product summary
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company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
Hepatic Sinusoidal Endothelial Cells Antibody (SE-1) - BSA Free
catalog :
NB110-68095
quantity :
0.1 ml (also 0.025 ml)
price :
399 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
SE-1
reactivity :
mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
citations: 78
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - paraffin section; rat
Mollbrink A, Augsten M, Hultcrantz R, Eriksson L, Stål P. Sorafenib prolongs liver regeneration after hepatic resection in rats. J Surg Res. 2013;184:847-54 pubmed publisher
  • immunocytochemistry; mouse
  • immunohistochemistry; mouse
Zuo D, Yu X, Guo C, Wang H, Qian J, Yi H, et al. Scavenger receptor A restrains T-cell activation and protects against concanavalin A-induced hepatic injury. Hepatology. 2013;57:228-38 pubmed publisher
  • immunocytochemistry; mouse
  • immunohistochemistry; mouse
Ellett J, Atkinson C, Evans Z, Amani Z, Balish E, Schmidt M, et al. Toll-like receptor 4 knockout mice are protected from endothelial overactivation in the absence of Kupffer cells after total hepatic ischemia/reperfusion. Liver Transpl. 2011;17:1089-98 pubmed publisher
  • immunocytochemistry; mouse
  • immunohistochemistry; mouse
Ellett J, Atkinson C, Evans Z, Amani Z, Balish E, Schmidt M, et al. Murine Kupffer cells are protective in total hepatic ischemia/reperfusion injury with bowel congestion through IL-10. J Immunol. 2010;184:5849-58 pubmed publisher
  • immunohistochemistry; rat
Braet F, Wisse E. Structural and functional aspects of liver sinusoidal endothelial cell fenestrae: a review. Comp Hepatol. 2002;1:1 pubmed
  • immunohistochemistry; rat
  • western blot; rat
Tokairin T, Nishikawa Y, Doi Y, Watanabe H, Yoshioka T, Su M, et al. A highly specific isolation of rat sinusoidal endothelial cells by the immunomagnetic bead method using SE-1 monoclonal antibody. J Hepatol. 2002;36:725-33 pubmed
  • immunocytochemistry; rat
Morita M, Qun W, Watanabe H, Doi Y, Mori M, Enomoto K. Analysis of the sinusoidal endothelial cell organization during the developmental stage of the fetal rat liver using a sinusoidal endothelial cell specific antibody, SE-1. Cell Struct Funct. 1998;23:341-8 pubmed
  • immunohistochemistry; rat
  • western blot; rat
Ohmura T, Enomoto K, Satoh H, Sawada N, Mori M. Establishment of a novel monoclonal antibody, SE-1, which specifically reacts with rat hepatic sinusoidal endothelial cells. J Histochem Cytochem. 1993;41:1253-7 pubmed
Gil M, Khouri L, Raurell I, Rafael D, Andrade F, Abasolo I, et al. Optimization of Statin-Loaded Delivery Nanoparticles for Treating Chronic Liver Diseases by Targeting Liver Sinusoidal Endothelial Cells. Pharmaceutics. 2023;15: pubmed publisher
Tian C, Li L, Fan L, Brown A, Norris E, Morrison M, et al. A hepatoprotective role of peritumoral non-parenchymal cells in early liver tumorigenesis. Dis Model Mech. 2023;16: pubmed publisher
You K, Wang Y, Chen X, Yang Z, Chen Y, Tan S, et al. Neutralizing serum amyloid a protects against sinusoidal endothelial cell damage and platelet aggregation during acetaminophen-induced liver injury. Biochem Biophys Res Commun. 2023;639:20-28 pubmed publisher
Bhandari S, Li R, Simon Santamaria J, McCourt P, Johansen S, Smedsrød B, et al. Transcriptome and proteome profiling reveal complementary scavenger and immune features of rat liver sinusoidal endothelial cells and liver macrophages. BMC Mol Cell Biol. 2020;21:85 pubmed publisher
Nakura M, Miyashita T, Yamamoto Y, Takada S, Kanou S, Tajima H, et al. Inhibitory Effects of Beraprost Sodium in Murine Hepatic Sinusoidal Obstruction Syndrome. Anticancer Res. 2020;40:5171-5180 pubmed publisher
Maruyama S, Kono H, Furuya S, Shimizu H, Saito R, Shoda K, et al. Platelet C-Type Lectin-Like Receptor 2 Reduces Cholestatic Liver Injury in Mice. Am J Pathol. 2020;190:1833-1842 pubmed publisher
Kanou S, Miyashita T, Yamamoto Y, Takada S, Nakura M, Okazaki M, et al. Prophylactic Effect of Recombinant Human Soluble Thrombomodulin for Hepatic Sinusoidal Obstruction Syndrome Model Mice. In Vivo. 2020;34:1037-1045 pubmed publisher
Wang C, Teo C, Sabapathy K. p53-Related Transcription Targets of TAp73 in Cancer Cells-Bona Fide or Distorted Reality?. Int J Mol Sci. 2020;21: pubmed publisher
de Vries R, Pendexter C, Cronin S, Marques B, Hafiz E, Muzikansky A, et al. Cell release during perfusion reflects cold ischemic injury in rat livers. Sci Rep. 2020;10:1102 pubmed publisher
Kumar S, Talluri S, Pal J, Yuan X, Lu R, Nanjappa P, et al. Role of apurinic/apyrimidinic nucleases in the regulation of homologous recombination in myeloma: mechanisms and translational significance. Blood Cancer J. 2018;8:92 pubmed publisher
Makino E, Gutmann V, Kosnopfel C, Niessner H, Forschner A, Garbe C, et al. Melanoma cells resistant towards MAPK inhibitors exhibit reduced TAp73 expression mediating enhanced sensitivity to platinum-based drugs. Cell Death Dis. 2018;9:930 pubmed publisher
Oldani G, Peloso A, Vijgen S, Wilson E, Slits F, Gex Q, et al. Chimeric liver transplantation reveals interspecific graft remodelling. J Hepatol. 2018;69:1025-1036 pubmed publisher
Yang L, Yang X, Tang Y, Zhang D, Zhu L, Wang S, et al. Inhibition of DNA‑PK activity sensitizes A549 cells to X‑ray irradiation by inducing the ATM‑dependent DNA damage response. Mol Med Rep. 2018;17:7545-7552 pubmed publisher
Serra M, Marongiu M, Contini A, Miki T, Cadoni E, Laconi E, et al. Evidence of Amniotic Epithelial Cell Differentiation toward Hepatic Sinusoidal Endothelial Cells. Cell Transplant. 2018;27:23-30 pubmed publisher
Papaspyropoulos A, Bradley L, Thapa A, Leung C, Toskas K, Koennig D, et al. RASSF1A uncouples Wnt from Hippo signalling and promotes YAP mediated differentiation via p73. Nat Commun. 2018;9:424 pubmed publisher
Boylan J, Francois Vaughan H, Gruppuso P, Sanders J. Engraftment and Repopulation Potential of Late Gestation Fetal Rat Hepatocytes. Transplantation. 2017;101:2349-2359 pubmed publisher
Lee T, Pelletier J. Dependence of p53-deficient cells on the DHX9 DExH-box helicase. Oncotarget. 2017;8:30908-30921 pubmed publisher
Gonzalez R, De La Rosa A, Rufini A, Rodríguez Hernández M, Navarro Villarán E, Marchal T, et al. Role of p63 and p73 isoforms on the cell death in patients with hepatocellular carcinoma submitted to orthotopic liver transplantation. PLoS ONE. 2017;12:e0174326 pubmed publisher
Kono H, Fujii H, Suzuki Inoue K, Inoue O, Furuya S, Hirayama K, et al. The platelet-activating receptor C-type lectin receptor-2 plays an essential role in liver regeneration after partial hepatectomy in mice. J Thromb Haemost. 2017;15:998-1008 pubmed publisher
Prabhu V, Hong B, Allen J, Zhang S, Lulla A, Dicker D, et al. Small-Molecule Prodigiosin Restores p53 Tumor Suppressor Activity in Chemoresistant Colorectal Cancer Stem Cells via c-Jun-Mediated ΔNp73 Inhibition and p73 Activation. Cancer Res. 2016;76:1989-99 pubmed publisher
Jensen B, Elfwing M, Elsey R, Wang T, Crossley D. Coronary blood flow in the anesthetized American alligator (Alligator mississippiensis). Comp Biochem Physiol A Mol Integr Physiol. 2016;191:44-52 pubmed publisher
Brahimi Horn M, Lacas Gervais S, Adaixo R, Ilc K, Rouleau M, Notte A, et al. Local mitochondrial-endolysosomal microfusion cleaves voltage-dependent anion channel 1 to promote survival in hypoxia. Mol Cell Biol. 2015;35:1491-505 pubmed publisher
El Machhour F, Keuylian Z, Kavvadas P, Dussaule J, Chatziantoniou C. Activation of Notch3 in Glomeruli Promotes the Development of Rapidly Progressive Renal Disease. J Am Soc Nephrol. 2015;26:1561-75 pubmed publisher
Venkatanarayan A, Raulji P, Norton W, Chakravarti D, Coarfa C, Su X, et al. IAPP-driven metabolic reprogramming induces regression of p53-deficient tumours in vivo. Nature. 2015;517:626-30 pubmed publisher
Chowdhury P, Lin G, Liu K, Song Y, Lin F, Lin W. Targeting TopBP1 at a convergent point of multiple oncogenic pathways for cancer therapy. Nat Commun. 2014;5:5476 pubmed publisher
Lu H, Yan C, Quan X, Yang X, Zhang J, Bian Y, et al. CK2 phosphorylates and inhibits TAp73 tumor suppressor function to promote expression of cancer stem cell genes and phenotype in head and neck cancer. Neoplasia. 2014;16:789-800 pubmed publisher
Bale S, Golberg I, Jindal R, McCarty W, Luitje M, Hegde M, et al. Long-term coculture strategies for primary hepatocytes and liver sinusoidal endothelial cells. Tissue Eng Part C Methods. 2015;21:413-22 pubmed publisher
Nakadate K, Motojima K, Tanaka Nakadate S. Dilatation of sinusoidal capillary and swelling of sinusoidal fenestration in obesity: an ultrastructural study. Ultrastruct Pathol. 2015;39:30-7 pubmed publisher
Zoric A, Horvat A, Slade N. Differential effects of diverse p53 isoforms on TAp73 transcriptional activity and apoptosis. Carcinogenesis. 2013;34:522-9 pubmed publisher
Malatesta M, Peschiaroli A, Memmi E, Zhang J, Antonov A, Green D, et al. The Cul4A-DDB1 E3 ubiquitin ligase complex represses p73 transcriptional activity. Oncogene. 2013;32:4721-6 pubmed publisher
Santag S, Jager W, Karsten C, Kati S, Pietrek M, Steinemann D, et al. Recruitment of the tumour suppressor protein p73 by Kaposi's Sarcoma Herpesvirus latent nuclear antigen contributes to the survival of primary effusion lymphoma cells. Oncogene. 2013;32:3676-85 pubmed publisher
Brune M, Muller M, Melino G, Bierhaus A, Schilling T, Nawroth P. Depletion of the receptor for advanced glycation end products (RAGE) sensitizes towards apoptosis via p53 and p73 posttranslational regulation. Oncogene. 2013;32:1460-8 pubmed publisher
Zhou M, Xu A, Tam P, Lam K, Huang B, Liang Y, et al. Upregulation of UCP2 by adiponectin: the involvement of mitochondrial superoxide and hnRNP K. PLoS ONE. 2012;7:e32349 pubmed publisher
Hu X, Wu N, Xia P, Yu S, Sun F, Chen J. Correlation between low-level expression of the tumor suppressor gene TAp73 and the chemoresistance of human glioma stem cells. Cancer Chemother Pharmacol. 2012;69:1205-12 pubmed publisher
Agostini M, Tucci P, Steinert J, Shalom Feuerstein R, Rouleau M, Aberdam D, et al. microRNA-34a regulates neurite outgrowth, spinal morphology, and function. Proc Natl Acad Sci U S A. 2011;108:21099-104 pubmed publisher
Jankowski V, Tölle M, Santos R, Günthner T, Krause E, Beyermann M, et al. Angioprotectin: an angiotensin II-like peptide causing vasodilatory effects. FASEB J. 2011;25:2987-95 pubmed publisher
Mair W. Doubling the dose. PLoS Biol. 2011;9:e1001017 pubmed publisher
Tebbi A, Guittet O, Cottet M, Vesin M, Lepoivre M. TAp73 induction by nitric oxide: regulation by checkpoint kinase 1 (CHK1) and protection against apoptosis. J Biol Chem. 2011;286:7873-84 pubmed publisher
Kruewel T, Schenone S, Radi M, Maga G, Rohrbeck A, Botta M, et al. Molecular characterization of c-Abl/c-Src kinase inhibitors targeted against murine tumour progenitor cells that express stem cell markers. PLoS ONE. 2010;5:e14143 pubmed publisher
Tonino S, van Laar J, Van Oers M, Wang J, Eldering E, Kater A. ROS-mediated upregulation of Noxa overcomes chemoresistance in chronic lymphocytic leukemia. Oncogene. 2011;30:701-13 pubmed publisher
Klein A, Maldonado C, Vargas L, Gonzalez M, Robledo F, Perez de Arce K, et al. Oxidative stress activates the c-Abl/p73 proapoptotic pathway in Niemann-Pick type C neurons. Neurobiol Dis. 2011;41:209-18 pubmed publisher
Wierda W, Castro J, Aguillon R, Sampath D, Jalayer A, McMannis J, et al. A phase I study of immune gene therapy for patients with CLL using a membrane-stable, humanized CD154. Leukemia. 2010;24:1893-900 pubmed publisher
Arfaoui A, Kriaa L, El Hadj O, Ben Hmida M, Khiari M, Khalfallah T, et al. Association of a p73 exon 2 GC/AT polymorphism with colorectal cancer risk and survival in Tunisian patients. Virchows Arch. 2010;457:359-68 pubmed publisher
Ma Y, Yu W, Trump D, Johnson C. 1,25D3 enhances antitumor activity of gemcitabine and cisplatin in human bladder cancer models. Cancer. 2010;116:3294-303 pubmed publisher
Cho M, Chan I, Flores E. ?Np63 transcriptionally regulates brachyury, a gene with diverse roles in limb development, tumorigenesis and metastasis. Cell Cycle. 2010;9:2434-41 pubmed
Rosenbluth J, Johnson K, Tang L, Triplett T, Pietenpol J. Evaluation of p63 and p73 antibodies for cross-reactivity. Cell Cycle. 2009;8:3702-6 pubmed
Alonso R, Lopez Guerra M, Upshaw R, Bantia S, Smal C, Bontemps F, et al. Forodesine has high antitumor activity in chronic lymphocytic leukemia and activates p53-independent mitochondrial apoptosis by induction of p73 and BIM. Blood. 2009;114:1563-75 pubmed publisher
Marqués García F, Ferrandiz N, Fernández Alonso R, González Cano L, Herreros Villanueva M, Rosa Garrido M, et al. p73 plays a role in erythroid differentiation through GATA1 induction. J Biol Chem. 2009;284:21139-56 pubmed publisher
Liu K, Bellam N, Lin H, Wang B, Stockard C, Grizzle W, et al. Regulation of p53 by TopBP1: a potential mechanism for p53 inactivation in cancer. Mol Cell Biol. 2009;29:2673-93 pubmed publisher
Tomasini R, Tsuchihara K, Tsuda C, Lau S, Wilhelm M, Rufini A, et al. TAp73 regulates the spindle assembly checkpoint by modulating BubR1 activity. Proc Natl Acad Sci U S A. 2009;106:797-802 pubmed publisher
Sampath D, Calin G, Puduvalli V, Gopisetty G, Taccioli C, Liu C, et al. Specific activation of microRNA106b enables the p73 apoptotic response in chronic lymphocytic leukemia by targeting the ubiquitin ligase Itch for degradation. Blood. 2009;113:3744-53 pubmed publisher
Ma Y, Yu W, Hershberger P, Flynn G, Kong R, Trump D, et al. 1alpha,25-Dihydroxyvitamin D3 potentiates cisplatin antitumor activity by p73 induction in a squamous cell carcinoma model. Mol Cancer Ther. 2008;7:3047-55 pubmed publisher
Marinovic Terzic I, Yoshioka Yamashita A, Shimodaira H, Avdievich E, Hunton I, Kolodner R, et al. Apoptotic function of human PMS2 compromised by the nonsynonymous single-nucleotide polymorphic variant R20Q. Proc Natl Acad Sci U S A. 2008;105:13993-8 pubmed publisher
Rosenbluth J, Mays D, Pino M, Tang L, Pietenpol J. A gene signature-based approach identifies mTOR as a regulator of p73. Mol Cell Biol. 2008;28:5951-64 pubmed publisher
Alvarez A, Klein A, Castro J, Cancino G, Amigo J, Mosqueira M, et al. Imatinib therapy blocks cerebellar apoptosis and improves neurological symptoms in a mouse model of Niemann-Pick type C disease. FASEB J. 2008;22:3617-27 pubmed publisher
Lunghi P, Giuliani N, Mazzera L, Lombardi G, Ricca M, Corradi A, et al. Targeting MEK/MAPK signal transduction module potentiates ATO-induced apoptosis in multiple myeloma cells through multiple signaling pathways. Blood. 2008;112:2450-62 pubmed publisher
Cancino G, Toledo E, Leal N, Hernandez D, Yévenes L, Inestrosa N, et al. STI571 prevents apoptosis, tau phosphorylation and behavioural impairments induced by Alzheimer's beta-amyloid deposits. Brain. 2008;131:2425-42 pubmed publisher
Li L, Morales J, Hwang A, Wagner M, Boothman D. DNA mismatch repair-dependent activation of c-Abl/p73alpha/GADD45alpha-mediated apoptosis. J Biol Chem. 2008;283:21394-403 pubmed publisher
Mor I, Sklan E, Podoly E, Pick M, Kirschner M, Yogev L, et al. Acetylcholinesterase-R increases germ cell apoptosis but enhances sperm motility. J Cell Mol Med. 2008;12:479-95 pubmed publisher
Kurihara A, Nagoshi H, Yabuki M, Okuyama R, Obinata M, Ikawa S. Ser46 phosphorylation of p53 is not always sufficient to induce apoptosis: multiple mechanisms of regulation of p53-dependent apoptosis. Genes Cells. 2007;12:853-61 pubmed
Bozzetti C, Nizzoli R, Musolino A, Martella E, Crafa P, Lagrasta C, et al. p73 and p53 pathway in human breast cancers. J Clin Oncol. 2007;25:1451-3; author reply 1453-4 pubmed
Limesand K, Schwertfeger K, Anderson S. MDM2 is required for suppression of apoptosis by activated Akt1 in salivary acinar cells. Mol Cell Biol. 2006;26:8840-56 pubmed
Thottassery J, Westbrook L, Someya H, Parker W. c-Abl-independent p73 stabilization during gemcitabine- or 4'-thio-beta-D-arabinofuranosylcytosine-induced apoptosis in wild-type and p53-null colorectal cancer cells. Mol Cancer Ther. 2006;5:400-10 pubmed
Dominguez G, Garcia J, Peña C, Silva J, Garcia V, Martínez L, et al. DeltaTAp73 upregulation correlates with poor prognosis in human tumors: putative in vivo network involving p73 isoforms, p53, and E2F-1. J Clin Oncol. 2006;24:805-15 pubmed
Cui R, Nguyen T, Taube J, Stratton S, Feuerman M, Barton M. Family members p53 and p73 act together in chromatin modification and direct repression of alpha-fetoprotein transcription. J Biol Chem. 2005;280:39152-60 pubmed
Sayan A, Paradisi A, Vojtesek B, Knight R, Melino G, Candi E. New antibodies recognizing p73: comparison with commercial antibodies. Biochem Biophys Res Commun. 2005;330:186-93 pubmed
Bernassola F, Salomoni P, Oberst A, Di Como C, Pagano M, Melino G, et al. Ubiquitin-dependent degradation of p73 is inhibited by PML. J Exp Med. 2004;199:1545-57 pubmed
Frasca F, Vella V, Aloisi A, Mandarino A, Mazzon E, Vigneri R, et al. p73 tumor-suppressor activity is impaired in human thyroid cancer. Cancer Res. 2003;63:5829-37 pubmed
Vella V, Zhu J, Frasca F, Li C, Vigneri P, Vigneri R, et al. Exclusion of c-Abl from the nucleus restrains the p73 tumor suppression function. J Biol Chem. 2003;278:25151-7 pubmed
Shimodaira H, Yoshioka Yamashita A, Kolodner R, Wang J. Interaction of mismatch repair protein PMS2 and the p53-related transcription factor p73 in apoptosis response to cisplatin. Proc Natl Acad Sci U S A. 2003;100:2420-5 pubmed
product information
master code :
NB110-68095
SKU :
NB110-68095
product name :
Hepatic Sinusoidal Endothelial Cells Antibody (SE-1) - BSA Free
unit size :
0.1 ml (also 0.025 ml)
description :
The Hepatic Sinusoidal Endothelial Cells Antibody (SE-1) - BSA Free from Novus is a mouse monoclonal antibody to Hepatic Sinusoidal Endothelial Cells. This antibody reacts with human,mouse,rat. The Hepatic Sinusoidal Endothelial Cells Antibody (SE-1) - BSA Free has been validated for the following applications: IF/IHC,Flow Cytometry,Immunohistochemistry,Western Blot,Immunohistochemistry-Paraffin,Immunocytochemistry/ Immunofluorescence,Immunohistochemistry-Frozen.
target :
Hepatic Sinusoidal Endothelial Cells
category :
Primary Antibodies
buffer :
PBS
clonality :
Monoclonal
clone :
SE-1
concentration :
1 mg/ml
conjugate :
Unconjugated
host :
Mouse
immunogen :
Rat Hepatic Sinusoidal Endothelial Cells
isotype :
IgG2a Kappa
purity :
Protein A purified
species :
Human,Mouse,Rat
Antibody validation :
Biological Validation
applications :
IF/IHC,Flow Cytometry,Immunohistochemistry,Western Blot,Immunohistochemistry-Paraffin,Immunocytochemistry/ Immunofluorescence,Immunohistochemistry-Frozen
USD :
399 USD
alt names :
Hepatic cells, Hepatic Sinusoidal Endothelial Cells, HSE, SE1, Sinusoidal Endothelial Cells
storage :
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
more info or order :
company information
Novus Biologicals
10771 E Easter Ave
Centennial, CO 80112
novus@novusbio.com
https://www.novusbio.com
3037301950
headquarters: USA
Novus Biologicals licenses, manufactures, and markets antibodies to over 20,000 unique targets to support a wide array of research areas. Novus is built on honesty, collaboration and strong relationships and continues to provide quality tools that accelerate research. Every product is backed by our 100% guarantee.