product summary
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company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
Beclin 1 Antibody - BSA Free
catalog :
NB110-87318
quantity :
0.05 ml (also 0.025 ml)
price :
409 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
clone name :
6C5cc
reactivity :
human, mouse, rat, dogs
application :
western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section
more info or order :
citations: 49
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; loading ...; fig 3e
Barnard R, Regan D, Hansen R, Maycotte P, Thorburn A, Gustafson D. Autophagy Inhibition Delays Early but Not Late-Stage Metastatic Disease. J Pharmacol Exp Ther. 2016;358:282-93 pubmed publisher
  • western blot; mouse; fig 9
Song J, Sun Y, Peluso I, Zeng Y, Yu X, Lu J, et al. A novel curcumin analog binds to and activates TFEB in vitro and in vivo independent of MTOR inhibition. Autophagy. 2016;12:1372-89 pubmed publisher
Salemi S, Kranzb xfc hler B, Baumgartner V, Breitenmoser L, Kuzmanov A, Lehner F, et al. Simultaneous Autophagy and Androgen Receptor Inhibition in a Prostate Cancer Xenograft Model. Cancers (Basel). 2024;16: pubmed publisher
Saddouk F, Kuzemczak A, Saito J, Greif D. Endothelial HIFα/PDGF-B to smooth muscle Beclin1 signaling sustains pathological muscularization in pulmonary hypertension. JCI Insight. 2024;9: pubmed publisher
Jeong G, Shin S, Kim S, Na Y, Park B, Cho J, et al. Ginsenoside Re prevents 3-methyladenine-induced catagen phase acceleration by regulating Wnt/β-catenin signaling in human dermal papilla cells. J Ginseng Res. 2023;47:440-447 pubmed publisher
Bi Y, Yang G, Guo Z, Cai W, Chen S, Zhou X, et al. Chronic high‑salt intake induces cardiomyocyte autophagic vacuolization during left ventricular maladaptive remodeling in spontaneously hypertensive rats. Exp Ther Med. 2023;25:148 pubmed publisher
Xu R, Wang J, Wang M, Gao L, Zhang R, Zhao L, et al. Exosomes Derived from Yak Follicular Fluid Increase 2-Hydroxyestradiol Secretion by Activating Autophagy in Cumulus Cells. Animals (Basel). 2022;12: pubmed publisher
Wen Y, Chen Z, Tian Y, Yang M, Dong Q, Yang Y, et al. Incomplete autophagy promotes the proliferation of Mycoplasma hyopneumoniae through the JNK and Akt pathways in porcine alveolar macrophages. Vet Res. 2022;53:62 pubmed publisher
Izumi H, Li Y, Yasunami M, Sato S, Mae T, Kaneko Y, et al. Asymmetric Pericentrosomal CD133 Endosomes Induce the Unequal Autophagic Activity During Cytokinesis in CD133-Positive Human Neuroblastoma Cells. Stem Cells. 2022;40:371-384 pubmed publisher
Chen Y, Chen S, Li T, Lin T, Chen C, Yen G. 4-Acetylantroquinonol B enhances cell death and inhibits autophagy by downregulating the PI3K/Akt/MDR1 pathway in gemcitabine-resistant pancreatic cancer cells. Oncol Lett. 2022;23:128 pubmed publisher
Wang Y, Liu T, Shen C, Lin S, Hung C, Hsu L, et al. K48/K63-linked polyubiquitination of ATG9A by TRAF6 E3 ligase regulates oxidative stress-induced autophagy. Cell Rep. 2022;38:110354 pubmed publisher
Zhang X, Xiao R, Lu B, Wu H, Jiang C, Li P, et al. Kinase DYRK2 acts as a regulator of autophagy and an indicator of favorable prognosis in gastric carcinoma. Colloids Surf B Biointerfaces. 2022;209:112182 pubmed publisher
Huang P, Chiu C, Hsiao M, Yow J, Tzang B, Hsu T. Potential of antiviral drug oseltamivir for the treatment of liver cancer. Int J Oncol. 2021;59: pubmed publisher
Wang C, Lin S, Huang Y, Hsieh C, Chang H, Chen H, et al. Paired-like homeodomain 2B contributes to tumour progression and anti-autophagy in human lung cancer. Am J Cancer Res. 2021;11:4900-4918 pubmed
Parry H, Randall R, Hyatt H, Hood W, Kavazis A. Short and long-term effect of reproduction on mitochondrial dynamics and autophagy in rats. Heliyon. 2021;7:e08070 pubmed publisher
Wang Z, Wen Y, Zhou B, Tian Y, Ning Y, Ding H. Incomplete autophagy promotes the replication of Mycoplasma hyopneumoniae. J Microbiol. 2021;59:782-791 pubmed publisher
Ilnytska O, Lai K, Gorshkov K, Schultz M, Tran B, Jeziorek M, et al. Enrichment of NPC1-deficient cells with the lipid LBPA stimulates autophagy, improves lysosomal function, and reduces cholesterol storage. J Biol Chem. 2021;297:100813 pubmed publisher
Fei M, Zhang L, Wang H, Zhu Y, Niu W, Tang T, et al. Inhibition of Cathepsin S Induces Mitochondrial Apoptosis in Glioblastoma Cell Lines Through Mitochondrial Stress and Autophagosome Accumulation. Front Oncol. 2020;10:516746 pubmed publisher
Chang C, Islam A, Liu P, Zhan J, Chueh P. Capsaicin acts through tNOX (ENOX2) to induce autophagic apoptosis in p53-mutated HSC-3 cells but autophagy in p53-functional SAS oral cancer cells. Am J Cancer Res. 2020;10:3230-3247 pubmed
Gao K, Niu J, Dang X. Neuroprotection of melatonin on spinal cord injury by activating autophagy and inhibiting apoptosis via SIRT1/AMPK signaling pathway. Biotechnol Lett. 2020;42:2059-2069 pubmed publisher
Pandey K, Yu X, Steinmetz A, Alberini C. Autophagy coupled to translation is required for long-term memory. Autophagy. 2020;: pubmed publisher
Han D, Jiang L, Gu X, Huang S, Pang J, Wu Y, et al. SIRT3 deficiency is resistant to autophagy-dependent ferroptosis by inhibiting the AMPK/mTOR pathway and promoting GPX4 levels. J Cell Physiol. 2020;: pubmed publisher
Xie B, Zhao M, Song D, Wu K, Yi L, Li W, et al. Induction of autophagy and suppression of type I IFN secretion by CSFV. Autophagy. 2020;:1-23 pubmed publisher
Hale A, Merchant M, White M. Detection and analysis of autophagy in the American alligator (Alligator mississippiensis). J Exp Zool B Mol Dev Evol. 2020;334:192-207 pubmed publisher
Challa T, Wueest S, Lucchini F, Dedual M, Modica S, Borsigova M, et al. Liver ASK1 protects from non-alcoholic fatty liver disease and fibrosis. EMBO Mol Med. 2019;11:e10124 pubmed publisher
Gatz C, Hathazi D, Münchberg U, Buchkremer S, Labisch T, Munro B, et al. Identification of Cellular Pathogenicity Markers for SIL1 Mutations Linked to Marinesco-Sjögren Syndrome. Front Neurol. 2019;10:562 pubmed publisher
Challa T, Wueest S, Lucchini F, Dedual M, Modica S, Borsigova M, et al. Liver ASK1 protects from non-alcoholic fatty liver disease and fibrosis. EMBO Mol Med. 2019;: pubmed publisher
Lin Y, Liang W, Chen C, Tsang H, Chiou J, Liu X, et al. Network analysis and mechanisms of action of Chinese herb-related natural compounds in lung cancer cells. Phytomedicine. 2019;58:152893 pubmed publisher
Luo Z, Xu X, Sho T, Luo W, Zhang J, Xu W, et al. Effects of n-acetyl-cysteine supplementation in late gestational diet on maternal-placental redox status, placental NLRP3 inflammasome, and fecal microbiota in sows1. J Anim Sci. 2019;97:1757-1771 pubmed publisher
Visa A, Sallán M, Maiques O, Alza L, Talavera E, López Ortega R, et al. T-Type Cav3.1 Channels Mediate Progression and Chemotherapeutic Resistance in Glioblastoma. Cancer Res. 2019;79:1857-1868 pubmed publisher
Rawat P, Teodorof Diedrich C, Spector S. Human immunodeficiency virus Type-1 single-stranded RNA activates the NLRP3 inflammasome and impairs autophagic clearance of damaged mitochondria in human microglia. Glia. 2019;67:802-824 pubmed publisher
Pyo K, Kim C, Lee M, Kim J, Kim K, Baek S. ULK1 O-GlcNAcylation Is Crucial for Activating VPS34 via ATG14L during Autophagy Initiation. Cell Rep. 2018;25:2878-2890.e4 pubmed publisher
Luo Z, Xu X, Sho T, Zhang J, Xu W, Yao J, et al. ROS-induced autophagy regulates porcine trophectoderm cell apoptosis, proliferation, and differentiation. Am J Physiol Cell Physiol. 2019;316:C198-C209 pubmed publisher
Muñoz Galdeano T, Reigada D, Del Águila A, Velez I, Caballero López M, Maza R, et al. Cell Specific Changes of Autophagy in a Mouse Model of Contusive Spinal Cord Injury. Front Cell Neurosci. 2018;12:164 pubmed publisher
Ji S, Kim Y, Jung S, Kim D, Kang S, Park J, et al. Oleuropein attenuates hydrogen peroxide-induced autophagic cell death in human adipose-derived stem cells. Biochem Biophys Res Commun. 2018;499:675-680 pubmed publisher
Nager M, Sallán M, Visa A, Pushparaj C, Santacana M, Macià A, et al. Inhibition of WNT-CTNNB1 signaling upregulates SQSTM1 and sensitizes glioblastoma cells to autophagy blockers. Autophagy. 2018;14:619-636 pubmed publisher
Nüchel J, Ghatak S, Zuk A, Illerhaus A, Morgelin M, Schönborn K, et al. TGFB1 is secreted through an unconventional pathway dependent on the autophagic machinery and cytoskeletal regulators. Autophagy. 2018;14:465-486 pubmed publisher
Valera E, Spencer B, Mott J, Trejo M, Adame A, Mante M, et al. MicroRNA-101 Modulates Autophagy and Oligodendroglial Alpha-Synuclein Accumulation in Multiple System Atrophy. Front Mol Neurosci. 2017;10:329 pubmed publisher
Fink S, Jayewickreme T, Molony R, Iwawaki T, Landis C, Lindenbach B, et al. IRE1α promotes viral infection by conferring resistance to apoptosis. Sci Signal. 2017;10: pubmed publisher
Mortezavi A, Salemi S, Rupp N, Rüschoff J, Hermanns T, Poyet C, et al. Negative LC3b immunoreactivity in cancer cells is an independent prognostic predictor of prostate cancer specific death. Oncotarget. 2017;8:31765-31774 pubmed publisher
Li Y, Wang F, Luo Y. Ginsenoside Rg1 protects against sepsis-associated encephalopathy through beclin 1-independent autophagy in mice. J Surg Res. 2017;207:181-189 pubmed publisher
Tan X, Wang H, Liang R, Chuang S. Human Rad23A plays a regulatory role in autophagy. Biochem Biophys Res Commun. 2016;478:1772-9 pubmed publisher
Pei J, Deng J, Ye Z, Wang J, Gou H, Liu W, et al. Absence of autophagy promotes apoptosis by modulating the ROS-dependent RLR signaling pathway in classical swine fever virus-infected cells. Autophagy. 2016;12:1738-1758 pubmed
Choi M, Kim H, Ham M, Choi D, Lee T, Shin D. Amber Light (590 nm) Induces the Breakdown of Lipid Droplets through Autophagy-Related Lysosomal Degradation in Differentiated Adipocytes. Sci Rep. 2016;6:28476 pubmed publisher
Lee Y, Chen H, Su L, Chueh P. Sirtuin 1 (SIRT1) Deacetylase Activity and NAD⁺/NADH Ratio Are Imperative for Capsaicin-Mediated Programmed Cell Death. J Agric Food Chem. 2015;63:7361-70 pubmed publisher
Lin C, Jan M, Kuo J. Exploring MicroRNA Expression Profiles Related to the mTOR Signaling Pathway in Mouse Embryonic Fibroblast Cells Treated with Polyethylenimine. Mol Pharm. 2015;12:2858-68 pubmed publisher
Yao J, Zheng K, Li C, Liu H, Shan X. Interference of Notch1 inhibits the growth of glioma cancer cells by inducing cell autophagy and down-regulation of Notch1-Hes-1 signaling pathway. Med Oncol. 2015;32:610 pubmed publisher
Lin H. In Vitro and in Vivo Atheroprotective Effects of Gossypetin against Endothelial Cell Injury by Induction of Autophagy. Chem Res Toxicol. 2015;28:202-15 pubmed
Wang W, Lin S, Chang W, Liu L, Li T, Kuo C, et al. Hinokitiol induces autophagy in murine breast and colorectal cancer cells. Environ Toxicol. 2016;31:77-84 pubmed publisher
product information
master code :
NB110-87318
SKU :
NB110-87318
product name :
Beclin 1 Antibody - BSA Free
unit size :
0.05 ml (also 0.025 ml)
description :
The Beclin 1 Antibody - BSA Free from Novus is a rabbit polyclonal antibody to Beclin 1. This antibody reacts with alligator,canine,human,mouse,porcine,primate,rat. The Beclin 1 Antibody - BSA Free has been validated for the following applications: Western Blot,IF/IHC,Knockdown Validated,Immunocytochemistry/ Immunofluorescence,Immunohistochemistry,Immunohistochemistry-Paraffin,Simple Western.
target :
Beclin 1
category :
Primary Antibodies
buffer :
PBS, 0.02 Sodium Azide
clonality :
Polyclonal
concentration :
1 mg/ml
conjugate :
Unconjugated
host :
Rabbit
immunogen :
Synthetic peptide made to an internal portion of human Beclin 1 (within residues 150-300). [Swiss-Prot: Q14457]
isotype :
IgG
purity :
Immunogen affinity purified
species :
Alligator,Canine,Human,Mouse,Porcine,Primate,Rat
theoretical molecular weight :
51 kDa
gene symbol :
BECN1
applications :
Western Blot,IF/IHC,Knockdown Validated,Immunocytochemistry/ Immunofluorescence,Immunohistochemistry,Immunohistochemistry-Paraffin,Simple Western
USD :
409 USD
alt names :
ATG6, ATG6 autophagy related 6 homolog, beclin 1 (coiled-coil, moesin-like BCL2 interacting protein), beclin 1 (coiled-coil, moesin-like BCL2-interacting protein), beclin 1, autophagy related, beclin1, beclin-1, Coiled-coil myosin-like BCL2-interacting protein, GT197, Protein GT197, VPS30
storage :
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
more info or order :
company information
Novus Biologicals
10771 E Easter Ave
Centennial, CO 80112
novus@novusbio.com
https://www.novusbio.com
3037301950
headquarters: USA
Novus Biologicals licenses, manufactures, and markets antibodies to over 20,000 unique targets to support a wide array of research areas. Novus is built on honesty, collaboration and strong relationships and continues to provide quality tools that accelerate research. Every product is backed by our 100% guarantee.