SIAH2 Antibody (24E6H3) - BSA Free | Novus Biologicals NB110-88113 product information

product summary

company name :

Novus Biologicals

other brands :

IMGENEX

product type :

antibody

product name :

SIAH2 Antibody (24E6H3) - BSA Free

catalog :

NB110-88113

quantity :

0.5 ml (also 0.125 ml)

price :

409 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

24E6H3

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

more info or order :

Novus Biologicals product webpage

citations: 38

Published Application/Species/Sample/Dilution	Reference
western blot; human; 1:500; fig 5	Ma B, Cheng H, Gao R, Mu C, Chen L, Wu S, et al. Zyxin-Siah2-Lats2 axis mediates cooperation between Hippo and TGF-β signalling pathways. Nat Commun. 2016;7:11123 pubmed publisher
immunohistochemistry - paraffin section; human	Qin R, Smyrk T, Reed N, Schmidt R, Schnelldorfer T, Chari S, et al. Combining clinicopathological predictors and molecular biomarkers in the oncogenic K-RAS/Ki67/HIF-1Î± pathway to predict survival in resectable pancreatic cancer. Br J Cancer. 2015;112:514-22 pubmed publisher
immunohistochemistry - paraffin section; human	Tanaka T, Li T, Urata Y, Goto S, Ono Y, Kawakatsu M, et al. Increased expression of PHD3 represses the HIF-1 signaling pathway and contributes to poor neovascularization in pancreatic ductal adenocarcinoma. J Gastroenterol. 2015;50:975-83 pubmed publisher
immunohistochemistry - paraffin section; human immunohistochemistry; human; 1:40; fig 4	Ma B, Chen Y, Chen L, Cheng H, Mu C, Li J, et al. Hypoxia regulates Hippo signalling through the SIAH2 ubiquitin E3 ligase. Nat Cell Biol. 2015;17:95-103 pubmed publisher
immunohistochemistry - paraffin section; human	Rizzardi A, Rosener N, Koopmeiners J, Isaksson Vogel R, Metzger G, Forster C, et al. Evaluation of protein biomarkers of prostate cancer aggressiveness. BMC Cancer. 2014;14:244 pubmed publisher
immunohistochemistry; human	Qi J, Tripathi M, Mishra R, Sahgal N, Fazli L, Fazil L, et al. The E3 ubiquitin ligase Siah2 contributes to castration-resistant prostate cancer by regulation of androgen receptor transcriptional activity. Cancer Cell. 2013;23:332-46 pubmed publisher
immunohistochemistry; human	Chan P, Möller A, Liu M, Sceneay J, Wong C, Waddell N, et al. The expression of the ubiquitin ligase SIAH2 (seven in absentia homolog 2) is mediated through gene copy number in breast cancer and is associated with a basal-like phenotype and p53 expression. Breast Cancer Res. 2011;13:R19 pubmed publisher
immunohistochemistry; human western blot; human	Ahmed A, Schmidt R, Park C, Reed N, Hesse S, Thomas C, et al. Effect of disrupting seven-in-absentia homolog 2 function on lung cancer cell growth. J Natl Cancer Inst. 2008;100:1606-29 pubmed publisher
flow cytometry; human immunocytochemistry; human immunohistochemistry; human western blot; human	Schmidt R, Park C, Ahmed A, Gundelach J, Reed N, Cheng S, et al. Inhibition of RAS-mediated transformation and tumorigenesis by targeting the downstream E3 ubiquitin ligase seven in absentia homologue. Cancer Res. 2007;67:11798-810 pubmed
	Liu Q, Luo Q, Feng J, Zhao Y, Ma B, Cheng H, et al. Hypoxia-induced proteasomal degradation of DBC1 by SIAH2 in breast cancer progression. elife. 2022;11: pubmed publisher
	Yan T, Zhou D, Shi Y, Cui D, Jiang J, Han B, et al. Targeting ADT-Induced Activation of the E3 Ubiquitin Ligase Siah2 to Delay the Occurrence of Castration-Resistant Prostate Cancer. Front Oncol. 2021;11:637040 pubmed publisher
	Zhang X, Liu S, Zhang C, Zhang S, Yue Y, Zhang Y, et al. The role of AMPKα2 in the HFD-induced nonalcoholic steatohepatitis. Biochim Biophys Acta Mol Basis Dis. 2020;1866:165854 pubmed publisher
	Herum K, Romaine A, Wang A, Melleby A, Strand M, Pacheco J, et al. Syndecan-4 Protects the Heart From the Profibrotic Effects of Thrombin-Cleaved Osteopontin. J Am Heart Assoc. 2020;9:e013518 pubmed publisher
	Waise S, Parker R, Rose Zerilli M, Layfield D, Wood O, West J, et al. An optimised tissue disaggregation and data processing pipeline for characterising fibroblast phenotypes using single-cell RNA sequencing. Sci Rep. 2019;9:9580 pubmed publisher
	Hughes S, Hemenway E, Guo F, Yi K, Yu Z, Hawley R. The E3 ubiquitin ligase Sina regulates the assembly and disassembly of the synaptonemal complex in Drosophila females. PLoS Genet. 2019;15:e1008161 pubmed publisher
	Zhu J, Kovacs L, Han W, Liu G, Huo Y, Lucas R, et al. ROS-Dependent Calpain Activation Contributes to Airway and Pulmonary Vascular Remodeling in COPD. Antioxid Redox Signal. 2019;: pubmed publisher
	Majumder S, Ren L, Pushpakumar S, Sen U. Hydrogen sulphide mitigates homocysteine-induced apoptosis and matrix remodelling in mesangial cells through Akt/FOXO1 signalling cascade. Cell Signal. 2019;61:66-77 pubmed publisher
	Ma B, Cheng H, Mu C, Geng G, Zhao T, Luo Q, et al. The SIAH2-NRF1 axis spatially regulates tumor microenvironment remodeling for tumor progression. Nat Commun. 2019;10:1034 pubmed publisher
	Kovacs L, Cao Y, Han W, Meadows L, Kovacs Kasa A, Kondrikov D, et al. PFKFB3 in Smooth Muscle Promotes Vascular Remodeling in Pulmonary Arterial Hypertension. Am J Respir Crit Care Med. 2019;: pubmed publisher
	Wang X, Pan J, Liu H, Zhang M, Liu D, Lu L, et al. AIM2 gene silencing attenuates diabetic cardiomyopathy in type 2 diabetic rat model. Life Sci. 2019;221:249-258 pubmed publisher
	Grigorova Y, Wei W, Petrashevskaya N, Zernetkina V, Juhasz O, Fenner R, et al. Dietary Sodium Restriction Reduces Arterial Stiffness, Vascular TGF-β-Dependent Fibrosis and Marinobufagenin in Young Normotensive Rats. Int J Mol Sci. 2018;19: pubmed publisher
	Ma Z, Wei Q, Zhang M, Chen J, Dong Z. Dicer deficiency in proximal tubules exacerbates renal injury and tubulointerstitial fibrosis and upregulates Smad2/3. Am J Physiol Renal Physiol. 2018;315:F1822-F1832 pubmed publisher
	Shen M, Hu M, Fedak P, Oudit G, Kassiri Z. Cell-Specific Functions of ADAM17 Regulate the Progression of Thoracic Aortic Aneurysm. Circ Res. 2018;123:372-388 pubmed publisher
	Oztay F, Sancar Bas S, Gezginci Oktayoglu S, Ercin M, Bolkent S. Exendin-4 partly ameliorates - hyperglycemia-mediated tissue damage in lungs of streptozotocin-induced diabetic mice. Peptides. 2018;99:99-107 pubmed publisher
	Song L, Xiang F, Ye H, Huang H, Yang J, Yu F, et al. Inhibition of angiotensin II and calpain attenuates pleural fibrosis. Pulm Pharmacol Ther. 2018;48:46-52 pubmed publisher
	Jing Y, Nguyen M, Wang D, Pascal L, Guo W, Xu Y, et al. DHX15 promotes prostate cancer progression by stimulating Siah2-mediated ubiquitination of androgen receptor. Oncogene. 2017;: pubmed publisher
	Herum K, Choppe J, Kumar A, Engler A, McCulloch A. Mechanical regulation of cardiac fibroblast profibrotic phenotypes. Mol Biol Cell. 2017;28:1871-1882 pubmed publisher
	Cai P, Kovacs L, Dong S, Wu G, Su Y. BMP4 inhibits PDGF-induced proliferation and collagen synthesis via PKA-mediated inhibition of calpain-2 in pulmonary artery smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2017;312:L638-L648 pubmed publisher
	Kim J, Wang S, Hyun J, Guy C, Jung Y. Hedgehog Signaling is Associated with Liver Response to Fractionated Irradiation in Mice. Cell Physiol Biochem. 2016;40:263-276 pubmed
	van Reesema L, Zheleva V, Winston J, Jansen R, O Connor C, Isbell A, et al. SIAH and EGFR, Two RAS Pathway Biomarkers, are Highly Prognostic in Locally Advanced and Metastatic Breast Cancer. EBioMedicine. 2016;11:183-198 pubmed publisher
	van der Willik K, Timmermans M, van Deurzen C, Look M, Reijm E, van Zundert W, et al. SIAH2 protein expression in breast cancer is inversely related with ER status and outcome to tamoxifen therapy. Am J Cancer Res. 2016;6:270-84 pubmed
	Jadhav S, Ajay A, Trivedi P, Seematti J, Pellegrini K, Craciun F, et al. RNA-binding Protein Musashi Homologue 1 Regulates Kidney Fibrosis by Translational Inhibition of p21 and Numb mRNA. J Biol Chem. 2016;291:14085-94 pubmed publisher
	Livingston M, Ding H, Huang S, Hill J, Yin X, Dong Z. Persistent activation of autophagy in kidney tubular cells promotes renal interstitial fibrosis during unilateral ureteral obstruction. Autophagy. 2016;12:976-98 pubmed publisher
	Bornes T, Jomha N, Mulet Sierra A, Adesida A. Optimal Seeding Densities for In Vitro Chondrogenesis of Two- and Three-Dimensional-Isolated and -Expanded Bone Marrow-Derived Mesenchymal Stromal Stem Cells Within a Porous Collagen Scaffold. Tissue Eng Part C Methods. 2016;22:208-20 pubmed publisher
	Moreno P, Lara Chica M, Soler Torronteras R, Caro T, Medina M, Alvarez A, et al. The Expression of the Ubiquitin Ligase SIAH2 (Seven In Absentia Homolog 2) Is Increased in Human Lung Cancer. PLoS ONE. 2015;10:e0143376 pubmed publisher
	Wong C, Chen A, Liu M, Parker B, MÃ¶ller A. Loss of Siah2 does not impact angiogenic potential of murine endothelial cells. Microvasc Res. 2015;102:38-45 pubmed publisher
	Chen Y, Huang J, Hu C, Hua K. Relationship of advanced glycation end products and their receptor to pelvic organ prolapse. Int J Clin Exp Pathol. 2015;8:2288-99 pubmed
	Chen A, Wong C, Liu M, House C, Sceneay J, Bowtell D, et al. The ubiquitin ligase Siah is a novel regulator of Zeb1 in breast cancer. Oncotarget. 2015;6:862-73 pubmed

product information

brand :

Novus

catalog number base :

NB110-88113

SKU :

NB110-88113

product name :

SIAH2 Antibody (24E6H3) - BSA Free

units size :

0.5 ml (also 0.125 ml)

description :

The SIAH2 Antibody (24E6H3) - BSA Free from Novus is a mouse monoclonal antibody to SIAH2. This antibody reacts with drosophila,human,insect - drosophila,mouse,mouse (negative),porcine. The SIAH2 Antibody (24E6H3) - BSA Free has been validated for the following applications: IF/IHC,Flow Cytometry,Immunohistochemistry,Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Flow (Intracellular),Immunocytochemistry/ Immunofluorescence.

target :

SIAH2

category :

Primary Antibodies

buffer :

Tissue culture supernatant

clonality :

Monoclonal

clone :

24E6H3

conjugate :

Unconjugated

all_available conjugate :

Unconjugated

host :

Mouse

immunogen :

Synthetic peptide made to an N-terminal portion of the drosophila SINA protein (within residues 1-100). [Swiss-Prot# P21461]

isotype :

IgG1

purity :

Tissue culture supernatant

species :

Drosophila,Human,Insect - Drosophila,Mouse,Mouse (Negative),Porcine

specificity :

Lys20p and Lys21p

gene symbol :

SIAH2

top caption :

Immunohistochemistry: SIAH2 Antibody (24E6H3) [NB110-88113]

applications :

IF/IHC,Flow Cytometry,Immunohistochemistry,Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Flow (Intracellular),Immunocytochemistry/ Immunofluorescence

USD :

409 USD

alt names :

E3 ubiquitin-protein ligase SIAH2, EC 6.3.2, EC 6.3.2.-, hSiah2, seven in absentia (Drosophila) homolog 2, Seven in absentia homolog 2, seven in absentia homolog 2 (Drosophila), siah-2

storage :

Store at 4C. Do not freeze.

more info or order :

Novus Biologicals product webpage