product summary
Loading...
company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
Tenascin C Antibody (4C8MS) - BSA Free
catalog :
NB110-68136
quantity :
0.1 ml (also 0.025 ml)
price :
419 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
4C8MS
reactivity :
human, mouse, rat
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
citations: 70
Published Application/Species/Sample/DilutionReference
  • western blot; human; 1:1000; loading ...; fig 1b
Bhattacharyya S, Wang W, Morales Nebreda L, Feng G, Wu M, Zhou X, et al. Tenascin-C drives persistence of organ fibrosis. Nat Commun. 2016;7:11703 pubmed publisher
  • immunohistochemistry - paraffin section; rat
  • immunohistochemistry - paraffin section; human
de Sousa A, Gurgel C, Ramos E, Trindade R, de Faro Valverde L, Carneiro T, et al. Infrared LED light therapy influences the expression of fibronectin and tenascin in skin wounds of malnourished rats--a preliminary study. Acta Histochem. 2014;116:1185-91 pubmed publisher
  • western blot; mouse
James M, Ross A, Nicola T, Steele C, Ambalavanan N. VARA attenuates hyperoxia-induced impaired alveolar development and lung function in newborn mice. Am J Physiol Lung Cell Mol Physiol. 2013;304:L803-12 pubmed publisher
  • immunohistochemistry; rat
Ago K, Kemmochi S, Morita R, Yafune A, Shiraki A, Mitsumori K, et al. Direct progression of capsular invasive carcinomas from subcapsular focal hyperplasias induced by hypothyroidism-mediated tumor promotion in a rat two-stage thyroid carcinogenesis model. J Cancer Res Clin Oncol. 2013;139:395-401 pubmed publisher
  • immunohistochemistry; rat
Kemmochi S, Yamamichi S, Shimamoto K, Onda N, Hasumi K, Suzuki K, et al. Lac color inhibits development of rat thyroid carcinomas through targeting activation of plasma hyaluronan-binding protein. Exp Biol Med (Maywood). 2012;237:728-38 pubmed publisher
  • immunohistochemistry; rat
Kemmochi S, Shimamoto K, Shiraki A, Onda N, Hasumi K, Suzuki K, et al. Promoting effects of carminic acid-enriched cochineal extracts on capsular invasive thyroid carcinomas through targeting activation of angiogenesis in rats. J Toxicol Sci. 2012;37:475-82 pubmed
  • immunohistochemistry - paraffin section; rat
Yamamoto M, Okui N, Tatebe M, Shinohara T, Hirata H. Regeneration of the perineurium after microsurgical resection examined with immunolabeling for tenascin-C and alpha smooth muscle actin. J Anat. 2011;218:413-25 pubmed publisher
  • ELISA; human
Balasenthil S, Chen N, Lott S, Chen J, Carter J, Grizzle W, et al. A migration signature and plasma biomarker panel for pancreatic adenocarcinoma. Cancer Prev Res (Phila). 2011;4:137-49 pubmed publisher
  • immunohistochemistry - frozen section; human
  • immunohistochemistry; human
  • ELISA; human
Richter P, Tost M, Franz M, Altendorf Hofmann A, Junker K, Borsi L, et al. B and C domain containing tenascin-C: urinary markers for invasiveness of urothelial carcinoma of the urinary bladder?. J Cancer Res Clin Oncol. 2009;135:1351-8 pubmed publisher
  • immunohistochemistry; human
El Karef A, Kaito M, Tanaka H, Ikeda K, Nishioka T, Fujita N, et al. Expression of large tenascin-C splice variants by hepatic stellate cells/myofibroblasts in chronic hepatitis C. J Hepatol. 2007;46:664-73 pubmed
  • immunohistochemistry - paraffin section; human
Kääriäinen E, Nummela P, Soikkeli J, Yin M, Lukk M, Jahkola T, et al. Switch to an invasive growth phase in melanoma is associated with tenascin-C, fibronectin, and procollagen-I forming specific channel structures for invasion. J Pathol. 2006;210:181-91 pubmed
  • immunohistochemistry - paraffin section; mouse
Tamaoki M, Imanaka Yoshida K, Yokoyama K, Nishioka T, Inada H, Hiroe M, et al. Tenascin-C regulates recruitment of myofibroblasts during tissue repair after myocardial injury. Am J Pathol. 2005;167:71-80 pubmed
  • immunohistochemistry - paraffin section; human
  • western blot; human
Tsunoda T, Inada H, Kalembeyi I, Imanaka Yoshida K, Sakakibara M, Okada R, et al. Involvement of large tenascin-C splice variants in breast cancer progression. Am J Pathol. 2003;162:1857-67 pubmed
Li J, Sina A, Antaw F, Fielding D, M xf6 ller A, Lobb R, et al. Digital Decoding of Single Extracellular Vesicle Phenotype Differentiates Early Malignant and Benign Lung Lesions. Adv Sci (Weinh). 2022;10:e2204207 pubmed publisher
Ni Y, Wu G, Cai J, Zhang R, Zheng Y, Liu J, et al. Tubule-mitophagic secretion of SerpinG1 reprograms macrophages to instruct anti-septic acute kidney injury efficacy of high-dose ascorbate mediated by NRF2 transactivation. Int J Biol Sci. 2022;18:5168-5184 pubmed publisher
Louisthelmy R, Burke B, Cornelison R. Brain cancer cell-derived matrices and effects on astrocyte migration. Cells Tissues Organs. 2022;: pubmed publisher
Dorchin Ashkenazi H, Ginat Koton R, Gabet Y, Klein Y, Chaushu S, Dorchin H, et al. The Balance between Orthodontic Force and Radiation in the Jawbone: Microstructural, Histological, and Molecular Study in a Rat Model. Biology (Basel). 2021;10: pubmed publisher
Lee Y, Ricky S, Lim T, Kim H, Lee E, Song Y, et al. An atmospheric plasma jet induces expression of wound healing genes in progressive burn wounds in a comb burn rat model: a pilot study. J Burn Care Res. 2021;: pubmed publisher
Otsuka T, Mengsteab P, Laurencin C. Control of mesenchymal cell fate via application of FGF-8b in vitro. Stem Cell Res. 2021;51:102155 pubmed publisher
Gao Q, Wei A, Chen F, Chen X, Ding W, Ding Z, et al. Enhancing PPARγ by HDAC inhibition reduces foam cell formation and atherosclerosis in ApoE deficient mice. Pharmacol Res. 2020;160:105059 pubmed publisher
Werkman I, Kövilein J, de Jonge J, Baron W. Impairing committed cholesterol biosynthesis in white matter astrocytes, but not grey matter astrocytes, enhances in vitro myelination. J Neurochem. 2020;: pubmed publisher
Wang D, Hiebl V, Schachner D, Ladurner A, Heiss E, Atanasov A, et al. Soraphen A enhances macrophage cholesterol efflux via indirect LXR activation and ABCA1 upregulation. Biochem Pharmacol. 2020;177:114022 pubmed publisher
Marshall J, Courage E, Elliott R, Fitzpatrick M, Kim A, Lopez Clavijo A, et al. THP-1 macrophage cholesterol efflux is impaired by palmitoleate through Akt activation. PLoS ONE. 2020;15:e0233180 pubmed publisher
Salonurmi T, Nabil H, Ronkainen J, Hyötyläinen T, Hautajärvi H, Savolainen M, et al. 4β-Hydroxycholesterol Signals From the Liver to Regulate Peripheral Cholesterol Transporters. Front Pharmacol. 2020;11:361 pubmed publisher
Koga M, Kanaoka Y, Inada K, Omine S, Kataoka Y, Yamauchi A. Hesperidin blocks varenicline-aggravated atherosclerotic plaque formation in apolipoprotein E knockout mice by downregulating net uptake of oxidized low-density lipoprotein in macrophages. J Pharmacol Sci. 2020;143:106-111 pubmed publisher
Meng X, Yin J, Yu X, Guo Y. MicroRNA-205-5p Promotes Unstable Atherosclerotic Plaque Formation In Vivo. Cardiovasc Drugs Ther. 2020;34:25-39 pubmed publisher
Haydont V, Neiveyans V, Perez P, Busson E, Lataillade J, Asselineau D, et al. Fibroblasts from the Human Skin Dermo-Hypodermal Junction are Distinct from Dermal Papillary and Reticular Fibroblasts and from Mesenchymal Stem Cells and Exhibit a Specific Molecular Profile Related to Extracellular Matrix Organization and Modeling. Cells. 2020;9: pubmed publisher
Ishikawa K, Kohno R, Mori K, Murakami Y, Nakao S, Akiyama M, et al. Increased expression of periostin and tenascin-C in eyes with neovascular glaucoma secondary to PDR. Graefes Arch Clin Exp Ophthalmol. 2020;258:621-628 pubmed publisher
Koga M, Kanaoka Y, Okamoto M, Nakao Y, Inada K, Takayama S, et al. Varenicline aggravates atherosclerotic plaque formation in nicotine-pretreated ApoE knockout mice due to enhanced oxLDL uptake by macrophages through downregulation of ABCA1 and ABCG1 expression. J Pharmacol Sci. 2020;142:9-15 pubmed publisher
Xu Y, Xu Y, Zhu Y, Sun H, Juguilon C, Li F, et al. Macrophage miR-34a Is a Key Regulator of Cholesterol Efflux and Atherosclerosis. Mol Ther. 2020;28:202-216 pubmed publisher
Urano Y, Ho Vo D, Hirofumi A, Noguchi N. 24(S)-Hydroxycholesterol induces ER dysfunction-mediated unconventional cell death. Cell Death Discov. 2019;5:113 pubmed publisher
Wu A, Grela E, Wojtowicz K, Filipczak N, Hamon Y, Luchowski R, et al. ABCA1 transporter reduces amphotericin B cytotoxicity in mammalian cells. Cell Mol Life Sci. 2019;: pubmed publisher
Wang H, Zhang X, Yu B, Peng X, Liu Y, Wang A, et al. Cyclodextrin Ameliorates the Progression of Atherosclerosis via Increasing High-Density Lipoprotein Cholesterol Plasma Levels and Anti-inflammatory Effects in Rabbits. J Cardiovasc Pharmacol. 2019;73:334-342 pubmed publisher
Sedgeman L, Beysen C, Ramirez Solano M, Michell D, Sheng Q, Zhao S, et al. Beta cell secretion of miR-375 to HDL is inversely associated with insulin secretion. Sci Rep. 2019;9:3803 pubmed publisher
Yuan C, Guo X, Zhou Q, Du F, Jiang W, Zhou X, et al. OAB-14, a bexarotene derivative, improves Alzheimer's disease-related pathologies and cognitive impairments by increasing β-amyloid clearance in APP/PS1 mice. Biochim Biophys Acta Mol Basis Dis. 2019;1865:161-180 pubmed publisher
Nishino T, Horie T, Baba O, Sowa N, Hanada R, Kuwabara Y, et al. SREBF1/MicroRNA-33b Axis Exhibits Potent Effect on Unstable Atherosclerotic Plaque Formation In Vivo. Arterioscler Thromb Vasc Biol. 2018;38:2460-2473 pubmed publisher
Harris M, Hussain S, Inouye C, Castle A, Castle J. Reinterpretation of the localization of the ATP binding cassette transporter ABCG1 in insulin-secreting cells and insights regarding its trafficking and function. PLoS ONE. 2018;13:e0198383 pubmed publisher
Qian K, Feng L, Sun Y, Xiong B, Ding Y, Han P, et al. Overexpression of Salusin-α Inhibits Vascular Intimal Hyperplasia in an Atherosclerotic Rabbit Model. Biomed Res Int. 2018;2018:8973986 pubmed publisher
Wang L, Eftekhari P, Schachner D, Ignatova I, Palme V, Schilcher N, et al. Novel interactomics approach identifies ABCA1 as direct target of evodiamine, which increases macrophage cholesterol efflux. Sci Rep. 2018;8:11061 pubmed publisher
Sonett J, Goldklang M, Sklepkiewicz P, Gerber A, Trischler J, Zelonina T, et al. A critical role for ABC transporters in persistent lung inflammation in the development of emphysema after smoke exposure. FASEB J. 2018;:fj201701381 pubmed publisher
Ying F, Cai Y, Wong H, Chen X, Huang I, Vanhoutte P, et al. EP4 emerges as a novel regulator of bile acid synthesis and its activation protects against hypercholesterolemia. Biochim Biophys Acta Mol Cell Biol Lipids. 2018;1863:1029-1040 pubmed publisher
Wang D, Hiebl V, Ladurner A, Latkolik S, Bucar F, Heiß E, et al. 6-Dihydroparadol, a Ginger Constituent, Enhances Cholesterol Efflux from THP-1-Derived Macrophages. Mol Nutr Food Res. 2018;:e1800011 pubmed publisher
Becerril S, Rodriguez A, Catalan V, Méndez Giménez L, Ramirez B, Sainz N, et al. Targeted disruption of the iNOS gene improves adipose tissue inflammation and fibrosis in leptin-deficient ob/ob mice: role of tenascin C. Int J Obes (Lond). 2018;42:1458-1470 pubmed publisher
Li Y, Shen S, Ding S, Wang L. Toll-like receptor 2 downregulates the cholesterol efflux by activating the nuclear factor-κB pathway in macrophages and may be a potential therapeutic target for the prevention of atherosclerosis. Exp Ther Med. 2018;15:198-204 pubmed publisher
Cuffe H, Liu M, Key C, Boudyguina E, Sawyer J, Weckerle A, et al. Targeted Deletion of Adipocyte Abca1 (ATP-Binding Cassette Transporter A1) Impairs Diet-Induced Obesity. Arterioscler Thromb Vasc Biol. 2018;38:733-743 pubmed publisher
Canfrán Duque A, Rotllan N, Zhang X, Fernández Fuertes M, Ramírez Hidalgo C, Araldi E, et al. Macrophage deficiency of miR-21 promotes apoptosis, plaque necrosis, and vascular inflammation during atherogenesis. EMBO Mol Med. 2017;9:1244-1262 pubmed publisher
de Aguiar Vallim T, Lee E, Merriott D, Goulbourne C, Cheng J, Cheng A, et al. ABCG1 regulates pulmonary surfactant metabolism in mice and men. J Lipid Res. 2017;58:941-954 pubmed publisher
Mariani M, Malm T, Lamb R, Jay T, Neilson L, Casali B, et al. Neuronally-directed effects of RXR activation in a mouse model of Alzheimer's disease. Sci Rep. 2017;7:42270 pubmed publisher
Jiang M, Li X. Activation of PPAR? does not contribute to macrophage ABCA1 expression and ABCA1-mediated cholesterol efflux to apoAI. Biochem Biophys Res Commun. 2017;482:849-856 pubmed publisher
Wang L, Palme V, Rotter S, Schilcher N, Cukaj M, Wang D, et al. Piperine inhibits ABCA1 degradation and promotes cholesterol efflux from THP-1-derived macrophages. Mol Nutr Food Res. 2017;61: pubmed publisher
Janune D, Abd El Kader T, Aoyama E, Nishida T, Tabata Y, Kubota S, et al. Novel role of CCN3 that maintains the differentiated phenotype of articular cartilage. J Bone Miner Metab. 2017;35:582-597 pubmed publisher
Cheng H, Gaddis D, Wu R, McSkimming C, Haynes L, Taylor A, et al. Loss of ABCG1 influences regulatory T cell differentiation and atherosclerosis. J Clin Invest. 2016;126:3236-46 pubmed publisher
Lai L, Azzam K, Lin W, Rai P, Lowe J, Gabor K, et al. MicroRNA-33 Regulates the Innate Immune Response via ATP Binding Cassette Transporter-mediated Remodeling of Membrane Microdomains. J Biol Chem. 2016;291:19651-60 pubmed publisher
Aryal B, Rotllan N, Araldi E, Ramírez C, He S, Chousterman B, et al. ANGPTL4 deficiency in haematopoietic cells promotes monocyte expansion and atherosclerosis progression. Nat Commun. 2016;7:12313 pubmed publisher
Mostafa A, Hamdy N, Abdel Rahman S, El Mesallamy H. Effect of vildagliptin and pravastatin combination on cholesterol efflux in adipocytes. IUBMB Life. 2016;68:535-43 pubmed publisher
Tarling E, Edwards P. Intracellular Localization of Endogenous Mouse ABCG1 Is Mimicked by Both ABCG1-L550 and ABCG1-P550-Brief Report. Arterioscler Thromb Vasc Biol. 2016;36:1323-7 pubmed publisher
Zhang X, Hu J, Zhong L, Wang N, Yang L, Liu C, et al. Quercetin stabilizes apolipoprotein E and reduces brain A? levels in amyloid model mice. Neuropharmacology. 2016;108:179-92 pubmed publisher
Leng S, Iwanowycz S, Saaoud F, Wang J, Wang Y, Sergin I, et al. Ursolic acid enhances macrophage autophagy and attenuates atherogenesis. J Lipid Res. 2016;57:1006-16 pubmed publisher
Shi H, Mao X, Zhong Y, Liu Y, Zhao X, Yu K, et al. Lanatoside C Promotes Foam Cell Formation and Atherosclerosis. Sci Rep. 2016;6:20154 pubmed publisher
Mostafa A, Hamdy N, El Mesallamy H, Abdel Rahman S. Glucagon-like peptide 1 (GLP-1)-based therapy upregulates LXR-ABCA1/ABCG1 cascade in adipocytes. Biochem Biophys Res Commun. 2015;468:900-5 pubmed publisher
Matsuo K, Yamamoto S, Wakamatsu T, Takahashi Y, Kawamura K, Kaneko Y, et al. Increased Proinflammatory Cytokine Production and Decreased Cholesterol Efflux Due to Downregulation of ABCG1 in Macrophages Exposed to Indoxyl Sulfate. Toxins (Basel). 2015;7:3155-66 pubmed publisher
Daffu G, Shen X, Senatus L, Thiagarajan D, Abedini A, Hurtado del Pozo C, et al. RAGE Suppresses ABCG1-Mediated Macrophage Cholesterol Efflux in Diabetes. Diabetes. 2015;64:4046-60 pubmed publisher
Lee T, Lu K, Yu Y, Lee H, Tsai F. β Common Receptor Mediates Erythropoietin-Conferred Protection on OxLDL-Induced Lipid Accumulation and Inflammation in Macrophages. Mediators Inflamm. 2015;2015:439759 pubmed publisher
de Boussac H, Maqdasy S, Trousson A, Zelcer N, Volle D, Lobaccaro J, et al. Enolase is regulated by Liver X Receptors. Steroids. 2015;99:266-71 pubmed publisher
Park S, Paek J, Shin D, Lee J, Lim S, Kang Y. Purple perilla extracts with α-asarone enhance cholesterol efflux from oxidized LDL-exposed macrophages. Int J Mol Med. 2015;35:957-65 pubmed publisher
Zheng W, Mast N, Saadane A, Pikuleva I. Pathways of cholesterol homeostasis in mouse retina responsive to dietary and pharmacologic treatments. J Lipid Res. 2015;56:81-97 pubmed publisher
Frisdal E, Le Lay S, Hooton H, Poupel L, Olivier M, Alili R, et al. Adipocyte ATP-binding cassette G1 promotes triglyceride storage, fat mass growth, and human obesity. Diabetes. 2015;64:840-55 pubmed publisher
Janune D, Kubota S, Nishida T, Kawaki H, Perbal B, Iida S, et al. Novel effects of CCN3 that may direct the differentiation of chondrocytes. FEBS Lett. 2011;585:3033-40 pubmed publisher
Guttery D, Shaw J, Lloyd K, Pringle J, Walker R. Expression of tenascin-C and its isoforms in the breast. Cancer Metastasis Rev. 2010;29:595-606 pubmed publisher
Yoshimura H, Michishita M, Ohkusu Tsukada K, Takahashi K. Increased presence of stromal myofibroblasts and tenascin-C with malignant progression in canine mammary tumors. Vet Pathol. 2011;48:313-21 pubmed publisher
product information
master code :
NB110-68136
SKU :
NB110-68136
product name :
Tenascin C Antibody (4C8MS) - BSA Free
unit size :
0.1 ml (also 0.025 ml)
description :
The Tenascin C Antibody (4C8MS) - BSA Free from Novus is a mouse monoclonal antibody to Tenascin C. This antibody reacts with feline,human,mouse,rat. The Tenascin C Antibody (4C8MS) - BSA Free has been validated for the following applications: IF/IHC,ELISA,Flow Cytometry,Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunocytochemistry/ Immunofluorescence,Immunohistochemistry,Flow (Intracellular),CyTOF-ready.
target :
Tenascin C
category :
Primary Antibodies
buffer :
PBS
clonality :
Monoclonal
clone :
4C8MS
concentration :
1.0 mg/ml
conjugate :
Unconjugated
host :
Mouse
immunogen :
Recombinant human Tenascin C [Swiss-Prot# P24821].
isotype :
IgG1
purity :
Protein A purified
species :
Feline,Human,Mouse,Rat
specificity :
NB110-68136 specifically reacts with Domain B on FNIII repeats of Tenascin C
gene symbol :
TNC
Antibody validation :
Biological Validation
accessionNumbers :
P24821
applications :
IF/IHC,ELISA,Flow Cytometry,Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunocytochemistry/ Immunofluorescence,Immunohistochemistry,Flow (Intracellular),CyTOF-ready
USD :
419 USD
product details :
Tenascin C is an extracellular matrix protein that is expressed in various tissues during development, disease or injury. Tenascin C inhibits HIV infection in immune cells by binding to a chemokine coreceptor site on the HIV-1 envelope protein, thereby blocking the virus' entry into the host cells. Tenascin C expression in the stroma of certain tumors is often associated with a poor prognosis.
alt names :
150-225, Cytotactin, Glioma-associated-extracellular matrix antigen, GMEM, GP 150-225, Hexabrachion, hexabrachion (tenascin C, cytotactin), hexabrachion (tenascin), HXBcytotactin, JI, MGC167029, Myotendinous antigen, neuronectin, tenascin, tenascin C, Tenascin-C, tenascin-C isoform 14/AD1/16, TN-C, TNGP
storage :
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
more info or order :
company information
Novus Biologicals
10771 E Easter Ave
Centennial, CO 80112
novus@novusbio.com
https://www.novusbio.com
3037301950
headquarters: USA
Novus Biologicals licenses, manufactures, and markets antibodies to over 20,000 unique targets to support a wide array of research areas. Novus is built on honesty, collaboration and strong relationships and continues to provide quality tools that accelerate research. Every product is backed by our 100% guarantee.