order :
company information
Novus Biologicals
10771 E Easter Ave
Centennial, CO 80112
novus@novusbio.com
https://www.novusbio.com
3037301950
headquarters: USA
Novus Biologicals licenses, manufactures, and markets antibodies to over 20,000 unique targets to support a wide array of research areas. Novus is built on honesty, collaboration and strong relationships and continues to provide quality tools that accelerate research. Every product is backed by our 100% guarantee.