| Published Application/Species/Sample/Dilution | Reference |
|---|
- western blot; human; 1:500; fig 5
| Ma B, Cheng H, Gao R, Mu C, Chen L, Wu S, et al. Zyxin-Siah2-Lats2 axis mediates cooperation between Hippo and TGF-β signalling pathways. Nat Commun. 2016;7:11123 pubmed publisher |
- immunohistochemistry - paraffin section; human
| Qin R, Smyrk T, Reed N, Schmidt R, Schnelldorfer T, Chari S, et al. Combining clinicopathological predictors and molecular biomarkers in the oncogenic K-RAS/Ki67/HIF-1α pathway to predict survival in resectable pancreatic cancer. Br J Cancer. 2015;112:514-22 pubmed publisher |
- immunohistochemistry - paraffin section; human
| Tanaka T, Li T, Urata Y, Goto S, Ono Y, Kawakatsu M, et al. Increased expression of PHD3 represses the HIF-1 signaling pathway and contributes to poor neovascularization in pancreatic ductal adenocarcinoma. J Gastroenterol. 2015;50:975-83 pubmed publisher |
- immunohistochemistry - paraffin section; human
- immunohistochemistry; human; 1:40; fig 4
| Ma B, Chen Y, Chen L, Cheng H, Mu C, Li J, et al. Hypoxia regulates Hippo signalling through the SIAH2 ubiquitin E3 ligase. Nat Cell Biol. 2015;17:95-103 pubmed publisher |
- immunohistochemistry - paraffin section; human
| Rizzardi A, Rosener N, Koopmeiners J, Isaksson Vogel R, Metzger G, Forster C, et al. Evaluation of protein biomarkers of prostate cancer aggressiveness. BMC Cancer. 2014;14:244 pubmed publisher |
- immunohistochemistry; human
| Qi J, Tripathi M, Mishra R, Sahgal N, Fazli L, Fazil L, et al. The E3 ubiquitin ligase Siah2 contributes to castration-resistant prostate cancer by regulation of androgen receptor transcriptional activity. Cancer Cell. 2013;23:332-46 pubmed publisher |
- immunohistochemistry; human
| Chan P, Möller A, Liu M, Sceneay J, Wong C, Waddell N, et al. The expression of the ubiquitin ligase SIAH2 (seven in absentia homolog 2) is mediated through gene copy number in breast cancer and is associated with a basal-like phenotype and p53 expression. Breast Cancer Res. 2011;13:R19 pubmed publisher |
- immunohistochemistry; human
- western blot; human
| Ahmed A, Schmidt R, Park C, Reed N, Hesse S, Thomas C, et al. Effect of disrupting seven-in-absentia homolog 2 function on lung cancer cell growth. J Natl Cancer Inst. 2008;100:1606-29 pubmed publisher |
- flow cytometry; human
- immunocytochemistry; human
- immunohistochemistry; human
- western blot; human
| Schmidt R, Park C, Ahmed A, Gundelach J, Reed N, Cheng S, et al. Inhibition of RAS-mediated transformation and tumorigenesis by targeting the downstream E3 ubiquitin ligase seven in absentia homologue. Cancer Res. 2007;67:11798-810 pubmed |
| Liu Q, Luo Q, Feng J, Zhao Y, Ma B, Cheng H, et al. Hypoxia-induced proteasomal degradation of DBC1 by SIAH2 in breast cancer progression. elife. 2022;11: pubmed publisher |
| Yan T, Zhou D, Shi Y, Cui D, Jiang J, Han B, et al. Targeting ADT-Induced Activation of the E3 Ubiquitin Ligase Siah2 to Delay the Occurrence of Castration-Resistant Prostate Cancer. Front Oncol. 2021;11:637040 pubmed publisher |
| Zhang X, Liu S, Zhang C, Zhang S, Yue Y, Zhang Y, et al. The role of AMPKα2 in the HFD-induced nonalcoholic steatohepatitis. Biochim Biophys Acta Mol Basis Dis. 2020;1866:165854 pubmed publisher |
| Herum K, Romaine A, Wang A, Melleby A, Strand M, Pacheco J, et al. Syndecan-4 Protects the Heart From the Profibrotic Effects of Thrombin-Cleaved Osteopontin. J Am Heart Assoc. 2020;9:e013518 pubmed publisher |
| Waise S, Parker R, Rose Zerilli M, Layfield D, Wood O, West J, et al. An optimised tissue disaggregation and data processing pipeline for characterising fibroblast phenotypes using single-cell RNA sequencing. Sci Rep. 2019;9:9580 pubmed publisher |
| Hughes S, Hemenway E, Guo F, Yi K, Yu Z, Hawley R. The E3 ubiquitin ligase Sina regulates the assembly and disassembly of the synaptonemal complex in Drosophila females. PLoS Genet. 2019;15:e1008161 pubmed publisher |
| Zhu J, Kovacs L, Han W, Liu G, Huo Y, Lucas R, et al. ROS-Dependent Calpain Activation Contributes to Airway and Pulmonary Vascular Remodeling in COPD. Antioxid Redox Signal. 2019;: pubmed publisher |
| Majumder S, Ren L, Pushpakumar S, Sen U. Hydrogen sulphide mitigates homocysteine-induced apoptosis and matrix remodelling in mesangial cells through Akt/FOXO1 signalling cascade. Cell Signal. 2019;61:66-77 pubmed publisher |
| Ma B, Cheng H, Mu C, Geng G, Zhao T, Luo Q, et al. The SIAH2-NRF1 axis spatially regulates tumor microenvironment remodeling for tumor progression. Nat Commun. 2019;10:1034 pubmed publisher |
| Kovacs L, Cao Y, Han W, Meadows L, Kovacs Kasa A, Kondrikov D, et al. PFKFB3 in Smooth Muscle Promotes Vascular Remodeling in Pulmonary Arterial Hypertension. Am J Respir Crit Care Med. 2019;: pubmed publisher |
| Wang X, Pan J, Liu H, Zhang M, Liu D, Lu L, et al. AIM2 gene silencing attenuates diabetic cardiomyopathy in type 2 diabetic rat model. Life Sci. 2019;221:249-258 pubmed publisher |
| Grigorova Y, Wei W, Petrashevskaya N, Zernetkina V, Juhasz O, Fenner R, et al. Dietary Sodium Restriction Reduces Arterial Stiffness, Vascular TGF-β-Dependent Fibrosis and Marinobufagenin in Young Normotensive Rats. Int J Mol Sci. 2018;19: pubmed publisher |
| Ma Z, Wei Q, Zhang M, Chen J, Dong Z. Dicer deficiency in proximal tubules exacerbates renal injury and tubulointerstitial fibrosis and upregulates Smad2/3. Am J Physiol Renal Physiol. 2018;315:F1822-F1832 pubmed publisher |
| Shen M, Hu M, Fedak P, Oudit G, Kassiri Z. Cell-Specific Functions of ADAM17 Regulate the Progression of Thoracic Aortic Aneurysm. Circ Res. 2018;123:372-388 pubmed publisher |
| Oztay F, Sancar Bas S, Gezginci Oktayoglu S, Ercin M, Bolkent S. Exendin-4 partly ameliorates - hyperglycemia-mediated tissue damage in lungs of streptozotocin-induced diabetic mice. Peptides. 2018;99:99-107 pubmed publisher |
| Song L, Xiang F, Ye H, Huang H, Yang J, Yu F, et al. Inhibition of angiotensin II and calpain attenuates pleural fibrosis. Pulm Pharmacol Ther. 2018;48:46-52 pubmed publisher |
| Jing Y, Nguyen M, Wang D, Pascal L, Guo W, Xu Y, et al. DHX15 promotes prostate cancer progression by stimulating Siah2-mediated ubiquitination of androgen receptor. Oncogene. 2017;: pubmed publisher |
| Herum K, Choppe J, Kumar A, Engler A, McCulloch A. Mechanical regulation of cardiac fibroblast profibrotic phenotypes. Mol Biol Cell. 2017;28:1871-1882 pubmed publisher |
| Cai P, Kovacs L, Dong S, Wu G, Su Y. BMP4 inhibits PDGF-induced proliferation and collagen synthesis via PKA-mediated inhibition of calpain-2 in pulmonary artery smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2017;312:L638-L648 pubmed publisher |
| Kim J, Wang S, Hyun J, Guy C, Jung Y. Hedgehog Signaling is Associated with Liver Response to Fractionated Irradiation in Mice. Cell Physiol Biochem. 2016;40:263-276 pubmed |
| van Reesema L, Zheleva V, Winston J, Jansen R, O Connor C, Isbell A, et al. SIAH and EGFR, Two RAS Pathway Biomarkers, are Highly Prognostic in Locally Advanced and Metastatic Breast Cancer. EBioMedicine. 2016;11:183-198 pubmed publisher |
| van der Willik K, Timmermans M, van Deurzen C, Look M, Reijm E, van Zundert W, et al. SIAH2 protein expression in breast cancer is inversely related with ER status and outcome to tamoxifen therapy. Am J Cancer Res. 2016;6:270-84 pubmed |
| Jadhav S, Ajay A, Trivedi P, Seematti J, Pellegrini K, Craciun F, et al. RNA-binding Protein Musashi Homologue 1 Regulates Kidney Fibrosis by Translational Inhibition of p21 and Numb mRNA. J Biol Chem. 2016;291:14085-94 pubmed publisher |
| Livingston M, Ding H, Huang S, Hill J, Yin X, Dong Z. Persistent activation of autophagy in kidney tubular cells promotes renal interstitial fibrosis during unilateral ureteral obstruction. Autophagy. 2016;12:976-98 pubmed publisher |
| Bornes T, Jomha N, Mulet Sierra A, Adesida A. Optimal Seeding Densities for In Vitro Chondrogenesis of Two- and Three-Dimensional-Isolated and -Expanded Bone Marrow-Derived Mesenchymal Stromal Stem Cells Within a Porous Collagen Scaffold. Tissue Eng Part C Methods. 2016;22:208-20 pubmed publisher |
| Moreno P, Lara Chica M, Soler Torronteras R, Caro T, Medina M, Alvarez A, et al. The Expression of the Ubiquitin Ligase SIAH2 (Seven In Absentia Homolog 2) Is Increased in Human Lung Cancer. PLoS ONE. 2015;10:e0143376 pubmed publisher |
| Wong C, Chen A, Liu M, Parker B, Möller A. Loss of Siah2 does not impact angiogenic potential of murine endothelial cells. Microvasc Res. 2015;102:38-45 pubmed publisher |
| Chen Y, Huang J, Hu C, Hua K. Relationship of advanced glycation end products and their receptor to pelvic organ prolapse. Int J Clin Exp Pathol. 2015;8:2288-99 pubmed |
| Chen A, Wong C, Liu M, House C, Sceneay J, Bowtell D, et al. The ubiquitin ligase Siah is a novel regulator of Zeb1 in breast cancer. Oncotarget. 2015;6:862-73 pubmed |
